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Cited by 425

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Meta‐analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis

Bota, Simona, Herkner, Harald, Sporea, Ioan, Salzl, Petra, Sirli, Roxana, Neghina, Adriana M., Peck‐Radosavljevic, Markus·2013·Liver International

Abstract

Aims: This meta‐analysis aims to compare the diagnostic performance of acoustic radiation force impulse (ARFI) elastography and transient elastography (TE) in the assessment of liver fibrosis using liver biopsy (LB) as ‘gold‐standard’. Methods: PubMed, Medline, Lilacs, Scopus, Ovid, EMBASE, Cochrane and Medscape databases were searched for all studies published until 31 May 2012 that evaluated the liver stiffness by means of ARFI, TE and LB. Information abstracted from each study according to a fixed protocol included study design and methodological characteristics, patient characteristics, interventions, outcomes and missing outcome data. Results: Thirteen studies (11 full‐length articles and 2 abstracts) including 1163 patients with chronic hepatopathies were included in the analysis. Inability to obtain reliable measurements was more than thrice as high for TE as that of ARFI (6.6% vs. 2.1%, P < 0.001). For detection of significant fibrosis, (F ≥ 2) the summary sensitivity (Se) was 0.74 (95% CI: 0.66–0.80) and specificity (Sp) was 0.83 (95% CI: 0.75–0.89) for ARFI, while for TE the Se was 0.78 (95% CI: 0.72–0.83) and Sp was 0.84 (95% CI: 0.75–0.90). For the diagnosis of cirrhosis, the summary Se was 0.87 (95% CI: 0.79–0.92) and Sp was 0.87 (95% CI: 0.81–0.91) for ARFI elastography, and, respectively, 0.89 (95% CI: 0.80–0.94) and 0.87 (95% CI: 0.82–0.91) for TE. The diagnostic odds ratio of ARFI and TE did not differ significantly in the detection of significant fibrosis [mean difference in rDOR = 0.27 (95% CI: 0.69–0.14)] and cirrhosis [mean difference in rDOR = 0.12 (95% CI: 0.29–0.52)]. Conclusion: Acoustic radiation force impulse elastography seems to be a good method for assessing liver fibrosis, and shows higher rate of reliable measurements and similar predictive value to TE for significant fibrosis and cirrhosis.

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Metadata

Authors
Bota, S., Herkner, H., Sporea, I., Salzl, P., Sirli, R., Neghina, A. M., & Peck‐Radosavljevic, M.
Venue
Liver International
Publisher
Wiley
Published
2013-07-16
Volume
33
Issue
8
Pages
1138-1147
ISSN
  • 0106-9543 (ISSN-L)
  • 1478-3223
  • 1478-3231
OpenAlex
W2089622382
Cited by
425
References
49
FWCI
30.48
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Meta‐analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis. https://app.cochat.ai/papers/10.1111/liv.12240
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Bota, S., Herkner, H., Sporea, I., Salzl, P., Sirli, R., Neghina, A. M., & Peck‐Radosavljevic, M. (2013). Meta‐analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis. Liver International. https://doi.org/10.1111/liv.12240

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