The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
The physiological role of α‐synuclein and its relationship to Parkinson’s Disease
Open accessAbstract
The protein α‐synuclein has a central role in the pathogenesis of Parkinson’s disease (PD). In this review, we discuss recent results concerning its primary function, which appears to be on cell membranes. The pre‐synaptic location of synuclein has suggested a role in neurotransmitter release and it apparently associates with synaptic vesicles because of their high curvature. Indeed, synuclein over‐expression inhibits synaptic vesicle exocytosis. However, loss of synuclein has not yet been shown to have a major effect on synaptic transmission. Consistent with work showing that synuclein can promote as well as sense membrane curvature, recent analysis of synuclein triple knockout mice now shows that synuclein accelerates dilation of the exocytic fusion pore. This form of regulation affects primarily the release of slowly discharged lumenal cargo such as neural peptides, but presumably also contributes to maintenance of the release site. image This article is part of the Special Issue “Synuclein”.
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Self-citation
Cited by
Trudler, D., Sanz-Blasco, S., Eisele, Y. S., Ghatak, S., Bodhinathan, K., Akhtar, M. W., Lynch, W. P., Piña-Crespo, J. C., Talantova, M., Kelly, J. W., et al. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.1871-20.2020 · Cited by 104
Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's disease
Kasen, A., Houck, C., Burmeister, A. R., Sha, Q., Brundin, L., & Brundin, P. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105654 · Cited by 78
Boiten, W., van Steenoven, I., Xiao, M.-F., Worley, P., Noli, B., Cocco, C., Ferri, G.-L., Lemstra, A., & Teunissen, C. (2020) · Cells · doi:10.3390/cells10010038 · Cited by 42
Intramolecular interaction kinetically regulates fibril formation by human and mouse α-synuclein
Ohgita, T., Kono, H., Morita, I., Oyama, H., Shimanouchi, T., Kobayashi, N., & Saito, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-38070-4 · Cited by 20
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Metadata
- Authors
- Sulzer, D., & Edwards, R. H.
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2019-07-28
- Volume
- 150
- Issue
- 5
- Pages
- 475-486
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W2955272631
- Cited by
- 312
- References
- 156
- FWCI
- 20.71
- Type
- journal article
- Language
- en
- Open access
- green
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