DQB1*0602 predicts interindividual differences in physiologic sleep, sleepiness, and fatigue
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OBJECTIVE: The human leukocyte antigen (HLA) DQB1*0602 allele is closely associated with narcolepsy, a neurologic disorder characterized by excessive daytime sleepiness, fragmented sleep, and shortened REM sleep latency. We evaluated whether DQB1*0602 was a novel marker of interindividual differences by determining its relationship to sleep homeostatic, sleepiness, and cognitive responses to baseline and chronic partial sleep deprivation (PSD) conditions. METHODS: Ninety-two DQB1*0602-negative and 37 DQB1*0602-positive healthy adults participated in a protocol of 2 baseline 10 hours time in bed (TIB) nights followed by 5 consecutive 4 hours TIB nights. DQB1*0602 allelic frequencies did not differ significantly between Caucasians and African Americans. RESULTS: During baseline, although DQB1*0602-positive subjects were subjectively sleepier and more fatigued, they showed greater sleep fragmentation, and decreased sleep homeostatic pressure and differentially sharper declines during the night (measured by non-REM EEG slow-wave energy [SWE]). During PSD, DQB1*0602-positive subjects were sleepier and showed more fragmented sleep, despite SWE elevation comparable to negative subjects. Moreover, they showed differentially greater REM sleep latency reductions and smaller stage 2 reductions, along with differentially greater increases in fatigue. Both groups demonstrated comparable cumulative decreases in cognitive performance. CONCLUSIONS: DQB1*0602 positivity in a healthy population may represent a continuum of some sleep-wake features of narcolepsy. DQB1*0602 was associated with interindividual differences in sleep homeostasis, physiologic sleep, sleepiness, and fatigue-but not in cognitive measures-during baseline and chronic PSD. Thus, DQB1*0602 may represent a genetic biomarker for predicting such individual differences in basal and sleep loss conditions.
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There are large and highly replicable, trait-like individual differences in the magnitude of fatigue, sleepiness, sleep homeostatic, and cognitive performance vulnerability to acute total sleep deprivation and to chronic sleep restriction.
“We have repeatedly demonstrated that there are large and highly replicable, trait-like individual differences in the magnitude of fatigue, sleepiness, sleep homeostatic, and cognitive performance vulnerability to acute total sleep deprivation170,171 and to chronic sleep restriction.32,148,172,173”
From Circadian rhythms, sleep deprivation, and human performance (2013) · cites this paper as [172]
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- Goel N, Banks S, Mignot E, Dinges DF. PER3 polymor- phism predicts cumulative sleep homeostatic but not neu- robehavioral changes to chronic sleep restriction. PLoS ONE 2009;4:e5874.
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Genetic Ancestry for Sleep Research
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Correlation of daytime sleepiness with urine metabolites in patients with obstructive sleep apnea
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Genetics and Genomic Basis of Sleep in Healthy Humans
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Exploring Genetic Attributions Underlying Radiotherapy-Induced Fatigue in Prostate Cancer Patients
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Physiological and Neurobehavioral Consequences of Chronic Sleep Restriction in Rodent Models
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Genetics and Genomic Basis of Sleep Disorders in Humans
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Baseline Sleep Dysfunction Among Matriculating Interns
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Distribution of HLA-DQB1 in Czech Patients with Central Hypersomnias
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Editorial: Resident work hours
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Sleepiness profiles in mice submitted to acute and chronic sleep deprivation
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Precision Medicine for Sleep Loss and Fatigue Management
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- Authors
- Goel, N., Banks, S., Mignot, E., & Dinges, D. F.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Neurology
- Published
- 2010-10-26
- Volume
- 75
- Issue
- 17
- Pages
- 1509-1519
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC2974463
- OpenAlex
- W2024563693
- Cited by
- 92
- References
- 40
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 7 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 4 · 2014: 12 · 2013: 16 · 2012: 15
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Aeronautics and Space Administration (NCC958)
- Institute for Translational Medicine and Therapeutics (UL1-RR024134)
- National Space Biomedical Research Institute (NCC 9‐58)
- National Institutes of Health (NCC9-58, CTRC UL1RR024134)
- National Institute of Nursing Research (NR004281, R01NR004281)
- National Institute of Neurological Disorders and Stroke (P50NS023724, NS-23724)
- National Center for Research Resources (UL1RR024134)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- HLA-DQB1*0602, narcolepsy, sleep homeostasis, sleepiness, fatigue, sleep fragmentation, REM latency, sleep restriction, slow-wave activity, genetic biomarkers, individual differences, cognitive performance
- MeSH terms
- Adult, Analysis of Variance, Cognition Disorders, Electroencephalography, Fatigue, Female, HLA-DQ Antigens, Humans, Individuality, Sleep Initiation and Maintenance Disorders, Male, Membrane Glycoproteins, Middle Aged, Neuropsychological Tests, Sleep, Polysomnography, Young Adult, Executive Function, HLA-DQ beta-Chains
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