Dental plaque-induced gingival conditions

Murakami, Shinya; Mealey, Brian L.; Mariotti, Angelo; Chapple, Iain L.C.

doi:10.1111/jcpe.12937

Cited by 358Oral microbiology and periodontitis researchOral and gingival health researchOral Health Pathology and Treatment

Dental plaque-induced gingival conditions

Open access

Murakami, Shinya, Mealey, Brian L., Mariotti, Angelo, Chapple, Iain L.C.·2018·Journal of Clinical Periodontology

DOI 10.1111/jcpe.12937

Open this paper in CoChat — free account Open PDF

Abstract

Objective: This review proposes revisions to the current classification system for gingival diseases and provides a rationale for how it differs from the 1999 classification system. Importance: Gingival inflammation in response to bacterial plaque accumulation (microbial biofilms) is considered the key risk factor for the onset of periodontitis. Thus, control of gingival inflammation is essential for the primary prevention of periodontitis. Findings: The clinical characteristics common to dental plaque–induced inflammatory gingival conditions include: a) clinical signs and symptoms of inflammation that are confined to the gingiva: b) reversibility of the inflammation by removing or disrupting the biofilm; c) the presence of a high bacterial plaque burden to initiate the inflammation; d) systemic modifying factors (e.g., hormones, systemic disorders, drugs) which can alter the severity of the plaque‐induced inflammation and; e) stable (i.e., non‐changing) attachment levels on a periodontium which may or may not have experienced a loss of attachment or alveolar bone. The simplified taxonomy of gingival conditions includes: 1) introduction of the term “incipient gingivitis;” 2) a description of the extent and severity of gingival inflammation; 3) a description of the extent and severity of gingival enlargement and; 4) a reduction of categories in the dental plaque–induced gingival disease taxonomy. Conclusions: Dental plaque–induced gingival inflammation is modified by various systemic and oral factors. The appropriate intervention is crucial for the prevention of periodontitis.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1111/jcpe.12937

