Enhanced accumulation of glycogen, lipids and polyhydroxybutyrate under optimal nutrients and light intensities in the cyanobacterium Synechocystis sp. PCC 6803
Abstract
AIMS: Glycogen (GL) and lipids (LP) are efficient biofuel substrates, whereas polyhydroxybutyrate (PHB) is a potent biodegradable plastic. This study aimed to increase accumulation of these three compounds in Synechocystis sp. PCC 6803. METHODS AND RESULTS: Under autophototrophic growth, co-accumulation of the three compounds reached maximum level in a mid-stationary phase at 39·2% of dry weight (22·7% GL, 14·1% LP and 2·4% PHB). Nitrogen deprivation increased this to 61·5% (36·8% GL, 11·2% LP and 13·5% PHB), higher than that achieved by phosphorus, sulfur, iron or calcium deprivation. Combining nitrogen deprivation with 0·4% (w/v) glucose addition for heterophototrophic growth and optimizing the light intensity (200 μmol photons m(-2) s(-1) ) synergistically enhanced combined accumulation to 71·1% of biomass (41·3% GL, 16·7% LP and 13·1% PHB), a higher level than previously reported in Synechocystis. However, the maximum coproductivity of GL, LP and PHB (at 0·72 g l(-1) ) was obtained in the 12-day heterophototrophic culture without nitrogen deprivation. CONCLUSION: Accumulation of GL, LP and PHB was enhanced under both autophototrophic and heterophototrophic conditions by optimizations of nutrient and light supplies. SIGNIFICANCE AND IMPACT OF THE STUDY: This study provides a means for increasing co-production of potent bioenergy substrates and useful biomaterials in Synechocystis which may also be applicable to other cyanobacteria.
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Glycogen can be degraded via enzymatic hydrolysis (saccharification) and fermented into bioethanol.
“This polysaccharide can be degraded via enzymatic hydrolysis (saccharification) and fermented into bioethanol [28].”
From Arthrospira platensis as a Feasible Feedstock for Bioethanol Production (2021) · cites this paper as [28]
Monshupanee and Incharoensakdi found that total glycogen content increased from 15.1 to 28.9% DW under phosphorus deprivation, with biomass production not compromised.
“Another example of the enhancement in the production of glycogen via phosphorus deprivation is in Monshupanee and Incharoensakdi [28], where the total glycogen content increased from 15.1 to 28.9% DW.”
From Arthrospira platensis as a Feasible Feedstock for Bioethanol Production (2021) · cites this paper as [28]
Cites
Generic Assignments, Strain Histories and Properties of Pure Cultures of Cyanobacteria
Rippka, R., Stanier, R. Y., Deruelles, J., Herdman, M., & Waterbury, J. B. (1979) · Microbiology · doi:10.1099/00221287-111-1-1 · Cited by 7,606 · see citing works
Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
Hu, Q., Sommerfeld, M., Jarvis, E., Ghirardi, M., Posewitz, M., Seibert, M., & Darzins, A. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03492.x · Cited by 3,745 · see citing works
Micro and macroalgal biomass: a renewable source for bioethanol
John, R. P., Anisha, G. S., Nampoothiri, K. M., & Pandey, A. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2010.06.139 · Cited by 1,090 · see citing works
From Bacterial Glycogen to Starch: Understanding the Biogenesis of the Plant Starch Granule
Ball, S. G., & Morell, M. K. (2003) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.54.031902.134927 · Cited by 748 · see citing works
A rapid chemical method for quantification of lipids separated by thin-layer chromatography
Amenta, J. S. (1964) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40251-2 · Cited by 393 · see citing works
