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Cited by 42Oral microbiology and periodontitis researchChronic Obstructive Pulmonary Disease (COPD) ResearchDental Health and Care Utilization

Chronic periodontitis and reduced respiratory function.

Winning, Lewis, Patterson, Christopher C., Cullen, Kathy M., Kee, Frank, Linden, Gerard J.·2019·Journal Of Clinical Periodontology
DOI 10.1111/jcpe.13076
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Abstract

Abstract Objective To investigate whether there was an association between chronic periodontitis (CP) and reduced respiratory function. Methods A group of dentate 58‐ to 72‐year‐old men in Northern Ireland had a comprehensive periodontal examination. Parallel to the periodontal examination, participants completed questionnaires gathering information on their medical history, social circumstances, demographic background and tobacco use. A physical examination assessed anthropometric measures. Fasting blood samples were obtained and analysed for high‐sensitivity C‐reactive protein (hs‐CRP). Spirometry measures were performed using a wedge bellows spirometer (Vitalograph S Model). The primary outcome variable of interest was the percentage predicted forced expiratory volume in one‐second (% predictedFEV1). Analysis included multiple linear regression with adjustment for various confounders and a regression‐based mediation analysis. Results A total of 1,380 men were included in the analysis. The mean age was 63.7 years (SD3.0). Multiple linear regression analysis showed that a doubling in mean clinical attachment loss (CAL) equated to a −3.33% (95%CI: −4.80, −1.86),p < 0.001 change in % predictedFEV1after adjustment for all other potential confounding variables. Systemic inflammation, as measured by hs‐CRP, only accounted for a minor mediating pathway effect (9%). Conclusions In this homogenous group of dentate men, CP was significantly associated with a reduced respiratory function.

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  • Poor oral hygiene habits can lead to the accumulation of many periodontal microorganisms in the oral cavity, and oral dysbiosis can accelerate lung function decline, which in turn can increase the incidence of pneumonia.

    “Poor oral hygiene habits can lead to the accumulation of many periodontal microorganisms in the oral cavity, and oral dysbiosis can accelerate lung function decline (Takeuchi et al., 2018; Winning et al., 2019), which in turn can increase the incidence of pneumonia (Kumar, 2017).”

    From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Winning et al., 2019

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Authors
Winning, L., Patterson, C. C., Cullen, K. M., Kee, F., & Linden, G. J.
Affiliations
Queen's University Belfast (GB)
Corresponding author
Winning, Lewis
ORCID
Venue
Journal Of Clinical Periodontology
Publisher
Wiley
Published
2019-02-27
Volume
46
Issue
3
Pages
266-275
ISSN
  • 0303-6979 (ISSN-L)
  • 1600-051X
DOI
10.1111/jcpe.13076
OpenAlex
W2914241051
Cited by
42
References
47
Citations by year
2026: 3 · 2025: 1 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 8 · 2020: 8 · 2019: 1
FWCI
6.38
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal Of Clinical Periodontology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (Queen's University Belfast) (submittedVersion)
Funders
British Heart Foundation
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
  • Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
Keywords
chronic periodontitis, respiratory function, FEV1, clinical attachment loss, systemic inflammation, C-reactive protein, mediation analysis
MeSH terms
Aged, C-Reactive Protein, Forced Expiratory Volume, Humans, Male, Middle Aged, Northern Ireland, Spirometry, Chronic Periodontitis

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