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Cited by 8Dermatologic Treatments and ResearchSkin Protection and Agingmelanin and skin pigmentation

Efficacy and safety of Resveratrol combined with Ablative Fractional CO2 laser system in the treatment of skin photoaging

Du, Yi‐Mei, Zeng, Jing, Li, Meng, Wang, Yang‐Bin, Wu, Yan, Qi, Rui‐Qun, Gao, Xing‐Hua, Chen, Hong‐Duo·2021·Journal of Cosmetic Dermatology
DOI 10.1111/jocd.14569
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Abstract

Objective: To evaluate the efficacy and safety of resveratrol combined with ablative fractional CO 2 laser system (AFL) treating skin photoaging. Methods: Thirty‐two subjects were assigned to the treatment group (TG) or the control group (CG), respectively, applied test product (resveratrol essence) or control product twice daily for 6 months. Each subject was given an AFL treatment or no laser treatment on left or right side of the face randomly. Subjective evaluations by investigators and subjects themselves were conducted after treatment. Melanin index, erythema index, and cuticle moisture content were conducted at baseline and after treatments. Adverse events (AEs) were evaluated during the study period. Results: All subjects in TG achieved improvements of their photoaging signs compared to pre‐treatment both the laser side and the non‐laser side at 6 months (p < 0.05). On the laser side, TG produced a better improvement than CG at 6 months (p < 0.05). On the laser side, the difference values of MI in TG at the 2 months after enrollment (M2), M3, and M4 were more obvious than those in CG (p < 0.05). On the non‐laser side, the difference values of MI in TG at M3, M4, M5, and M6 were more obvious than those of CG (p < 0.05). Subjects in TG were more likely to have tingling and had a faster subsidence of erythema mild edema, and pigmentation induced by AFL compared to CG. Conclusion: The resveratrol can improve photoaging alone and add an efficacy to the AFL treatment and subside the AEs induced by AFL.

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Crossref · 10.1111/jocd.14569

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  • Du et al. study on Resveratrol combined with Ablative Fractional CO2 laser was classified as Level II evidence and was limited by short follow-up and lack of detailed adverse effects.

    “According to the Oxford Centre for Evidence‐Based Medicine's Levels of Evidence, this study can be classified as Level II evidence, as it is a well‐designed randomized controlled trial.”

    From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [22]

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Authors
Du, Y., Zeng, J., Li, M., Wang, Y., Wu, Y., Qi, R., Gao, X., & Chen, H.
Affiliations
  • Department of Dermatology The First Hospital of China Medical University Shenyang China
  • First Hospital of China Medical University (CN)
Corresponding author
Wu, Yan
ORCID
Venue
Journal of Cosmetic Dermatology
Publisher
Wiley
Published
2021-10-31
Volume
20
Issue
12
Pages
3880-3888
ISSN
  • 1473-2130 (ISSN-L)
  • 1473-2165
DOI
10.1111/jocd.14569
OpenAlex
W3209329071
Cited by
8
References
13
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Journal of Cosmetic Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords
resveratrol, ablative fractional CO2 laser, photoaging, combination therapy, melanin index, erythema, adverse events, facial rejuvenation
MeSH terms
Resveratrol, Carbon Dioxide, Erythema, Humans, Skin Aging, Treatment Outcome, Lasers, Gas

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