Gründel, M., Scheunemann, R., Lockau, W., & Zilliges, Y. (2012) · Microbiology · doi:10.1099/mic.0.062950-0 · Cited by 289 · see citing works
Ball, S. G., Colleoni, C., Cenci, U., Raj, J. N., & Tirtiaux, C. (2011) · Journal of Experimental Botany · doi:10.1093/jxb/erq411 · Cited by 273 · see citing works
Cyanobacterial biofuel production
Machado, I. M. P., & Atsumi, S. (2012) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2012.03.005 · Cited by 271 · see citing works
Schwarz, R., & Forchhammer, K. (2005) · Microbiology · doi:10.1099/mic.0.27883-0 · Cited by 240 · see citing works
The Metabolic Network of Synechocystis sp. PCC 6803: Systemic Properties of Autotrophic Growth
Knoop, H., Zilliges, Y., Lockau, W., & Steuer, R. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.157198 · Cited by 195 · see citing works
Evaluation of methods to extract and quantify lipids from Synechocystis PCC 6803
Sheng, J., Vannela, R., & Rittmann, B. E. (2011) · Bioresource Technology · doi:10.1016/j.biortech.2010.08.007 · Cited by 184 · see citing works
Panda, B., Jain, P. K., Sharma, L., & Mallick, N. (2005) · Bioresource Technology · doi:10.1016/j.biortech.2005.05.013 · Cited by 165 · see citing works
Lipid Analysis: Isolation, Separation, Identification and Structural Analysis of Lipids
Dils, R. (1974) · Biochemical Society Transactions · doi:10.1042/bst0020759 · Cited by 159 · see citing works
Determination of solubility parameters for poly(3-hydroxyalkanoates)
TERADA, M., & MARCHESSAULT, R. H. (1999) · International Journal of Biological Macromolecules · doi:10.1016/s0141-8130(99)00036-7 · Cited by 154 · see citing works
Glycogen content and nitrogenase activity in Anabaena variabilis
Ernst, A., Kirschenlohr, H. L., Díez, J., & B�ger, P. (1984) · Archives of Microbiology · doi:10.1007/bf00454913 · Cited by 139 · see citing works
Panda, B., & Mallick, N. (2006) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2006.02048.x · Cited by 138 · see citing works
The Responses of Cyanobacteria to Environmental Conditions: Light and Nutrients
Grossman, A. R., Schaefer, M. R., Chiang, G. G., & Collier, J. L. (1994) · Springer eBooks · doi:10.1007/978-94-011-0227-8_21 · Cited by 137 · see citing works
Aikawa, S., Izumi, Y., Matsuda, F., Hasunuma, T., Chang, J.-S., & Kondo, A. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.01.004 · Cited by 136 · see citing works
Xu, Y., Guerra, T., Li, Z., Ludwig, M., Dismukes, G. C., & Bryant, D. A. (2012) · Metabolic Engineering · doi:10.1016/j.ymben.2012.12.002 · Cited by 132 · see citing works
Wegener, K. M., Singh, A. K., Jacobs, J., Elvitigala, T. R., Welsh, E. A., Keren, N., Gritsenko, M. A., Ghosh, B. K., Camp, D., Smith, R. D., et al. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.000109 · Cited by 124 · see citing works
Effect of iron deficiency and iron restoration on ultrastructure of Anacystis nidulans
Sherman, D. M., & Sherman, L. A. (1983) · Journal of Bacteriology · doi:10.1128/jb.156.1.393-401.1983 · Cited by 122 · see citing works
Schlebusch, M., & Forchhammer, K. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00484-10 · Cited by 121 · see citing works
The relocation of starch metabolism to chloroplasts: when, why and how
Deschamps, P., Haferkamp, I., d’Hulst, C., Neuhaus, H. E., & Ball, S. G. (2008) · Trends in Plant Science · doi:10.1016/j.tplants.2008.08.009 · Cited by 102 · see citing works
Miyake, M., Erata, M., & Asada, Y. (1996) · Journal of Fermentation and Bioengineering · doi:10.1016/s0922-338x(97)86995-4 · Cited by 102 · see citing works
Glycogen and poly- -hydroxybutyrate synthesis in Spirulina maxima
Philippis, R. D., Sili, C., & VINCENZINI, M. T. (1992) · Journal of General Microbiology · doi:10.1099/00221287-138-8-1623 · Cited by 98 · see citing works
