Residual sleepiness in sleep apnea patients treated by continuous positive airway pressure

Gasa, Merce; Tamisier, Renaud; Launois, Sandrine H.; Sapene, Marc; Martin, Francis; Stach, Bruno; Grillet, Yves; Levy, Patrick; Pepin, Jean‐Louis

doi:10.1111/jsr.12039

Cited by 209Obstructive Sleep Apnea ResearchSleep and related disordersSleep and Work-Related Fatigue

Residual sleepiness in sleep apnea patients treated by continuous positive airway pressure

Gasa, Merce, Tamisier, Renaud, Launois, Sandrine H., Sapene, Marc, Martin, Francis, Stach, Bruno, Grillet, Yves, Levy, Patrick +1 more·2013·Journal of Sleep Research

DOI 10.1111/jsr.12039

Open this paper in CoChat — free account

Abstract

Hypoxic brain damage might explain persistent sleepiness in some continuous positive airway pressure-compliant obstructive sleep apnea called residual excessive sleepiness. Although continuous positive airway pressure may not be fully efficient in treating this symptom, wake-promoting drug prescription in residual excessive sleepiness is no longer allowed by the European Medicines Agency. The aim of this study is to describe residual excessive sleepiness phenotypes in a large prospective sample of patients with obstructive sleep apnea. Residual excessive sleepiness was defined by an Epworth Sleepiness Scale score ≥ 11. Eligible patients from the French National Sleep Registry attending follow-up continuous positive airway pressure visits numbered 1047. Patients using continuous positive airway pressure < 3 h (n = 275), with residual apnea-hypopnea index > 15 h⁻¹ (n = 31) or with major depression were excluded (n = 150). Residual excessive sleepiness prevalence in continuous positive airway pressure-treated obstructive sleep apnea was 13% (18% for those with an initial Epworth Sleepiness Scale score > 11), and significantly decreased with continuous positive airway pressure use (9% in ≥ 6 h night⁻¹ continuous positive airway pressure users, P < 0.005). At the time of diagnosis, patients with residual excessive sleepiness had worse subjective appreciation of their disease (general health scale, Epworth Sleepiness Scale and fatigue score), and complained more frequently of continuous positive airway pressure side-effects. Residual excessive sleepiness prevalence was lower in severe obstructive sleep apnea than in moderate obstructive sleep apnea (11% when AHI > 30 h⁻¹ versus 18% when AHI 15-30, P < 0.005). There was no relationship between residual excessive sleepiness and body mass index, cardiovascular co-morbidities or diabetes. Continuous positive airway pressure improved symptoms in the whole population, but to a lower extent in patients with residual excessive sleepiness (fatigue scale: -5.2 versus -2.7 in residual excessive sleepiness- and residual excessive sleepiness+ patients, respectively, P < 0.001). Residual excessive sleepiness prevalence decreased with continuous positive airway pressure compliance. Hypoxic insult is unlikely to explain residual excessive sleepiness as obstructive sleep apnea severity does not seem to be critical. Residual symptoms are not limited to sleepiness, suggesting a true 'continuous positive airway pressure-resistant syndrome', which may justify treatment by wake-promoting drugs.

Integrity signals

Registry

Crossref · 10.1111/jsr.12039

Cites

19 of 19 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Despite positive airway pressure therapy, at least 10% of patients still suffer from residual excessive daytime sleepiness.
“Despite PAP therapy, at least 10% of patients still suffer from residual EDS (rEDS) (Fietze et al., 2021;Gasa et al., 2013;Javaheri & Javaheri, 2020;Launois et al., 2013;Pépin et al., 2009).”
From Effects of mindfulness meditation and Acceptance and commitment therapy in patients with obstructive sleep apnea with residual excessive sleepiness: A randomized controlled pilot study (2023) · cites this paper as Gasa et al., 2013

