New insights into the role of TREM2 in Alzheimer’s disease

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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2016 Alzheimer's disease facts and figures

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Inflammation and Alzheimer’s disease

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Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

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Neuropathological alterations in Alzheimer disease

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<i>TREM2</i> Variants in Alzheimer's Disease

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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Identification of a unique TGF-β–dependent molecular and functional signature in microglia

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Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

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Role of Genes and Environments for Explaining Alzheimer Disease

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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736 · see citing works

Neuroinflammation in Alzheimer's disease: current evidence and future directions

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The role of apolipoprotein E in Alzheimer's disease

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

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Uber eine eigenartige Erkrankung der Hirnrinde

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An english translation of alzheimer’s 1907 paper, “über eine eigenartige erkankung der hirnrinde”

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Alzheimer’s Disease: The Challenge of the Second Century

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The SYK tyrosine kinase: A crucial player in diverse biological functions

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

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Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

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Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes

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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

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Inflammation in Neurodegenerative Disease—A Double-Edged Sword

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Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

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Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

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Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

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The Role of Microglia in the Healthy Brain: Figure 1.

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Aβ42‐driven cerebral amyloidosis in transgenic mice reveals early and robust pathology

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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

Yeh, F. L., Wang, Y., Tom, I., Gonzalez, L. C., & Sheng, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.015 · Cited by 943 · see citing works

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

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Adult mouse astrocytes degrade amyloid-β in vitro and in situ

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151948 · Cited by 840 · see citing works

Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Zhao, Y., Wu, X., Li, X., Jiang, L.-L., Gui, X., Liu, Y., Sun, Y., Zhu, B., Piña-Crespo, J. C., Zhang, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.031 · Cited by 763 · see citing works

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

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Cutting Edge: TREM-2 Attenuates Macrophage Activation

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Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

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Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

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The prevalence and causes of dementia in people under the age of 65 years

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Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

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CSF phosphorylated tau protein correlates with neocortical neurofibrillary pathology in Alzheimer's disease

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Alzheimer Disease

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ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C., & Holtzman, D. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220484110 · Cited by 556 · see citing works

TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy

Leyns, C. E. G., Ulrich, J. D., Finn, M. B., Stewart, F. R., Koscal, L. J., Remolina Serrano, J., Robinson, G. O., Anderson, E., Colonna, M., & Holtzman, D. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1710311114 · Cited by 517 · see citing works

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

Hsieh, C. L., Koike, M., Spusta, S. C., Niemi, E. C., Yenari, M., Nakamura, M. C., & Seaman, W. E. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06042.x · Cited by 475 · see citing works

A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells

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Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

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TREM2, microglia, and neurodegenerative diseases

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Microglia Mediate the Clearance of Soluble Aβ through Fluid Phase Macropinocytosis

Mandrekar, S., Jiang, Q., Lee, C. Y. D., Koenigsknecht-Talboo, J., Holtzman, D. M., & Landreth, G. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5572-08.2009 · Cited by 415 · see citing works

TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis

Takahashi, K., Prinz, M., Stagi, M., Chechneva, O., & Neumann, H. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040124 · Cited by 414 · see citing works

TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1

Peng, Q., Malhotra, S., Torchia, J. A., Kerr, W. G., Coggeshall, K. M., & Humphrey, M. B. (2010) · Science Signaling · doi:10.1126/scisignal.2000500 · Cited by 413 · see citing works

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

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Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

Lee, C. Y. D., Daggett, A., Gu, X., Jiang, L.-L., Langfelder, P., Li, X., Wang, N., Zhao, Y., Park, C. S., Cooper, Y., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.02.002 · Cited by 396 · see citing works

GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease

Cruchaga, C., Kauwe, J. S. K., Harari, O., Jin, S. C., Cai, Y., Karch, C. M., Benitez, B. A., Jeng, A. T., Skorupa, T., Carrell, D., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.026 · Cited by 383 · see citing works

Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke

Kawabori, M., Kacimi, R., Kauppinen, T., Calosing, C., Kim, J. Y., Hsieh, C. L., Nakamura, M. C., & Yenari, M. A. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2620-14.2015 · Cited by 375 · see citing works

Heterogeneous expression of the triggering receptor expressed on myeloid cells‐2 on adult murine microglia

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TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury

Mazaheri, F., Snaidero, N., Kleinberger, G., Madore, C., Daria, A., Werner, G., Krasemann, S., Capell, A., Trümbach, D., Wurst, W., et al. (2017) · The EMBO Reports · doi:10.15252/embr.201743922 · Cited by 351 · see citing works

Cerebrospinal fluid soluble TREM2 is higher in Alzheimer disease and associated with mutation status

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Patterns of gliosis in alzheimer's disease and aging cerebrum

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Upregulation of TREM2 Ameliorates Neuropathology and Rescues Spatial Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease

Jiang, T., Tan, L., Zhu, X.-C., Zhang, Q.-Q., Cao, L., Tan, M.-S., Gu, L.-Z., Wang, H.-F., Ding, Z.-Z., Zhang, Y.-D., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.164 · Cited by 320 · see citing works

DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features

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Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12

Hamerman, J. A., Tchao, N. K., Lowell, C. A., & Lanier, L. L. (2005) · Nature Immunology · doi:10.1038/ni1204 · Cited by 318 · see citing works

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Zheng, H., Jia, L., Liu, C.-C., Rong, Z., Zhong, L., Yang, L., Chen, X.-F., Fryer, J. D., Wang, X., Zhang, Y.-W., et al. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.2459-16.2017 · Cited by 317 · see citing works

Coding variants in TREM2 increase risk for Alzheimer's disease

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Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine

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Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism

Song, W. M., Joshita, S., Zhou, Y., Ulland, T. K., Gilfillan, S., & Colonna, M. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171529 · Cited by 305 · see citing works

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

Ulrich, J. D., Finn, M. B., Wang, Y., Shen, A., Mahan, T. E., Jiang, H., Stewart, F. R., Piccio, L., Colonna, M., & Holtzman, D. M. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-20 · Cited by 302 · see citing works

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

Bemiller, S. M., McCray, T. J., Allan, K., Formica, S. V., Xu, G., Wilson, G., Kokiko-Cochran, O. N., Crish, S. D., Lasagna-Reeves, C. A., Ransohoff, R. M., et al. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0216-6 · Cited by 299 · see citing works

Alzheimer's disease‐associated TREM2 variants exhibit either decreased or increased ligand‐dependent activation

Song, W., Hooli, B., Mullin, K., Jin, S. C., Cella, M., Ulland, T. K., Wang, Y., Tanzi, R. E., & Colonna, M. (2017) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2016.07.004 · Cited by 297 · see citing works

ApoE facilitates the microglial response to amyloid plaque pathology

Ulrich, J. D., Ulland, T. K., Mahan, T. E., Nyström, S., Nilsson, K. P., Song, W. M., Zhou, Y., Reinartz, M., Choi, S., Jiang, H., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171265 · Cited by 297 · see citing works

Efficient colonic mucosal wound repair requires Trem2 signaling

Seno, H., Miyoshi, H., Brown, S. L., Geske, M. J., Colonna, M., & Stappenbeck, T. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0803343106 · Cited by 292 · see citing works

Pattern Recognition by TREM-2: Binding of Anionic Ligands

Daws, M. R., Sullam, P. M., Niemi, E. C., Chen, T. T., Tchao, N. K., & Seaman, W. E. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.594 · Cited by 291 · see citing works

A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology

Matarin, M., Salih, D. A., Yasvoina, M., Cummings, D. M., Guelfi, S., Liu, W., Nahaboo Solim, M. A., Moens, T. G., Paublete, R. M., Ali, S. S., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2014.12.041 · Cited by 290 · see citing works

Structure and Function of Syk Protein-Tyrosine Kinase

Sada, K., Takano, T., Yanagi, S., & Yamamura, H. (2001) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a002970 · Cited by 289 · see citing works

Blockade of TREM‐2 exacerbates experimental autoimmune encephalomyelitis

Piccio, L., Buonsanti, C., Mariani, M., Cella, M., Gilfillan, S., Cross, A. H., Colonna, M., & Panina‐Bordignon, P. (2007) · European Journal of Immunology · doi:10.1002/eji.200636837 · Cited by 284 · see citing works

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

Cuyvers, E., & Sleegers, K. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)00127-7 · Cited by 284 · see citing works

Microglial neuroinflammation contributes to tau accumulation in chronic traumatic encephalopathy