Cites

104 of 104 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Periodontal Disease in Pregnancy I. Prevalence and Severity
Löe, H. A., & Silness, J. (1963) · Acta Odontologica Scandinavica · doi:10.3109/00016356309011240 · Cited by 7,234 · see citing works
The Gingival Index, the Plaque Index and the Retention Index Systems
Löe, H. (1967) · The Journal of Periodontology · doi:10.1902/jop.1967.38.6.610 · Cited by 4,247 · see citing works
Experimental gingivitis in man
Löe, H., Theilade, E., & Jensen, S. B. (1965) · The Journal of Periodontology · doi:10.1902/jop.1965.36.3.177 · Cited by 3,481 · see citing works
The pathogenesis of human periodontitis: an introduction.
Page, R., & Kornman, K. (1997) · Periodontology 2000 · doi:10.1111/j.1600-0757.1997.tb00189.x · Cited by 1,104 · see citing works
Diabetes and periodontal diseases: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases
Chapple, I. L. C., Genco, R., & on behalf of working group 2 of the joint EFP/AAP workshop (2013) · Journal of Periodontology · doi:10.1902/jop.2013.1340011 · Cited by 852 · see citing works
Self-citation
Natural history of periodontal disease in man: Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age
Löe, H., Anerud, A., Boysen, H., & Morrison, E. (1986) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1986.tb01487.x · Cited by 839 · see citing works
Molecular aspects of the pathogenesis of periodontitis
Meyle, J., & Chapple, I. (2015) · Periodontology 2000 · doi:10.1111/prd.12104 · Cited by 705 · see citing works
Self-citation
Position Paper: Epidemiology of Periodontal Diseases
Burt, B. A. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.8.1406 · Cited by 537 · see citing works
Interaction of lifestyle, behaviour or systemic diseases with dental caries and periodontal diseases: consensus report of group 2 of the joint <scp>EFP</scp> / <scp>ORCA</scp> workshop on the boundaries between caries and periodontal diseases
Chapple, I. L. C., Bouchard, P., Cagetti, M. G., Campus, G., Carra, M., Cocco, F., Nibali, L., Hujoel, P., Laine, M. L., Lingström, P., et al. (2017) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12685 · Cited by 488 · see citing works
Self-citation
The pathogenesis of drug-induced gingival overgrowth.
Seymour, R., Thomason, J., & Ellis, J. (1996) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1996.tb02072.x · Cited by 432 · see citing works
Prevalence of Periodontal Disease in Insulin-Dependent Diabetes Mellitus (Juvenile Diabetes)
Cianciola, L. J., Park, B. H., Bruck, E., Mosovich, L. L., & Genco, R. J. (1982) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1982.0240 · Cited by 396 · see citing works
Global periodontal disease epidemiology
Dye, B. A. (2011) · Periodontology 2000 · doi:10.1111/j.1600-0757.2011.00413.x · Cited by 360 · see citing works
Dental Plaque‐Induced Gingival Diseases
Mariotti, A. J. (1999) · Annals of Periodontology · doi:10.1902/annals.1999.4.1.7 · Cited by 334 · see citing works
Self-citation
Gingivitis as a risk factor in periodontal disease
Lang, N. P., Schätzle, M. A., & Löe, H. (2009) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01415.x · Cited by 332 · see citing works
The Role of the Immune System in Metabolic Health and Disease
Zmora, N., Bashiardes, S., Levy, M., & Elinav, E. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.02.006 · Cited by 323 · see citing works
Risk factors for drug‐induced gingival overgrowth
Seymour, R. A., Ellis, J. S., & Thomason, J. M. (2000) · Journal of Clinical Periodontology · doi:10.1034/j.1600-051x.2000.027004217.x · Cited by 310 · see citing works
Periodontal health
Lang, N. P., & Bartold, P. M. (2018) · Journal of Periodontology · doi:10.1002/jper.16-0517 · Cited by 302 · see citing works
Adult Dental Health Survey 2009: common oral health conditions and their impact on the population
White, D. A., Tsakos, G., Pitts, N. B., Fuller, E., Douglas, G. V. A., Murray, J. J., & Steele, J. G. (2012) · BDJ · doi:10.1038/sj.bdj.2012.1088 · Cited by 296 · see citing works
Drug-Induced Gingival Overgrowth: Old Problem, New Problem
Hassell, T. M., & Hefti, A. F. (1991) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411910020010201 · Cited by 288 · see citing works
Current perspective of the impact of smoking on the progression and treatment of periodontitis
Nociti, F. H., Casati, M. Z., & Duarte, P. M. (2015) · Periodontology 2000 · doi:10.1111/prd.12063 · Cited by 282 · see citing works
Initial observation that cyclosporin‐A induces gingival enlargement in man
Rateitschak‐Plüss, E. M., Hefti, A., Lortscher, R. H., & Thiel, G. (1983) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1983.tb01272.x · Cited by 264 · see citing works
Characteristics of 2000 patients who visited a halitosis clinic
Quirynen, M., Dadamio, J., den Velde, S. V., Smit, M. D., Dekeyser, C., Tornout, M. V., & Vandekerckhove, B. N. A. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01478.x · Cited by 261 · see citing works
The Prevalence of Inflammatory Periodontitis Is Negatively Associated with Serum Antioxidant Concentrations
Chapple, I., Milward, M. R., & Dietrich, T. (2007) · Journal of Nutrition · doi:10.1093/jn/137.3.657 · Cited by 239 · see citing works
Self-citation
Incidence of diphenylhydantoin gingival hyperplasia
Angelopoulos, A. P., & Goaz, P. W. (1972) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(72)90228-9 · Cited by 233 · see citing works
Periodontal Disease: Prevalence and Incidence
Marshall‐Day, C. D., Stephens, R. G., & Quigley, L. F. (1955) · Journal of Periodontology · doi:10.1902/jop.1955.26.3.185 · Cited by 225 · see citing works
Bacterial Community Development in Experimental Gingivitis
Kistler, J. O., Booth, V., Bradshaw, D. J., & Wade, W. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071227 · Cited by 224 · see citing works
Sex Steroid Hormones and Cell Dynamics in the Periodontium
Mariotti, A. J. (1994) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411940050010201 · Cited by 222 · see citing works
Self-citation
Primary and secondary prevention of periodontal and peri‐implant diseases
Tonetti, M. S., Chapple, I., Jepsen, S. V., & Sanz, M. (2015) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12382 · Cited by 213 · see citing works
Self-citation
Clinical and pharmacologic correlations in cyclosporine-induced gingival hyperplasia
Daley, T. D., Wysocki, G. P., & Day, C. (1986) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(86)90291-4 · Cited by 209 · see citing works
Advances in the pathogenesis of periodontitiss: Group B consensus report of the fifth European workshop in periodontology
Kinane, D. F., Attström, R., & on behalf of the European Workshop in Periodontology group B (2005) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00823.x · Cited by 205 · see citing works
Relation Between Control of Diabetes and Gingival Bleeding
Ervasti, T., Knuuttila, M. L. E., Pohjamo, L., & Haukipuro, K. (1985) · Journal of Periodontology · doi:10.1902/jop.1985.56.3.154 · Cited by 197 · see citing works
The incidence and severity of nifedipine‐induced gingival overgrowth
Barclay, S., Thomason, J. M., Idle, J. R., & Seymour, R. A. (1992) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1992.tb00650.x · Cited by 190 · see citing works
Cyclosporin and the gingival tissues
Seymour, R. A., & Jacobs, D. J. (1992) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1992.tb01140.x · Cited by 189 · see citing works
The clinical course of chronic periodontitis: IV. Gingival inflammation as a risk factor in tooth mortality
Schätzle, M., Löe, H., Lang, N. P., Bürgin, W., Ånerud, Å., & Boysen, H. (2004) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00634.x · Cited by 188 · see citing works
Clinical course of chronic periodontitis
Schätzle, M. A., Löe, H. A., Bürgin, W., Ånerud, Å., Boysen, H., & Lang, N. P. (2003) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2003.00414.x · Cited by 180 · see citing works
Cyclosporin-induced gingival overgrowth: Correlation with dental plaque scores, gingivitis scores, and cyclosporin levels in serum and saliva
McGaw, T., Lam, S., & Coates, J. (1987) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(87)90007-7 · Cited by 178 · see citing works
The influence of margins of restorations on the periodontal tissues over 26 years
Schätzle, M., Lang, N. P., Ånerud, Å., Boysen, H., Bürgin, W., & Löe, H. (2001) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2001.280109.x · Cited by 170 · see citing works
The influence of margins of restorations on the periodontal tissues over 26 years
Schätzle, M. A., Lang, N. P., Ånerud, Å., Boysen, H., Bürgin, W., & Löe, H. A. (2001) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2001.280109.x · Cited by 170 · see citing works
Gingival hyperplasia induced by cyclosporin-A
Tyldesley, W. R., & Rotter, E. (1984) · BDJ · doi:10.1038/sj.bdj.4805474 · Cited by 167 · see citing works
The influence of cigarette smoking on the development of experimental gingivitis
Bergström, J., & Preber, H. (1986) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1986.tb01504.x · Cited by 166 · see citing works
Epidemiology of gingivitis
Stamm, J. W. (1986) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1986.tb01473.x · Cited by 161 · see citing works
Pyrosequencing Analysis of Subgingival Microbiota in Distinct Periodontal Conditions
Park, O.-J., Yi, H., Jeon, J. H., Kang, S., Koo, K., Kum, K., Chun, J., Yun, C., & Han, S. H. (2015) · Journal of Dental Research · doi:10.1177/0022034515583531 · Cited by 155 · see citing works
Molecular and Clinical Aspects of Drug-induced Gingival Overgrowth
Trackman, P. C., & Kantarci, A. (2015) · Journal of Dental Research · doi:10.1177/0022034515571265 · Cited by 155 · see citing works
Periodontitis Modified by Systemic Factors
Kinane, D. F. (1999) · Annals of Periodontology · doi:10.1902/annals.1999.4.1.54 · Cited by 149 · see citing works
The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients
Seymour, R. A., Smith, D., & Rogers, S. (1987) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1987.tb01524.x · Cited by 148 · see citing works
Predictive modeling of gingivitis severity and susceptibility via oral microbiota
Huang, S. W., Li, R., Zeng, X., He, T., Zhao, H., Chang, A., Bo, C., Chen, J., Yang, F., Knight, R. D., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.32 · Cited by 145 · see citing works
Periodontal Changes in Pregnancy
Löe, H. A. (1965) · Journal of Periodontology · doi:10.1902/jop.1965.36.3.209 · Cited by 142 · see citing works
Non–plaque‐induced gingival diseases
Holmstrup, P., Plemons, J. M., & Meyle, J. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12938 · Cited by 136 · see citing works
The influence of smoking on host responses in periodontal infections
Ryder, M. I. (2007) · Periodontology 2000 · doi:10.1111/j.1600-0757.2006.00163.x · Cited by 133 · see citing works
A longitudinal study of gingivitis and puberty
Sutcliffe, P. (1972) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1972.tb00631.x · Cited by 127 · see citing works
Effect of pregnancy on gingival inflammation in systemically healthy women: a systematic review
Figuero, E., de Albornoz, A. C., Martín, C., Tobı́as, A., & Herrera, D. (2012) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12053 · Cited by 116 · see citing works
A Five Year Longitudinal Study of the Gingival Condition of a Group of Children in England
Parfitt, G. J. (1957) · Journal of Periodontology · doi:10.1902/jop.1957.28.1.26 · Cited by 113 · see citing works
Puberty Gingivitis in Insulin‐dependent Diabetic Children: I. Cross‐sectional Observations