Epidemiology of Obstructive Sleep Apnea: A Population Health Perspective
Young, T., Peppard, P. E., & Gottlieb, D. J. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2109080 · Cited by 4,244 · see citing works
Reliability and factor analysis of the Epworth Sleepiness Scale.
Johns, M. (1992) · Sleep · doi:10.1093/sleep/15.4.376 · Cited by 2,193 · see citing works
Obstructive Sleep Apnea and Risk of Motor Vehicle Crash: Systematic Review and Meta-Analysis
Tregear, S., Reston, J. T., Schoelles, K. M., & Phillips, B. A. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27662 · Cited by 807 · see citing works
The Effect of CPAP in Normalizing Daytime Sleepiness, Quality of Life, and Neurocognitive Function in Patients with Moderate to Severe OSA
Antic, N. A., Catcheside, P., Buchan, C., Hensley, M., Naughton, M. T., Rowland, S., Williamson, B., Windler, S., & McEvoy, R. D. (2011) · Sleep · doi:10.1093/sleep/34.1.111 · Cited by 533 · see citing works
Daytime Sleepiness and Sleep Habits of Australian Workers
Johns, M. W., & Hocking, B. (1997) · SLEEP · doi:10.1093/sleep/20.10.844 · Cited by 516 · see citing works
Continuous Positive Airway Pressure Therapy for Treating gess in a Diverse Population With Obstructive Sleep Apnea
Patel, S. R., White, D. P., Malhotra, A., Stanchina, M. L., & Ayas, N. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.5.565 · Cited by 462 · see citing works
Continuous positive airway pressure reduces daytime sleepiness in mild to moderate obstructive sleep apnoea: a meta-analysis
Marshall, N. S. (2006) · Thorax · doi:10.1136/thx.2005.050583 · Cited by 224 · see citing works
Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study
Pépin, J., Viot-Blanc, V., Escourrou, P., Jl, R., Sapène, M., Levy, P. A., Dervaux, B., Lenne, X., & Mallart, A. (2009) · European Respiratory Journal · doi:10.1183/09031936.00016808 · Cited by 209 · see citing works
Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study
Alchanatis, M., Deligiorgis, N., Zias, N., Amfilochiou, A., Gotsis, E., Karakatsani, A., & Papadimitriou, A. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00127603 · Cited by 150 · see citing works
Determining the level of sleepiness in the American population and its correlates
Ohayon, M. M. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.06.008 · Cited by 111 · see citing works
Predictors of residual sleepiness in adequately treated obstructive sleep apnoea patients
Koutsourelakis, I., Perraki, E., Economou, N.-T., Dimitrokalli, P., Vagiakis, E., Roussos, C., & ZAKYNTHINOS, S. G. (2009) · European Respiratory Journal · doi:10.1183/09031936.00124708 · Cited by 105 · see citing works
Residual sleepiness in obstructive sleep apnoea: phenotype and related symptoms
Vernet, C., Redolfi, S., Attali, V., Konofal, É., Brion, A., Orvoën-Frija, E., Pottier, M., Similowski, T., & Arnulf, I. (2011) · European Respiratory Journal · doi:10.1183/09031936.00040410 · Cited by 103 · see citing works
<i>DQB1*0602</i> predicts interindividual differences in physiologic sleep, sleepiness, and fatigue
Goel, N., Banks, S., Mignot, E., & Dinges, D. F. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f9615d · Cited by 92 · see citing works
[Brief self-evaluation questionnaire for depressive, asthenic and anxious dimensions].
Pichot, P., & Jp, B. (1984) · PubMed · Cited by 88 · see citing works
Behavioral and genetic markers of sleepiness
Goel, N., & Dinges, D. F. (2011) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.1348 · Cited by 40 · see citing works
Prevalence of High Epworth Sleepiness Scale Scores in a Rural Population
Pahwa, P., Karunanayake, C. P., Hagel, L. M., Gjevre, J. A., Rennie, D., Lawson, J. A., & Dosman, J. A. (2012) · Canadian Respiratory Journal · doi:10.1155/2012/287309 · Cited by 39 · see citing works
Modafinil Improves Functional Outcomes in Patients with Residual Excessive Sleepiness Associated with CPAP Treatment
Weaver, T. E., Chasens, E. R., & Arora, S. (2009) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.27648 · Cited by 32 · see citing works
Post‐CPAP sleepiness – a specific syndrome?
Stradling, J. R., SMITH, D., & CROSBY, J. (2007) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2007.00617.x · Cited by 29 · see citing works
Residual subjective daytime sleepiness under CPAP treatment in initially somnolent apnea patients: A pilot study using data mining methods
Nguyên, X.-L., Rakotonanahary, D., Chaskalovic, J., Philippe, C., Hausser‐Hauw, C., Lebeau, B., & Fleury, B. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.07.016 · Cited by 23 · see citing works

