The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mst‐1 deficiency promotes post‐traumatic spinal motor neuron survival via enhancement of autophagy flux
Abstract
The mammalian Ste20‐like kinase 1 (Mst‐1) is a serine‐threonine kinase and a component of the Hippo tumor suppressor pathway, which reacts to pathologically relevant stress and regulates cell death. However, little is known about its role in spinal cord injury. Here, we found that p‐Mst‐1, the activated form of Mst‐1, was induced in the post‐traumatic spinal motor neurons. In vivo evidence demonstrated that Mst‐1 deficiency promoted post‐traumatic spinal motor neuron survival, Basso mouse scale scores, and synapse survival. Moreover, we found that autophagosome formation and autolysosome degradation enhanced by Mst‐1 deficiency were crucial to attenuate the death of injured spinal motor neurons. Taken together, our findings demonstrate that Mst‐1 deficiency promotes post‐traumatic spinal motor neuron survival via enhancement of autophagy flux. image
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“Some of these targets—including Mst-1, BIM, and MLK3—contribute to the cell death processes of secondary injury [85,86].”
From MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord (2022) · cites this paper as [85]
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Cited by
Sorted by citations
Maza, R. M., Barreda-Manso, M. A., Reigada, D., Silván, Á., Muñoz-Galdeano, T., Soto, A., del Águila, Á., & Nieto-Díaz, M. (2022) · Biomedicines · doi:10.3390/biomedicines10071559 · Cited by 12
Metadata
- Authors
- Zhang, M., Tao, W., Yuan, Z., & Liu, Y.
- Affiliations
- Institute of Neuroscience Jiangsu Key Laboratory of Translational Research and Therapy for Neuro‐Psycho‐Diseases Soochow University Suzhou China
- Obstetrics & Gynecology Hospital and Institute of Developmental Biology and Molecular Medicine Collaborative Innovation Center of Genetics and Development School of Life Sciences Fudan University Shanghai China
- Brain Science Center at the Institute of Basic Medical Science Haidian District Beijing China
- ORCID
- Liu, Yaobo
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2017-09-19
- Volume
- 143
- Issue
- 2
- Pages
- 244-256
- ISSN
- 0022-3042
- 1471-4159
- Cited by
- 26
- References
- 4
- Language
- en
- Funders
- National Natural Science Foundation of China (81330026, 81771330, 31271259)
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