Sharma, L., Singh, A. K., Panda, B., & Mallick, N. (2006) · Bioresource Technology · doi:10.1016/j.biortech.2006.04.016 · Cited by 97 · see citing works
Taroncher‐Oldenburg, G., Nishina, K. A., & Stephanopoulos, G. N. (2000) · Applied and Environmental Microbiology · doi:10.1128/aem.66.10.4440-4448.2000 · Cited by 89 · see citing works
Awai, K., Watanabe, H., Christoph Benning, A., & Nishida, I. (2007) · Plant and Cell Physiology · doi:10.1093/pcp/pcm134 · Cited by 86 · see citing works
Miao, X., Wu, Q., Wu, G., & Zhao, N. (2003) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2003.tb11500.x · Cited by 84 · see citing works
Poly‐β‐hydroxybutyrate accumulation in cyanobacteria under photoautotrophy
Bhati, R., Samantaray, S., Sharma, L., & Mallick, N. (2010) · Biotechnology Journal · doi:10.1002/biot.201000252 · Cited by 80 · see citing works
Singh, A. K., & Sherman, L. A. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.7.2368-2376.2005 · Cited by 75 · see citing works
Characterization of biofilm-forming cyanobacteria for biomass and lipid production
Bruno, L., Pippo, F. D., Antonaroli, S., Gismondi, A., Valentini, C., & Albertano, P. B. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05416.x · Cited by 66 · see citing works
Lipid and fatty acid composition of freshwater cyanobacteria
Sallal, A. K. J., Nimer, N. A., & Radwan, S. S. (1990) · Journal of General Microbiology · doi:10.1099/00221287-136-10-2043 · Cited by 51 · see citing works
Yoo, S., Keppel, C., Spalding, M. H., & Jane, J. (2006) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2006.11.009 · Cited by 50 · see citing works
Eberly, J. O., & Ely, R. L. (2012) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-012-1092-2 · Cited by 34 · see citing works
Effects of Light and Dark Incubation on the Lipid and Fatty Acid Composition of Marine Cyanobacteria
Al-Hasan, R. H., Ali, A., & Radwan, S. S. (1989) · Microbiology · doi:10.1099/00221287-135-4-865 · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 37 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Troschl, C., Meixner, K., & Drosg, B. (2017) · Bioengineering · doi:10.3390/bioengineering4020026 · Cited by 175 · see citing works
Khetkorn, W., Incharoensakdi, A., Lindblad, P. C., & Jantaro, S. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.05.014 · Cited by 148 · see citing works
Cyanobacteria as an eco‐friendly resource for biofuel production: A critical review
Farrokh, P., Sheikhpour, M., Kasaeian, A., Asadi, H., & Bavandi, R. (2019) · Biotechnology Progress · doi:10.1002/btpr.2835 · Cited by 125 · see citing works
Monshupanee, T., Nimdach, P., & Incharoensakdi, A. (2016) · Scientific Reports · doi:10.1038/srep37121 · Cited by 115 · see citing works
Accumulation of PHA in the Microalgae Scenedesmus sp. under Nutrient-Deficient Conditions
García, G. P., Sosa‐Hernández, J. E., Rodas-Zuluaga, L. I., Castillo-Zacarías, C., Iqbal, H. M. N., & Parra‐Saldívar, R. (2020) · Polymers · doi:10.3390/polym13010131 · Cited by 117 · see citing works
Quantitative insights into the cyanobacterial cell economy
Zavřel, T., Faizi, M., Loureiro, C., Poschmann, G., Stühler, K., Sinetova, M. A., Zorina, A. A., Steuer, R., & Červený, J. (2019) · eLife · doi:10.7554/elife.42508 · Cited by 114 · see citing works
Arias, D. M., Garcı́a, J., & Uggetti, E. (2019) · New Biotechnology · doi:10.1016/j.nbt.2019.09.001 · Cited by 109 · see citing works
Kaewbai-ngam, A., Incharoensakdi, A., & Monshupanee, T. (2016) · Bioresource Technology · doi:10.1016/j.biortech.2016.04.035 · Cited by 104 · see citing works
Trends and advances in sustainable bioethanol production by marine microalgae: A critical review