Flagged first, then by citations

Sorted by citations

Diagnosis and Management of Obstructive Sleep Apnea: A Review
Gottlieb, D. J., & Punjabi, N. M. (2020) · JAMA · doi:10.1001/jama.2020.3514 · Cited by 1,482 · see citing works
Obstructive sleep apnoea syndrome
Lévy, P., Kohler, M., McNicholas, W. T., Barbé, F., McEvoy, R. D., Somers, V. K., Lavie, L., & Pépin, J.-L. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.15 · Cited by 1,235 · see citing works
Self-citation
Solriamfetol for Excessive Sleepiness in Obstructive Sleep Apnea (TONES 3). A Randomized Controlled Trial
Schweitzer, P. K., Rosenberg, R. P., Zammit, G. K., Gotfried, M. H., Chen, D., Carter, L. P., Wang, H., Lü, Y., Black, J. E., Malhotra, A., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201806-1100oc · Cited by 321 · see citing works
Pitolisant for Daytime Sleepiness in Patients with Obstructive Sleep Apnea Who Refuse Continuous Positive Airway Pressure Treatment. A Randomized Trial
Dauvilliers, Y. A., Verbraecken, J. A., Partinen, M., Hedner, J. A., Saaresranta, T., Georgiev, O. B., Tiholov, R., Lecomte, I., Tamisier, R., Levy, P. A., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201907-1284oc · Cited by 268 · see citing works
Excessive Daytime Sleepiness in Obstructive Sleep Apnea. Mechanisms and Clinical Management
Lal, C., Weaver, T. E., Bae, C. J., & Strohl, K. P. (2021) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202006-696fr · Cited by 253 · see citing works
Long-term study of the safety and maintenance of efficacy of solriamfetol (JZP-110) in the treatment of excessive sleepiness in participants with narcolepsy or obstructive sleep apnea
Malhotra, A., Shapiro, C. M., Pépin, J., Hedner, J., Ahmed, M., Foldvary‐Schaefer, N., Strollo, P. J., Mayer, G., Sarmiento, K. F., Baladi, M. G., et al. (2019) · SLEEP · doi:10.1093/sleep/zsz220 · Cited by 250 · see citing works
Understanding and approaching excessive daytime sleepiness
Pérez‐Carbonell, L., Mignot, E. J.-M., Leschziner, G. D., & Dauvilliers, Y. A. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01018-2 · Cited by 232 · see citing works
Obstructive Sleep Apnea: A Cluster Analysis at Time of Diagnosis
Bailly, S., Destors, M., Grillet, Y., Richard, P., Stach, B., Vivodtzev, I., Timsit, J., Levy, P. A., Tamisier, R., & Pépin, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157318 · Cited by 185 · see citing works
“5 [3;14] 12 [6;19] 10 [4;17] 14 [8;20] 16 [10;22] Depression scale 3 [1; 7] 4 [1;7] 2 [0;5] 3 [1;7] 2 [0;5] 4 [1;7] 5 [2;8] Epworth scale 10 [6; 14] 12 [8;15] 8 [5;12] 9 [6;13] 10 [6;14] 11 [7;14] 11 [7;14]”
Background
The economic and societal burden of excessive daytime sleepiness in patients with obstructive sleep apnea
Léger, D., & Stepnowsky, C. J. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101275 · Cited by 175 · see citing works
Comorbidities, Health-Related Quality of Life, and Work Productivity Among People With Obstructive Sleep Apnea With Excessive Sleepiness: Findings From the 2016 US National Health and Wellness Survey
Stepnowsky, C. J., Sarmiento, K. F., Bujanover, S., Villa, K. F., Li, V. W., & Flores, N. M. (2019) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7624 · Cited by 123 · see citing works
Update on Persistent Excessive Daytime Sleepiness in OSA
Javaheri, S., & Javaheri, S. (2020) · Chest · doi:10.1016/j.chest.2020.02.036 · Cited by 122 · see citing works
Does remote monitoring change OSA management and CPAP adherence?
Pépin, J., Tamisier, R., Hwang, D., Mereddy, S., & Parthasarathy, S. (2017) · Respirology · doi:10.1111/resp.13183 · Cited by 102 · see citing works
Characterization of the Neurochemical and Behavioral Effects of Solriamfetol (JZP-110), a Selective Dopamine and Norepinephrine Reuptake Inhibitor
Baladi, M. G., Forster, M. J., Gatch, M. B., Mailman, R. B., Hyman, D. L., Carter, L. P., & Janowsky, A. J. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.248120 · Cited by 92 · see citing works
European Respiratory Society statement on sleep apnoea, sleepiness and driving risk
Bonsignore, M. R., Randerath, W., Schiza, S., Verbraecken, J., Elliott, M. W., Riha, R., Barbe, F., Bouloukaki, I., Castrogiovanni, A., Deleanu, O., et al. (2021) · European Respiratory Journal · doi:10.1183/13993003.01272-2020 · Cited by 84 · see citing works
Long‐term adherence with non‐invasive ventilation improves prognosis in obese <scp>COPD</scp> patients
Borel, J., Pepin, J., Pison, C., Vesin, A., Gonzalez‐Bermejo, J., Court‐Fortune, I., & Timsit, J. (2014) · Respirology · doi:10.1111/resp.12327 · Cited by 83 · see citing works
Solriamfetol for the Treatment of Excessive Sleepiness in OSA
Strollo, P. J., Hedner, J. A., Collop, N. A., Lorch, D. G., Chen, D., Carter, L. P., Lü, Y., Lee, L., Black, J. E., Pépin, J., et al. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.11.005 · Cited by 82 · see citing works
Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP
Pépin, J., Georgiev, O. B., Tiholov, R., Attali, V., Verbraecken, J. A., Buyse, B., Partinen, M., Fietze, I., Belev, G., Dokic, D., et al. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.09.281 · Cited by 77 · see citing works
Excessive Daytime Sleepiness in Obstructive Sleep Apnea Patients Treated With Continuous Positive Airway Pressure: Data From the European Sleep Apnea Database
Bonsignore, M. R., Pépin, J., Cibella, F., Barbera, C. D. G., Marrone, O., Verbraecken, J. A., Saaresranta, T., Başoğlu, Ö. K., Trakada, G., Bouloukaki, I., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.690008 · Cited by 72 · see citing works
“On the other hand, data at follow-up were obtained by sleep studies in many patients, whereas other studies relied exclusively on data downloaded from CPAP machines (12).”
BackgroundMethodInfluential
Clinical considerations for the diagnosis of idiopathic hypersomnia
Dauvilliers, Y. A., Bogan, R., Arnulf, I., Scammell, T. E., Louis, E. K. S., & Thorpy, M. J. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101709 · Cited by 72 · see citing works
“EDS can persist in OSA despite adherence to continuous positive airway pressure (CPAP) therapy [53,54].”
Background
Telemedicine in the diagnosis and treatment of sleep apnoea
Bruyneel, M. (2019) · European Respiratory Review · doi:10.1183/16000617.0093-2018 · Cited by 72 · see citing works
The Different Facets of Heart Rate Variability in Obstructive Sleep Apnea
Qin, H., Steenbergen, N., Glos, M., Wessel, N., Kraemer, J. F., Vaquerizo-Villar, F., & Penzel, T. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.642333 · Cited by 71 · see citing works
“There are still 13% of patients with residual EDS after optimal CPAP treatment (152).”
Background
Depressive Symptoms Before and After Long-term CPAP Therapy in Patients With Sleep Apnea
Gagnadoux, F., Vaillant, M. L., Goupil, F., Pigeanne, T., Chollet, S., Masson, P., Bizieux‐Thaminy, A., Humeau, M. P., & Meslier, N. (2014) · CHEST Journal · doi:10.1378/chest.13-2373 · Cited by 70 · see citing works
