Comparison of QT Interval Readings in Normal Sinus Rhythm Between a Smartphone Heart Monitor and a 12‐Lead ECG for Healthy Volunteers and Inpatients Receiving Sotalol or Dofetilide
Abstract
QT Interval Readings With a Smartphone Heart Monitor: Introduction: A variety of medications ranging from antiarrhythmics to psychotropics, as well as conditions such as bradycardia, can prolong the QT interval, increasing the risk for life‐threatening arrhythmias. Monitoring the corrected QT interval (QTc) is therefore critical for patient safety. The recent development of smart phone heart monitors (SHM) may allow for easier QTc monitoring. We sought to evaluate the accuracy of an SHM for assessing the QTc, as compared to the standard 12‐lead ECG. Methods and Results: We compared the QTc interval in lead‐I and lead‐II between an SHM and 12‐lead ECG. Healthy volunteers and hospitalized patients in sinus rhythm being loaded on dofetilide or sotalol were included. Manual and automatic measurements were studied. Across 99 healthy volunteers, the SHM QTc demonstrated good agreement (bias = 4 milliseconds, standard deviation of bias = 11 milliseconds) compared to the 12‐lead ECG, using the Bland–Altman method of agreement. Across all hospitalized patients, the SHM was capable of demonstrating QTc prolongation. Between the 12‐lead ECG and SHM, lead‐I measurements had reasonable agreement (bias = 3 milliseconds, standard deviation of bias = 46 milliseconds). A QTc of > 500 milliseconds was associated with a higher likelihood (OR = 12.0; 95% CI 1.5–111.4; P = 0.02) to not achieve perfect agreement. Conclusion: The SHM is accurate in measuring QTc interval in sinus rhythm when compared to 12‐lead ECG in healthy volunteers. For patients receiving QT prolonging antiarrhythmics, SHM is capable of detecting QTc prolongation, and lead‐I of the SHM is most accurate in measuring the QTc if < 500 milliseconds.
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In Garabelli et al., Alivecor is accurate in measuring QTc interval (P < .01).
“Alivecor is accurate in measuring QTc interval (P < .01)”
From Portable out-of-hospital electrocardiography: A review of current technologies (2018) · cites this paper as [13]
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- Authors
- GARABELLI, P., STAVRAKIS, S., ALBERT, M., KOOMSON, E., PARWANI, P., CHOHAN, J., SMITH, L., ALBERT, D., XIE, R., XIE, Q., REYNOLDS, D., & PO, S.
- Affiliations
- University of Oklahoma Health Sciences Center (US)
- AliveCor Oklahoma City Oklahoma USA
- Corresponding author
- GARABELLI, PAUL
- Venue
- Journal of Cardiovascular Electrophysiology
- Publisher
- Wiley
- Published
- 2016-04-29
- Volume
- 27
- Issue
- 7
- Pages
- 827-832
- ISSN
- 1045-3873 (ISSN-L)
- 1540-8167
- OpenAlex
- W2316598919
- Cited by
- 98
- References
- 24
- Citations by year
- 2025: 5 · 2024: 8 · 2023: 9 · 2022: 5 · 2021: 28 · 2020: 24 · 2019: 8 · 2018: 7 · 2017: 2 · 2016: 2
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- QTc interval, QTc prolongation, 12-lead ECG, sotalol, dofetilide, QT prolongation, antiarrhythmic drugs, arrhythmia risk, measurement agreement, lead I, hospitalized patients, healthy volunteers
- MeSH terms
- Smartphone, Action Potentials, Aged, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Electrocardiography, Female, Heart Rate, Humans, Inpatients, Male, Middle Aged, Phenethylamines, Predictive Value of Tests, Sotalol, Sulfonamides, Reproducibility of Results, Case-Control Studies, Mobile Applications, Healthy Volunteers
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