Maity, S., & Mallick, N. (2022) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2022.131153 · Cited by 102 · see citing works
Valorization of polyhydroxyalkanoates production process by co-synthesis of value-added products
Kumar, P., & Kim, B. S. (2018) · Bioresource Technology · doi:10.1016/j.biortech.2018.08.120 · Cited by 93 · see citing works
Yashavanth, P. R., Das, M., & Maiti, S. K. (2021) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2021.105379 · Cited by 92 · see citing works
Damrow, R., Maldener, I., & Zilliges, Y. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00966 · Cited by 84 · see citing works
López, N. I., Pettinari, M. J., Nikel, P. I., & Méndez, B. S. (2015) · Advances in applied microbiology · doi:10.1016/bs.aambs.2015.06.001 · Cited by 81 · see citing works
The state of autotrophic ethanol production in Cyanobacteria
Dexter, J., Armshaw, P., Sheahan, C., & Pembroke, J. T. (2015) · Journal of Applied Microbiology · doi:10.1111/jam.12821 · Cited by 81 · see citing works
Arias, D. M., Uggetti, E., García-Galán, M. J., & Garcı́a, J. (2018) · New Biotechnology · doi:10.1016/j.nbt.2018.01.001 · Cited by 75 · see citing works
A review of biopolymer (Poly-β-hydroxybutyrate) synthesis in microbes cultivated on wastewater
Amadu, A. A., Qiu, S., Ge, S., Addico, G. N. D., Ameka, G. K., Yu, Z., Xia, W., Abbew, A.-W., Shao, D. D., Champagne, P., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.143729 · Cited by 75 · see citing works
Depraetere, O., Deschoenmaeker, F., Badri, H., Monsieurs, P., Foubert, I., Leys, N., Wattiez, R., & Muylaert, K. (2015) · PLOS ONE · doi:10.1371/journal.pone.0132461 · Cited by 68 · see citing works
Arias, D. M., Ortíz-Sánchez, E., Okoye, P. U., Rodriguez-Rangel, H., Ortega, A. B., Longoria, A., Domínguez-Espíndola, R. B., & Sebastian, P. J. (2021) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2021.148636 · Cited by 71 · see citing works
Sirohi, R., Lee, J. S., Yu, B. S., Roh, H., & Sim, S. J. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.125751 · Cited by 64 · see citing works
Green Synthesis of Bioplastics from Microalgae: A State-of-the-Art Review
Adetunji, A. I., & Erasmus, M. (2024) · Polymers · doi:10.3390/polym16101322 · Cited by 65 · see citing works
Cyanobacterial Polyhydroxyalkanoate Production: Status Quo and Quo Vadis?
Koller, M. (2015) · Current Biotechnology · doi:10.2174/2211550104666150917010849 · Cited by 60 · see citing works
Sarnaik, A. P., Abernathy, M. H., Han, X., Ouyang, Y., Xia, K., Chen, Y., Cress, B. F., Zhang, F., Lali, A. M., Pandit, R. A., et al. (2018) · Algal Research · doi:10.1016/j.algal.2018.11.010 · Cited by 56 · see citing works
Dutt, V., & Srivastava, S. (2017) · Photosynthesis Research · doi:10.1007/s11120-017-0464-x · Cited by 55 · see citing works
Hirokawa, Y., Suzuki, I., & Hanai, T. (2014) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2014.10.005 · Cited by 53 · see citing works
Krasaesueb, N., Incharoensakdi, A., & Khetkorn, W. (2019) · Biotechnology Reports · doi:10.1016/j.btre.2019.e00345 · Cited by 53 · see citing works
Senatore, V., Rueda, E., Bellver, M., Díez-Montero, R., Ferrer, I., Zarra, T., Naddeo, V., & Garcı́a, J. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.159343 · Cited by 52 · see citing works
Gracioso, L. H., Bellan, A., Karolski, B., Cardoso, L. O. B., Perpetuo, E. A., do Nascimento, C. A. O., Giudici, R., Pizzocchero, V., Basaglia, M., & Morosinotto, T. (2020) · Bioresource Technology · doi:10.1016/j.biortech.2020.124379 · Cited by 51 · see citing works
Poly-β-hydroxybutyrate (PHB) production by Synechocystis PCC6803 from CO2: Model development
