The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Molecular mechanisms of ferroptosis and its role in cancer therapy
Open accessAbstract
Ferroptosis is a newly defined programmed cell death process with the hallmark of the accumulation of iron‐dependent lipid peroxides. The term was first coined in 2012 by the Stockwell Lab, who described a unique type of cell death induced by the small molecules erastin or RSL3. Ferroptosis is distinct from other already established programmed cell death and has unique morphological and bioenergetic features. The physiological role of ferroptosis during development has not been well characterized. However, ferroptosis shows great potentials during the cancer therapy. Great progress has been made in exploring the mechanisms of ferroptosis. In this review, we focus on the molecular mechanisms of ferroptosis, the small molecules functioning in ferroptosis initiation and ferroptosis sensitivity in different cancers. We are also concerned with the new arising questions in this particular research area that remains unanswered.
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Citations
Cites
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
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Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
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Ferroptosis as a p53-mediated activity during tumour suppression
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A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
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Autophagy promotes ferroptosis by degradation of ferritin
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Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
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Ferroptosis as a target for protection against cardiomyopathy
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Cited by
Ferroptosis in cancer and cancer immunotherapy
Zhao, L., Zhou, X., Xie, F., Zhang, L., Yan, H., Huang, J., Zhang, C., Zhou, F., Chen, J., & Zhang, L. (2022) · Cancer Communications · doi:10.1002/cac2.12250 · Cited by 684
Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
Battaglia, A. M., Chirillo, R., Aversa, I., Sacco, A., Costanzo, F., & Biamonte, F. (2020) · Cells · doi:10.3390/cells9061505 · Cited by 561
Bai, T., Li, M., Liu, Y., Qiao, Z., & Wang, Z. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.07.026 · Cited by 532
Self-citationGPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
Liu, Y., Wan, Y., Jiang, Y., Zhang, L., & Cheng, W. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188890 · Cited by 528
Self-citationLipid composition of the cancer cell membrane
Szlasa, W., Zendran, I., Zalesińska, A., Tarek, M., & Kulbacka, J. (2020) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-020-09846-4 · Cited by 435
Metadata
- Authors
- Xu, T., Ding, W., Ji, X., Ao, X., Liu, Y., Yu, W., & Wang, J.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2019-06-24
- Volume
- 23
- Issue
- 8
- Pages
- 4900-4912
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- OpenAlex
- W2953831294
- Cited by
- 639
- References
- 100
- FWCI
- 46.62
- Type
- journal article
- Language
- en
- Open access
- gold
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- Xu, T., Ding, W., Ji, X., Ao, X., Liu, Y., Yu, W., & Wang, J. (2019). Molecular mechanisms of ferroptosis and its role in cancer therapy. Journal of Cellular and Molecular Medicine. https://doi.org/10.1111/jcmm.14511
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
