Melatonin and inflammation-Story of a double-edged blade

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works

Melatonin as an antioxidant: under promises but over delivers

Reiter, R. J., Mayo, J. C., Tan, D. X., Sainz, R. M., Alatorre-Jiménez, M. A., & Qin, L. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12360 · Cited by 1,741 · see citing works

Sleep and immune function

Besedovsky, L., Lange, T., & Born, J. (2012) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-1044-0 · Cited by 1,153 · see citing works

Inflammaging and ‘Garb-aging’

Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works

Inflammation in CNS neurodegenerative diseases

Stephenson, J., Nutma, E., van der Valk, P., & Amor, S. (2018) · Immunology · doi:10.1111/imm.12922 · Cited by 966 · see citing works

Melatonin: Nature’s most versatile biological signal?

Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875 · see citing works

Melatonin—A pleiotropic, orchestrating regulator molecule

Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.12.004 · Cited by 843 · see citing works

Melatonin: Buffering the Immune System

Carrillo‐Vico, A., Lardone, P. J., Álvarez‐Sánchez, N., Rodríguez-Rodríguez, A., & Guerrero, J. M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14048638 · Cited by 744 · see citing works

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

Lyssenko, V., Nagorny, C. L. F., Erdos, M. R., Wierup, N., Jonsson, A., Spégel, P., Bugliani, M., Saxena, R., Fex, M., Pulizzi, N., et al. (2009) · Nature Genetics · doi:10.1038/ng.288 · Cited by 742 · see citing works

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 670 · see citing works

A Review of the Multiple Actions of Melatonin on the Immune System

Carrillo‐Vico, A., Guerrero, J. M., Lardone, P. J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:189 · Cited by 664 · see citing works

Is Alzheimer’s disease a type 3 diabetes? A critical appraisal

Kandimalla, R., Thirumala, V., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.08.018 · Cited by 621 · see citing works

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

Chang, H.-C., & Guarente, L. (2013) · Cell · doi:10.1016/j.cell.2013.05.027 · Cited by 615 · see citing works

Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels

Ju, Y.-E. S., Ooms, S. J., Sutphen, C., Macauley, S. L., Zangrilli, M. A., Jerome, G., Fagan, A. M., Mignot, E., Zempel, J. M., Claassen, J. A. H. R., et al. (2017) · Brain · doi:10.1093/brain/awx148 · Cited by 604 · see citing works

Circadian patterns of gene expression in the human brain and disruption in major depressive disorder

Li, J. Z., Bunney, B. G., Meng, F., Hagenauer, M. H., Walsh, D. M., Vawter, M. P., Evans, S. J., Choudary, P. V., Cartagena, P., Barchas, J. D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305814110 · Cited by 589 · see citing works

Melatonin mitigates mitochondrial malfunction

León, J., Acuña-Castroviejo, D., Escames, G., Tan, D. X., & Reiter, R. J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00181.x · Cited by 515 · see citing works

Effects of Melatonin Treatment in Septic Newborns

Gitto, E., Karbownik‐Lewińska, M., Reiter, R. J., Tan, D. X., Cuzzocrea, S., Chiurazzi, P., Cordaro, S., Corona, G., Trimarchi, G. R., & Barberi, I. (2001) · Pediatric Research · doi:10.1203/00006450-200112000-00021 · Cited by 507 · see citing works

Melatonin-Immune System Relationships

Guerrero, J. M., & Reiter, R. J. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394335 · Cited by 476 · see citing works

Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines

Hardeland, R., Tan, D., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00701.x · Cited by 474 · see citing works

Role of the Toll Like receptor (TLR) radical cycle in chronic inflammation: Possible treatments targeting the TLR4 pathway

Lucas, K., & Maes, M. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8425-7 · Cited by 466 · see citing works

Brain metabolic dysfunction at the core of Alzheimer's disease

de la Monte, S. M., & Tong, M. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.12.012 · Cited by 462 · see citing works

Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling

Hardeland, R., Madrid, J. A., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00934.x · Cited by 449 · see citing works

The immune system in extreme longevity

Sansoni, P., Vescovini, R., Fagnoni, F. F., Biasini, C., Zanni, F., Zanlari, L., Telera, A. R., Lucchini, G., Passeri, G., Monti, D., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.008 · Cited by 442 · see citing works