Carpine, R., Raganati, F., Olivieri, G., Hellingwerf, K. J., Pollio, A., Salatino, P., & Marzocchella, A. (2017) · Algal Research · doi:10.1016/j.algal.2017.11.011 · Cited by 47 · see citing works
Cui, J., Sun, H., Chen, R., Sun, J., Mo, G., Luan, G., & Lü, X. (2023) · Green Carbon · doi:10.1016/j.greenca.2023.11.004 · Cited by 48 · see citing works
Tarawat, S., Incharoensakdi, A., & Monshupanee, T. (2020) · Journal of Applied Phycology · doi:10.1007/s10811-020-02040-4 · Cited by 44 · see citing works
Nematollahi, M. A., Laird, D. W., Hughes, L. J., Raeisossadati, M., & Moheimani, N. R. (2020) · Algal Research · doi:10.1016/j.algal.2020.101844 · Cited by 43 · see citing works
Polymer accumulation in mixed cyanobacterial cultures selected under the feast and famine strategy
Arias, D. M., Fradinho, J. C., Uggetti, E., García, J., Oehmen, A., & Reis, M. A. M. (2018) · Algal Research · doi:10.1016/j.algal.2018.04.027 · Cited by 38 · see citing works
Challenges, progress, and future perspectives for cyanobacterial polyhydroxyalkanoate production
Rueda, E., Gonzalez-Flo, E., Mondal, S., Forchhammer, K., Arias, D. M., Ludwig, K., Drosg, B., Fritz, I., Gonzalez‐Esquer, C. R., Pacheco, S. L., et al. (2024) · Reviews in Environmental Science and Bio/Technology · doi:10.1007/s11157-024-09689-0 · Cited by 42 · see citing works
The effect of enhanced acetate influx on Synechocystis sp. PCC 6803 metabolism
Thiel, K., Vuorio, E., Aro, E., & Kallio, P. T. (2017) · Microbial Cell Factories · doi:10.1186/s12934-017-0640-x · Cited by 42 · see citing works
Taepucharoen, K., Tarawat, S., Puangcharoen, M., Incharoensakdi, A., & Monshupanee, T. (2017) · Bioresource Technology · doi:10.1016/j.biortech.2017.05.029 · Cited by 40 · see citing works
Verma, E., Singh, S. S., Niveshika, & Mishra, A. K. (2018) · International Journal of Environmental Science and Technology · doi:10.1007/s13762-018-1720-0 · Cited by 39 · see citing works
Strategies for Biosynthesis of C1 Gas-derived Polyhydroxyalkanoates: A review
Yoon, J., & Oh, M. (2021) · Bioresource Technology · doi:10.1016/j.biortech.2021.126307 · Cited by 40 · see citing works
Rueda, E., Altamira-Algarra, B., & Garcı́a, J. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.127330 · Cited by 39 · see citing works
Bioplastic production by harnessing cyanobacteria-rich microbiomes for long-term synthesis
Altamira-Algarra, B., Lage, A., Meléndez, A. L., Arnau, M., Gonzalez-Flo, E., & García, J. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176136 · Cited by 38 · see citing works
López-Pacheco, I. Y., Rodas-Zuluaga, L. I., Cuéllar‐Bermúdez, S. P., Hidalgo-Vázquez, E., Molina-Vázquez, A., Araújo, R. G., Martínez-Ruiz, M., Varjani, S., Barceló, ., Iqbal, H. M. N., et al. (2022) · Marine Drugs · doi:10.3390/md20100601 · Cited by 38 · see citing works
Kharwar, S., Bhattacharjee, S., Chakraborty, S., & Mishra, A. K. (2021) · Biologia · doi:10.1007/s11756-021-00819-5 · Cited by 35 · see citing works
Monshupanee, T., Chairattanawat, C., & Incharoensakdi, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-44729-8 · Cited by 34 · see citing works
Ofaim, S., Sulheim, S., Almaas, E., Sher, D., & Segrè, D. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.586293 · Cited by 34 · see citing works
Cyanobacterial photo-driven mixotrophic metabolism and its advantages for biosynthesis
Wan, N., Abernathy, M. H., Tang, J. K., Tang, Y., & You, L. (2015) · Frontiers of Chemical Science and Engineering · doi:10.1007/s11705-015-1521-7 · Cited by 33 · see citing works
Recovery of value-added products by mining microalgae
Liu, R., Li, S., Tu, Y., Hao, X., & Qiu, F. (2022) · Journal of Environmental Management · doi:10.1016/j.jenvman.2022.114512 · Cited by 33 · see citing works