Gusberti, F. A., Syed, S. A., Bacon, G., Grossman, N. S., & Loesche, W. J. (1983) · Journal of Periodontology · doi:10.1902/jop.1983.54.12.714 · Cited by 112 · see citing works
Hyposalivation and Xerostomia
Turner, M. D. (2016) · Dental Clinics of North America · doi:10.1016/j.cden.2015.11.003 · Cited by 108 · see citing works
Sex and the subgingival microbiome: Do female sex steroids affect periodontal bacteria?
Kumar, P. (2012) · Periodontology 2000 · doi:10.1111/j.1600-0757.2011.00398.x · Cited by 107 · see citing works
Endocrinology of sex steroid hormones and cell dynamics in the periodontium
Mariotti, A. J., & Mawhinney, M. (2012) · Periodontology 2000 · doi:10.1111/j.1600-0757.2011.00424.x · Cited by 103 · see citing works
Self-citation
Modulation of clinical expression of plaque‐induced gingivitis
Tatakis, D. N., & Trombelli, L. (2004) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00477.x · Cited by 95 · see citing works
Gingival Overgrowth in Cyclosporine A Treated Multiple Sclerosis Patients
Hefti, A. F., Eshenaur, A. E., Hassell, T. M., & Stone, C. (1994) · Journal of Periodontology · doi:10.1902/jop.1994.65.8.744 · Cited by 89 · see citing works
Prevalence of gingival overgrowth in transplant patients immunosuppressed with tacrolimus
Ellis, J. S., Seymour, R. A., Taylor, J. J., & Thomason, J. M. (2004) · Journal Of Clinical Periodontology · doi:10.1111/j.0303-6979.2004.00459.x · Cited by 89 · see citing works
Mouthbreathing, lip seal and upper lip coverage and their relationship with gingival inflammation in 11–14 year‐old schoolchildren
Wagaiyu, E. G., & Ashley, F. P. (1991) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1991.tb00112.x · Cited by 88 · see citing works
Initial Oral Manifestations of Leukemia
Lynch, M. A., & Ship, I. I. (1967) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1967.0301 · Cited by 87 · see citing works
Modulation of clinical expression of plaque‐induced gingivitis
Trombelli, L., Scapoli, C., Orlandini, E., Tosi, M., Bottega, S., & Tatakis, D. N. (2004) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2004.00479.x · Cited by 85 · see citing works
Gingival Transcriptome Patterns During Induction and Resolution of Experimental Gingivitis in Humans
Offenbacher, S., Barros, S. P., Paquette, D. W., Winston, J. L., Biesbrock, A. R., Thomason, R. G., Gibb, R., Fulmer, A. W., Tiesman, J. P., Juhlin, K. D., et al. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080645 · Cited by 83 · see citing works
Relationship between xerostomia and gingival condition in young adults
Mizutani, S., Ekuni, D., Tomofuji, T., AZUMA, T., Kataoka, K., Yamane, M., Iwasaki, Y., & Morita, M. (2014) · Journal of Periodontal Research · doi:10.1111/jre.12183 · Cited by 82 · see citing works
Diagnosis and Classification of the Periodontal Diseases
Suzuki, J. B. (1988) · Dental Clinics of North America · doi:10.1016/s0011-8532(22)00337-8 · Cited by 78 · see citing works
Gingivitis in pregnant women. A longitudinal clinical study.
Hugoson, A. (1971) · PubMed · Cited by 78 · see citing works
Periodontal Health of 14‐17‐year‐old US Schoolchildren
Bhat, M. (1991) · Journal of Public Health Dentistry · doi:10.1111/j.1752-7325.1991.tb02168.x · Cited by 75 · see citing works
Gingival health and gingivitis development during puberty
Mombelli, A., Gusberti, F. A., van Oosten, M. A. C., & Lang, N. P. (1989) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1989.tb01674.x · Cited by 73 · see citing works
Phenytoin induced gingival overgrowth in institutionalized epileptics
Hassell, T. M., O'Donnell, J., Pearlman, J. A., Tesini, D. A., Murphy, T., & Best, H. (1984) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1984.tb02214.x · Cited by 71 · see citing works
Periodontal Status During Pregnancy
Arafat, A. (1974) · Journal of Periodontology · doi:10.1902/jop.1974.45.8.2.641 · Cited by 68 · see citing works
Gingival overgrowth: Part 1: aetiology and clinical diagnosis
Beaumont, J. L., Chesterman, J., Kellett, M., & Durey, K. (2017) · BDJ · doi:10.1038/sj.bdj.2017.71 · Cited by 64 · see citing works
Label-Free Quantitative Proteomics Reveals Differentially Regulated Proteins in Experimental Gingivitis
Bostancı, N., Ramberg, P., Wåhlander, Å., Grossman, J., Jönsson, D., Barnes, V. M., & Papapanou, P. N. (2012) · Journal of Proteome Research · doi:10.1021/pr300761e · Cited by 63 · see citing works
Effects of Menstrual Cycle on Periodontal Health and Gingival Crevicular Fluid Markers
Becerik, S., Özçaka, Ö., Nalbantsoy, A., Atilla, G., Celec, P., Behuliak, M., & Emingil, G. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.090590 · Cited by 63 · see citing works
The influence of experimental gingivitis on plaque formation
Hillam, D. G., & Hull, P. S. (1977) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1977.tb01883.x · Cited by 63 · see citing works
Suppression of overt gingival inflammation in tobacco smokers – clinical and mechanistic considerations
Scott, D. A., & Singer, D. L. (2004) · International Journal of Dental Hygiene · doi:10.1111/j.1601-5037.2004.00079.x · Cited by 62 · see citing works
Scurvy: more than historical relevance.
Kc, O. (1993) · PubMed · Cited by 53 · see citing works
Gingival Inflammation and Interleukin‐1 β and Tumor Necrosis Factor‐Alpha Levels in Gingival Crevicular Fluid During the Menstrual Cycle
Başer, Ü., Çekici, A., Tanrıkulu-Küçük, S., Kantarcı, A., Ademoğlu, E., & Yalçın, F. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.090076 · Cited by 52 · see citing works
Gingival tissue transcriptomes in experimental gingivitis
Jönsson, D., Ramberg, P., Demmer, R. T., Kebschull, M., Dahlén, G., & Papapanou, P. N. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2011.01719.x · Cited by 52 · see citing works
Sodium Dilantin Gingival Hyperplasia
Esterberg, H. L., & White, P. H. (1945) · The Journal of the American Dental Association · doi:10.14219/jada.archive.1945.0016 · Cited by 50 · see citing works
Periodontal health and disease in young people: screening for priority care.
Löe, H., & Morrison, E. (1986) · PubMed · Cited by 50 · see citing works
Risk Factors in Phenytoin‐Induced Gingival Hyperplasia
Addy, V., McElnay, J. C., Eyre, D. G., Campbell, N., & D’Arcy, P. F. (1983) · Journal of Periodontology · doi:10.1902/jop.1983.54.6.373 · Cited by 48 · see citing works
Development of phenytoin-induced gingival overgrowth in non-institutionalized epileptic children subjected to different plaque control programs
Modéer, T., & Dahllöf, G. (1987) · Acta Odontologica Scandinavica · doi:10.3109/00016358709098361 · Cited by 48 · see citing works
Supportive periodontal care: the effect of periodic subgingival debridement compared with supragingival prophylaxis with respect to clinical outcomes
Heasman, P. A., McCracken, G., & Steen, N. D. (2002) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.29.s3.9.x · Cited by 46 · see citing works
Oral contraceptives and the periodontium
Preshaw, P. M. (2012) · Periodontology 2000 · doi:10.1111/j.1600-0757.2011.00399.x · Cited by 43 · see citing works
Distinguishing the Signals of Gingivitis and Periodontitis in Supragingival Plaque: a Cross-Sectional Cohort Study in Malawi
Shaw, L. P., Harjunmaa, U., Doyle, R., Mulewa, S., Charlie, D., Maleta, K. M., Callard, R. E., Walker, A. S., Balloux, F., Ashorn, P., et al. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.01756-16 · Cited by 43 · see citing works
Tooth‐Related Issues
Blieden, T. M. (1999) · Annals of Periodontology · doi:10.1902/annals.1999.4.1.91 · Cited by 42 · see citing works
Gingivitis Susceptibility and its Relation to Periodontitis in Men
Dietrich, T., Krall, E. A., Nunn, M. E., Dyke, T. E. V., & García, R. I. (2006) · Journal of Dental Research · doi:10.1177/154405910608501213 · Cited by 39 · see citing works
Experimental gingivitis in relation to age in individuals not susceptible to periodontal destruction
Winkel, E. G., Abbas, F., van der Velden, U., Vroom, T. M., Scholte, G., & Hart, A. A. M. (1987) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1987.tb00990.x · Cited by 38 · see citing works
Oral health status of diabetes mellitus patients in Southwest Cameroon.
Bissong, M., Azodo, C. C., Agbor, A. M., Nkuo-Akenji, T., & Fon, P. (2015) · PubMed · Cited by 38 · see citing works
Drug‐induced gingival overgrowth: a study in the F rench P harmacovigilance D atabase
Bondon‐Guitton, E., Bagheri, H., & Montastruc, J. (2012) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2012.01878.x · Cited by 36 · see citing works
Impact of smoking on experimental gingivitis. A clinical, microbiological and immunological prospective study
Peruzzo, D. C., Gimenes, J., Taiete, T., Casarin, R. C. V., Feres, M., Sallum, E. A., Casati, M. Z., Kantovitz, K. R., & Nociti, F. H. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12363 · Cited by 35 · see citing works
Phenytoin‐Induced Gingival Overgrowth Control in Severely Retarded Children
Steinberg, S. C., & Steinberg, A. D. (1982) · Journal of Periodontology · doi:10.1902/jop.1982.53.7.429 · Cited by 33 · see citing works
Bleeding/plaque ratio
van der Velden, U., Winkel, E. G., & Abbas, F. (1985) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1985.tb01363.x · Cited by 31 · see citing works
Gingival Overgrowth Among Patients Medicated With Cyclosporin A and Tacrolimus Undergoing Renal Transplantation: A Prospective Study
Paixão, C. G., Sekiguchi, R. T., Saraiva, L. M., Pannuti, C. M., Junior, H. T. S., Pestana, J. O. M., & Romito, G. A. (2010) · Journal of Periodontology · doi:10.1902/jop.2010.100368 · Cited by 31 · see citing works
Chemotherapy-associated oral hemorrhages in adults with acute leukemia
Dreizen, S., McCredie, K. B., & Keating, M. J. (1984) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(84)90306-2 · Cited by 30 · see citing works
The effect of menstrual cycle on periodontal health - a clinical and microbiological study.
Shourie, V., Dwarakanath, C., Prashanth, G. V., Ramesh, A., Padmanabhan, S., & Bali, S. (2012) · PubMed · Cited by 29 · see citing works
Diseases of the Salivary Glands
Crumley, R. L. (1987) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1987.01860090104034 · Cited by 29 · see citing works
Periodic exacerbation of gingival inflammation during the menstrual cycle
Koreeda, N., Iwano, Y., Kishida, M., Otsuka, A., Kawamoto, A., Sugano, N., & Ito, K. (2005) · Journal of Oral Science · doi:10.2334/josnusd.47.159 · Cited by 25 · see citing works
Experimental gingivitis in relation to susceptibility to periodontal disease II. Phase‐contrast microbiological features and some host‐response observations
Abbas, F., van der Velden, U., Moorer, W. R., Everts, V. E., Vroom, T. M., & Scholte, G. (1986) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.1986.tb00846.x · Cited by 25 · see citing works
Ascorbic acid and periodontal disease: a review of the literature.
Woolfe, S. N., Hume, W. R., & Kenney, E. B. (1980) · PubMed · Cited by 20 · see citing works
A Basic Classification of “Gingival Enlargement”
Glickman, I. (1950) · Journal of Periodontology · doi:10.1902/jop.1950.21.3.131 · Cited by 15 · see citing works
Gingival Hemorrhage, Myelodysplastic Syndromes, and Acute Myeloid Leukemia. A Case Report
Chapple, I., Saxby, M. S., & Murray, J. A. H. (1999) · Journal of Periodontology · doi:10.1902/jop.1999.70.10.1247 · Cited by 12 · see citing works
Self-citation
Gingivitis in Basel schoolchildren.
Hefti, A., Engelberger, T., & Büttner, M. (1981) · PubMed · Cited by 9 · see citing works
Gingivitis intermenstrualis
K.H.T (1949) · Oral Surgery Oral Medicine Oral Pathology · doi:10.1016/0030-4220(49)90271-6 · Cited by 4 · see citing works