S3-Leitlinie Nicht erholsamer Schlaf/Schlafstörungen – Kapitel „Schlafbezogene Atmungsstörungen“
(2016) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-016-0093-1 · Cited by 66 · see citing works
Novel avenues to approach non-CPAP therapy and implement comprehensive obstructive sleep apnoea care
Pépin, J., Eastwood, P. R., & Eckert, D. J. (2021) · European Respiratory Journal · doi:10.1183/13993003.01788-2021 · Cited by 67 · see citing works
Association between Excessive Daytime Sleepiness and Risk of Cardiovascular Disease and All-Cause Mortality: A Systematic Review and Meta-Analysis of Longitudinal Cohort Studies
Wang, L., Liu, Q., Heizhati, M., Yao, X., Luo, Q., & Li, N. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.05.023 · Cited by 67 · see citing works
Sleep-Disordered Breathing and Excessive Daytime Sleepiness
He, K., & Kapur, V. K. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2017.03.010 · Cited by 63 · see citing works
Cognitive impairment in obstructive sleep apnea syndrome: a descriptive review
Caporale, M., Palmeri, R., Corallo, F., Muscarà, N., Romeo, L., Bramanti, A., Marino, S., & Buono, V. L. (2020) · Sleep And Breathing · doi:10.1007/s11325-020-02084-3 · Cited by 61 · see citing works
“It causes arousals, intermittent hypoxemia and hypercapnia, and excessive daytime sleepiness [47].”
Background
Investigation and management of residual sleepiness in CPAP-treated patients with obstructive sleep apnoea: the European view
Craig, S., Pépin, J., Randerath, W. J., Caussé, C., Verbraecken, J. A., Asin, J., Barbé, F., & Bonsignore, M. R. (2022) · European Respiratory Review · doi:10.1183/16000617.0230-2021 · Cited by 60 · see citing works
Effect of Wakefulness-Promoting Agents on Sleepiness in Patients with Sleep Apnea Treated with CPAP: A Meta-Analysis
Sukhal, S., Khalid, M., & Tulaimat, A. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.5096 · Cited by 54 · see citing works
Residual excessive daytime sleepiness in patients treated for obstructive sleep apnea: guidance for assessment, diagnosis, and management
Rosenberg, R. P., Schweitzer, P. K., Steier, J. S., & Pépin, J. (2021) · Postgraduate Medicine · doi:10.1080/00325481.2021.1948305 · Cited by 52 · see citing works
“(BMI) are not risk factors for residual EDS in patients who are adherent to CPAP [4,14,15,18].”
BackgroundResultInfluential
Understanding the burden of illness of excessive daytime sleepiness associated with obstructive sleep apnea: a qualitative study
Waldman, L. T., Parthasarathy, S., Villa, K. F., Bron, M., Bujanover, S., & Brod, M. I. (2020) · Health and Quality of Life Outcomes · doi:10.1186/s12955-020-01382-4 · Cited by 48 · see citing works
White matter structural differences in OSA patients experiencing residual daytime sleepiness with high CPAP use: a non-Gaussian diffusion MRI study
Zhang, J., Weaver, T. E., Zhong, Z., Nisi, R. A., Martin, K. R., Steffen, A. D., Karaman, M., & Zhou, X. J. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.09.011 · Cited by 47 · see citing works
“Although the effectiveness of CPAP therapy has been widely demonstrated, it is interesting to note that this treatment fails in a substantial number of highly adherent patients [11].”
Background
Residual Daytime Sleepiness in Obstructive Sleep Apnea After Continuous Positive Airway Pressure Optimization
Chapman, J. L., Serinel, Y., Marshall, N. S., & Grunstein, R. R. (2016) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.05.005 · Cited by 44 · see citing works
Neurocognitive function in patients with residual excessive sleepiness from obstructive sleep apnea: a prospective, controlled study
Werli, K. S., Otuyama, L. J., Bertolucci, P. H. F., Rizzi, C. F., Guilleminault, C., Tufik, S. B., & Poyares, D. R. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.06.028 · Cited by 42 · see citing works
“Therefore, it is known that the excessive sleepiness before treatment, fatigue, and changes in attentional functions are symptoms experienced by patients with OSA, and that sleepiness can significantly influence quality of life and can lead to psychological and cognitive problems [2].”
Background
Residual excessive sleepiness in patients with obstructive sleep apnea on treatment with continuous positive airway pressure
Dongol, E. M., & Williams, A. J. (2016) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000324 · Cited by 41 · see citing works
“In one study, the presence of diabetes mellitus and cardiovascular system disorders were related to RES [15], whereas no relation is found in another [16].”
BackgroundInfluential
Association between glaucoma and sleep apnea in a large French multicenter prospective cohort
Aptel, F., Chiquet, C., Tamisier, R., Sapène, M., Martin, F., Stach, B., Grillet, Y., Levy, P. A., & Pépin, J. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2013.11.790 · Cited by 41 · see citing works
Effects of Solriamfetol on Quality-of-Life Measures from a 12-Week Phase 3 Randomized Controlled Trial
Weaver, T., Drake, C., Benes̆, H., Stern, T., Maynard, J., Thein, S., Andry, J., Hudson, J., Chen, D., Carter, L., et al. (2020) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202002-136oc · Cited by 25 · see citing works
The role of home sleep testing for evaluation of patients with excessive daytime sleepiness: focus on obstructive sleep apnea and narcolepsy
Rosenberg, R. P., Hirshkowitz, M., Rapoport, D. M., & Kryger, M. H. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2019.01.014 · Cited by 40 · see citing works
Modafinil improves daytime sleepiness in patients with mild to moderate obstructive sleep apnoea not using standard treatments: a randomised placebo-controlled crossover trial
Chapman, J. L., Kempler, L., Chang, C. L., Williams, S. C., Sivam, S., WONG, K. K. H., Yee, B. J., Grunstein, R. R., & Marshall, N. S. (2013) · Thorax · doi:10.1136/thoraxjnl-2013-203796 · Cited by 40 · see citing works
Impact of a Multimodal Telemonitoring Intervention on CPAP Adherence in Symptomatic OSA and Low Cardiovascular Risk
Tamisier, R., Treptow, E. C., Joyeux‐Faure, M., Levy, P. A., Sapène, M., Benmerad, M., Bailly, S., Grillet, Y., Stach, B., Muir, J., et al. (2020) · CHEST Journal · doi:10.1016/j.chest.2020.05.613 · Cited by 38 · see citing works
Randomized Controlled Trial of Solriamfetol for Excessive Daytime Sleepiness in OSA
Schweitzer, P. K., Mayer, G., Rosenberg, R. P., Malhotra, A., Zammit, G. K., Gotfried, M. H., Chandler, P. A., Baladi, M. G., & Strohl, K. P. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.02.033 · Cited by 37 · see citing works
“308 Original Research population-based studies.(6,7) In addition, other studies have shown that a substantial percentage of patients who use CPAP treatment for $ 7 h/night do not achieve normal responses on standard measures of sleepiness and functional outcomes.”
