Nocturnal nasal obstruction is frequent and reduces sleep quality in patients with obstructive sleep apnea
Open accessAbstract
Summary: The prevalence and consequences of nasal obstruction in untreated obstructive sleep apnea patients are not known. The study objectives were to investigate the frequency of subjective and objective nasal obstruction in untreated sleep apnea patients and the associations with sleep and quality of life. Patients in the Icelandic Sleep Apnea Cohort were subjected to a type 3 sleep study, answered questionnaires and had their nasal dimensions measured by acoustic rhinometry. In total, 810 patients participated (including 153 females), aged 54.5 ± 10.6 years [mean ± standard deviation (SD)] with an apnea/hypopnea index 44.7 ± 20.7 h−1. Nocturnal nasal obstruction (greater than or equal to three times per week) was reported by 35% of the patients. These patients had smaller nasal dimensions measured by the minimum cross‐sectional area within the smaller nasal valve (0.42 ± 0.17 versus 0.45 ± 0.16 cm 2, P = 0.013), reported more daytime sleepiness (Epworth Sleepiness Scale score 12.5 ± 4.9 versus 10.8 ± 5.0; P < 0.001) and slightly lower mental quality of life than patients without nocturnal nasal obstruction. Nocturnal nasal obstruction is reported in one‐third of the sleep apnea patients and they are more likely to suffer from daytime sleepiness and slightly reduced quality of life than other sleep apnea patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Multiple observational studies found that increased objective nasal resistance on anterior rhinomanometry predicted nasal PAP intolerability.
“Multiple observational studies found that increased objective nasal resistance on anterior rhinomanometry was predictive of nasal PAP intolerability.544,1169”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [1169]
The Methods (Acoustic rhinometry; page unavailable) describe measuring nasal dimensions with acoustic rhinometry, not nasal resistance with anterior rhinomanometry. The study assessed patients before PAP treatment and examined nasal obstruction, sleep symptoms, and quality of life; searches for rhinomanometry and PAP intolerance or adherence found no passage reporting that nasal resistance predicted PAP intolerability. (LLM, conf=0.78)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
WARE, J. E., KOSINSKI, M., & KELLER, S. D. (1996) · Medical Care · doi:10.1097/00005650-199603000-00003 · Cited by 17,392 · cited 1× · see citing works
“Health-related quality of life was examined with the Short Form Health Survey (SF-12) questionnaire (Ware et al., 1996).”
MethodA New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364 · see citing works
Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study
Heinzer, R., Vat, S., Marques-Vidal, P., Marti-Soler, H., Andries, D., Tobback, N., Mooser, V, Preisig, M., Malhotra, A., Waeber, G., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00043-0 · Cited by 2,481 · see citing works
Basic Nordic Sleep Questionnaire (BNSQ): a quantitated measure of subjective sleep complaints
Partinen, M., & Gíslason, Þ. (1995) · Journal of Sleep Research · doi:10.1111/j.1365-2869.1995.tb00205.x · Cited by 528 · see citing works
Nasal obstruction as a risk factor for sleep-disordered breathing
Young, T., Finn, L., & Kim, H. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70124-6 · Cited by 505 · see citing works
Consensus report on acoustic rhinometry and rhinomanometry.
Clement, P. A. R., & Gordts, F. (2005) · PubMed · Cited by 421 · see citing works
Hoffstein, V., Viner, S., Mateika, S., & Conway, J. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.4_pt_1.841 · Cited by 317 · see citing works
Berry, R. B., Gamaldo, C. E., Harding, S. M., Brooks, R., Lloyd, R. M., Vaughn, B. V., & Marcus, C. L. (2015) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.5176 · Cited by 260 · see citing works
Respiratory Symptoms and Nocturnal Gastroesophageal Reflux
Gíslason, Þ., Janson, C., Vermeire, P. A., Plaschke, P. P., Bjornsson, E. H., Gíslason, D., & Boman, G. (2002) · CHEST Journal · doi:10.1378/chest.121.1.158 · Cited by 240 · see citing works
The role of the nose in snoring and obstructive sleep apnoea: an update
Georgalas, C. (2011) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-010-1469-7 · Cited by 239 · see citing works
Mols, F., Pelle, A. J. M., & Kupper, N. H. M. (2009) · Quality of Life Research · doi:10.1007/s11136-009-9455-5 · Cited by 199 · see citing works
Hilberg, O. (2002) · Allergy · doi:10.1046/j.0908-665x.2001.all.doc.x · Cited by 188 · see citing works
Critical Appraisal and Meta-Analysis of Nasal Surgery for Obstructive Sleep Apnea
Li, H.-Y., Wang, P.-C., Chen, Y.-P., Lee, L.-A., Fang, T.-J., & Lin, H.-C. (2011) · American Journal of Rhinology & Allergy · doi:10.2500/ajra.2011.25.3558 · Cited by 134 · cited 4× · see citing works
“Our results are therefore in agreement with previous studies showing that nasal obstruction has an impact upon daytime sleepiness (Ishii et al., 2015; Li et al., 2011; V€arendh et al., 2017).”
BackgroundResultInfluentialRandomised trial of nasal surgery for fixed nasal obstruction in obstructive sleep apnoea
Koutsourelakis, I., Georgoulopoulos, G., Perraki, E., Vagiakis, E., Roussos, C., & Zakynthinos, S. G. (2008) · European Respiratory Journal · doi:10.1183/09031936.00087607 · Cited by 131 · see citing works
Measuring and Characterizing the Human Nasal Cycle
Kahana-Zweig, R., Geva‐Sagiv, M., Weissbrod, A., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162918 · Cited by 129 · see citing works
Does Nasal Surgery Improve OSA in Patients with Nasal Obstruction and OSA? A Meta‐analysis
Ishii, L., Roxbury, C., Godoy, A., Ishman, S., & Ishii, M. (2015) · Otolaryngology–Head and Neck Surgery · doi:10.1177/0194599815594374 · Cited by 127 · see citing works
Arnardóttir, E. S., Maislin, G., Schwab, R. J., Staley, B. A., Benediktsdóttir, B., Ólafsson, Í., Júlíusson, S., Romer, M. A., Gíslason, Þ., & Pack, A. I. (2012) · SLEEP · doi:10.5665/sleep.1952 · Cited by 125 · see citing works
Fitzpatrick, M., Driver, H. S., Chatha, N., Voduc, N., & Girard, A. M. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00658.2002 · Cited by 113 · see citing works
Pevernagie, D., Meyer, M. M. D. D., & Claeys, S. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.02.002 · Cited by 62 · see citing works
Wu, J., Zhao, G., Li, Y., Zang, H., Wang, T., Wang, D., & Han, D. (2017) · Medicine · doi:10.1097/md.0000000000006008 · Cited by 61 · see citing works
Nocturnal sweating—a common symptom of obstructive sleep apnoea: the Icelandic sleep apnoea cohort
Arnardóttir, E. S., Janson, C., Björnsdóttir, E., Benediktsdóttir, B., Júlíusson, S., Kuna, S. T., Pack, A. I., & Gíslason, Þ. (2013) · BMJ Open · doi:10.1136/bmjopen-2013-002795 · Cited by 51 · see citing works
Emilsson, Ö. I., Janson, C., Benediktsdóttir, B., et al. (2011) · Respiratory Medicine · doi:10.1016/j.rmed.2011.12.004 · Cited by 46 · see citing works
Vidigal, T. D. A., Haddad, F. L. M., Gregório, L. C., Poyares, D. R., Tufik, S. B., & Bittencourt, L. (2012) · Sleep And Breathing · doi:10.1007/s11325-012-0667-5 · Cited by 42 · see citing works
Värendh, M., Johannisson, A., Hrubos‐Strøm, H., & Andersson, M. (2017) · Rhinology Journal · doi:10.4193/rhin16.065 · Cited by 39 · see citing works
Self-citationEriksson, J., Ekerljung, L., Pullerits, T., Holmberg, K., Rönmark, E., Lötvall, J. O., & Lundbäck, B. (2010) · International Archives of Allergy and Immunology · doi:10.1159/000320230 · Cited by 36 · see citing works
Arnardóttir, E. S., Verbraecken, J. A., Gonçalves, M., et al. (2015) · Journal of Sleep Research · doi:10.1111/jsr.12353 · Cited by 36 · see citing works
Prevalence of potential nonallergic rhinitis at a community-based sleep medical center
Krakow, B. J., Foley-Shea, M. R., Ulibarri, V. A., McIver, N. D., & Honsinger, R. W. (2016) · Sleep And Breathing · doi:10.1007/s11325-016-1322-3 · Cited by 12 · see citing works
Quality of life in nonallergic rhinitis.
Hellgren, J. (2007) · PubMed · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
International Consensus Statement on Obstructive Sleep Apnea
Chang, J. L., Goldberg, A. N., Alt, J. A., Mohammed, A., Ashbrook, L., Auckley, D., Ayappa, I., Bakhtiar, H., Barrera, J. E., Bartley, B. L., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23079 · Cited by 350 · see citing works
Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease?
Giombi, F., Pace, G. M., Pirola, F., Cerasuolo, M., Ferreli, F., Mercante, G., Spriano, G., Canonica, G. W., Heffler, E., Ferri, S., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020730 · Cited by 25 · see citing works
PAP treatment in patients with OSA does not induce long‐term nasal obstruction
Värendh, M., Andersson, M., Björnsdóttir, E., Arnardóttir, E. S., Gislason, T., Pack, A. I., Hrubos‐Strøm, H., Johannisson, A., & Juliusson, S. (2019) · Journal of Sleep Research · doi:10.1111/jsr.12768 · Cited by 9 · see citing works
Self-citation
- Authors
- Värendh, M., Andersson, M., Bjørnsdottir, E., Hrubos‐Strøm, H., Johannisson, A., Arnardottir, E. S., Gislason, T., & Juliusson, S.
- Affiliations
- Lund University (SE)
- Department of Respiratory Medicine and Sleep Landspitali – The National University Hospital of Iceland Reykjavík Iceland
- Akershus University Hospital (NO)
- Department of Otolaryngology – Head and Neck Surgery Landspitali – The National University Hospital of Iceland Reykjavík Reykjavík Iceland
- Corresponding author
- Värendh, Maria
- Venue
- Journal of Sleep Research
- Publisher
- Wiley
- Published
- 2017-11-06
- Volume
- 27
- Issue
- 4
- Pages
- e12631-e12631
- ISSN
- 0962-1105 (ISSN-L)
- 1365-2869
- PMC
- PMC5936679
- OpenAlex
- W2767591090
- Semantic Scholar
- c028afb001f2175fdcc98f943a2183a1cd22cde8
- Cited by
- 39
- References
- 28
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 1
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Sleep Research (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Opin vísindi (Opin vísindi) (submittedVersion, cc-by)
- Hirsla (Landspítali University Hospital) (submittedVersion)
- Funders
- National Institutes of Health (R01HL072067)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- obstructive sleep apnea, acoustic rhinometry, daytime sleepiness, quality of life, sleep quality
- MeSH terms
- Adult, Aged, Cross-Sectional Studies, Female, Humans, Iceland, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Sleep, Cohort Studies, Nasal Obstruction, Polysomnography, Sleep Apnea, Obstructive
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