Effect of 1 Night of Total Sleep Deprivation on Cerebrospinal Fluid β-Amyloid 42 in Healthy Middle-Aged Men: A Randomized Clinical Trial

Ooms, S., Overeem, S., Besse, K., Rikkert, M. O., Verbeek, M., & Claassen, J. A. H. R. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1173 · Cited by 438 · see citing works

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

Guarani, V., Deflorian, G., Franco, C. A., Krüger, M., Phng, L., Bentley, K., Toussaint, L., Dequiedt, F., Mostoslavsky, R., Schmidt, M. H. H., et al. (2011) · Nature · doi:10.1038/nature09917 · Cited by 385 · see citing works

Melatonin prevents D rp1‐mediated mitochondrial fission in diabetic hearts through SIRT 1‐ PGC 1α pathway

Ding, M., Feng, N., Tang, D., Feng, J., Li, Z., Jia, M., Liu, Z., Gu, X., Wang, Y., Fu, F., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12491 · Cited by 384 · see citing works

Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes

García‐Mauriño, S., González-Haba, M. G., Calvo, J. R., Rafii-El-Idrissi, M., Sánchez‐Margalet, V., Goberna, R., & Guerrero, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.2.574 · Cited by 380 · see citing works

Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus

Rehman, K., Akash, M. S. H., Liaqat, A., Kamal, S., Qadir, M. I., & Rasul, A. (2017) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukaryotgeneexpr.2017019712 · Cited by 378 · see citing works

Melatonin alleviates inflammasome‐induced pyroptosis through inhibiting NF ‐κB/ GSDMD signal in mice adipose tissue

Liu, Z., Gan, L., Xu, Y., Luo, D., Ren, Q., Wu, S., & Sun, C. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12414 · Cited by 363 · see citing works

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT 3‐dependent regulation of oxidative stress and apoptosis

Zhai, M., Li, B., Duan, W., Jing, L., Zhang, B., Zhang, M., Yu, L., Liu, Z., Yu, B., Ren, K., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12419 · Cited by 351 · see citing works

How does brain insulin resistance develop in Alzheimer's disease?

De Felice, F. G., Lourenco, M. V., & Ferreira, S. T. (2014) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2013.12.004 · Cited by 337 · see citing works

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

Matsubara, E., Bryant‐Thomas, T., Pacheco Quinto, J., Henry, T. L., Poeggeler, B., Herbert, D., Cruz‐Sanchez, F., Chyan, Y., Smith, M. A., Perry, G., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01654.x · Cited by 332 · see citing works

Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages

Mayo, J. C., Sainz, R. M., Tan, D., Hardeland, R., León, J., Rodrı́guez, C., & Reiter, R. J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.05.002 · Cited by 332 · see citing works

Melatonin Antioxidative Defense: Therapeutical Implications for Aging and Neurodegenerative Processes

Pandi-Perumal, S. R., BaHammam, A. S., Brown, G. M., Spence, D. W., Bharti, V. K., Kaur, C., Hardeland, R., & Cardinali, D. P. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9337-4 · Cited by 320 · see citing works

Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF‐κB and Nrf2 cascades

Negi, G., Kumar, A., & Sharma, S. S. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00821.x · Cited by 314 · see citing works

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis

Lowes, D. A., Webster, N. R., Murphy, M. P., & Galley, H. F. (2013) · British Journal of Anaesthesia · doi:10.1093/bja/aes577 · Cited by 314 · see citing works

Type 3 diabetes is sporadic Alzheimer׳s disease: Mini-review

de la Monte, S. M. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.06.008 · Cited by 312 · see citing works

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

Rosales‐Corral, S., Acuña-Castroviejo, D., Coto‐Montes, A. M., Boga, J. A., Manchester, L. C., Fuentes‐Broto, L., Korkmaz, A., Ma, S., Tan, D. X., & Reiter, R. J. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00937.x · Cited by 293 · see citing works

Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms

Hardeland, R. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12090 · Cited by 285 · see citing works

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

Zhang, Y., Li, X., Grailer, J. J., Wang, N., Wang, M., Yao, J., Zhong, R., Gao, G. F., Ward, P. A., Tan, D. X., et al. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12322 · Cited by 282 · see citing works

Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide‐induced multiple organ dysfunction syndrome in rats

