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Cited by 44Gestational Diabetes Research and ManagementPregnancy and preeclampsia studiesPregnancy and Medication Impact

Comparison of pregnancy outcomes between women with early‐onset and late‐onset gestational diabetes in a retrospective multi‐institutional study in Japan

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Usami, Tomoka, Yokoyama, Maki, Ueno, Megumi, Iwama, Noriyuki, Sagawa, Norimasa, Kawano, Reo, Waguri, Masako, Sameshima, Hiroshi +3 more·2020·Journal of Diabetes Investigation
DOI 10.1111/jdi.13101PMC PMC6944816
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Abstract

Aims/Introduction: To compare pregnancy outcomes between women with gestational diabetes mellitus (GDM) diagnosed early and late in pregnancy in Japan. Materials and Methods: We examined women diagnosed with GDM in this multi‐institutional retrospective study. Women were divided into two groups by gestational age at diagnosis: <24 weeks of gestation (early group, 14.4 ± 4.2 weeks) and ≥24 weeks of gestation (late group, 29.6 ± 3.4 weeks). Dietary counseling with self‐monitoring of blood glucose with or without insulin therapy was initiated for both groups. Pregnancy outcomes were compared between the groups. Results: Data from 600 early and 881 late group participants from 40 institutions were included. Although pre‐pregnancy body mass index was higher in the early group than in the late group, gestational weight gain was lower in the early group. Hypertensive disorders of pregnancy and cesarean section were more prevalent in the early than in the late group (9.3% vs 4.8%, P < 0.001; 34.2% vs 32.0%, P < 0.001, respectively). The prevalence of large‐for‐gestational‐age infants was higher in the late than in the early group (24.6% vs 19.7%, respectively, P = 0.025). There was no significant difference in other neonatal adverse outcomes between the groups. Multiple logistic regression analysis showed that early group, nulliparity and pre‐pregnancy body mass index were associated with hypertensive disorders of pregnancy. Conclusions: These results suggest that maternal complications, including hypertensive disorders of pregnancy and cesarean delivery, were higher in the early group than in the late group. Earlier intervention for GDM might be associated with a reduction in large‐for‐gestational‐age infants.

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  • A GDM diagnosis in early pregnancy is associated with adverse pregnancy outcomes compared with a GDM diagnosis in late pregnancy using previous diagnostic criteria in Japan.

    “We also previously showed that a GDM diagnosis in early pregnancy was associated with adverse pregnancy outcomes compared with a GDM diagnosis in late pregnancy using a previous diagnostic criteria in Japan 11 .”

    From Clinical challenges in early pregnancy in Japan: An update on gestational diabetes (2024) · cites this paper as [11]

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Cited by

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Authors
Usami, T., Yokoyama, M., Ueno, M., Iwama, N., Sagawa, N., Kawano, R., Waguri, M., Sameshima, H., Hiramatsu, Y., Sugiyama, T., & for the Japan Diabetes and Pregnancy Study Group
Affiliations
  • Ehime University (JP)
  • Tohoku University Hospital (JP)
  • Rakuwakai Otowa Hospital (JP)
  • Hiroshima University Hospital (JP)
  • Osaka Women's and Children's Hospital (JP)
  • University of Miyazaki (JP)
  • Okayama Medical Center (JP)
Corresponding author
Sugiyama, Takashi
ORCID
Venue
Journal of Diabetes Investigation
Publisher
Wiley
Published
2019-06-27
Volume
11
Issue
1
Pages
216-222
ISSN
  • 2040-1116 (ISSN-L)
  • 2040-1124
DOI
10.1111/jdi.13101
PMC
PMC6944816
OpenAlex
W2949702570
Cited by
44
References
4
Citations by year
2026: 3 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 4 · 2019: 3
FWCI
5.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Diabetes Investigation (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Japan Society for the Promotion of Science (19K09825)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
Keywords
gestational diabetes mellitus, timing of diagnosis, hypertensive disorders of pregnancy, cesarean section, large for gestational age, neonatal outcomes, pre-pregnancy body mass index, nulliparity, gestational weight gain, nutrition counseling, insulin therapy, self-monitoring of blood glucose
MeSH terms
Adult, Diabetes Mellitus, Type 2, Female, Follow-Up Studies, Gestational Age, Humans, Infant, Infant, Newborn, Infant, Newborn, Diseases, Japan, Pregnancy, Pregnancy Complications, Pregnancy Outcome, Retrospective Studies, Incidence, Diabetes, Gestational, Age of Onset

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