The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Bridging Critically Ill Patients With Cirrhosis to Transplant With Renal Replacement Therapy: A Multicenter Cohort Study
Abstract
Background & Aims: The efficacy of renal replacement therapy (RRT) in critically ill patients with cirrhosis remains dubious. We aimed to assess the impact of RRT on these patients' outcomes. Methods: Multicenter retrospective cohort study including adult patients with cirrhosis admitted to intensive care units at University of Alberta Hospital (Edmonton, Canada) and Northwestern Memorial Hospital (Chicago, US) from January 2010 to December 2017. Primary exposure was receipt of RRT on ICU days 1 to 3. Fine and Gray multivariable regression with competing endpoints, in‐hospital liver transplant (LT) and mortality, was performed. Results: Among 898 patients, median (IQR) age was 57 (49–64) years and 539 (60.0%) were males. RRT on days 1 to 3 was used in 249 (27.7%) patients. Patients on RRT on days 1 to 3 had higher CLIF‐C‐ACLF scores on days 1 (61 vs. 55, p < 0.001) and 3 (59 vs. 50; p < 0.001) than others. During the hospital stay, 97 (10.8%) patients were transplanted and 296 (33.0%) died. Following adjustment for aetiology, number of extra‐renal organ failures, and year of inclusion, using mortality as competing event, RRT on days 1 to 3 was associated with higher hazard of LT (HR (95% CI) = 1.54 (1.02–2.32); p = 0.039). Conversely, using LT as competing event, RRT on days 1 to 3 was not associated with mortality (HR (95% CI) = 1.15 (0.90–1.47); p = 0.25). Conclusions: Among critically ill patients with cirrhosis, early RRT, while offered more often to the sickest patients, was associated with a higher likelihood of receiving LT, but not with mortality.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Elm, E. V., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., & Vandenbroucke, J. P. (2007) · BMJ · doi:10.1136/bmj.39335.541782.ad · Cited by 10,766
Malinchoc, M., Kamath, P. S., Gordon, F. D., Peine, C. J., Rank, J., & ter Borg, P. C. J. (2000) · Hepatology · doi:10.1053/he.2000.5852 · Cited by 2,893
Timing of renal-replacement therapy in patients with acute kidney injury and sepsis.
Barbar, S. D., Clere-Jehl, R., Bourredjem, A., Hernu, R., Montini, F., Bruyère, R., Lebert, C., Bohé, J., Badie, J., Eraldi, J.-P., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1803213 · Cited by 777
Timing of initiation of renal-replacement therapy in acute kidney injury.
The STARRT-AKI Investigators (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2000741 · Cited by 771
Competing risk analysis using R: an easy guide for clinicians
Scrucca, L., Santucci, A., & Aversa, F. (2007) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705727 · Cited by 699
Clinical Course of acute‐on‐chronic liver failure syndrome and effects on prognosis
Gustot, T., Fernández, J., García, E., Morando, F., Caraceni, P., Alessandria, C., Laleman, W., Trebicka, J., Elkrief, L., Hopf, C., et al. (2015) · Hepatology · doi:10.1002/hep.27849 · Cited by 657
Regression modeling of competing risk using R: an in depth guide for clinicians
Scrucca, L., Santucci, A., & Aversa, F. (2010) · Bone Marrow Transplantation · doi:10.1038/bmt.2009.359 · Cited by 458
Artru, F., Louvet, A., Ruiz, I., Levesque, É., Labreuche, J., Bedoya, J. U., Lassailly, G., Dharancy, S., Boleslawski, E., Lebuffe, G., et al. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.06.009 · Cited by 392
Prognostic Importance of the Cause of Renal Failure in Patients With Cirrhosis
Martín–Llahí, M., Guevara, M., Torre, A., Fagundes, C., Restuccia, T., Gilabert, R., Solá, E., Pereira, G., Marinelli, M., Pavesi, M., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.07.043 · Cited by 372
Fagundes, C., Barreto, R., Guevara, M., García, E., Solà, E., Rodríguez, E., Graupera, I., Ariza, X., Pereira, G., Alfaro, I., et al. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.036 · Cited by 314
Nadim, M. K., Kellum, J. A., Davenport, A., Wong, F. S.-H., Davis, C. L., Pannu, N., Tolwani, A., Bellomo, R., & Genyk, Y. (2012) · Critical Care · doi:10.1186/cc11188 · Cited by 197
Predictors of Mortality and Resource Utilization in Cirrhotic Patients Admitted to the Medical ICU
Aggarwal, A., Ong, J. P., Younossi, Z. M., Nelson, D. R., Hoffman-Hōgg, L., & Arroliga, A. C. (2001) · CHEST Journal · doi:10.1378/chest.119.5.1489 · Cited by 171
Nanchal, R. S., Subramanian, R., Karvellas, C. J., Hollenberg, S. M., Peppard, W., Singbartl, K., Truwit, J. D., Al-Khafaji, A. H., Killian, A. J., Alquraini, M., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004192 · Cited by 162