Background
Telemedicine in Sleep-Disordered Breathing
Verbraecken, J. A. (2021) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2021.05.009 · Cited by 35 · see citing works
Obstructive sleep apnoea in obesity: A review
Tai, J. E., Phillips, C. L., Yee, B. J., & Grunstein, R. R. (2024) · Clinical Obesity · doi:10.1111/cob.12651 · Cited by 33 · see citing works
Profile of Solriamfetol in the Management of Excessive Daytime Sleepiness Associated with Narcolepsy or Obstructive Sleep Apnea: Focus on Patient Selection and Perspectives
Abad, V. C. (2021) · Nature and Science of Sleep · doi:10.2147/nss.s245020 · Cited by 33 · see citing works
Hypersomnia
Saini, P., & Rye, D. B. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.10.013 · Cited by 30 · see citing works
Relationship between sleep efficacy endpoints and measures of functional status and health‐related quality of life in participants with narcolepsy or obstructive sleep apnea treated for excessive daytime sleepiness
Weaver, T. E., Mathias, S. D., Crosby, R. D., Bron, M., Bujanover, S., Menno, D. M., Villa, K. F., & Drake, C. L. (2020) · Journal of Sleep Research · doi:10.1111/jsr.13210 · Cited by 30 · see citing works
“For many patients, primary airway therapy is not sufficient to resolve EDS; it has been estimated that 9%–22% of those treated with CPAP have persistent EDS (Gasa et al., 2013; Pepin et al., 2009; Weaver et al., 2007).”
Background
Determination of thresholds for minimally important difference and clinically important response on the functional outcomes of sleep questionnaire short version in adults with narcolepsy or obstructive sleep apnea
Weaver, T. E., Menno, D. M., Bron, M., Crosby, R. D., Morris, S. J., & Mathias, S. D. (2021) · Sleep And Breathing · doi:10.1007/s11325-020-02270-3 · Cited by 28 · see citing works
On treatment but still sleepy
Launois, S. H., Tamisier, R., Levy, P. A., & Pépin, J. (2013) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328365ab4a · Cited by 30 · see citing works
Socioeconomic and humanistic burden of illness of excessive daytime sleepiness severity associated with obstructive sleep apnoea in the European Union 5
Jennum, P., Coaquira, J., Mettam, S., Kharkevitch, T., & Cambron‐Mellott, M. J. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2021.05.010 · Cited by 27 · see citing works
Sleepiness in the Elderly
Zalai, D. M., Bingeliene, A., & Shapiro, C. M. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2017.03.015 · Cited by 27 · see citing works
A Phase I, Randomized, Crossover, Open-label Study of the Pharmacokinetics of Solriamfetol (JZP-110) in Healthy Adult Subjects With and Without Food
Zomorodi, K., Kankam, M. K., & Lü, Y. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.12.001 · Cited by 27 · see citing works
Comparative Efficacy and Safety of Wakefulness-Promoting Agents for Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnea
Pitre, T., Mah, J. C., Roberts, S., Desai, K., Gu, Y., Ryan, C. M., Busse, J. W., & Zeraatkar, D. (2023) · Annals of Internal Medicine · doi:10.7326/m22-3473 · Cited by 27 · see citing works
Strategies to Assess the Effect of Continuous Positive Airway Pressure on Long-Term Clinically Important Outcomes among Patients with Symptomatic Obstructive Sleep Apnea: An Official American Thoracic Society Workshop Report
Donovan, L. M., Hoyos, C. M., Kimoff, R. J., Morrell, M. J., Bosch, N. A., Chooljian, D. M., McEvoy, R. D., Sawyer, A. M., Wagner, T. H., Al-Lamee, R. R., et al. (2023) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202303-258st · Cited by 27 · see citing works
Obstructive sleep apnoea syndrome in patients living with diabetes: Which patients should be screened?
Borel, A., Tamisier, R., Böhme, P., Priou, P., Avignon, A., Benhamou, P., Hanaire, H. P., Pépin, J., Kessler, L., Valensi, P. E., et al. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.08.006 · Cited by 26 · see citing works
Pitolisant versus placebo for excessive daytime sleepiness in narcolepsy and obstructive sleep apnea: A meta-analysis from randomized controlled trials
Wang, J., Li, X., Yang, S., Wang, T., Xu, Z., Xu, J., Gao, H., & Chen, G. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105522 · Cited by 25 · see citing works
Relationship between Self-reported Sleepiness and Positive Airway Pressure Treatment Adherence in Obstructive Sleep Apnea
Cistulli, P. A., Armitstead, J. P., Malhotra, A., Yan, Y., Vuong, V., Sterling, K. L., Barrett, M., Nuñez, C. M., Pépin, J., & Benjafield, A. (2023) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202206-482oc · Cited by 23 · see citing works
Recommendations for clinical management of excessive daytime sleepiness in obstructive sleep apnoea – A Delphi consensus study
Steier, J. S., Bogan, R., Pumarega, I. C., Fleetham, J. A., Insalaco, G., Lal, C., Pépin, J., Randerath, W. J., Redline, S. S., & Malhotra, A. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.10.001 · Cited by 24 · see citing works
Long-term effects of solriamfetol on quality of life and work productivity in participants with excessive daytime sleepiness associated with narcolepsy or obstructive sleep apnea
Weaver, T., Pépin, J., Schwab, R., Shapiro, C., Hedner, J., Ahmed, M., Foldvary-Schaefer, N., Strollo, P., Mayer, G., Sarmiento, K., et al. (2021) · Journal of Clinical Sleep Medicine (JCSM) · doi:10.5664/jcsm.9384 · Cited by 13 · see citing works
Long-Term Efficacy and Safety of Pitolisant for Residual Sleepiness Due to OSA
Pépin, J., Attali, V., Caussé, C., Verbraecken, J. A., Hedner, J. A., Lecomte, I., Tamisier, R., Levy, P. A., Lehert, P., & Dauvilliers, Y. A. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.11.017 · Cited by 22 · see citing works
Continuous positive airway pressure treatment impact on memory processes in obstructive sleep apnea patients: a randomized sham-controlled trial
Joyeux‐Faure, M., Naëgelé, B., Pépin, J., Tamisier, R., Levy, P. A., & Launois, S. H. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.06.023 · Cited by 22 · see citing works
Efficacy and safety of solriamfetol for excessive sleepiness in narcolepsy and obstructive sleep apnea: findings from randomized controlled trials
Wang, J., Yang, S., Li, X., Wang, T., Xu, Z., Xu, X. M., Gao, H., & Chen, G. (2021) · Sleep Medicine · doi:10.1016/j.sleep.2020.12.039 · Cited by 22 · see citing works
Solriamfetol treatment of excessive daytime sleepiness in participants with narcolepsy or obstructive sleep apnea with a history of depression
Krystal, A. D., Benca, R. M., Rosenberg, R. P., Schweitzer, P. K., Malhotra, A., Babson, K. A., Lee, L., Bujanover, S., & Strohl, K. P. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.08.018 · Cited by 23 · see citing works
Effects of solriamfetol in a long-term trial of participants with obstructive sleep apnea who are adherent or nonadherent to airway therapy
