Regulatory mechanisms related to biofuel tolerance in producing microbes

Fu, Y.; Chen, L.; Zhang, W.

doi:10.1111/jam.13162

Cited by 13Microbial Metabolic Engineering and BioproductionBacterial Genetics and BiotechnologyBiofuel production and bioconversion

Regulatory mechanisms related to biofuel tolerance in producing microbes

Fu, Y., Chen, L., Zhang, W.·2016·Journal of Applied Microbiology

DOI 10.1111/jam.13162

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Abstract

Production of renewable biofuels through either native or engineered microbes has drawn significant attention in recent years, mostly due to the increasing concerns on the energy crisis and the environmental consequences of the overutilization of petroleum-based fuels. Although significant progress has been achieved thus far, further advances are still necessary in order to decrease the manufacturing cost so that the producing processes can be more competitive to petroleum fuels. Among various possible approaches, the increase in biofuel tolerance in microbes has been suggested as one aspect which is important for the success of biofuel production at industry-scale. In this article, we critically summarize recent advances in deciphering regulatory mechanisms for enhancing biofuel tolerance in various micro-organisms, focusing on functions and utilization of several well-studied regulatory mechanisms in microbes, such as two-component signal transduction systems, sigma factors, transcription factors, noncoding RNA and other regulators.

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Due to complexity of sugar utilization and stress resistance traits involving multiple levels of genes, proteins, regulatory factors, and stress behaviors, it is difficult to achieve the desired result through simple genetic or metabolic engineering.
“Due to the complexity of sugar utilization and stress resistance traits, which involve multiple levels of genes, proteins, regulatory factors, and stress behaviors, it is difficult to achieve the desired result through simple genetic or metabolic engineering [89].”
From Recent Developments in Lignocellulosic Biofuels, a Renewable Source of Bioenergy (2022) · cites this paper as [89]

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Authors: Fu, Y., Chen, L., & Zhang, W.
Affiliations: Tianjin University (CN)
Corresponding author: Chen, L.
ORCID: Fu, Y.
Venue: Journal of Applied Microbiology
Publisher: Oxford University Press (OUP)
Published: 2016-06-28
Volume: 121
Issue: 2
Pages: 320-332
ISSN: 1364-5072 (ISSN-L)
DOI: 10.1111/jam.13162
OpenAlex: W2342639597
Cited by: 13
References: 103
Citations by year: 2025: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1
FWCI: 0.09
Type: journal article
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Applied Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Basic Research Program of China (2014CB745101)
National High-tech RD Program of China (2012AA02A707)
National Natural Science Foundation of China (31470217)
Natural Science Foundation of Tianjin City (15JCZDJC32500)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
Keywords: regulatory mechanisms, two-component systems, sigma factor, transcription factors, non-coding RNA, engineered microorganisms, renewable biofuels
MeSH terms: Butanols, Escherichia coli, Signal Transduction, Synechocystis, Clostridium acetobutylicum, Biofuels, Bioengineering

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Regulatory mechanisms related to biofuel tolerance in producing microbes

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