Crespo, E., Macías, M. J., Pozo, D., Escames, G., Martı́n, M., Vives, F., Guerrero, J. M., & Acuña-Castroviejo, D. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1537 · Cited by 280 · see citing works

Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells

Zhang, W., Huang, Q., Zeng, Z., Wu, J., Zhang, Y., & Chen, Z. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7543973 · Cited by 276 · see citing works

RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20‐hydroxy‐ and 20,23‐dihydroxyvitamin D

Slominski, A. T., Kim, T., Takeda, Y., Janjetović, Z., Brożyna, A. A., Skobowiat, C., Wang, J., Postlethwaite, A. E., Li, W., Tuckey, R. C., et al. (2014) · The FASEB Journal · doi:10.1096/fj.13-242040 · Cited by 271 · see citing works

Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding

Deng, W., Tang, S.-T., Tseng, H.-P., & Wu, K. K. (2006) · Blood · doi:10.1182/blood-2005-09-3691 · Cited by 267 · see citing works

The Nuclear Receptor for Melatonin Represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes

Steinhilber, D., Brungs, M., Werz, O., Wiesenberg, I., Danielsson, C., Kahlen, J.-P., Nayeri, S., Schräder, M., & Carlberg, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7037 · Cited by 264 · see citing works

Increased melatonin signaling is a risk factor for type 2 diabetes

Tuomi, T., Nagorny, C. L. F., Singh, P., Bennet, H., Yu, Q., Alenkvist, I., Isomaa, B., Östman, B., Söderström, J., Pesonen, A.-K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.04.009 · Cited by 262 · see citing works

Protection against cognitive deficits and markers of neurodegeneration by long‐term oral administration of melatonin in a transgenic model of Alzheimer disease

Olcese, J., Cao, C., Mori, T., Mamcarz, M. B., Maxwell, A. K., Runfeldt, M. J., Wang, L., Zhang, C., Lin, X., Zhang, G., et al. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00692.x · Cited by 260 · see citing works

The immunotherapeutic potential of melatonin

Maestroni, G. J. M. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.3.467 · Cited by 254 · see citing works

Melatonin Stimulates the SIRT 1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide ( LPS )‐Induced Oxidative Stress to Rescue Postnatal Rat Brain

Shah, S. A., Khan, M., Jo, M. H., Jo, M. G., Amin, F. U., & Kim, M. O. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12588 · Cited by 242 · see citing works

Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

Chen, X., Wu, S., Chen, C., Xie, B., Fang, Z., Hu, W., Chen, J., Fu, H., & He, H.-F. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0917-3 · Cited by 241 · see citing works

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT 1‐dependent mechanism during ischemic‐stroke in mice

Yang, Y., Jiang, S., Dong, Y., Fan, C., Zhao, L., Yang, X., Li, J., Di, S., Yue, L., Liang, G., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12193 · Cited by 239 · see citing works

An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease

Pappolla, M. A., Chyan, Y., Pöeggeler, B., Frangione, B., Wilson, G. L., Ghiso, J. A., & Reiter, R. J. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050018 · Cited by 239 · see citing works

Nuclear sirtuins and inflammatory signaling pathways

Mendes, K. L., Lelis, D. D. F., & Santos, S. H. S. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.11.001 · Cited by 237 · see citing works

Sirtuin regulation in aging and injury

Poulose, N., & Raju, R. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.017 · Cited by 236 · see citing works

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

Jung-Hynes, B. D., Reiter, R. J., & Ahmad, N. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00729.x · Cited by 234 · see citing works

Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma

Smolensky, M. H., Lemmer, B., & Reinberg, A. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.016 · Cited by 234 · see citing works

Melatonin as an anti-inflammatory agent modulating inflammasome activation

Favero, G., Franceschetti, L., Bonomini, F., Rodella, L. F., & Rezzani, R. (2017) · International Journal of Endocrinology · doi:10.1155/2017/1835195 · Cited by 233 · see citing works

Melatonin: Signaling mechanisms of a pleiotropic agent

Hardeland, R. (2009) · BioFactors · doi:10.1002/biof.23 · Cited by 227 · see citing works

Melatonin in Alzheimer's disease and other neurodegenerative disorders

Srinivasan, V. J., Pandi-Perumal, S. R., Cardinali, D. P., Pöeggeler, B., & Hardeland, R. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-15 · Cited by 226 · see citing works