Flagged first, then by citations

Research works printed but not linked: 3

Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. Lab Invest. 1976;33:235-249.
Hefti A, Engelberger T, Buttner M. Gingivitis in Basel school chil- dren. Helv Odontol Acta. 1981;25:25-42.
Bondon-Guitton E, Bagheri H. Montastruc J-L. Drug-induced gin- gival overgrowth: A study in the French network of regional phar- macovigilance database. J Clin Periodontol. 2012;39:513-518.

Sorted by citations

A new classification scheme for periodontal and peri‐implant diseases and conditions – Introduction and key changes from the 1999 classification
Caton, J. G., Armitage, G. C., Berglundh, T., Chapple, I., Jepsen, S. V., Kornman, K. S., Mealey, B. L., Papapanou, P. N., Sanz, M., & Tonetti, M. S. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12935 · Cited by 1,680 · see citing works
Self-citation
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions
Chapple, I., Mealey, B. L., Dyke, T. E. V., Bartold, P. M., Dommisch, H., Eickholz, P., Geisinger, M. L., Genco, R. J., Glogauer, M., Goldstein, M., et al. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12940 · Cited by 677 · see citing works
Self-citation
Plaque‐induced gingivitis: Case definition and diagnostic considerations
Trombelli, L., Fariña, R., Silva, C. O., & Tatakis, D. N. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12939 · Cited by 453 · see citing works
Implementation of the new classification of periodontal diseases: Decision‐making algorithms for clinical practice and education
Tonetti, M. S., & Sanz, M. (2019) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13104 · Cited by 284 · see citing works
Periodontal health
Lang, N. P., & Bartold, P. M. (2018) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12936 · Cited by 162 · see citing works
Diagnostic sensitivity and specificity of host‐derived salivary biomarkers in periodontal disease amongst adults: Systematic review
Sukriti, K. C., Wang, X. Z., & Gallagher, J. E. (2019) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13218 · Cited by 144 · see citing works
Conventional diagnostic criteria for periodontal diseases (plaque‐induced gingivitis and periodontitis)
Heitz‐Mayfield, L. J. A. (2024) · Periodontology 2000 · doi:10.1111/prd.12579 · Cited by 141 · see citing works
Clinical periodontal diagnosis
Salvi, G. E., Roccuzzo, A., Imber, J., Stähli, A., Klinge, B., & Lang, N. P. (2023) · Periodontology 2000 · doi:10.1111/prd.12487 · Cited by 119 · see citing works
Hyaluronic acid: comprehensive review of a multifunctional biopolymer
Salih, A. R. C., Farooqi, H. M. U., Amin, H. H., Karn, P. R., Meghani, N. M., & Nagendran, S. (2024) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-024-00636-y · Cited by 118 · see citing works
Periodontal ligament stem cells in the periodontitis niche: inseparable interactions and mechanisms
Zhang, Z., Deng, M., Hao, M., & Tang, J. (2021) · Journal of Leukocyte Biology · doi:10.1002/jlb.4mr0421-750r · Cited by 72 · see citing works
Synergism of Streptococcus mutans and Candida albicans Reinforces Biofilm Maturation and Acidogenicity in Saliva: An In Vitro Study
Kim, H., Liu, Y., Dhall, A., Bawazir, M., Koo, H., & Hwang, G. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.623980 · Cited by 90 · see citing works
The efficacy of powered toothbrushes: A systematic review and network meta‐analysis
Thomassen, T. M. J. A., van der Weijden, G. A., & Slot, D. E. (2021) · International Journal of Dental Hygiene · doi:10.1111/idh.12563 · Cited by 81 · see citing works
The effect of the “Oral-Gut” axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations
Zhou, T., Xu, W., Wang, Q., Jiang, C., Li, H., Chao, Y., Sun, Y., & Lan, A. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1132420 · Cited by 82 · see citing works
Effect of the Mediterranean diet on gingivitis: A randomized controlled trial
Bartha, V., Exner, L., Schweikert, D., Woelber, J. P., Vach, K., Meyer, A., Basrai, M., Bischoff, S. C., Meller, C., & Wolff, D. (2021) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13576 · Cited by 69 · see citing works
The increasing importance of the oral microbiome in periodontal health and disease
Siddiqui, R., Badran, Z., Boghossian, A., Alharbi, A. M., Alfahemi, H., & Khan, N. (2023) · Future Science OA · doi:10.2144/fsoa-2023-0062 · Cited by 65 · see citing works
Clinical efficacy of probiotics in the treatment of gingivitis: A systematic review and meta‐analysis
Akram, Z., Shafqat, S. S., Aati, S. Y., Kujan, O., & Fawzy, A. (2019) · Australian Dental Journal · doi:10.1111/adj.12733 · Cited by 60 · see citing works
Clinical efficacy of photodynamic therapy as an adjunct to scaling and root planing in the treatment of chronic periodontitis among cigarette smokers: A systematic review and meta-analysis
Akram, Z., Raffat, M. A., Shafqat, S. S., Mirza, S., & Ikram, S. (2019) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2019.04.027 · Cited by 58 · see citing works
GC–MS analysis, molecular docking, and pharmacokinetic studies of Multidentia crassa extracts’ compounds for analgesic and anti-inflammatory activities in dentistry
Chikowe, I., Bwaila, K., Ugbaja, S. C., & Abouzied, A. S. (2024) · Scientific Reports · doi:10.1038/s41598-023-47737-x · Cited by 56 · see citing works
Efficacy of propolis-based mouthwashes on dental plaque and gingival inflammation: a systematic review
Halboub, E. S., Al‐Maweri, S. A., Al-Wesabi, M., Al-Kamel, A., Shamala, A., Al-Sharani, A. A., & Koppolu, P. (2020) · BMC Oral Health · doi:10.1186/s12903-020-01185-5 · Cited by 54 · see citing works
Progress in salivary glands: Endocrine glands with immune functions
Shang, Y. F., Shen, Y. Y., Zhang, M. C., Lv, M. C., Wang, T. Y., Chen, X. Q., & Lin, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1061235 · Cited by 52 · see citing works
Antibacterial and anti-biofilm activity of silver nanoparticles on multi-drug resistance pseudomonas aeruginosa isolated from dental-implant
El‐Telbany, M., & SHARAKI, A. E. (2021) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2021.12.002 · Cited by 50 · see citing works
Classificação das Doenças e Condições Periodontais e Peri-implantares 2018: guia Prático e Pontos-Chave
Steffens, J. P., & Marcantonio, R. A. C. (2018) · Revista de Odontologia da UNESP · doi:10.1590/1807-2577.04704 · Cited by 60 · see citing works
Effects of stabilized stannous fluoride dentifrice on dental calculus, dental plaque, gingivitis, halitosis and stain: A systematic review
Johannsen, A., Emilson, C.-G., Johannsen, G., Konradsson, K., Lingström, P., & Ramberg, P. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e02850 · Cited by 47 · see citing works
“Gingivitis, inflammation of the gum, is one of the most common diseases in the world [2].”
Background
Dental and periodontal health in adults with eating disorders: A case-control study
Pallier, A., Каримова, А. З., Boillot, A., Colon, P., Ringuenet, D., Bouchard, P., & Rangé, H. (2019) · Journal of Dentistry · doi:10.1016/j.jdent.2019.03.005 · Cited by 44 · see citing works
Interleukin-1 Genotype in Periodontitis
Brodzikowska, A., Górska, R., & Kowalski, J. (2019) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-019-00555-4 · Cited by 43 · see citing works
Socio-demographic determinants as predictors of oral hygiene status and gingivitis in schoolchildren aged 7-12 years old: A cross-sectional study
Bashirian, S., Sabounchi, S. S., Shirahmadi, S., Soltanian, A. R., Karimi‐Shahanjarini, A., & Vahdatinia, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208886 · Cited by 42 · see citing works
A Reciprocal Link between Oral, Gut Microbiota during Periodontitis: The Potential Role of Probiotics in Reducing Dysbiosis-Induced Inflammation
Stefano, M. D., Santonocito, S., Polizzi, A., Mauceri, R., Troiano, G., Giudice, A. L., Romano, A., Mascitti, M., & Isola, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021084 · Cited by 44 · see citing works
Cinnamic acid decreases periodontal inflammation and alveolar bone loss in experimental periodontitis
Karataş, Ő., Yüce, H. B., Taşkan, M. M., Gevrek, F., Alkan, C., Kara, G. I., & Temiz, C. (2020) · Journal of Periodontal Research · doi:10.1111/jre.12754 · Cited by 38 · see citing works
Therapeutic Potential of Polyphenol and Nanoparticles Mediated Delivery in Periodontal Inflammation: A Review of Current Trends and Future Perspectives
Jayusman, P. A., Nasruddin, N. S., Apandi, N. I. M., Ibrahim, N., & Budin, S. B. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.847702 · Cited by 38 · see citing works
Periodontal diseases- A brief review
Dubey, P., & Mittal, N. (2020) · International Journal of Oral Health Dentistry · doi:10.18231/j.ijohd.2020.038 · Cited by 37 · see citing works
Antimicrobial efficacy of indocyanine green-mediated photodynamic therapy compared with Salvadora persica gel application in the treatment of moderate and deep pockets in periodontitis.
Niazi, F., Noushad, M., Tanvir, S. B., Ali, S., Al-Khalifa, K., Qamar, Z., & Alsheikh, R. (2020) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2020.101665 · Cited by 35 · see citing works
The recovery of the microbial community after plaque removal depends on periodontal health status
Li, X., Yu, C., Zhang, B., Shan, X., Mao, W., Zhang, Z., Wang, C., Jin, X., Wang, J., & Zhao, H. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00441-0 · Cited by 34 · see citing works
Current Global Status and the Epidemiology of Entamoeba gingivalis in Humans: A Systematic Review and Meta-analysis
Badri, M., Olfatifar, M., Abdoli, A., Houshmand, E., Zarabadipour, M., Abadi, P. A., Johkool, M. G., Ghorbani, A., & Eslahi, A. V. (2021) · Acta Parasitologica · doi:10.1007/s11686-021-00423-2 · Cited by 36 · see citing works
Salivary Oral Microbiome of Children With Juvenile Idiopathic Arthritis: A Norwegian Cross-Sectional Study
