Cited by 216Skin Protection and AgingSirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant Activities

Resveratrol as an active ingredient for cosmetic and dermatological applications: a review

Ratz-Łyko, Anna, Arct, Jacek·2019·Journal of Cosmetic and Laser Therapy

Abstract

Resveratrol is now being increasingly used in cosmetology and dermatology. This polyphenolic phytoalexin present in large amounts in red grapes and berries has a number of scientifically proven health-promoting properties associated with a positive effect on the cardiovascular system, lowering the concentration of low-density lipoprotein, and the ability to inhibit the cyclooxygenases activity. Additionally, it has antiproliferative, anti-angiogenic, anti-inflammatory, antioxidant, and antimicrobial properties. Its popularity in cosmetology and dermatology is primarily associated with proven ability to penetrate the skin barrier and antiaging activity. It has been shown that formulations with resveratrol can stimulate the proliferation of fibroblasts and contributing to the increase in the concentration of collagen III. Resveratrol has an affinity for the estrogen protein receptors (both ERα and ERβ), thereby contributing to the stimulation of collagen types I and II production. Moreover, resveratrol also has the antioxidant properties, thus can protect cells against oxidative damage associated with the effects of free radicals and UV radiation on the skin by reducing the expression of AP-1 and NF-kB factors and it slows down the process of photoaging of the skin. This study reviews literature on the skin care properties of resveratrol and its dermal bioavailability, metabolism, and dermal safety of application.

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Registry

Crossref · 10.1080/14764172.2018.1469767

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71 of 71 references verified0 citation errors · 0 not checkable

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  • The Ratz-Łyko and Arct 26 review lacks in-depth analysis and critical evaluation of the existing literature.

    “While the review provides a comprehensive summary of the current research on resveratrol, it lacks in‐depth analysis and critical evaluation of the existing literature.”

    From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [26]

  • The Ratz-Łyko and Arct 26 review article falls under Level V evidence according to the Oxford Centre for Evidence-Based Medicine.

    “According to the Oxford Centre for Evidence‐Based Medicine, this review article falls under Level V evidence”

    From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [26]

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Authors
Ratz-Łyko, A., & Arct, J.
Affiliations
  • Cosmetology, The Academy of Cosmetics and Health Care, Warsaw, Poland
  • Academy of Cosmetics and Health Care in Warsaw (PL)
Venue
Journal of Cosmetic and Laser Therapy
Published
2018-05-08
Volume
21
Issue
2
Pages
84-90
ISSN
  • 1476-4172 (ISSN-L)
  • 1476-4180
OpenAlex
W2801231397
Cited by
216
References
71
Citations by year
2026: 24 · 2025: 38 · 2024: 39 · 2023: 29 · 2022: 30 · 2021: 22 · 2020: 20 · 2019: 12 · 2018: 1
FWCI
2.21
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cosmetic and Laser Therapy (publishedVersion)
  • PubMed (publishedVersion)
Funders
This study was not supported
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
resveratrol, cosmetic applications, dermatological applications, skin care, anti-aging, dermal bioavailability, skin barrier penetration, collagen synthesis, fibroblast proliferation, estrogen receptor, antioxidant activity, anti-inflammatory activity, antiangiogenic activity, photoaging, ultraviolet radiation, NF-kB, AP-1, antimicrobial activity, cyclooxygenase inhibition, polyphenols
MeSH terms
Resveratrol, Acne Vulgaris, Antioxidants, Cosmetic Techniques, Humans, Receptors, Estrogen, Skin, Skin Aging, Reactive Oxygen Species, Inflammation Mediators, Sirtuins, Skin Lightening Preparations

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