Long‐term melatonin treatment delays ovarian aging

Tamura, H., Kawamoto, M., Sato, S., Tamura, I., Maekawa, R., Taketani, T., Asada, H., Takaki, E., Nakai, A., Reiter, R. J., et al. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12381 · Cited by 225 · see citing works

Disruption of the NF-κB/NLRP3 connection by melatonin requires retinoid-related orphan receptor-α and blocks the septic response in mice

García, J. A. G., Volt, H., Venegas, C., Doerrier, C., Escames, G., López, L. C., & Acuña-Castroviejo, D. (2015) · The FASEB Journal · doi:10.1096/fj.15-273656 · Cited by 224 · see citing works

Activation of human monocytes by the pineal hormone melatonin.

Morrey, K. M., McLachlan, J. A., Serkin, C. D., & Bakouche, O. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2671 · Cited by 221 · see citing works

The modulatory role of melatonin on immune responsiveness.

Carrillo‐Vico, A., Reiter, R. J., Lardone, P. J., Herrera, J. L., Fernández-Montesinos, R., Guerrero, J. M., & Pozo, D. (2006) · PubMed · Cited by 217 · see citing works

EXPRESSION OF CONCERN: Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT 1 signaling

Zhao, L., An, R. F., Yang, Y., Yang, X., Liu, H., Yue, L., Li, X., Yan, L., Reiter, R. J., & Qu, Y. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12254 · Cited by 217 · see citing works

Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications

Sharma, A., Tate, M., Mathew, G., Vince, J. E., Ritchie, R. H., & de Haan, J. B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00114 · Cited by 216 · see citing works

Melatonin signaling in T cells: Functions and applications

Ren, W., Liu, G., Chen, S., Yin, J., Wang, J., Tan, B., Wu, G., Bazer, F. W., Peng, Y., Li, Y., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12394 · Cited by 213 · see citing works

Role of the pineal gland in immunity: II. Melatonin enhances the antibody response via an opiatergic mechanism.

Maestroni, G. J. M., Conti, A. M. F., & Pierpaoli, W. (1987) · PubMed · Cited by 210 · see citing works

Melatonin alleviates cadmium‐induced liver injury by inhibiting the TXNIP‐NLRP3 inflammasome

Cao, Z., Fang, Y., Lu, Y., Tan, D. X., Du, C., Li, Y., Ma, Q., Yu, J., Chen, M., Zhou, C., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12389 · Cited by 206 · see citing works

Melatonin ameliorates myocardial ischemia/reperfusion injury in type 1 diabetic rats by preserving mitochondrial function: role of AMPK-PGC-1α-SIRT3 signaling

Yu, L., Gong, B., Duan, W., Fan, C., Zhang, J., Li, Z., Xue, X., Xu, Y., Meng, D., Li, B., et al. (2017) · Scientific Reports · doi:10.1038/srep41337 · Cited by 205 · see citing works

Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment.

Hardeland, R. (2012) · Europe PMC (PubMed Central) · Cited by 202 · see citing works

Melatonin receptor‐mediated protection against myocardial ischemia/reperfusion injury: role of SIRT 1

Yu, L., Sun, Y., Cheng, L., Jin, Z., Yang, Y., Zhai, M., Pei, H., Wang, X., Zhang, H., Meng, Q., et al. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12161 · Cited by 194 · see citing works

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

Rodriguez, G. A., Tai, L. M., LaDu, M. J., & Rebeck, G. W. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-111 · Cited by 193 · see citing works

Melatonin counteracts lipopolysaccharide‐induced expression and activity of mitochondrial nitric oxide synthase in rats

Escames, G., León, J., Macías, M. J., Khaldy, H., & Acuña-Castroviejo, D. (2003) · The FASEB Journal · doi:10.1096/fj.02-0692fje · Cited by 191 · see citing works

Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications

Hamed, S. A. (2017) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2017.1293521 · Cited by 190 · see citing works

Melatonin and brain inflammaging

Hardeland, R., Cardinali, D. P., Brown, G. M., & Pandi-Perumal, S. R. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.02.001 · Cited by 186 · see citing works

