Therapeutic performance of needle injection versus needle-free jet injector system for polynucleotide filler in skin rejuvenation

A combination of PN with non-insulated microneedle radio frequency has demonstrated enhanced skin elasticity and wrinkle reduction.

“A combination of PN with non-insulated microneedle radio frequency has demonstrated enhanced skin elasticity and wrinkle reduction [171].”

HPT and similar innovations have been adapted for PN-based products.

“More recently, HPT and similar innovations have also been adapted for PN-based products.”

Despite limited sample size in some reported studies, PN treatment has yielded improvements in facial fine lines, overall skin texture, wrinkles, and tone.

“Despite the limited sample size in some reported studies, PN treatment has also yielded improvements in facial fine lines, overall skin texture, wrinkles, and tone [15,153,171,172].”

In Hong et al., no significant pre- to post-treatment differences were observed in conventional needle injection areas for pore index or wrinkle index.

“whereas no significant pre- to post-treatment differences were observed in the conventional needle injection areas for either parameter.”

In Hong et al., pore index improved significantly in needle-free jet injection areas at two weeks.

“statistically significant improvements in pore index (p=0.009) and wrinkle index (p<0.001) in the needle-free jet injection areas at two weeks”

In Hong et al., wrinkle index improved significantly in needle-free jet injection areas at two weeks.

“statistically significant improvements in pore index (p=0.009) and wrinkle index (p<0.001) in the needle-free jet injection areas at two weeks”

In Hong et al., pain intensity was significantly lower with needle-free jet injection than with conventional needle injection.

“Pain intensity was significantly lower in the needle-free jet injection group (VAS 2.9±1.52) compared with the conventional needle injection group (VAS 5.4±1.42; p=0.017).”

In Hong et al., overall patient satisfaction scores were significantly greater following needle-free injection than following conventional injection.

“Overall patient satisfaction scores were also significantly greater following needle-free injection (4.5±0.53 versus 3.9±0.73; p=0.019).”

In Hong et al., GAIS scores assessed by two independent dermatologists were significantly higher in CureJet-treated areas than in manually injected areas.

“Global Aesthetic Improvement Scale (GAIS) scores assessed by two independent dermatologists were significantly higher in the CureJet-treated areas (3.85±0.63) compared with the manually injected areas (3.60±0.52; p=0.037).”

Studies judged as having some concerns included Hong et al. [11], Vera et al. [14], and Kim et al. [8], primarily because of insufficient reporting of allocation concealment, deviations from intended interventions, or incomplete reporting of prespecified analyses.

“Studies judged as having some concerns included Hong et al. [11], Vera et al. [14], and Kim et al. [8], primarily because of insufficient reporting of allocation concealment, deviations from intended interventions, or incomplete reporting of prespecified analyses.”

DNA fragment Optimizing Technology (DOTTM), developed by PharmaResearch Co. Ltd., has been used in the production of both PN and PDRN formulations.

“DNA fragment Optimizing Technology (DOT™), developed by PharmaResearch Co. Ltd., has been used in the production of both PN and PDRN formulations [24,169,170,171].”