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Elevated IGF ‐1 concentrations in children with low grade glioma: A descriptive analysis in a retrospective national cohort
Abstract
Children with low grade glioma (LGG) may present with, or develop, elevated concentrations of insulin‐like growth factor 1 (IGF‐1). The prevalence, pathophysiology, or its possible clinical effects are poorly understood. Our aim was to evaluate the prevalence of such elevated IGF‐1 concentrations and to describe its association with linear growth, body mass index (BMI), pituitary outcome, and tumor behavior in a large retrospective national cohort. From a nationwide retrospective cohort of pediatric brain tumor survivors diagnosed between 2002 and 2012, tumor, treatment, endocrine, and auxological data of children with LGG were collected ( n = 358). Prevalence and risk factors for elevated IGF‐1 concentrations, as well as the association between having elevated IGF‐1 concentrations and receiving tumor treatment, were explored. IGF‐1 concentrations had only been measured in 45.5% of cases ( n = 163/358). In 18.4% of 163 children with available IGF‐1 measurements, IGF‐1 concentrations were found elevated. No association was described between having an elevated IGF‐1 concentration and tumor behavior or height SDS at last moment of follow‐up. Multivariate logistic regression identified posterior pituitary disorder (OR 6.14 95% CI: 2.21–17.09) and BMI SDS at follow‐up (OR 1.56 95% CI: 1.09–2.20) to be significantly associated with elevated IGF‐1 concentrations. In this retrospective cohort of children with LGG, IGF‐1 was found elevated in 18.4% of children with available IGF‐1 measurements. Elevated IGF‐1 seems to be related to hypothalamic dysfunction worsening over time. Larger prospective cohort studies are needed.
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“In young children with suprasellar tumors, hypothalamic dysfunction may result in the overproduction of pituitary hormones, resulting in central precocious puberty or increased concentrations of insulin-like growth factor (IGF)-1 (21).”
From Management of Acquired Hypothalamic Dysfunction and the Hypothalamic Syndrome; It Is More Than Obesity (2025) · cites this paper as [21]
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“The elevated IGF-1 concentrations normalize in time in most cases (21).”
From Management of Acquired Hypothalamic Dysfunction and the Hypothalamic Syndrome; It Is More Than Obesity (2025) · cites this paper as [21]
In the citing paper
“Young children may however also present with central precocious puberty or increased IGF-1 concentrations.”
From Management of Acquired Hypothalamic Dysfunction and the Hypothalamic Syndrome; It Is More Than Obesity (2025) · cites this paper as [21]
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Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., et al. (2016) · Nature · doi:10.1038/nature19329 · Cited by 315
Research works printed but not linked: 28
- 10.1200/JCO.2017.73.0242 · DOI · Paper page
- 10.1097/MOP.0000000000000717 · doi:10.1097/mop.0000000000000717
- 10.1093/neuonc/noaa153 · doi:10.1093/neuonc/noaa153
- 10.1210/jc.2015-2028 · DOI
- 10.3390/cancers14030747 · DOI
- Traunwieser T, 2020, Long‐term cognitive deficits in pediatric low‐grade glioma (LGG) survivors reflect pretreatment conditions‐report from the German LGG studies, Neurooncol Adv, 2
- 10.1542/peds.2004-2237 · DOI
- 10.1016/S0022-3476(70)80370-5 · doi:10.1016/s0022-3476(70)80370-5
- 10.1023/B:REMD.0000016121.58762.6d · DOI
- 10.1210/clinem/dgac157 · DOI
- 10.1159/000514217 · DOI
- Roessel IMAA, 2022, Transition from diencephalic syndrome to hypothalamic obesity in children with Suprasellar low grade glioma: a case series, Front Endocrinol, 13, 13
- 10.1136/bcr-2017-220171 · DOI
- Hawkes CP, 2015, Insulin‐like growth factor‐I is a marker for the nutritional state, Pediatr Endocrinol Rev, 13, 499
- 10.1053/j.gastro.2019.12.020 · DOI
- 10.1530/EJE-21-1186 · DOI · Paper page
- 10.1016/j.ghir.2006.10.007 · DOI · Paper page
- 10.1126/scitranslmed.3001845 · DOI · Paper page
- 10.1158/1055-9965.EPI-11-0179 · doi:10.1158/1055-9965.epi-11-0179
- 10.1016/j.ecl.2012.04.017 · DOI · Paper page
- 10.1200/JCO.2016.67.5025 · DOI
- 10.2471/BLT.07.043497 · DOI · Paper page
- 10.1136/bmj.39238.399444.55 · DOI · Paper page
- 10.1136/bmj.320.7244.1240 · DOI · Paper page
- 10.5483/BMBRep.2015.48.4.272 · DOI · Paper page
- 10.1210/er.2018-00017 · DOI · Paper page
- Paszynska E, 2016, Salivary and serum insulin‐like growth factor (IGF‐1) assays in anorexic patients, World J Biol Psychiatry, 17, 615
- Gan H, 2013, Disease‐ and treatment‐related factors implicated in late neuroendocrine morbidity after paediatric optic pathway gliomas: a preliminary multivariate analysis of 128 patients over 30 years, Eur J Cancer, 49
Cited by
van Santen, H. M., & Müller, H. L. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf025 · Cited by 21
Metadata
- Authors
- van Schaik, J., van Roessel, I. M. A. A., Bos, I. D., Claashen‐van der Grinten, H. L., Clement, S. C., van Iersel, L., Bakker, B., Meijer, L., Kremer, L., Schouten‐van Meeteren, A. Y. N., & van Santen, H. M.
- Affiliations
- Division of Pediatric Endocrinology, Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands
- Department of Pediatrics, Radboud University Medical Center Amalia Children's Hospital Nijmegen The Netherlands
- Department of Pediatric Oncology Princess Máxima Center for Pediatric Oncology Utrecht The Netherlands
- Venue
- Journal of Neuroendocrinology
- Publisher
- Wiley
- Published
- 2023-07-13
- Volume
- 35
- Issue
- 8
- ISSN
- 0953-8194
- 1365-2826
- Cited by
- 2
- References
- 1
- Language
- en
- Funders
- Stichting Kinderen Kankervrij
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- van Schaik, J., van Roessel, I. M. A. A., Bos, I. D., Claashen‐van der Grinten, H. L., Clement, S. C., van Iersel, L., Bakker, B., Meijer, L., Kremer, L., Schouten‐van Meeteren, A. Y. N., & van Santen, H. M. (2023). Elevated IGF ‐1 concentrations in children with low grade glioma: A descriptive analysis in a retrospective national cohort. Journal of Neuroendocrinology. https://doi.org/10.1111/jne.13317
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
