The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Melatonin alleviates inflammasome‐induced pyroptosis through inhibiting NF‐κB/GSDMD signal in mice adipose tissue
Abstract
Pyroptosis is a proinflammatory form of cell death that is associated with pathogenesis of many chronic inflammatory diseases. Melatonin is substantially reported to possess anti‐inflammatory properties by inhibiting inflammasome activation. However, the effects of melatonin on inflammasome‐induced pyroptosis in adipocytes remain elusive. Here, we demonstrated that melatonin alleviated lipopolysaccharides (LPS)‐induced inflammation and NLRP 3 inflammasome formation in mice adipose tissue. The NLRP 3 inflammasome‐mediated pyroptosis was also inhibited by melatonin in adipocytes. Further analysis revealed that gasdermin D (GSDMD), the key executioner of pyroptosis, was the target for melatonin inhibition of adipocyte pyroptosis. Importantly, we determined that nuclear factor κB (NF‐κB) signal was required for the GSDMD‐mediated pyroptosis in adipocytes. We also confirmed that melatonin alleviated adipocyte pyroptosis by transcriptional suppression of GSDMD. Moreover, GSDMD physically interacted with interferon regulatory factor 7 (IRF 7) and subsequently formed a complex to promote adipocyte pyroptosis. Melatonin also attenuated NLRP 3 inflammasome activation and pyroptosis, which was induced by LPS or obesity. In summary, our results demonstrate that melatonin alleviates inflammasome‐induced pyroptosis by blocking NF‐κB/GSDMD signal in mice adipose tissue. Our data reveal a novel function of melatonin on adipocyte pyroptosis, suggesting a new potential therapy for melatonin to prevent and treat obesity caused systemic inflammatory response.
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Cites
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
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Pyroptosis: host cell death and inflammation
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Cited by
Arioz, B. I., Tastan, B., Tarakcioglu, E., Tufekci, K. U., Olcum, M., Ersoy, N., Bagriyanik, A., Genc, K., & Genc, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01511 · Cited by 516
Melatonin and inflammation-Story of a double-edged blade
Hardeland, R. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12525 · Cited by 455
Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease
Chitimus, D. M., Popescu, M. R., Voiculescu, S. E., Panaitescu, A. M., Pavel, B., Zagrean, L., & Zagrean, A.-M. (2020) · Biomolecules · doi:10.3390/biom10091211 · Cited by 354
Aging, melatonin, and the pro- and anti-inflammatory networks
Hardeland, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051223 · Cited by 337
Wang, Z., Chen, W.-H., Li, S.-X., He, Z.-M., Zhu, W.-L., Ji, Y.-B., Wang, Z., Zhu, X.-M., Yuan, K., Bao, Y.-P., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01113-1 · Cited by 307
Metadata
- Authors
- Liu, Z., Gan, L., Xu, Y., Luo, D., Ren, Q., Wu, S., & Sun, C.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2017-05-22
- Volume
- 63
- Issue
- 1
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2607216106
- Cited by
- 361
- References
- 69
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Liu, Z., Gan, L., Xu, Y., Luo, D., Ren, Q., Wu, S., & Sun, C. (2017). Melatonin alleviates inflammasome‐induced pyroptosis through inhibiting NF‐κB/GSDMD signal in mice adipose tissue. Journal of Pineal Research. https://doi.org/10.1111/jpi.12414
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