Schweitzer, P. K., Strohl, K. P., Mayer, G., Rosenberg, R. P., Chandler, P. A., Baladi, M. G., Lee, L., & Malhotra, A. (2020) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.8992 · Cited by 22 · see citing works
Indirect treatment comparison of solriamfetol, modafinil, and armodafinil for excessive daytime sleepiness in obstructive sleep apnea
Ronnebaum, S. M., Bron, M., Patel, D. A., Menno, D. M., Bujanover, S., Kratochvil, D., Lucas, E. J., & Stepnowsky, C. J. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9610 · Cited by 22 · see citing works
Effect of CPAP Therapy in Improving Daytime Sleepiness in Indian Patients with Moderate and Severe OSA
Battan, G. (2016) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2016/23800.8876 · Cited by 20 · see citing works
Solriamfetol for the treatment of daytime sleepiness in obstructive sleep apnea
Abad, V. C., & Guilleminault, C. (2018) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2018.1541742 · Cited by 19 · see citing works
Current Management of Residual Excessive Daytime Sleepiness Due to Obstructive Sleep Apnea: Insights for Optimizing Patient Outcomes
Mehra, R., Heinzer, R. C., & Castillo, P. R. (2021) · Neurology and Therapy · doi:10.1007/s40120-021-00289-6 · Cited by 22 · see citing works
The individual and societal prices of non-adherence to continuous positive airway pressure, contributors, and strategies for improvement
Mendelson, M., Duval, J., Bettega, F., Tamisier, R., Baillieul, S., Bailly, S., & Pépin, J. (2023) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2023.2202853 · Cited by 19 · see citing works
“However, in the largest study to date available in the field [10], residual excessive sleepiness prevalence in CPAPtreated obstructive sleep apnea patients was 13% (18% for those with an initial Epworth Sleepiness Scale score >11), and significantly decreased with CPAP use (9% in ≥6 h night 1 CPAP users).”
Background
Acute and long-term effects of acetazolamide in presumed high loop gain sleep apnea
Ni, Y.-N., Holzer, R. S., & THOMAS, R. J. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.04.010 · Cited by 19 · see citing works
Safety and pharmacodynamics of a single infusion of danavorexton in adults with obstructive sleep apnea experiencing excessive daytime sleepiness despite adequate use of CPAP
Bogan, R., Maynard, J., Neuwirth, R. B., Faessel, H. M., Swick, T. J., & Olsson, T. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.05.001 · Cited by 19 · see citing works
Work-Related Sleep Disorders: Causes and Impacts
Gusman, E., Standlee, J., Reid, K. J., & Wolfe, L. F. (2023) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0043-1767787 · Cited by 17 · see citing works
Excessive daytime sleepiness in obstructive sleep apnea: Indirect treatment comparison of wake-promoting agents in patients adherent/nonadherent to primary OSA therapy
Wang, Y., Zhang, W., Ye, H., & Xiao, Y. (2024) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2024.101997 · Cited by 17 · see citing works
Solriamfetol for the treatment of excessive daytime sleepiness associated with narcolepsy
Yang, J., & Gao, J. (2019) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2019.1632705 · Cited by 17 · see citing works
Turning Over a New Leaf—Pharmacologic Therapy in Obstructive Sleep Apnea
Hedner, J. A., & Zou, D. (2022) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2022.06.010 · Cited by 16 · see citing works
Microstructural Changes in the Cerebral White Matter After 12 Months of CPAP Treatment for Moderate to Severe Obstructive Sleep Apnoea: A TBSS Study
Liu, X., Wei, Z., Ting, L., Liu, X., Shu, Y., Huang, L., Li, L., Liu, Y., Xia, G.-J., Peng, D., et al. (2024) · Nature and Science of Sleep · doi:10.2147/nss.s460919 · Cited by 15 · see citing works
“11 Although some of the reasons may be poor patient compliance, resulting in poor CPAP efficacy, 12 this does not explain the efficacy response in some patients with significantly improved clinical parameters.”
Prevalence of sleepiness and associations with quality of life in patients with sleep apnea in an online cohort
Wanberg, L. J., Rottapel, R. E., Reid, M., Bertisch, S. M., Bron, M., Kapur, V. K., Bujanover, S., Harrington, Z., Bakker, J. P., Javaheri, S., et al. (2021) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.9436 · Cited by 15 · see citing works
Solriamfetol improves chronic sleep fragmentation-induced increases in sleep propensity and ameliorates explicit memory in male mice
Puech, C., Badran, M., Barrow, M. B., Runion, A. R., & Gozal, D. (2023) · SLEEP · doi:10.1093/sleep/zsad057 · Cited by 14 · see citing works
Treatment of sleep apnoea with tonsillectomy: a retrospective analysis using long-term follow-up data
Sjöblom, H. M., Nahkuri, M., Suomela, M., Jero, J., & Piitulainen, J. M. (2022) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-022-07350-6 · Cited by 14 · see citing works
“Residual sleepiness is nearly twice as prevalent in patients suffering from moderate OSA when compared to patients with severe OSA [5, 6].”
Background
Application of Inverse-Probability-of-Treatment Weighting to Estimate the Effect of Daytime Sleepiness in Patients with Obstructive Sleep Apnea
Bettega, F., Leyrat, C., Tamisier, R., Mendelson, M., Grillet, Y., Sapène, M., Bonsignore, M. R., Pépin, J., Kattan, M. W., & Bailly, S. (2022) · Annals of the American Thoracic Society · doi:10.1513/annalsats.202109-1036oc · Cited by 14 · see citing works
Effects of solriamfetol on on‐the‐road driving performance in participants with excessive daytime sleepiness associated with obstructive sleep apnoea
Vinckenbosch, F. R. J., Asin, J., de Vries, N., Vonk, P. E., Donjacour, C. E. H. M., Lammers, G. J., Overeem, S., Janssen, H. C. J. P., Wang, G., Chen, D., et al. (2022) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2845 · Cited by 14 · see citing works
Evaluation of the add-on NOWAPI® medical device for remote monitoring of compliance to Continuous Positive Airway Pressure and treatment efficacy in obstructive sleep apnea
Léger, D., Elbaz, M., Piednoir, B., Carron, A., & Texereau, J. (2016) · BioMedical Engineering OnLine · doi:10.1186/s12938-016-0139-4 · Cited by 13 · see citing works
“A minimum of 3–4 h of treatment every night is necessary to obtain long term benefit [6, 7].”
Background
Examining the impact of excessive daytime sleepiness on utility scores in patients with obstructive sleep apnoea and/or narcolepsy in five European countries
Cambron‐Mellott, M. J., Mettam, S., Li, V. W., Rowland, J., & Coaquira, J. (2022) · BMC Neurology · doi:10.1186/s12883-022-02827-7 · Cited by 12 · see citing works
“The prevalence of OSA associated with EDS is approximately 3 to 7% for men and 2 to 5% for women in the general population [10], and it has been found that residual EDS remains in up to 13% of patients even after continuous positive airway pressure (CPAP) treatment [18].”
Background
