Cited by 127Blood Pressure and Hypertension StudiesCardiovascular Health and Disease PreventionCircadian rhythm and melatonin

Clinical and prognostic significance of a reverse dipping pattern on ambulatory monitoring: An updated review

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Cuspidi, Cesare, Sala, Carla, Tadic, Marijana, Gherbesi, Elisa, De Giorgi, Antonio, Grassi, Guido, Mancia, Giuseppe·2017·The Journal of Clinical Hypertension

Abstract

Reverse or inverted dipping (ie, the phenomenon characterized by higher nighttime compared with daytime blood pressure values) is an alteration of circadian blood pressure rhythm frequently documented in hypertension, type 2 diabetes mellitus, chronic kidney disease, and sleep apnea syndrome, and generally regarded as a harmful condition. Available literature on the clinical and prognostic implications of reverse dipping is scanty. The present article will review a number of relevant issues concerning reverse dipping, in particular: (1) its possible mechanisms; (2) prevalence and clinical correlates, (3) concomitant cardiac and extracardiac subclinical organ damage; (4) association with acute and chronic cardiovascular diseases; (5) prognostic value in predicting cardiovascular events and mortality; and (6) therapeutic interventions aimed at reverting this abnormal circadian blood pressure rhythm.

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  1. [10]10. Ohkubo T, Imai Y, Tsuji I, et al. Relation between nocturnal decline in blood pressure and mortality. Am J Hypertens. 1997;10:1201‐1207. [DOI] [PubMed] [Google Scholar]

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Authors
Cuspidi, C., Sala, C., Tadic, M., Gherbesi, E., De Giorgi, A., Grassi, G., & Mancia, G.
Affiliations
  • IRCCS Istituto Auxologico Italiano (IT)
  • University of Milan (IT)
  • University Hospital Center Dr Dragiša Mišović (RS)
  • Hypertension Centre Hospital V. Fazzi Lecce Italy
  • MultiMedica (IT)
  • University of Milano-Bicocca (IT)
Corresponding author
Cuspidi, Cesare
Venue
The Journal of Clinical Hypertension
Publisher
Wiley
Published
2017-07
Volume
19
Issue
7
Pages
713-721
ISSN
  • 1524-6175 (ISSN-L)
  • 1751-7176
OpenAlex
W2736301653
Cited by
127
References
62
Citations by year
2026: 8 · 2025: 11 · 2024: 16 · 2023: 16 · 2022: 19 · 2021: 20 · 2020: 15 · 2019: 14 · 2018: 6 · 2017: 1
FWCI
1.39
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Hypertension (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • BOA (University of Milano-Bicocca) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords
reverse dipping, circadian blood pressure rhythm, ambulatory blood pressure monitoring, hypertension, type 2 diabetes, chronic kidney disease, sleep apnea, cardiovascular risk, cardiovascular mortality, subclinical organ damage
MeSH terms
Adolescent, Adult, Aged, Blood Pressure, Cardiovascular Diseases, Circadian Rhythm, Diabetes Mellitus, Type 2, Female, Humans, Hypertension, Male, Middle Aged, Prognosis, Sleep, Sleep Apnea Syndromes, Prevalence, Blood Pressure Monitoring, Ambulatory, Renal Insufficiency, Chronic, Young Adult

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