Frid, P., Baraniya, D., Halbig, J., Rypdal, V., Songstad, N. T., Rosén, A., Berstad, J. R., Flatø, B., Alakwaa, F., Gil, E. G., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.602239 · Cited by 33 · see citing works
Correlations between different plaque indexes and bleeding on probing: A concurrent validity study
Carvalho, A. D. A. T., Moura, M. I. C., da Costa, F. N., & Cota, L. O. M. (2022) · Journal of Clinical and Experimental Dentistry · doi:10.4317/jced.60039 · Cited by 32 · see citing works
CLINICAL EFFICACY OF PROBIOTICS AS AN ADJUNCTIVE THERAPY TO SCALING AND ROOT PLANNING IN THE MANAGEMENT OF PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRAILS
Hu, D., Zhong, T., & Dai, Q. (2021) · Journal of Evidence Based Dental Practice · doi:10.1016/j.jebdp.2021.101547 · Cited by 32 · see citing works
Clinical efficacy of an Aloe Vera gel versus a 0.12% chlorhexidine gel in preventing traumatic ulcers in patients with fixed orthodontic appliances: a double-blind randomized clinical trial
Leiva-Cala, C., Lorenzo‐Pouso, A. I., Centenera-Centenera, B., Palafox, J. L., Vila, P. G., Garcı́a, A. G., & Pérez‐Sayáns, M. (2019) · Odontology · doi:10.1007/s10266-019-00468-w · Cited by 29 · see citing works
Periodontitis as a risk factor for head and neck cancer
GASPARONI, L. M., Alves, F. A., Holzhausen, M., Pannuti, C. M., & Serpa, M. (2020) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.24270 · Cited by 29 · see citing works
Oxidative Stress Inhibits Endotoxin Tolerance and May Affect Periodontitis
Yamaguchi, T., Yamamoto, Y., Egashira, K., Satô, A., Kondo, Y., Saiki, S., Kimura, M., Chikazawa, T., Yamamoto, Y., Ishigami, A., et al. (2022) · Journal of Dental Research · doi:10.1177/00220345221138523 · Cited by 28 · see citing works
Self-citation
To what extent does smoking affect gingival bleeding response to supragingival plaque? Site‐specific analyses in a population‐based study
Holde, G. E., Jönsson, B., Oscarson, N., & Müller, H. (2019) · Journal of Periodontal Research · doi:10.1111/jre.12713 · Cited by 27 · see citing works
ISP good clinical practice recommendations for gum care
Kumar, A., Grover, V., Satpathy, A., Jain, A. R., Grover, H. S., Khatri, M., Kolte, A. P., Dani, N., Melath, A., Chahal, G. S., et al. (2023) · Journal of Indian Society of Periodontology · doi:10.4103/jisp.jisp_561_22 · Cited by 29 · see citing works
Fixed and removable orthodontic retainers, effects on periodontal health compared: A systematic review
Quinzi, V., Carli, E., Mummolo, A., Benedictis, F. D., Salvati, S. E., & Mampieri, G. (2023) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2023.02.015 · Cited by 29 · see citing works
Understanding the Link Between Hormonal Changes and Gingival Health in Women: A Review
Jawed, S., & Jawed, K. T. K. (2025) · Cureus · doi:10.7759/cureus.85270 · Cited by 26 · see citing works
Oral health status of patients with leukemia: a systematic review with meta-analysis
Angst, P. D. M., Maier, J., Nogueira, R. D. S., Manso, I. S., & Tedesco, T. K. (2020) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2020.104948 · Cited by 26 · see citing works
Eating disorders through the periodontal lens
Rangé, H., Colon, P., Godart, N. T., Kapila, Y. L., & Bouchard, P. (2021) · Periodontology 2000 · doi:10.1111/prd.12391 · Cited by 26 · see citing works
Periodontal risk markers in children and adolescents with type 1 diabetes: A systematic review and meta‐analysis
Jensen, E. D., Allen, G., Bednarz, J., Couper, J., & Peña, A. S. (2020) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3368 · Cited by 25 · see citing works
Modified Gingival Index (MGI) Classification Using Dental Selfies
Tobias, G., & Spanier, A. B. (2020) · Applied Sciences · doi:10.3390/app10248923 · Cited by 25 · see citing works
Microbiomes in supragingival biofilms and saliva of adolescents with gingivitis and gingival health
Wirth, R., Maróti, G., Lipták, L., Mester, M., Ayoubi, A. A., Pap, B., Madléna, M., Minárovits, J., & Kovács, K. L. (2021) · Oral Diseases · doi:10.1111/odi.13883 · Cited by 25 · see citing works
Ubiquitin-specific proteases: Vital regulatory molecules in bone and bone-related diseases
Luo, W., Zhang, G., Wang, Z., Wu, Y., & Xiong, Y. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110075 · Cited by 23 · see citing works
Prevalence, Severity of Extension, and Risk Factors of Gingivitis in a 3-Month Pregnant Population: A Multicenter Cross-Sectional Study
Gare, J. V., Kanouté, A., Orsini, G., Gonçalves, L. S., Alshehri, F. A., Bourgeois, D. M., & Carrouel, F. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093349 · Cited by 23 · see citing works
Is There Any Association Between Chronic Periodontitis and Anxiety in Adults? A Systematic Review
Aragão, W. A. B., Souza‐Monteiro, D., Frazão, D. R., Né, Y. G. D. S., Ferreira, R. D. O., Rivera, L. F. S., Saito, M. T., Rõsing, C. K., Fagundes, N. C. F., Maia, L. C., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.710606 · Cited by 24 · see citing works
Treatment of gingivitis is associated with reduction of systemic inflammation and improvement of oral health‐related quality of life: A randomized clinical trial
Perić, M., Marhl, U., Gennai, S., Marruganti, C., & Graziani, F. (2022) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13690 · Cited by 24 · see citing works
Preliminary Study of the Antimicrobial, Anticoagulant, Antioxidant, Cytotoxic, and Anti-Inflammatory Activity of Five Selected Plants with Therapeutic Application in Dentistry
Villarreal, S. M. L., Elizondo‐Luévano, J. H., Pérez-Hernández, R. A., Sánchez-García, E., Verde‐Star, M. J., Ríos, R. C., Garza-Tapia, M., Rodríguez-Luis, O. E., & Chávez-Montes, A. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19137927 · Cited by 22 · see citing works
Success in periodontology: An evolutive concept
Prato, G. P., Gianfilippo, R. D., & Wang, H. (2019) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13150 · Cited by 22 · see citing works
Efficacy of photodynamic therapy and periodontal treatment in patients with gingivitis and fixed orthodontic appliances
Rosa, E. P., Murakami‐Malaquias‐Silva, F., Schalch, T. O., Teixeira, D. B., Horliana, R. F., Tortamano, A., Tortamano, I. P., Buscariolo, I. A., Longo, P. L., Negreiros, R. M., et al. (2020) · Medicine · doi:10.1097/md.0000000000019429 · Cited by 21 · see citing works
Oral Fluid Biomarkers for Diagnosing Gingivitis in Human: A Cross-Sectional Study
Hong, I., Pae, H., Song, Y. W., Cha, J., Lee, J., Paik, J., & Choi, S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061720 · Cited by 21 · see citing works
Localized microbially induced inflammation influences distant healthy tissues in the human oral cavity
Kerns, K. A., Bamashmous, S., Hendrickson, E. L., Kotsakis, G. A., Leroux, B. G., Daubert, D. M., Roberts, F. A., Chen, D., Trivedi, H. M., Darveau, R. P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2306020120 · Cited by 20 · see citing works
Ethanol binge drinking during pregnancy and its effects on salivary glands of offspring rats: oxidative stress, morphometric changes and salivary function impairments
Ferreira, R. D. O., Aragão, W. A. B., Bittencourt, L. O., Fernandes, L. M. P., Balbinot, K. M., Júnior, S. D. M. A., Pinheiro, J. D. J. V., Maia, C. D. S. F., Lopez, M. E. C., & Lima, R. R. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110979 · Cited by 20 · see citing works
Evaluation of Mouthwash Containing Citrus hystrix DC., Moringa oleifera Lam. and Azadirachta indica A. Juss. Leaf Extracts on Dental Plaque and Gingivitis
Buakaew, W., Sranujit, R. P., Noysang, C., Sangouam, S., Suphrom, N., Thongsri, Y., Potup, P., & Usuwanthim, K. (2021) · Plants · doi:10.3390/plants10061153 · Cited by 20 · see citing works
Periodontal and oral health status of people with Cystic Fibrosis: a systematic review
Coffey, N., O’Leary, F., Burke, F. M., Roberts, A., & Hayes, M. (2020) · Journal of Dentistry · doi:10.1016/j.jdent.2020.103509 · Cited by 19 · see citing works
The Significance of Oral Inflammation in Elite Sports: A Narrative Review
Merle, C. L., Wuestenfeld, J. C., Fenkse, F., Wolfarth, B., Haak, R., Schmalz, G., & Ziebolz, D. (2022) · Sports Medicine International Open · doi:10.1055/a-1964-8538 · Cited by 19 · see citing works
An Update on the Mechanisms of Phenytoin Induced Gingival Overgrowth
Farook, F. F., M. Nizam, M. N., & Alshammari, A. (2019) · The Open Dentistry Journal · doi:10.2174/1874210601913010430 · Cited by 18 · see citing works
Mobile Application-Based Support for Periodontal Treatment Improves Clinical, Cognitive, and Psychomotor Outcomes: A Randomized Controlled Trial Study
Hartono, V., Setiadharma, Y., Rizany, A. K., Sulijaya, B., Lessang, R., Haerani, N., Tadjoedin, E. S. S., Masulili, S. L. C., Tadjoedin, F. M., Soeroso, Y., et al. (2024) · Dentistry Journal · doi:10.3390/dj12030063 · Cited by 18 · see citing works
Hypoxia and collagen crosslinking in the healthy and affected sites of periodontitis patients
Taşkan, M. M., Karataş, Ő., Yüce, H. B., Kara, G. I., Gevrek, F., & Yarkaç, F. U. (2019) · Acta Odontologica Scandinavica · doi:10.1080/00016357.2019.1624819 · Cited by 17 · see citing works
Effects of l-arginine and l-ornithine supplementations on the treatment of chronic periodontitis: A preliminary randomized short-term clinical trial
Shynkevych, V. І., Коломієць, С. В., & Кайдашев, І. П. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08353 · Cited by 16 · see citing works
Gingival enlargement improvement following medication change from amlodipine to benidipine and periodontal therapy
Kamei, H., Furui, M., Matsubara, T., & Inagaki, K. (2022) · BMJ Case Reports · doi:10.1136/bcr-2022-249879 · Cited by 16 · see citing works
Mediterranean diet component oleic acid increases protective lipid mediators and improves trabecular bone in a Porphyromonas gingivalis inoculation model
Döding, A., Hüfner, M., Nachtsheim, F., Iffarth, V., Bölter, A., Bastian, A., Symmank, J., Andreas, N., Schädel, P., Thürmer, M., et al. (2022) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13751 · Cited by 17 · see citing works