Pitolisant 40 mg for excessive daytime sleepiness in obstructive sleep apnea patients treated or not by CPAP : Randomised phase 3 study
Dauvilliers, Y. A., Craig, S. E., Bonsignore, M. R., Barbé, F., Verbraecken, J. A., Asin, J., Georgiev, O. B., Tiholov, R., Caussé, C., Lecomte, J., et al. (2024) · Journal of Sleep Research · doi:10.1111/jsr.14373 · Cited by 12 · see citing works
“However, approximately 5% – 10% of patients with OSA experience residual EDS, despite regular use of CPAP treatment (Gasa et al., 2013; Lal et al., 2021; Pépin et al., 2009).”
The pharmacotherapeutic management of obstructive sleep apnea
Marra, S., Arnaldi, D., & Nobili, L. (2019) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2019.1652271 · Cited by 12 · see citing works
Detailed Structural Examination, Quantum Mechanical Studies of the Aromatic Compound Solarimfetol and Formation of Inclusion Compound with Cucurbituril
Pooventhiran, T., Mouna, C., Bhattacharyya, U., Irfan, A., Puchta, R., Sowrirajan, S., & Thomas, R. (2021) · Polycyclic aromatic compounds · doi:10.1080/10406638.2021.1937238 · Cited by 12 · see citing works
Different components of excessive daytime sleepiness and the change with positive airway pressure treatment in patients with obstructive sleep apnea: Results from the Icelandic Sleep Apnea Cohort (ISAC)
Thorarinsdottir, E. H., Janson, C., Aspelund, T., Benediktsdóttir, B., Júlíusson, S., Gíslason, Þ., Kuna, S. T., Pack, A. I., & Keenan, B. T. (2021) · Journal of Sleep Research · doi:10.1111/jsr.13528 · Cited by 12 · see citing works
“Estimatesofprevalenceofpersistentsleepiness were compared to those obtained using the traditional definition of residual sleepiness based solely on the ESS (Gasa et al., 2013; Koutsourelakisetal.,2009;Pépinetal.,2009).”
Exploring the impact of excessive daytime sleepiness caused by obstructive sleep apnea on patient and partner quality of life: a time trade-off utility study in the UK general public
Tolley, K. H., Noble-Longster, J., Mettam, S., Hibbs, R., Cawson, M., Stainer, L., Snell, T., & Manuel, A. R. (2022) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.10092 · Cited by 11 · see citing works
Synergic Integration of the miRNome, Machine Learning and Bioinformatics for the Identification of Potential Disease-Modifying Agents in Obstructive Sleep Apnea
Belmonte, T., Benitez, I. D., García‐Hidalgo, M. C., Molinero, M., Pinilla, L., Mínguez, O., Vaca, R., Aguilà, M., Moncusí‐Moix, A., Torres, G., et al. (2024) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2024.11.011 · Cited by 11 · see citing works
Solriamfetol enhances wakefulness and improves cognition and anxiety in a murine model of OSA
Badran, M., Puech, C., Barrow, M. B., Runion, A. R., & Gozal, D. (2023) · Sleep Medicine · doi:10.1016/j.sleep.2023.04.007 · Cited by 11 · see citing works
Current Knowledge and Perspectives for Pharmacological Treatment in OSA
Baillieul, S., Tamisier, R., Eckert, D. J., & Pépin, J. (2022) · Archivos de Bronconeumología · doi:10.1016/j.arbres.2021.12.013 · Cited by 11 · see citing works
The comparison of nasal surgery and CPAP on daytime sleepiness in patients with OSAS
Tagaya, M., Otake, H., Suzuki, K., Yasuma, F., Yamamoto, H., Noda, A., Nishimura, Y., Sone, M., Nakashima, T., & Nakata, S. (2017) · Rhinology Journal · doi:10.4193/rhin17.026 · Cited by 10 · see citing works
How many hours per night is enough? A systematic integrative review to identify optimal hours of CPAP therapy use for sleep apnoea
Chaplin, H., & Ward, K. L. (2022) · Health Sciences Review · doi:10.1016/j.hsr.2022.100061 · Cited by 10 · see citing works
Real-world impact of continuous positive airway pressure on sleepiness in patients with obstructive sleep apnea in a national registry
Jennum, P., Kjellberg, J., Carls, G. S., Ibsen, R., & Mettam, S. (2024) · Sleep Medicine · doi:10.1016/j.sleep.2024.03.011 · Cited by 10 · see citing works
Systolic pressure response to voluntary apnea predicts sympathetic tone in obstructive sleep apnea as a clinically useful index
Jouett, N., Hardisty, J. M., Mason, J. R., Niv, D., Romano, J. J., Watenpaugh, D. E., Burk, J. R., & Smith, M. L. (2015) · Autonomic Neuroscience · doi:10.1016/j.autneu.2015.12.003 · Cited by 10 · see citing works
Results of the Solriamfetol's Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-Controlled Study (SHARP)
Dongen, H. P. A. V., Leary, E. B., Drake, C. L., Bogan, R., Jaeger, J., Rosenberg, R. P., Streicher, C., & Tabuteau, H. (2024) · CHEST Journal · doi:10.1016/j.chest.2024.10.050 · Cited by 9 · see citing works
Efficacy and safety of pitolisant in residual excessive daytime sleepiness for patients with obstructive sleep apnea adhering to continuous positive airway pressure therapy in the HAROSA studies: An individual patient meta-analytical approach
Testelmans, D., Lehert, P., Asin, J., Imschoot, J., Caussé, C., & Pépin, J. (2025) · Sleep Medicine · doi:10.1016/j.sleep.2025.02.003 · Cited by 9 · see citing works
Comparative Efficacy and Safety of Multiple Wake-Promoting Agents for the Treatment of Residual Sleepiness in Obstructive Sleep Apnea Despite Continuous Positive Airway Pressure: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Tanayapong, P., Tantrakul, V., Liamsombut, S., Siriyotha, S., McKay, G. J., Attia, J., & Thakkinstian, A. (2025) · CNS Drugs · doi:10.1007/s40263-025-01175-7 · Cited by 9 · see citing works
“…AEs, serious AEs (SAEs), AEs leading to discontinuation, specified AEs, such as headache, nausea, insomnia, anxiety, etc.] The exclusion criteria for studies were any of the following: (1) included patients with comorbid psychiatric persist in 12–65% of patients adequately treated with CPAP [7, 8].”
Health-related impact of illness associated with excessive daytime sleepiness in patients with obstructive sleep apnea
Grandner, M., Min, J., Saad, R., Leary, E., Eldemir, L., & Hyman, D. (2023) · Postgraduate medicine · doi:10.1080/00325481.2023.2203623 · Cited by 7 · see citing works
“Populationbased studies estimate that approximately 9% to 22% of CPAPtreated patients have residual EDS, even when other potential causes of sleepiness are excluded [8,9].”
Background
Guidelines for the assessment and management of residual sleepiness in obstructive apnea-hypopnea syndrome: Endorsed by the French Sleep Research and Medicine Society (SFRMS) and the French Speaking Society of Respiratory Diseases (SPLF).
Barateau, L., Baillieul, S., Andrejak, C., Bequignon, E., Boutouyrie, P., Dauvilliers, Y., Gagnadoux, F., Geoffroy, P., Micoulaud-Franchi, J., Montani, D., et al. (2024) · Respiratory medical research · doi:10.1016/j.resmer.2024.101105 · Cited by 15 · see citing works
Theoretical Study of Adsorption of Solriamfetol Drug on Surface of the B12N12 Fullerene: A DFT/TD-DFT Approach
Yahyaei, H., Sharifi, S., Shаhаb, S., Sheikhi, M., & Ahmadianarog, M. (2020) · Letters in Organic Chemistry · doi:10.2174/1570178617999200818104322 · Cited by 9 · see citing works

Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre study
Pépin, J., Viot-Blanc, V., Escourrou, P., Jl, R., Sapène, M., Levy, P. A., Dervaux, B., Lenne, X., & Mallart, A. (2009) · European Respiratory Journal · doi:10.1183/09031936.00016808 · Cited by 209 · see citing works
Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the
Study, F. M. (2016)
Residual excessive sleepiness in patients with obstructive sleep apnea on treatment with continuous positive airway pressure
Dongol, E. M., & Williams, A. J. (2016) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000324 · Cited by 41 · see citing works
Prevalence of residual excessive sleepiness in obstructive sleep apnea patients treated by continuous positive airway pressure (CPAP).
Pépin, J., Escourrou, P., Krieger, J. E., Meslier, N., Sapène, M., Dervaux, B., Lenne, X., & Mallart, A. (2006) · HAL
Predictors of residual sleepiness in patients with obstructive sleep apnea syndrome on continuous positive airway pressure
Dongol, E. M., Drakatos, P., Muza, R., Badawy, A. Y., Badawy, M. S., & Williams, A. J. (2021) · Egyptian Journal of Chest Diseases and Tuberculosis · doi:10.4103/ejcdt.ejcdt_163_18 · Cited by 1 · see citing works

Authors: Gasa, M., Tamisier, R., Launois, S. H., Sapene, M., Martin, F., Stach, B., Grillet, Y., Levy, P., & Pepin, J.
Affiliations: INSERM U 1042, Joseph Fourier University HP2 Laboratory (Hypoxia: Pathophysiology) La Tronche France
Inserm (FR)
Unité Sommeil et Vigilance Polyclinique Bordeaux Cauderan Bordeaux France
Centre Hospitalier Compiègne-Noyon (FR)
Centre Hospitalier de Valenciennes (FR)
Pneumologie Cabinet privé Valence France
Corresponding author: Tamisier, Renaud
ORCID: Tamisier, Renaud
Levy, Patrick
Venue: Journal of Sleep Research
Publisher: Wiley
Published: 2013-02-15
Volume: 22
Issue: 4
Pages: 389-397
ISSN: 0962-1105 (ISSN-L)
1365-2869
DOI: 10.1111/jsr.12039
OpenAlex: W2011435303
Cited by: 209
References: 19
Citations by year: 2026: 11 · 2025: 16 · 2024: 20 · 2023: 24 · 2022: 35 · 2021: 30 · 2020: 21 · 2019: 12 · 2018: 14 · 2017: 7 · 2016: 8 · 2015: 3 · 2014: 5 · 2013: 3
FWCI: 4.40
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal of Sleep Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: obstructive sleep apnea, continuous positive airway pressure, CPAP adherence, hypoxic brain injury, wake-promoting drugs, Epworth Sleepiness Scale, apnea-hypopnea index, fatigue, CPAP side effects, prevalence, disease severity, patient-reported outcomes, REM sleep behavior disorder
MeSH terms: Fatigue, Female, France, Humans, Disorders of Excessive Somnolence, Male, Middle Aged, Patient Compliance, Prospective Studies, Registries, Sleep Stages, Syndrome, Comorbidity, Body Mass Index, Prevalence, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Residual sleepiness in sleep apnea patients treated by continuous positive airway pressure

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks