Varenicline in smokers with diabetes: a pooled analysis of 15 randomized, placebo-controlled studies of varenicline
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AIMS/INTRODUCTION: Stopping smoking deserves high priority in preventing complications of diabetes; however, only sparse data are available regarding the efficacy of pharmacotherapy in smokers with diabetes. We assessed the efficacy and safety of varenicline in smokers with diabetes who participated in 15 double-blind, randomized, placebo-controlled studies. MATERIALS AND METHODS: This retrospective pooled analysis included data from smokers of ≥10 cigarettes per day with diabetes. Participants received varenicline 1 mg b.i.d. or placebo for 12 weeks. We examined carbon monoxide-confirmed continuous abstinence rates (CARs) for weeks 9-12, 9-24 and 9-52, and compared safety in participants with and without diabetes. RESULTS: Of 6,771 participants, 323 had diabetes (varenicline n = 162; placebo n = 161). Week 9-12 CAR was higher with varenicline than placebo (43.8% vs 24.8%; odds ratio 2.36, 95% CI 1.47-3.79), as was week 9-24 CAR (27.5% vs 14.4%; odds ratio 2.25, 95% CI 1.27-4.00). Week 9-52 CAR was 18.4% for varenicline and 10.1% for placebo (odds ratio 2.00, 95% CI 0.90-4.49). The most commonly-reported adverse events in participants with diabetes for varenicline vs placebo were: nausea (27.2% vs 8.1%); headache (9.3% vs 9.9%); and insomnia (8.6% vs 5.6%), incidences that were similar in participants without diabetes (29.6% vs 9.7%; 13.4% vs 10.9%; and 11.4% vs 7.1%, respectively). Weight gain in quitters with diabetes (1.7 kg) was similar to that of those without diabetes (2.1 kg). CONCLUSIONS: Varenicline was an effective and well-tolerated aid for smoking cessation in individuals with diabetes. Safety was comparable with participants without diabetes.
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Pharmacologic therapy to assist with smoking cessation in people with diabetes is effective.
“Pharmacologic therapy to assist with smoking cessation in people with diabetes has been shown to be effective (288)”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:<i>Standards of Care in Diabetes—2023</i> (2023) · cites this paper as [288]
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- Authors
- Tonstad, S., & Lawrence, D.
- Affiliations
- Oslo University Hospital (NO)
- Pfizer (United States) (US)
- Corresponding author
- Tonstad, Serena
- ORCID
- Tonstad, Serena
- Venue
- Journal of Diabetes Investigation
- Publisher
- Wiley
- Published
- 2016-07-14
- Volume
- 8
- Issue
- 1
- Pages
- 93-100
- ISSN
- 2040-1116 (ISSN-L)
- 2040-1124
- PMC
- PMC5217903
- OpenAlex
- W2395133422
- Cited by
- 44
- References
- 34
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 9 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 7 · 2018: 4 · 2017: 1 · 2016: 1
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Diabetes Investigation (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Pfizer (NCT00141206, NCT00143364, NCT00285012, NCT00282984, NCT00150254, NCT00141167, NCT00139750, NCT00371813, NCT00594204, NCT00691483, NCT00717093, NCT00749944, NCT01078298, NCT01244061)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- varenicline, smoking cessation, diabetes mellitus, nicotine dependence, continuous abstinence rate, pharmacotherapy, adverse events, weight gain, nicotine replacement therapy
- MeSH terms
- Varenicline, Adolescent, Adult, Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Retrospective Studies, Tobacco Use Disorder, Randomized Controlled Trials as Topic, Smoking Cessation, Treatment Outcome, Nicotinic Agonists, Diabetes Complications, Young Adult
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