EXPRESSION OF CONCERN: Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling

Zhang, M., Lin, J. M., Wang, S., Cheng, Z., Hu, J., Wang, T., Man, W., Yin, T., Guo, W., Gao, E., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12418 · Cited by 185 · see citing works

Melatonin regulates mesenchymal stem cell differentiation: a review

Luchetti, F., Canonico, B., Bartolini, D., Arcangeletti, M., Ciffolilli, S., Murdolo, G., Piroddi, M., Papa, S., Reiter, R. J., & Galli, F. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12133 · Cited by 177 · see citing works

The orphan receptor family RZR/ROR, melatonin and 5‐lipoxygenase: An unexpected relationship

Carlberg, C., & Wiesenberg, I. (1995) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1995.tb00157.x · Cited by 175 · see citing works

Melatonin and sirtuins: A “not-so unexpected” relationship

Mayo, J. C., Sainz, R. M., González Menéndez, P., Cepas, V., Tan, D., & Reiter, R. J. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12391 · Cited by 175 · see citing works

Melatonin modulates TLR4‐mediated inflammatory genes through MyD88‐ and TRIF‐dependent signaling pathways in lipopolysaccharide‐stimulated RAW264.7 cells

Xia, M., Liang, Y., Wang, H., Chen, X., Huang, Y., Zhang, Z., Chen, Y., Zhang, C., Zhao, M., Xu, D., et al. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.01002.x · Cited by 175 · see citing works

Mechanisms of Melatonin in Alleviating Alzheimer’s Disease

Shukla, M., Govitrapong, P., Boontem, P., Reiter, R., & Satayavivad, J. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170313123454 · Cited by 173 · see citing works

Cognitive impairment and dementia: a new emerging complication of type 2 diabetes—The diabetologist’s perspective

Simó, R., Ciudin, A., Simó‐Servat, O., & Hernández, C. (2017) · Acta Diabetologica · doi:10.1007/s00592-017-0970-5 · Cited by 172 · see citing works

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating <scp>NLRP</scp> 3 inflammasome and apoptosis signaling

Dong, Y., Fan, C., Hu, W., Jiang, S., Ma, Z., Yan, X., Deng, C., Di, S., Xin, Z., Wu, G., et al. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12300 · Cited by 170 · see citing works

Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice

Song, C., Peng, W., Yin, S., Zhao, J., Fu, B., Zhang, J., Mao, T., Wu, H., & Zhang, Y. (2016) · Scientific Reports · doi:10.1038/srep35165 · Cited by 170 · see citing works

Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease

Zheng, F., Chang, Y. S., Cheng, Y., Zhang, B. W., Qu, Z., Qin, C., & Zhang, J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00144.x · Cited by 169 · see citing works

Correlation between nuclear melatonin receptor expression and enhanced cytokine production in human lymphocytic and monocytic cell lines

García‐Mauriño, S., Pozo, D., Calvo, J. R., et al. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.290301.x · Cited by 169 · see citing works

Human Lymphocyte-Synthesized Melatonin Is Involved in the Regulation of the Interleukin-2/Interleukin-2 Receptor System

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Melatonin as a potential therapy for sepsis: a phase I dose escalation study and an ex vivo whole blood model under conditions of sepsis

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Melatonin activates Th1 lymphocytes by increasing IL-12 production

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Melatonin counteracts inducible mitochondrial nitric oxide synthase‐dependent mitochondrial dysfunction in skeletal muscle of septic mice

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Inhibition of neuronal nitric oxide synthase activity by N1‐acetyl‐5‐methoxykynuramine, a brain metabolite of melatonin

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Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model

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The role of SIRT1 in diabetic cardiomyopathy

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Melatonin Reverses the Profibrillogenic Activity of Apolipoprotein E4 on the Alzheimer Amyloid Aβ Peptide

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Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation

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Pathophysiology of depression: Role of sleep and the melatonergic system

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Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity

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Melatonin ameliorates cerulein‐induced pancreatitis by the modulation of nuclear erythroid 2‐related factor 2 and nuclear factor‐kappaB in rats

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Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin

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Melatonin Protects Against Oxidative Organ Injury in a Rat Model of Sepsis

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Serotonin and Melatonin Synthesis in Peripheral Blood Mononuclear Cells: Stimulation by Interferon-7 as Part of an Immunomodulatory Pathway

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Melatonin blunts the mitochondrial/ NLRP 3 connection and protects against radiation‐induced oral mucositis

