Resveratrol as an active ingredient for cosmetic and dermatological applications: a review
Abstract
Resveratrol is now being increasingly used in cosmetology and dermatology. This polyphenolic phytoalexin present in large amounts in red grapes and berries has a number of scientifically proven health-promoting properties associated with a positive effect on the cardiovascular system, lowering the concentration of low-density lipoprotein, and the ability to inhibit the cyclooxygenases activity. Additionally, it has antiproliferative, anti-angiogenic, anti-inflammatory, antioxidant, and antimicrobial properties. Its popularity in cosmetology and dermatology is primarily associated with proven ability to penetrate the skin barrier and antiaging activity. It has been shown that formulations with resveratrol can stimulate the proliferation of fibroblasts and contributing to the increase in the concentration of collagen III. Resveratrol has an affinity for the estrogen protein receptors (both ERα and ERβ), thereby contributing to the stimulation of collagen types I and II production. Moreover, resveratrol also has the antioxidant properties, thus can protect cells against oxidative damage associated with the effects of free radicals and UV radiation on the skin by reducing the expression of AP-1 and NF-kB factors and it slows down the process of photoaging of the skin. This study reviews literature on the skin care properties of resveratrol and its dermal bioavailability, metabolism, and dermal safety of application.
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The Ratz-Łyko and Arct 26 review lacks in-depth analysis and critical evaluation of the existing literature.
“While the review provides a comprehensive summary of the current research on resveratrol, it lacks in‐depth analysis and critical evaluation of the existing literature.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [26]
The Ratz-Łyko and Arct 26 review article falls under Level V evidence according to the Oxford Centre for Evidence-Based Medicine.
“According to the Oxford Centre for Evidence‐Based Medicine, this review article falls under Level V evidence”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [26]
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“Overall, the review by Ratz-Łyko and Arct 26 provides valuable insight into the potential applications of resveratrol in cosmetics and dermatology.”
MethodDu, Y., Zeng, J., Li, M., Wang, Y., Wu, Y., Qi, R., Gao, X., & Chen, H. (2021) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14569 · Cited by 8 · see citing works
Resveratrol: A Promising Antiaging Agent for Cosmetic Skin Treatments
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- Authors
- Ratz-Łyko, A., & Arct, J.
- Affiliations
- Cosmetology, The Academy of Cosmetics and Health Care, Warsaw, Poland
- Academy of Cosmetics and Health Care in Warsaw (PL)
- Venue
- Journal of Cosmetic and Laser Therapy
- Publisher
- Informa UK Limited
- Published
- 2018-05-08
- Volume
- 21
- Issue
- 2
- Pages
- 84-90
- ISSN
- 1476-4172 (ISSN-L)
- 1476-4180
- OpenAlex
- W2801231397
- Cited by
- 216
- References
- 71
- Citations by year
- 2026: 24 · 2025: 38 · 2024: 39 · 2023: 29 · 2022: 30 · 2021: 22 · 2020: 20 · 2019: 12 · 2018: 1
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cosmetic and Laser Therapy (publishedVersion)
- PubMed (publishedVersion)
- Funders
- This study was not supported
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- resveratrol, cosmetic applications, dermatological applications, skin care, anti-aging, dermal bioavailability, skin barrier penetration, collagen synthesis, fibroblast proliferation, estrogen receptor, antioxidant activity, anti-inflammatory activity, antiangiogenic activity, photoaging, ultraviolet radiation, NF-kB, AP-1, antimicrobial activity, cyclooxygenase inhibition, polyphenols
- MeSH terms
- Resveratrol, Acne Vulgaris, Antioxidants, Cosmetic Techniques, Humans, Receptors, Estrogen, Skin, Skin Aging, Reactive Oxygen Species, Inflammation Mediators, Sirtuins, Skin Lightening Preparations
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