Association between diabetes mellitus/hyperglycaemia and peri‐implant diseases: Systematic review and meta‐analysis

Abstract

Aim: This systematic review investigates whether hyperglycaemia/diabetes mellitus is associated with peri‐implant diseases (peri‐implant mucositis and peri‐implantitis). Materials and Methods: Electronic and manual literature searching was conducted. An a priori case definition for peri‐implantitis was used as an inclusion criterion to minimize risk of bias. The Newcastle‐Ottawa Scale was used for quality assessment; random effect models were applied; and results were reported according to the PRISMA Statement. Results: Twelve studies were eligible for qualitative and seven of them for quantitative analyses. Meta‐analyses detected the risk of peri‐implantitis was about 50% higher in diabetes than in non‐diabetes (RR = 1.46; 95% CI: 1.21–1.77 and OR = 1.89; 95% CI: 1.31–2.46; z = 5.98; p < .001). Importantly, among non‐smokers, those with hyperglycaemia had 3.39‐fold higher risk for peri‐implantitis compared with normoglycaemia (95% CI: 1.06–10.81). Conversely, the association between diabetes and peri‐implant mucositis was not statistically significant (RR = 0.92; 95% CI: 0.72–1.16 and OR = 1.06; 95% CI: 0.84–1.27; z = 1.06, p = .29). Conclusions: Within its limits that demand great caution when interpreting its findings, this systematic review suggests that diabetes mellitus/hyperglycaemia is associated with greater risk of peri‐implantitis, independently of smoking, but not with peri‐implant mucositis.