Changes in serum omega fatty acids on a Mediterranean diet intervention in patients with gingivitis: An exploratory study
Bartha, V., Exner, L., Basrai, M., Bischoff, S. C., Schweikert, D., Adolph, M., Bruckner, T. M., Grueninger, D., Klein, D., Meller, C., et al. (2022) · Journal of Periodontal Research · doi:10.1111/jre.13056 · Cited by 15 · see citing works
Periodontal pathogens of the interdental microbiota in a 3 months pregnant population with an intact periodontium
Carrouel, F., Kanouté, A., Lvovschi, V.-E., & Bourgeois, D. M. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1275180 · Cited by 15 · see citing works
A proof of concept gene‐activated titanium surface for oral implantology applications
Laird, N. Z., Malkawi, W. I., Chakka, L. R. J., Acri, T. M., Elangovan, S., & Salem, A. K. (2020) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3026 · Cited by 15 · see citing works
Periodontal Inflamed Surface Area (PISA) associates with composites of salivary cytokines
Tang, V., Hamidi, B., Janal, M. N., Barber, C. A., Godder, B., Palomo, L., & Kamer, A. R. (2023) · PLOS ONE · doi:10.1371/journal.pone.0280333 · Cited by 14 · see citing works
“Since PD measures the past and present disease and BOP is the most reliable measure for assessing gingival inflammation [21], therefore, combining both measures in a single PISA index is best reflective of current clinical periodontal inflammatory status.”
Background
The association of work physical activity and recreational physical activity with periodontitis in the NHANES (2009–2014)
Pu, R., Fu, M., Yang, G., & Jiang, Z. (2023) · Journal of Periodontology · doi:10.1002/jper.23-0070 · Cited by 14 · see citing works
Osmunda japonica Extract Suppresses Pro-Inflammatory Cytokines by Downregulating NF-κB Activation in Periodontal Ligament Fibroblasts Infected with Oral Pathogenic Bacteria
Seong, J., Lee, J., Lim, Y. K., Yoon, W., Jung, S., Kook, J., & Lee, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072453 · Cited by 14 · see citing works
Nanoparticulate systems for dental drug delivery
Koopaie, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102985-5.00022-x · Cited by 14 · see citing works
Multi-way modelling of oral microbial dynamics and host-microbiome interactions during induced gingivitis
van der Ploeg, G. R., Brandt, B. W., Keijser, B. J. F., van der Veen, M. H., Volgenant, C. M. C., Zaura, E., Smilde, A. K., Westerhuis, J. A., & Heintz‐Buschart, A. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00565-x · Cited by 15 · see citing works
Patients’ awareness regarding the quality of their oral hygiene: development and validation of a new measurement instrument
Eidenhardt, Z., Busse, S., Margraf‐Stiksrud, J., & Deinzer, R. (2022) · BMC Oral Health · doi:10.1186/s12903-022-02659-4 · Cited by 13 · see citing works
Calcium channel blocker induced gingival enlargement following implant placement in a fibula free flap reconstruction of the mandible: a case report
Quach, H., & Ray–Chaudhuri, A. (2020) · International Journal of Implant Dentistry · doi:10.1186/s40729-020-00242-6 · Cited by 12 · see citing works
Effectiveness of Salvadora persica toothbrush and Salvadora persica chewing stick in plaque and gingivitis control: a randomized control trial
Azizan, N. F., Mohd, N., Azis, N. M. N., & Baharin, B. (2023) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-023-04295-z · Cited by 12 · see citing works
The Dental, Oral, Medical Epidemiological (DOME) Study: Protocol and Study Methods
Almoznino, G., Kedem, R., Turgeman, R., Bader, T., Yavnai, N., Zur, D., & Shay, B. (2020) · Methods of Information in Medicine · doi:10.1055/s-0040-1718582 · Cited by 12 · see citing works
Genetic Testing in Periodontitis: A Narrative Review on Current Applications, Limitations, and Future Perspectives
Modafferi, C., Grippaudo, C., Corvaglia, A., Cristi, V., Amato, M., Rigotti, P., Polizzi, A., & Isola, G. (2025) · Genes · doi:10.3390/genes16111308 · Cited by 11 · see citing works
Green tea extracts alleviate acetic acid‐induced oral inflammation and reconstruct oral microbial balance in mice
Pan, Y., Lv, H., Zhang, F., Chen, S., Cheng, Y., Shi-cheng, M., Hu, H., Liu, X., Cai, X., Fan, F., et al. (2023) · Journal of Food Science · doi:10.1111/1750-3841.16818 · Cited by 11 · see citing works
Effects of toothpaste containing inactivated Lacticaseibacillus paracasei Probio-01 on plaque-induced gingivitis and dental plaque microbiota
Li, X., Zhao, Z., Guo, S., Yang, C., Gao, Y., Li, L., Ning, K., Zhang, Q., Zhou, N., Zhang, H., et al. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106701 · Cited by 11 · see citing works
Evaluation of salivary melatonin and MMP-9 levels in periodontal diseases
Bayırlı, A. B., Gürhan, C., & Saruhan, E. (2024) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2024.106116 · Cited by 11 · see citing works
High serum ferritin levels are associated with a reduced periodontium in women with anorexia nervosa
Boillot, A., Ringuenet, D., Kapila, Y. L., Pallier, A., Colon, P., Bouchard, P., & Rangé, H. (2019) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/s40519-019-00832-3 · Cited by 11 · see citing works
Sponges containing tetracycline loaded-PLGA-zein microparticles as a periodontal controlled release device
de Sousa, F. F. O., Álvarez, A. L., Pérez‐Estévez, A., Seoane, R., & Blanco-Méndez, J. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.101858 · Cited by 11 · see citing works
S-PRG Filler Eluate Induces Oxidative Stress in Oral Microorganism: Suppression of Growth and Pathogenicity, and Possible Clinical Application
Kono, Y., Tamura, M., Cueno, M. E., Tonogi, M., & Imai, K. (2021) · Antibiotics · doi:10.3390/antibiotics10070816 · Cited by 11 · see citing works
Aggregation-Induced Emission-Based Nanoparticles for Synergistic Photothermal Antibacterial Therapy and Anti-Inflammatory Regulation in Periodontal Infections
Lou, S., Fang, Z., Shan, G., Gao, Y., Yan, D., Li, Q., Wang, D., Zhang, M., & Xu, Y. (2025) · ACS Nano · doi:10.1021/acsnano.5c08054 · Cited by 10 · see citing works
Individualized 3D-Printed Bone-Anchored Maxillary Protraction Device for Growth Modification in Skeletal Class III Malocclusion
Kim, M., Li, J. W., Kim, S., Kim, W., Kim, S.-H., Lee, S.-M., Park, Y. L., Yang, S., & Kim, J. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11111087 · Cited by 10 · see citing works
Knowledge, attitudes and professional practices of ortho-periodontal care of adults: a cross-sectional survey in France
Saloux, A. L., Couatarmanach, A., Chauvel, B., Jeanne, S., & Brézulier, D. (2022) · BMC Oral Health · doi:10.1186/s12903-022-02177-3 · Cited by 10 · see citing works
Increased nociceptive sensitivity is associated with periodontal inflammation and expression of chronic pain genes in gingival tissues of male rats
Toraman, A., Toraman, E., Özkaraca, M., & Budak, H. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110128 · Cited by 10 · see citing works
The current novel drug delivery system (natural and chemical composites) in dental infections for antibiotics resistance: a narrative review
Tahmasebi, E., Ardestani, A. K., Hassani, Z., Alam, M. M. R., Abbasi, K., Kahrizi, S., Madihi, N., Abbasiparashkouh, Z., Mohammadi, A., Shahab, P., et al. (2022) · Cellular and Molecular Biology · doi:10.14715/cmb/2022.68.10.23 · Cited by 10 · see citing works
Serum levels of antimicrobial peptides (Cathelicidins and Beta Defensins-1) in patients with periodontitis
Al-Daragi, F. Z., Al-Ghurabi, B. H., & Abdullah, N. N. (2024) · Journal of Baghdad College of Dentistry · doi:10.26477/jbcd.v36i1.3586 · Cited by 10 · see citing works
Association between oral health-related quality of life and periodontal status in patients with leukemia
Angst, P. D. M., Dutra, D. A. M., Manso, I. S., Moreira, C. H. C., & Kantorski, K. Z. (2020) · International Dental Journal · doi:10.1111/idj.12576 · Cited by 10 · see citing works
Comparative Effectiveness of a Commercial Mouthwash and an Herbal Infusion in Oral Health Care
Ciavoi, G., Dobjanschi, L., Jurca, T., Osser, G., Scrobotă, I., Pallag, A., Muresan, M. E., Vicaș, L. G., Marian, E., Bechir, F., et al. (2021) · Applied Sciences · doi:10.3390/app11073008 · Cited by 10 · see citing works
Assessment of the Relationship Between Matrix Metalloproteinase-9 Promoter Gene Polymorphism and Chronic Periodontitis
Bagde, H. S., Banakar, S., Waghmare, A., Bagde, A., Chaturvedi, S. S., & Patil, S. R. (2021) · Pesquisa Brasileira em Odontopediatria e Clínica Integrada · doi:10.1590/pboci.2021.123 · Cited by 9 · see citing works
Influence of decision-making algorithms on the diagnostic accuracy using the current classification of periodontal diseases—a randomized controlled trial
Bumm, C. V., Wölfle, U. C., Keßler, A., Werner, N., & Folwaczny, M. (2023) · Clinical Oral Investigations · doi:10.1007/s00784-023-05264-z · Cited by 9 · see citing works
The Impact of Cigarette Smoking and Vaping Use on the Development and Progression of Periodontitis: A Systematic Review
Aldalaeen, M. O., Haddad, R. H., Alhusamiah, B. K., & Abuejheisheh, A. J. (2025) · Health Science Reports · doi:10.1002/hsr2.71245 · Cited by 9 · see citing works
New classification of periodontal diseases and periimplant conditions (2017)
Borysenko, A. (2019) · SUCHASNA STOMATOLOHIYA · doi:10.33295/1992-576x-2019-3-24 · Cited by 9 · see citing works
Local and Systemic Effects of Cyclosporine A on the Severity of Gingival Overgrowth in Post-Transplant Renal Patients
Aboujaoude, S., Aoun, G., & Majzoub, Z. (2021) · Materia Socio Medica · doi:10.5455/msm.2021.33.51-55 · Cited by 9 · see citing works
Effect of ultrasonic scaling with adjunctive photodynamic therapy on the treatment of gingival inflammation among diabetic patients undergoing fixed orthodontic treatment
Mannakandath, M. L., Kamran, M. A., Udeabor, S. E., Hameed, M. S., Ajmal, M., & Alshahrani, I. (2021) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2021.102360 · Cited by 9 · see citing works