Aboim, J. B., de Oliveira, D. T., Ferreira, J. E., Siqueira, A. S., Dall’Agnol, L. T., Filho, G. N. D. R., Gonçalves, E. C., & do Nascimento, L. A. S. (2016) · RSC Advances · doi:10.1039/c6ra23268j · Cited by 33 · see citing works
Irfan, F., Tasnim, N., Razzak, S. A., & Uddin, S. (2024) · Journal of Cleaner Production · doi:10.1016/j.jclepro.2024.144576 · Cited by 35 · see citing works
Methods for Extraction of Valuable Products from Microalgae Biomass
Salinas‐Salazar, C., García‐Pérez, J. S., Chandra, R., Castillo-Zacarías, C., Iqbal, H. M. N., & Parra‐Saldívar, R. (2019) · Springer eBooks · doi:10.1007/978-981-13-2264-8_11 · Cited by 31 · see citing works
Production of 1,2‐propanediol in photoautotrophic Synechocystis is linked to glycogen turn‐over
David, C., Schmid, A., Adrian, L., Wilde, A., & Bühler, K. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26468 · Cited by 31 · see citing works
Phalanisong, P., Plangklang, P., & Reungsang, A. (2021) · Molecules · doi:10.3390/molecules26247613 · Cited by 29 · see citing works
Velmurugan, R., & Incharoensakdi, A. (2018) · Plant and Cell Physiology · doi:10.1093/pcp/pcy121 · Cited by 29 · see citing works
Diversity of Polysaccharides in Cyanobacteria
Bhatnagar, M., & Bhatnagar, A. (2019) · Springer eBooks · doi:10.1007/978-981-13-8315-1_15 · Cited by 29 · see citing works
Velmurugan, R., & Incharoensakdi, A. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00074 · Cited by 28 · see citing works
Rueda, E., Gonzalez-Flo, E., Roca, L., Carretero, J., & Garcı́a, J. (2022) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2022.107952 · Cited by 28 · see citing works
Chotchindakun, K., ., W. P.-A., Dumri, K., Ruangsuriya, J., Pumas, C., & Pekkoh, J. (2021) · Plants · doi:10.3390/plants10030503 · Cited by 27 · see citing works
Wu, H., Chen, S., Ji, M., Chen, Q., Shi, J., & Sun, J. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.02.004 · Cited by 26 · see citing works
Singhon, P., Phoraksa, O., Incharoensakdi, A., & Monshupanee, T. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02494-0 · Cited by 25 · see citing works
Mariotto, M., Egloff, S., Fritz, I., & Refardt, D. (2023) · Algal Research · doi:10.1016/j.algal.2023.103013 · Cited by 25 · see citing works
Arias, D. M., Uggetti, E., & Garcı́a, J. (2020) · Algal Research · doi:10.1016/j.algal.2020.102042 · Cited by 25 · see citing works
Glycogen Production in Marine Cyanobacterial Strain Synechococcus sp. NKBG 15041c
Badary, A., Takamatsu, S., Nakajima, M., Ferri, S. R., Lindblad, P. C., & Sode, K. (2018) · Marine Biotechnology · doi:10.1007/s10126-017-9792-2 · Cited by 24 · see citing works
Kato, Y., Hidese, R., Matsuda, M., Ohbayashi, R., Ashida, H., Kondo, A., & Hasunuma, T. (2024) · Communications Biology · doi:10.1038/s42003-024-05929-9 · Cited by 23 · see citing works
Andrews, F., Faulkner, M., Toogood, H. S., & Scrutton, N. S. (2021) · Biotechnology for Biofuels · doi:10.1186/s13068-021-02091-w · Cited by 23 · see citing works
Arthrospira platensis as a Feasible Feedstock for Bioethanol Production
Gonzalez Bautista, E., & Laroche, C. (2021) · Applied Sciences · doi:10.3390/app11156756 · Cited by 22 · see citing works
Polyhydroxyalkanoates production from microalgae for sustainable bioplastics: A review
Ilhami, S., Rahman, S. N. S. A., Iqhrammullah, M., Hamid, Z., Chai, Y. H., & Lam, M. K. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108529 · Cited by 24 · see citing works
Hirai, K., Nojo, M., Sato, Y., Tsuzuki, M., & Sato, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-56520-w · Cited by 21 · see citing works
