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Cited by 684Ferroptosis and cancer prognosisCell death mechanisms and regulationCancer Immunotherapy and Biomarkers

Ferroptosis in cancer and cancer immunotherapy

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Zhao, Lei, Zhou, Xiaoxue, Xie, Feng, Zhang, Lei, Yan, Haiyan, Huang, Jun, Zhang, Chong, Zhou, Fangfang +2 more·2022·Cancer Communications
DOI 10.1002/cac2.12250PMC PMC8822596
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Abstract

The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology, physiology and biochemistry. The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure. The effective rate of tumor immunotherapy as a new treatment method is less than 30%. Ferroptosis can be seen in radiotherapy, chemotherapy, and tumor immunotherapy; therefore, ferroptosis activation may be a potential strategy to overcome the drug resistance mechanism of traditional cancer treatments. In this review, the characteristics and causes of cell death by lipid peroxidation in ferroptosis are briefly described. In addition, the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized. Collectively, these findings suggest the vital role of ferroptosis in immunotherapy based on the interaction of ferroptosis with tumor immunotherapy, chemotherapy and radiotherapy, thus, indicating the remarkable potential of ferroptosis in cancer treatment.

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Cited by

Sorted by citations

Authors
Zhao, L., Zhou, X., Xie, F., Zhang, L., Yan, H., Huang, J., Zhang, C., Zhou, F., Chen, J., & Zhang, L.
Affiliations
  • Zhejiang Hospital (CN)
  • Zhejiang University (CN)
  • Soochow University (CN)
  • Ruian People's Hospital (CN)
Corresponding author
  • Zhang, Chong
  • Zhou, Fangfang
  • Chen, Jun
  • Zhang, Long
ORCID
Venue
Cancer Communications
Publisher
American Association for the Advancement of Science (AAAS)
Published
2022-02
Volume
42
Issue
2
Pages
88-116
ISSN
  • 1000-467X (ISSN-L)
  • 2523-3548
DOI
10.1002/cac2.12250
PMC
PMC8822596
OpenAlex
W4210867925
Cited by
684
References
29
Citations by year
2026: 108 · 2025: 185 · 2024: 227 · 2023: 119 · 2022: 44 · 2021: 1
FWCI
25.45
Type
journal article
Language
en
Open access
Licence
Locations
  • 癌症：英文版 (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
ferroptosis, lipid peroxidation, cancer cell death, cancer immunotherapy, chemoresistance, radiotherapy resistance, signaling crosstalk, tumor immune tolerance
MeSH terms
Ferroptosis, Humans, Immunotherapy, Neoplasms, Signal Transduction, Carcinogenesis

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