APOE ε 4 is also required in TREM 2 R47H variant carriers for Alzheimer's disease to develop
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The R47H variant of TREM2 has an effect size for increased Alzheimer's disease risk comparable to the APOEε4 allele, around a 3-fold increased risk.
“The risk from this variant has a comparable effect size with the APOEε4 allele (around 3-fold increased AD risk; 4,19–22).”
From <i>Trem2</i> promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions (2020) · cites this paper as [22]
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New insights into the role of TREM2 in Alzheimer’s disease
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Brain cell type-specific cholesterol metabolism and implications for learning and memory
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- Authors
- Murray, C. E., King, A., Troakes, C., Hodges, A., & Lashley, T.
- Affiliations
- National Hospital for Neurology and Neurosurgery (GB)
- King's College London (GB)
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2018-03
- Volume
- 45
- Issue
- 2
- Pages
- 183-186
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W2784785933
- Cited by
- 12
- References
- 12
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 3
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
- kclpure.kcl.ac.uk
- Licence
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Alzheimer's Society
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- APOE ε4, Alzheimer's disease, genetic risk factors, disease susceptibility, genetic interactions
- MeSH terms
- Aged, Alzheimer Disease, Humans, Male, Membrane Glycoproteins, Receptors, Immunologic, Microglia, Genetic Predisposition to Disease, Apolipoprotein E4
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