Meixner, K., Daffert, C., Dalnodar, D., Mrázová, K., Hrubanová, K., Krzyžánek, V., Nebesářová, J., Samek, O., Sedrlova, Z., Slaninová, E., et al. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02693-3 · Cited by 21 · see citing works
Altamira-Algarra, B., Lage, A., Garcı́a, J., & Gonzalez-Flo, E. (2024) · Algal Research · doi:10.1016/j.algal.2024.103469 · Cited by 19 · see citing works
Velmurugan, R., & Incharoensakdi, A. (2017) · Biochemical Engineering Journal · doi:10.1016/j.bej.2017.02.012 · Cited by 21 · see citing works
Mock, M., Schmid, A., & Bühler, K. (2019) · Algal Research · doi:10.1016/j.algal.2019.101645 · Cited by 21 · see citing works
Krasaesueb, N., Promariya, A., Raksajit, W., & Khetkorn, W. (2021) · Journal of Applied Phycology · doi:10.1007/s10811-021-02460-w · Cited by 21 · see citing works
Nur, M. M. A. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02738-7 · Cited by 20 · see citing works
“Bioplastics from microalgae”—Polyhydroxyalkanoate production by cyanobacteria
Koller, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818536-0.00022-1 · Cited by 20 · see citing works
Sathiyanarayanan, G., & Esteves, S. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1545438 · Cited by 20 · see citing works
Kettner, A., Noll, M., & Griehl, C. (2022) · Biomolecules · doi:10.3390/biom12040504 · Cited by 18 · see citing works
Sangtani, R., Nogueira, R., Yadav, A. K., & Bala, K. (2023) · Journal of Polymers and the Environment · doi:10.1007/s10924-023-02787-0 · Cited by 18 · see citing works
Velmurugan, R., & Incharoensakdi, A. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00148 · Cited by 18 · see citing works
Velmurugan, R., & Incharoensakdi, A. (2019) · Renewable Energy · doi:10.1016/j.renene.2019.07.025 · Cited by 18 · see citing works
Compatible solutes profiling and carbohydrate feedstock from diversified cyanobacteria
Keshari, N., Gugger, M. F., Zhu, T., & Lü, X. (2019) · Algal Research · doi:10.1016/j.algal.2019.101637 · Cited by 18 · see citing works
Screening cyanobacteria from marine coastal waters of Thailand for biohydrogen production
Tinpranee, N., Incharoensakdi, A., & Phunpruch, S. (2018) · Journal of Applied Phycology · doi:10.1007/s10811-018-1490-6 · Cited by 18 · see citing works
Cyanobacteria-based microbial cell factories for production of industrial products
Hamouda, R. A., & El‐Naggar, N. E. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821477-0.00007-6 · Cited by 20 · see citing works
Mishra, P., & Panda, B. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126503 · Cited by 16 · see citing works
Ángeles, R., Arnáiz, E., Gutiérrez, J., Muñoz, R., & Lebrero, R. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.129885 · Cited by 15 · see citing works
Spennati, E., Casazza, A. A., Converti, A., & Busca, G. (2023) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-023-04118-8 · Cited by 15 · see citing works
Altamira-Algarra, B., Garcı́a, J., & Gonzalez-Flo, E. (2025) · Bioresource Technology · doi:10.1016/j.biortech.2025.132231 · Cited by 14 · see citing works
Mahawar, L., Pandey, A., Ramasamy, K. P., Pandey, S., & Prasad, S. M. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02791-2 · Cited by 13 · see citing works
Yashavanth, P. R., & Maiti, S. K. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128067 · Cited by 13 · see citing works
Review of recent advances in improvement strategies for biofuels production from cyanobacteria
de Mescouto, V. A., Ferreira, L. D. C., Paiva, R. D. J., de Oliveira, D. T., de Oliveira, M. S., Filho, G. N. D. R., Luque, R., Noronha, R. C. R., & do Nascimento, L. A. S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40293 · Cited by 14 · see citing works
