Prevention of Torsade de Pointes in Hospital Settings: A Scientific Statement From the American Heart Association and the American College of Cardiology Foundation
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QTc values > 500 ms have been associated with an increased prevalence of torsades de pointes and other arrhythmias.
“This is clinically relevant as QTc values > 500 ms have been associated with an increased prevalence of torsades de pointes and other arrhythmias (34).”
From Effect of Hypoglycemia on QT Interval in Individuals With and Without Type 2 Diabetes: A Randomized Crossover Trial (2025) · cites this paper as [34]
The “Premonitory ECG Signs of TdP” section states that QTc >500 ms is associated with a two- to threefold higher risk of torsades de pointes in congenital long-QT syndrome studies, with similar increased risk described in drug-induced cases. The copy does not establish that this threshold is associated with increased prevalence of other arrhythmias; the Summary lists other ventricular events as warning signs for torsades, not as outcomes associated with QTc >500 ms. Page numbers were not available in the supplied copy. (LLM, conf=0.88)
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Self-citation
- Authors
- Drew, B. J., Ackerman, M. J., Funk, M., Gibler, W. B., Kligfield, P., Menon, V., Philippides, G. J., Roden, D. M., & Zareba, W.
- Venue
- Circulation
- Published
- 2010-03-02
- Volume
- 121
- Issue
- 8
- Pages
- 1047-1060
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC3056123
- OpenAlex
- W2082072065
- Cited by
- 821
- References
- 115
- Citations by year
- 2026: 32 · 2025: 37 · 2024: 49 · 2023: 41 · 2022: 48 · 2021: 81 · 2020: 90 · 2019: 69 · 2018: 51 · 2017: 62 · 2016: 46 · 2015: 39 · 2014: 43 · 2013: 43 · 2012: 38
- FWCI
- 28.78
- Type
- journal article
- Language
- en
- Update notices
- correction (2010-08-24)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL081642)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
- Keywords
- torsades de pointes, ventricular arrhythmia prevention, hospitalized patients, antiarrhythmic drugs, QT prolongation, drug-induced arrhythmia
- MeSH terms
- Electrocardiography, Heart Rate, Hospital Units, Humans, Monitoring, Physiologic, Risk Factors, United States, Torsades de Pointes
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