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Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll‐like receptor signaling pathway

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The Underlying Role of Oxidative Stress in Neurodegeneration: A Mechanistic Review

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Melatonin Metabolism in the Central Nervous System

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Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome

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High-mobility group box 1 is a novel deacetylation target of Sirtuin1

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Melatonin Metabolism in the Central Nervous System

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Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies

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The anti-inflammatory and antioxidant effects of melatonin on LPS-stimulated bovine mammary epithelial cells

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Partial sleep deprivation activates the DNA damage response (DDR) and the senescence-associated secretory phenotype (SASP) in aged adult humans

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Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance

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Gene regulation by melatonin linked to epigenetic phenomena

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Melatonin counteracts the inhibitory effect of PGE 2 on IL‐2 production in human lymphocytes via its mt1 membrane receptor

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Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia

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Reduced silent information regulator 1 signaling exacerbates myocardial ischemia–reperfusion injury in type 2 diabetic rats and the protective effect of melatonin

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Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse

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TREM2 in Alzheimer’s disease

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Melatonin protects rats from radiotherapy-induced small intestine toxicity

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Glia-Pinealocyte Network: The Paracrine Modulation of Melatonin Synthesis by Tumor Necrosis Factor (TNF)

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Melatonin attenuates airway inflammation via SIRT1 dependent inhibition of NLRP3 inflammasome and IL-1β in rats with COPD

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Melatonin ameliorates vascular endothelial dysfunction, inflammation, and atherosclerosis by suppressing the TLR 4/ NF ‐κB system in high‐fat‐fed rabbits

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Therapeutic potential of melatonin and its analogs in Parkinson’s disease: focus on sleep and neuroprotection

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Role of Melatonin in the Inflammatory Process and its Therapeutic Potential

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Dietary supplementation with melatonin reduces levels of amyloid beta‐peptides in the murine cerebral cortex

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Fasting protects liver from ischemic injury through Sirt1-mediated downregulation of circulating HMGB1 in mice

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Inhibitory effects of melatonin on titanium particle-induced inflammatory bone resorption and osteoclastogenesis via suppression of NF-κB signaling

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DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute‐on‐chronic liver injury in alcoholic liver disease

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Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice

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Osteoinductive Small Molecules: Growth Factor Alternatives for Bone Tissue Engineering

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Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

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Biology of Longevity: Role of the Innate Immune System

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Identification of Pathway-Biased and Deleterious Melatonin Receptor Mutants in Autism Spectrum Disorders and in the General Population

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Macrophage migration inhibitory factor exhibits a pronounced circadian rhythm relevant to its role as a glucocorticoid counter‐regulator

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Melatonin attenuates methamphetamine‐induced overexpression of pro‐inflammatory cytokines in microglial cell lines

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Novel Role of Resveratrol

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NLRP3 inflammasome activation in mesenchymal stem cells inhibits osteogenic differentiation and enhances adipogenic differentiation

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Melatonin administration to wild‐type mice and nontreated NLRP 3 mutant mice share similar inhibition of the inflammatory response during sepsis

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Neurons from senescence‐accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol

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Chronobiological theories of mood disorder

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Pineal indoles stimulate the gene expression of immunomodulating cytokines

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Dioscin protects against coronary heart disease by reducing oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways

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Melatonin reverses H2O2‐induced senescence in SH ‐ SY 5Y cells by enhancing autophagy via sirtuin 1 deacetylation of the RelA/p65 subunit of NF ‐κB

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Melatonin and the skeleton

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Insulin resistance, neuroinflammation, and Alzheimer’s disease

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Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

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Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

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Daily melatonin protects the endothelial lineage and functional integrity against the aging process, oxidative stress, and toxic environment and restores blood flow in critical limb ischemia area in mice

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Melatonin reduces acute lung injury in endotoxemic rats.

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Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway

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Tryptophan Metabolism in Central Nervous System Diseases: Pathophysiology and Potential Therapeutic Strategies

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Molecular mechanisms regulating NLRP3 inflammasome activation

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The Effects of Melatonin Treatment on Oxidative Stress Induced by Ovariohysterectomy in DogsPreprint

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Serum melatonin levels in melanoma patients after repeated oral administration

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Are the proposed benefits of melatonin-rich foods too hard to swallow?

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