Dental Plaque‐Induced Gingival Diseases
Mariotti, A. J. (1999) · Annals of Periodontology · doi:10.1902/annals.1999.4.1.7 · Cited by 334 · see citing works
Self-citation
Gingivitis inducida por biopelícula dental y enfermedades gingivales no inducidas por biopelícula dental
Dávila, L., Romero, I., Lugo, G., Gimenéz, X., Rojas, T., Yibrín, C., Sosa, L., Infante, J., Arteaga, S., Palacios, M., et al. (2020) · Revista Odontológica de Los Andes
Maladies gingivales induites par la plaque
Boschin, F., Boutigny, H., & Delcourt‐Debruyne, E. (2004) · EMC - Dentisterie · doi:10.1016/j.emcden.2004.02.005 · Cited by 5 · see citing works
A review of factors influencing the incidence and severity of plaque-induced gingivitis.
Trombelli, L., & Fariña, R. (2013) · PubMed · Cited by 60 · see citing works
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple, I., Mealey, B. L., Te, V. D., Bartold, P. M., Dommisch, H., Eickholz, P., Geisinger, M. L., Genco, R. J., Glogauer, M., Goldstein, M., et al. (2018) · Open Access CRIS of the University of Bern · doi:10.7892/boris.125351
Self-citation