Self-citationHernáez, R., Liu, Y., Kramer, J. R., Rana, A. A., El‐Serag, H. B., & Kanwal, F. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.06.005 · Cited by 150
Prognosis of cirrhotic patients admitted to intensive care unit: a meta-analysis
Weil, D., Levesque, E., McPhail, M., Cavallazzi, R., Theocharidou, E., Cholongitas, E., Galbois, A., Pan, H. C., Karvellas, C. J., Sauneuf, B., et al. (2017) · Annals of Intensive Care · doi:10.1186/s13613-017-0249-6 · Cited by 131
Self-citationPatidar, K. R., Belcher, J. M., Regner, K. R., Hillien, S. A. S., Simonetto, D. A., Asrani, S. K., Neyra, J. A., Sharma, P., Velez, J. C. Q., Wadei, H. M., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.07.010 · Cited by 104
McPhail, M. J. W., Parrott, F., Wendon, J. A., Harrison, D. A., Rowan, K., & Bernal, W. E. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000002961 · Cited by 81
Staufer, K., Roedl, K., Kivaranovic, D., Drolz, A., Horvatits, T., Rasoul‐Rockenschaub, S., Zauner, C., Trauner, M. A., & Fuhrmann, V. (2017) · Liver International · doi:10.1111/liv.13389 · Cited by 78
Karvellas, C. J., Garcia-Lopez, E., Fernandez, J., Saliba, F., Sy, E., Jalan, R., Pavesi, M., Gustot, T., Ronco, J. J., & Arroyo, V. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003369 · Cited by 62
Self-citationCardoso, F. S., Abraldeṣ, J. G., Sy, E. J., Ronco, J. J., Bagulho, L., McPhail, M. J. W., & Karvellas, C. J. (2019) · Liver International · doi:10.1111/liv.14083 · Cited by 58
Self-citationHernáez, R., Karvellas, C. J., Liu, Y., Sacleux, S., Khemichian, S., Stein, L. L., Shetty, K., Lindenmeyer, C. C., Boike, J. R., Simonetto, D. A., et al. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.05.028 · Cited by 55
Self-citationShaheen, A. A., Kong, K., Ma, C., Doktorchik, C. T. A., Coffin, C. S., Swain, M. G., Burak, K. W., Congly, S. E., Lee, S. S., Sadler, M. D., et al. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.10.030 · Cited by 51
Baudry, T., Hernu, R., Valleix, B., Jahandiez, V., Faucher, E., Simon, M., Cour, M., & Argaud, L. (2018) · Shock · doi:10.1097/shk.0000000000001282 · Cited by 23
Macedo, E. M., Bihorac, A., Siew, E. D., Palevsky, P. M., Kellum, J. A., Ronco, C., Mehta, R. L., Rosner, M. H., Haase, M., KASHANI, K. B., et al. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2020.04.056 · Cited by 22
Kim, M., Cardoso, F. S., Pawlowski, A. E., Wunderink, R. G., Ladner, D. P., Abraldeṣ, J. G., & Karvellas, C. J. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000038 · Cited by 22
Self-citationO’Brien, Z., Cass, A., Cole, L., Finfer, S. R., Gallagher, M., McArthur, C., McGuiness, S., Myburgh, J., Bellomo, R., & Mårtensson, J. (2017) · Blood Purification · doi:10.1159/000480224 · Cited by 16
Cardoso, F. S., Pereira, R., Laranjo, A., Gamelas, V., Bagulho, L., Germano, N., & Karvellas, C. J. (2020) · Journal of Critical Care · doi:10.1016/j.jcrc.2020.09.012 · Cited by 15
Self-citationCama-Olivares, A., Ouyang, T., Takeuchi, T., St. Hillien, S. A., Robinson, J. E., Chung, R. T., Cullaro, G., Karvellas, C. J., Levitsky, J., Orman, E. S., et al. (2025) · Kidney360 · doi:10.34067/kid.0000000589 · Cited by 13
Self-citationEarly serum ammonia variation in critically ill patients with cirrhosis: A multicentre cohort study
Cardoso, F. S., Kim, M., Pereira, R., Bagulho, L., Fidalgo, P., Pawlowski, A. E., Wunderink, R. G., Germano, N., Bagshaw, S. M., Abraldeṣ, J. G., et al. (2023) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17650 · Cited by 11
Self-citationDisease trajectory and competing risks of patients with cirrhosis in the US
Mohammadi, M., Hasjim, B. J., Balbale, S. N., Polineni, P., Huang, A. A., Paukner, M. J., Banea, T. E., Dentici, O., Vitello, D. J., Obayemi, J. E., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0313152 · Cited by 11
Hillien, S. A. S., Robinson, J. E., Ouyang, T., Patidar, K. R., Belcher, J. M., Cullaro, G., Regner, K. R., Chung, R. T., Ufere, N. N., Velez, J. C. Q., et al. (2024) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2024.10.023 · Cited by 8
Liao, T., Lu, Y.-Y., Su, T., Bei, L., Li, X., Yang, L., Ren, S., Huang, L., & Feng, L.-H. (2023) · Internal and Emergency Medicine · doi:10.1007/s11739-023-03436-z · Cited by 7
Metadata
- Authors
- Cardoso, F. S., Kim, M., Kok, B., Wunderink, R., Abraldes, J. G., & Karvellas, C. J.
- Venue
- Liver International
- Publisher
- Wiley
- Published
- 2026-03-18
- Volume
- 46
- Issue
- 4
- ISSN
- 1478-3223
- 1478-3231
- Cited by
- 1
- References
- 33
- Language
- en
- Licence
- creativecommons.org/licenses/by/4.0/ (vor)
- doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