Cherry, J. D., Tripodis, Y., Alvarez, V. E., Huber, B., Kiernan, P. T., Daneshvar, D., Mez, J., Montenigro, P., Solomon, T. M., Alosco, M., et al. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0382-8 · Cited by 267 · see citing works

<i>TREM2</i>Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

Cady, J., Koval, E. D., Benitez, B. A., Zaidman, C., Jockel-Balsarotti, J., Allred, P., Baloh, R. H., Ravits, J., Simpson, E., Appel, S. H., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6237 · Cited by 262 · see citing works

Impaired Differentiation of Osteoclasts in TREM-2–deficient Individuals

Cella, M., Buonsanti, C., Strader, C., Kondo, T., Salmaggi, A., & Colonna, M. (2003) · Journal of Experimental Medicine · doi:10.1084/jem.20022220 · Cited by 256 · see citing works

The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease

Cheng-Hathaway, P. J., Reed-Geaghan, E. G., Jay, T. R., Casali, B. T., Bemiller, S. M., Puntambekar, S. S., von Saucken, V. E., Williams, R. Y., Karlo, J. C., Moutinho, M., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0262-8 · Cited by 252 · see citing works

Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis

Neumann, H., & Takahashi, K. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.11.032 · Cited by 249 · see citing works

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody

Luo, W., Liu, W., Hu, X., Hanna, M., Caravaca, A., & Paul, S. M. (2015) · Scientific Reports · doi:10.1038/srep11161 · Cited by 241 · see citing works

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

N’Diaye, E.-N., Branda, C., Branda, S. S., Nevarez, L., Colonna, M., Lowell, C. A., Hamerman, J. A., & Seaman, W. E. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200808080 · Cited by 240 · see citing works

Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

Kober, D. L., Alexander-Brett, J. M., Karch, C. M., Cruchaga, C., Colonna, M., Holtzman, M. J., & Brett, T. J. (2016) · eLife · doi:10.7554/elife.20391 · Cited by 238 · see citing works

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

Sayed, F. A., Telpoukhovskaia, M., Kodama, L., Li, Y., Zhou, Y., Le, D., Hauduc, A., Ludwig, C., Gao, F., Clelland, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811411115 · Cited by 229 · see citing works

MRI and CSF studies in the early diagnosis of Alzheimer's disease

de Leon, M. J., DeSanti, S., Zinkowski, R. P., Mehta, P. D., Praticò, D., Segal, S., Clark, C. M., Kerkman, D. J., DeBernardis, J. F., Li, J., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01381.x · Cited by 221 · see citing works

TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy

Yuan, P., Condello, C., Keene, C. D., Wang, Y., Bird, T. D., Paul, S. M., Luo, W., Colonna, M., Baddeley, D., & Grutzendler, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.016 · Cited by 219 · see citing works

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Zhong, L., Wang, Z., Wang, D., Wang, Z., Martens, Y. A., Wu, L., Xu, Y., Wang, K., Li, J., Huang, R., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0247-7 · Cited by 217 · see citing works

TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

Wu, K., Byers, D. E., Jin, X., Agapov, E., Alexander-Brett, J., Patel, A. C., Cella, M., Gilfilan, S., Colonna, M., Kober, D. L., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141732 · Cited by 207 · see citing works

The role of <i>TREM2</i> R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

Lill, C. M., Rengmark, A., Pihlstrøm, L., Fogh, I., Shatunov, A., Sleiman, P. M., Wang, L., Liu, T., Lassen, C. F., Meissner, E., et al. (2015) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2014.12.009 · Cited by 205 · see citing works

The structural basis for intramembrane assembly of an activating immunoreceptor complex

Call, M., Wucherpfennig, K., & Chou, J. (2010) · Nature Immunology · doi:10.1038/ni.1943 · Cited by 192 · see citing works

Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia.