Authors: Murakami, S., Mealey, B. L., Mariotti, A., & Chapple, I. L. C.
Affiliations: The University of Osaka (JP)
The University of Texas at San Antonio Health Science Center (US)
The Ohio State University (US)
University of Birmingham (GB)
Corresponding author: Murakami, Shinya
ORCID: Murakami, Shinya
Mealey, Brian L.
Chapple, Iain L.C.
Venue: Journal of Clinical Periodontology
Publisher: Wiley
Published: 2018-06
Volume: 45
Issue: S20
Pages: S17-S27
ISSN: 0303-6979 (ISSN-L)
1600-051X
DOI: 10.1111/jcpe.12937
OpenAlex: W4211174507
Cited by: 358
References: 103
Citations by year: 2026: 28 · 2025: 50 · 2024: 35 · 2023: 69 · 2022: 52 · 2021: 50 · 2020: 38 · 2019: 29 · 2018: 7
FWCI: 4.53
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 19 d)
Locations: Journal Of Clinical Periodontology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
Health Sciences › Dentistry › Periodontics › Oral Health Pathology and Treatment
Keywords: gingival disease, dental plaque, gingivitis, gingival hyperplasia, periodontitis prevention, bacterial biofilms, systemic risk factors, attachment level
MeSH terms: Dental Plaque, Gingiva, Gingivitis, Humans, Periodontitis, Periodontium

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Dental plaque-induced gingival conditions

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks