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Anti‐diabetic effect of banana peel dietary fibers on type 2 diabetic mellitus mice induced by streptozotocin and high‐sugar and high‐fat diet
Open accessAbstract
We used a high-fat diet (HFD) and streptozotocin (STZ) to induce type 2 diabetic mellitus (T2DM) mice and evaluated the effect of banana peel dietary fibers (BP-DFs) as potential hypoglycemic agents. After 5 weeks of intervention with banana peel dietary fibers (BP-DFs), food intake was reduced, body weight was increased, blood lipids and glucose were reduced, fasting insulin and GLP-1 levels were increased, and liver and pancreatic tissue damage was reduced. Banana peel soluble dietary fiber (BP-SDF) has the most significant effect. The results of fecal microbiota analysis showed that BP-DFs could ameliorates gut microbiome dysbiosis, and all three types of dietary fibers have obvious effects. The results of fecal short-chain fatty acids (SCFAs) showed that the content of fecal SCFAs was increased after BP-DFs dietary intervention, and BP-SDF had the most obvious effect. RT-PCR experiment results show that BP-DFs can up-regulate the mRNA expression levels of PI3K, AKT, IRS-1, and FOXO1 in the liver of diabetic mice, which indicates that BD-DFs may play a role in improving insulin resistance and insulin signal transduction via the IRS/PI3K/AKT pathway, improving insulin resistance and insulin signal transduction. Our research may be extended to BP-DFs, especially BP-SDF, as the basis for potential dietary intervention to prevent or treat type 2 diabetic mellitus. This work supports future research studies of the anti-diabetic properties of BP-SDF in humans. PRACTICAL APPLICATIONS: Diabetes can lead to a variety of complications that have a huge impact on health. Dietary fiber may help in lowering blood sugar. Our experimental results showed that banana peel dietary fibers have the effect of reducing food intake, blood sugar, improving liver and pancreas function, increasing the abundance of intestinal flora, and improving the IRS/PI3K/AKT pathway in T2DM mice. Therefore, this study could provide a theoretical basis for the development of functional foods with banana peel dietary fiber.
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“FW can contain a considerable amount of fiber, which varies depending on the type of food and the discarded portion.”
From Valorization of Food Waste to Produce Value-Added Products Based on Its Bioactive Compounds (2023) · cites this paper as [112]
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“Banana peel, for instance, contains high levels of insoluble dietary fiber that exhibit desirable properties, including water-holding, oil-holding, and glucose adsorption abilities [112].”
From Valorization of Food Waste to Produce Value-Added Products Based on Its Bioactive Compounds (2023) · cites this paper as [112]
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References 36 · Cited by 29
Research works printed but not linked: 31
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Metadata
- Authors
- Wang, M., Yang, F., Yan, X., Chao, X., Zhang, W., Yuan, C., & Zeng, Q.
- Affiliations
- Hefei University of Technology (CN)
- Corresponding author
- Zeng, Qingmei
- Venue
- Journal of Food Biochemistry
- Publisher
- Wiley
- Published
- 2022-06-29
- Volume
- 46
- Issue
- 10
- Pages
- e14275-e14275
- ISSN
- 0145-8884 (ISSN-L)
- 1745-4514
- OpenAlex
- W4283734610
- Cited by
- 29
- References
- 36
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 1
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Food Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31071556, 33171844)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- type 2 diabetes, anti-diabetic effects, antidiabetic drugs, high-fat diet, streptozotocin-induced diabetes, soluble dietary fiber, gut dysbiosis, short-chain fatty acids, insulin resistance, functional foods, dietary intake
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2, Dietary Fiber, Glucose, Humans, Hypoglycemic Agents, Insulin, Insulin Resistance, Lipids, RNA, Messenger, Streptozocin, Phosphatidylinositol 3-Kinases, Musa, Proto-Oncogene Proteins c-akt, Mice, Glucagon-Like Peptide 1, Diet, High-Fat
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- CoChat. (2026). Citation check: Anti‐diabetic effect of banana peel dietary fibers on type 2 diabetic mellitus mice induced by streptozotocin and high‐sugar and high‐fat diet. https://app.cochat.ai/papers/10.1111/jfbc.14275
- The paper
- Wang, M., Yang, F., Yan, X., Chao, X., Zhang, W., Yuan, C., & Zeng, Q. (2022). Anti‐diabetic effect of banana peel dietary fibers on type 2 diabetic mellitus mice induced by streptozotocin and high‐sugar and high‐fat diet. Journal of Food Biochemistry. https://doi.org/10.1111/jfbc.14275