Cuyvers, E., Bettens, K., Philtjens, S., Langenhove, T. V., Gijselinck, I., van der Zee, J., Engelborghs, S., Vandenbulcke, M., Dongen, J. V., Geerts, N., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.009 · Cited by 191 · see citing works

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

Xiang, X., Werner, G., Bohrmann, B., Liesz, A., Mazaheri, F., Capell, A., Feederle, R., Knuesel, I., Kleinberger, G., & Haass, C. (2016) · EMBO Molecular Medicine · doi:10.15252/emmm.201606370 · Cited by 183 · see citing works

Insights into TREM2 biology by network analysis of human brain gene expression data

Forabosco, P., Ramasamy, A., Trabzuni, D., Walker, R., Smith, C., Bras, J., Levine, A. P., Hardy, J., Pocock, J. M., Guerreiro, R., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.001 · Cited by 180 · see citing works

TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice

Jiang, T., Zhang, Y.-D., Chen, Q., Gao, Q., Zhu, X.-C., Zhou, J.-S., Shi, J.-Q., Lu, H., Tan, L., & Yu, J.-T. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.01.028 · Cited by 176 · see citing works

Specific lipid recognition is a general feature of CD300 and TREM molecules

Cannon, J. P., O’Driscoll, M., & Litman, G. (2011) · Immunogenetics · doi:10.1007/s00251-011-0562-4 · Cited by 174 · see citing works

The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44

Allcock, R. J. N., Barrow, A. D., Forbes, S. A., Beck, S., & Trowsdale, J. (2003) · European Journal of Immunology · doi:10.1002/immu.200310033 · Cited by 173 · see citing works

The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Xiang, X., Piers, T. M., Wefers, B., Zhu, K., Mallach, A., Brunner, B., Kleinberger, G., Song, W., Colonna, M., Herms, J., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0280-6 · Cited by 170 · see citing works

Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

Sessa, G., Podini, P., Mariani, M., Meroni, A., Spreafico, R., Sinigaglia, F., Colonna, M., Panina, P., & Meldolesi, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03729.x · Cited by 165 · see citing works

TREM2 is associated with the risk of Alzheimer's disease in Spanish population

Benitez, B. A., Cooper, B., Pastor, P., Jin, S.-C., Lorenzo, E., Cervantes, S., & Cruchaga, C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.018 · Cited by 163 · see citing works

TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function

Humphrey, M. B., Daws, M. R., Spusta, S. C., Niemi, E. C., Torchia, J. A., Lanier, L. L., Seaman, W. E., & Nakamura, M. C. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051016 · Cited by 162 · see citing works

TREM2 R47H Variant as a Risk Factor for Early-Onset Alzheimer's Disease

Pottier, C. P., collaborators, G., Wallon, D., Rousseau, S., Rovelet‐Lecrux, A., Richard, A., Rollin‐Sillaire, A., Frébourg, T., Campion, D., & Hannequin, D. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122311 · Cited by 162 · see citing works

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

Malik, M., Parikh, I., Vasquez, J. B., Smith, C., Tai, L., Bu, G., LaDu, M. J., Fardo, D. W., Rebeck, G. W., & Estus, S. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0048-1 · Cited by 161 · see citing works

TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain

Kobayashi, M., Konishi, H., Sayo, A., Takai, T., & Kiyama, H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1238-16.2016 · Cited by 160 · see citing works

Accumulation of tau induced in neurites by microglial proinflammatory mediators

Gorlovoy, P., Larionov, S., Pham, T. T. H., & Neumann, H. (2009) · The FASEB Journal · doi:10.1096/fj.08-123877 · Cited by 156 · see citing works

<scp>TREM</scp>2 Protein Expression Changes Correlate with <scp>A</scp>lzheimer's Disease Neurodegenerative Pathologies in Post‐Mortem Temporal Cortices

Lue, L., Schmitz, C. T., Serrano, G., Sue, L. I., Beach, T. G., & Walker, D. G. (2015) · Brain Pathology · doi:10.1111/bpa.12190 · Cited by 154 · see citing works

Nuclear Receptors License Phagocytosis by Trem2⁺Myeloid Cells in Mouse Models of Alzheimer's Disease

Savage, J. C., Jay, T., Goduni, E., Quigley, C., Mariani, M. M., Malm, T., Ransohoff, R. M., Lamb, B. T., & Landreth, G. E. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4586-14.2015 · Cited by 154 · see citing works

TREM2 is associated with increased risk for Alzheimer’s disease in African Americans

Jin, S. C., Carrasquillo, M. M., Benitez, B. A., Skorupa, T., Carrell, D., Patel, D., Lincoln, S., Krishnan, S., Kachadoorian, M., Reitz, C., et al. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0016-9 · Cited by 153 · see citing works

The surface‐exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

Stefano, L., Racchetti, G., Bianco, F., Passini, N., Gupta, R. S., Panina‐Bordignon, P., & Meldolesi, J. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06130.x · Cited by 152 · see citing works

Nasu–Hakola Disease (Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy—PLOSL): A Dementia Associated with Bone Cystic Lesions. From Clinical to Genetic and Molecular Aspects

Bianchin, M., Capella, H., Chaves, D. L., Steindel, M., Grisard, E., Ganev, G. G., da Silva, J. P., Schaeffer, E., Poffo, M. A., Walz, R., et al. (2004) · Cellular and molecular neurobiology · doi:10.1023/b:cemn.0000012721.08168.ee · Cited by 147 · see citing works

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration

Bhattacharjee, S., Zhao, Y., Dua, P., Rogaev, E. I., & Lukiw, W. J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0150211 · Cited by 147 · see citing works

R47H Variant of<i>TREM2</i>Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study

Korvatska, O., Leverenz, J. B., Jayadev, S., McMillan, P., Kurtz, I., Guo, X., Rumbaugh, M., Matsushita, M., Girirajan, S., Dorschner, M. O., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0979 · Cited by 137 · see citing works

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer’s Disease

Melchior, B., Garcia, A., Hsiung, B., Lo, K. M., Doose, J. M., Thrash, J. C., Stalder, A. K., Staufenbiel, M., Neumann, H., & Carson, M. J. (2010) · ASN NEURO · doi:10.1042/an20100010 · Cited by 136 · see citing works

DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response

Zhong, L., Chen, X.-F., Zhang, Z.-L., Wang, Z., Shi, X.-Z., Xu, K., Zhang, Y.-W., Xu, H., & Bu, G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.645986 · Cited by 133 · see citing works

<i>R47H TREM2</i> variant increases risk of typical early‐onset Alzheimer's disease but not of prion or frontotemporal dementia

Slattery, C. F., Beck, J. A., Harper, L., Adamson, G., Abdi, Z., Uphill, J., Campbell, T., Druyeh, R., Mahoney, C. J., Rohrer, J. D., et al. (2014) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2014.05.1751 · Cited by 119 · see citing works

Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

Ruiz, A., Dols-Icardo, O., Bullido, M. J., Pastor, P., Rodríguez-Rodríguez, E., López de Munain, A., de Pancorbo, M. M., Pérez-Tur, J., Álvarez, V., Antonell, A., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.011 · Cited by 118 · see citing works

Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS

Kiialainen, A., Hovanes, K., Paloneva, J., Kopra, O., & Peltonen, L. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.007 · Cited by 114 · see citing works

SnapShot: genetics of Alzheimer's disease.

Guerreiro, R., Bras, J., & Hardy, J. (2013) · Cell · doi:10.1016/j.cell.2013.10.037 · Cited by 114 · see citing works

Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice

Jiang, T., Tan, L., Zhu, X.-C., Zhou, J.-S., Cao, L., Tan, M.-S., Wang, H.-F., Chen, Q., Zhang, Y.-D., & Yu, J.-T. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.08.019 · Cited by 111 · see citing works

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Zheng, H., Liu, C.-C., Atagi, Y., Chen, X.-F., Jia, L., Yang, L., He, W., Zhang, X., Kang, S. S., Rosenberry, T. L., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.03.004 · Cited by 110 · see citing works

Increased Expression of TREM2 in Peripheral Blood of Alzheimer's Disease Patients

Hu, N., Tan, M., Yu, J., Sun, L., Tan, L., Wang, Y.-L., Jiang, T., & Tan, L. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130854 · Cited by 109 · see citing works

Neuroprotective Effect of TREM-2 in Aging and Alzheimer’s Disease Model

Raha, A. A., Henderson, J. W., Stott, S., Vuono, R., Foscarin, S., Friedland, R. P., Zaman, S. H., & Raha‐Chowdhury, R. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160663 · Cited by 109 · see citing works

The triggering receptor expressed on myeloid cells 2 ( <i>TREM2</i> ) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

Roussos, P., Katsel, P., Fam, P., Tan, W., Purohit, D. P., & Haroutunian, V. (2015) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2014.10.013 · Cited by 103 · see citing works

TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer’s disease hippocampus

Celarain, N., de Gordoa, J. S., Zelaya, M. V., Roldán, M., Larumbe, R., Pulido, L., Echávarri, C., & Mendióroz, M. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0202-9 · Cited by 99 · see citing works

Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury

Saber, M., Kokiko‐Cochran, O. N., Puntambekar, S. S., Lathia, J. D., & Lamb, B. T. (2016) · Journal of Neurotrauma · doi:10.1089/neu.2016.4401 · Cited by 95 · see citing works

The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway

Jendresen, C., Årskog, V., Daws, M. R., & Nilsson, L. N. G. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0835-4 · Cited by 94 · see citing works

Inflammation in Alzheimer’s Disease and Molecular Genetics: Recent Update

Zhang, Z., Li, Y., Ng, C. T., & Song, Y. (2015) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-015-0351-0 · Cited by 87 · see citing works

Convergent Genetic and Expression Datasets Highlight TREM2 in Parkinson’s Disease Susceptibility

Liu, G., Liu, Y., Jiang, Q., Jiang, Y., Feng, R., Zhang, L., Chen, Z., Li, K., & Liu, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9416-7 · Cited by 83 · see citing works

TREM-2 promotes host resistance against Pseudomonas aeruginosa infection by suppressing corneal inflammation via a PI3K/Akt signaling pathway.

Sun, M.-X., Zhu, M., Chen, K., Nie, X.-X., Deng, Q., Hazlett, L., Wu, Y.-J., Li, M., Wu, M.-H., & Huang, X. (2013) · Investigative Ophthalmology and Visual Science · doi:10.1167/iovs.12-10938 · Cited by 71 · see citing works

Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer’s disease brains

Ma, L., Allen, M., Sakae, N., Ertekin-Taner, N., Graff-Radford, N. R., Dickson, D. W., Younkin, S. G., & Sevlever, D. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0137-9 · Cited by 70 · see citing works

Triggering receptor expressed on myeloid cells 2 variant is rare in late-onset Alzheimer's disease in Han Chinese individuals

Yu, J.-T., Jiang, T., Wang, Y.-L., Wang, H.-F., Zhang, W., Hu, N., Tan, L., Sun, L., Tan, M.-S., Zhu, X.-C., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.10.075 · Cited by 68 · see citing works

Immunohistochemical characterization of microglia in Nasu‐Hakola disease brains

Satoh, J., Tabunoki, H., Ishida, T., Yagishita, S., Jinnai, K., Futamura, N., Kobayashi, M., Toyoshima, I., Yoshioka, T., Enomoto, K., et al. (2010) · Neuropathology · doi:10.1111/j.1440-1789.2010.01174.x · Cited by 67 · see citing works

Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China

Jiao, B., Liu, X., Tang, B., Hou, L., Zhou, L., Zhang, F., Zhou, Y., Guo, J., Yan, X., & Shen, L. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.04.025 · Cited by 66 · see citing works

Increasing CSF phospho-tau levels during cognitive decline and progression to dementia

Andersson, C., Blennow, K., Almkvist, O., Andreasen, N., Engfeldt, P., Johansson, S., Lindau, M. P., & Eriksdotter, M. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.03.027 · Cited by 65 · see citing works

TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response

Jiang, T., Zhang, Y., Gao, Q., Ou, Z., Gong, P., Shi, J., Wu, L., & Zhou, J. (2018) · Inflammation · doi:10.1007/s10753-018-0735-5 · Cited by 65 · see citing works

Increased expression of TREM 2 in peripheral cells from mild cognitive impairment patients who progress into Alzheimer's disease

Casati, M., Ferri, E., Gussago, C., Mazzola, P., Abbate, C., Bellelli, G., Mari, D., Cesari, M., & Arosio, B. (2018) · European Journal of Neurology · doi:10.1111/ene.13583 · Cited by 64 · see citing works

Silencing of triggering receptor expressed on myeloid cells-2 enhances the inflammatory responses of alveolar macrophages to lipopolysaccharide

GAO, X., DONG, Y., LIU, Z., & NIU, B. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1268 · Cited by 60 · see citing works

Assessment of the Genetic Architecture of Alzheimer’s Disease Risk in Rate of Memory Decline

Del-Aguila, J. L., Fernández, M. V., Schindler, S., Ibanez, L., Deming, Y., Ma, S., Saef, B., Black, K., Budde, J., Norton, J., et al. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170834 · Cited by 60 · see citing works

TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection

Gonçalves, L. A., Rodrigues-Duarte, L., Rodo, J., de Moraes, L. V., Marques, I., & Penha‐Gonçalves, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306873110 · Cited by 55 · see citing works