Altamira-Algarra, B., Sun, L., León, D. S., Romero-Morillo, L., Vurro, L., Nogales, J., Gonzalez-Flo, E., & Garcı́a, J. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.164196 · Cited by 12 · see citing works
Iron reduction by the cyanobacterium Synechocystis sp. PCC 6803
Thorne, R. J., Schneider, K., Hu, H., & Cameron, P. J. (2015) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2015.05.015 · Cited by 12 · see citing works
Velmurugan, R., & Incharoensakdi, A. (2017) · Fuel · doi:10.1016/j.fuel.2017.08.073 · Cited by 12 · see citing works
Synthetic Gene Regulation in Cyanobacteria
Immethun, C. M., & Moon, T. S. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-0854-3_13 · Cited by 12 · see citing works
Velmurugan, R., & Incharoensakdi, A. (2016) · Algal Research · doi:10.1016/j.algal.2016.07.018 · Cited by 11 · see citing works
Pichaiyotinkul, P., Ruankaew, N., Incharoensakdi, A., & Monshupanee, T. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03476-1 · Cited by 10 · see citing works
Kaewbai-ngam, J., Sukkasam, N., Phoraksa, O., Incharoensakdi, A., & Monshupanee, T. (2022) · Journal of Applied Phycology · doi:10.1007/s10811-022-02759-2 · Cited by 10 · see citing works
Sukkasam, N., Incharoensakdi, A., & Monshupanee, T. (2022) · Plant and Cell Physiology · doi:10.1093/pcp/pcac100 · Cited by 10 · see citing works
Mudtham, N.-A., Promariya, A., Duangsri, C., Maneeruttanarungroj, C., Ngamkala, S., Akrimajirachoote, N., Powtongsook, S., Salminen, T. A., & Raksajit, W. (2024) · Biology · doi:10.3390/biology13020127 · Cited by 9 · see citing works
Sukkasam, N., Incharoensakdi, A., & Monshupanee, T. (2021) · Plant and Cell Physiology · doi:10.1093/pcp/pcab156 · Cited by 9 · see citing works
Improvement of polyhydroxybutyrate production by deletion of csrA in Escherichia coli
Wu, H., Li, S., Ji, M., Chen, Q., Shi, J., Blamey, J. M., & Sun, J. (2020) · Electronic Journal of Biotechnology · doi:10.1016/j.ejbt.2020.04.005 · Cited by 7 · see citing works
Maity, S., & Mallick, N. (2024) · Bioresource Technology · doi:10.1016/j.biortech.2024.131209 · Cited by 7 · see citing works
Sukkasam, N., Leksingto, J., Incharoensakdi, A., & Monshupanee, T. (2022) · Plant and Cell Physiology · doi:10.1093/pcp/pcac136 · Cited by 7 · see citing works
- Authors
- Monshupanee, T., & Incharoensakdi, A.
- Affiliations
- Chulalongkorn University (TH)
- Corresponding author
- Monshupanee, T.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-12-19
- Volume
- 116
- Issue
- 4
- Pages
- 830-838
- ISSN
- 1364-5072 (ISSN-L)
- OpenAlex
- W2037601555
- Cited by
- 133
- References
- 37
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 20 · 2023: 10 · 2022: 16 · 2021: 17 · 2020: 9 · 2019: 14 · 2018: 10 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 1
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Thailand Research Fund (MRG 5480109)
- Ratchadaphiseksomphot Endowment Fund of Chulalongkorn University (RES560530096-AM)
- National Research Council of Thailand
- Office of Higher Education Commission
- National Research University (FW 0659A)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Environmental Science › Environmental Chemistry › Aquatic Ecosystems and Phytoplankton Dynamics
- Keywords
- Synechocystis sp. PCC 6803, glycogen accumulation, lipid accumulation, polyhydroxybutyrate, nitrogen starvation, glucose supplementation, light intensity optimization, autotrophic growth, heterotrophic growth, biodegradable plastics, cyanobacteria
- MeSH terms
- Darkness, Glucose, Glycogen, Hydroxybutyrates, Light, Biomass, Synechocystis, Lipid Metabolism, Phototrophic Processes
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