Assessment of TREM2 rs75932628 association with Alzheimer's disease in a population-based sample: the Cache County Study

Murcia, J. D. G., Schmutz, C., Munger, C., Perkes, A. D., Gustin, A. J., Peterson, M., Ebbert, M., Norton, M. C., Tschanz, J. T., Munger, R. G., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.06.004 · Cited by 54 · see citing works

Different mechanisms of apolipoprotein E isoform‐dependent modulation of prostaglandin E ₂ production and triggering receptor expressed on myeloid cells 2 ( <i>TREM2</i> ) expression after innate immune activation of microglia

Li, X., Montine, K. S., Keene, C. D., & Montine, T. J. (2015) · The FASEB Journal · doi:10.1096/fj.14-262683 · Cited by 54 · see citing works

More evidence for association of a rare TREM2 mutation (R47H) with Alzheimer's disease risk

Rosenthal, S. L., Bamne, M. N., Wang, X., Berman, S., Snitz, B. E., Klunk, W. E., Sweet, R. A., Demirci, F. Y., López, O. L., & Kamboh, M. I. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.04.012 · Cited by 53 · see citing works

Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer's disease

Perez, S. E., Nadeem, M., He, B., Miguel, J. C., Malek‐Ahmadi, M. H., Chen, K., & Mufson, E. J. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.02.012 · Cited by 49 · see citing works

Upregulation of TREM2 Ameliorates Neuroinflammatory Responses and Improves Cognitive Deficits Triggered by Surgical Trauma in Appswe/PS1dE9 Mice

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Differential Modulation of TREM2 Protein during Postnatal Brain Development in Mice

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Anwar, S., & Rivest, S. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1738391 · Cited by 78 · see citing works

What are activated and reactive glia and what is their role in neurodegeneration?

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APOE4 confers transcriptomic and functional alterations to primary mouse microglia

Machlovi, S. I., Neuner, S. M., Hemmer, B. M., Khan, R., Liu, Y., Huang, M., Zhu, J. D., Castellano, J. M., Cai, D., Marcora, E., et al. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105615 · Cited by 73 · see citing works

The concept of resilience to Alzheimer’s Disease: current definitions and cellular and molecular mechanisms

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Beneficial and detrimental functions of microglia during viral encephalitis

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Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice

Qu, W., & Li, L. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2193-20.2020 · Cited by 70 · see citing works

Therapy for Alzheimer’s disease: Missing targets and functional markers?

Stoiljković, M., Horváth, T. L., & Hajós, M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101318 · Cited by 72 · see citing works

Melatonin and Microglia

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Toll-like receptors in Alzheimer's disease

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The VCAM1–ApoE pathway directs microglial chemotaxis and alleviates Alzheimer’s disease pathology

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TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer’s Disease: Lessons Learned from Transcriptomics

Xue, F., & Du, H. (2021) · Cells · doi:10.3390/cells10020321 · Cited by 71 · see citing works

Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease: Sensitivity, Specificity and Potential for Clinical Use

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Modifiable, Non-Modifiable, and Clinical Factors Associated with Progression of Alzheimer’s Disease

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Discovery and Validation of Key Biomarkers Based on Immune Infiltrates in Alzheimer’s Disease

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Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice

Delizannis, A. T., Nonneman, A., Tsering, W., Bondt, A. D., den Wyngaert, I. V., Zhang, B., Meymand, E. S., Olufemi, M. F., Koivula, P. P., Maimaiti, S., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01251-1 · Cited by 67 · see citing works

Region-specific glial homeostatic signature in prion diseases is replaced by a uniform neuroinflammation signature, common for brain regions and prion strains with different cell tropism

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TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation

Magno, L., Bunney, T. D., Mead, E., Svensson, F., & Bictash, M. N. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00436-5 · Cited by 64 · see citing works

Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer’s disease

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The Role of Butyrylcholinesterase and Iron in the Regulation of Cholinergic Network and Cognitive Dysfunction in Alzheimer’s Disease Pathogenesis

Jasiecki, J., Targońska, M., & Wasąg, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042033 · Cited by 64 · see citing works

Towards PET imaging of the dynamic phenotypes of microglia

Beaino, W., Janssen, B., Vugts, D. J., de Vries, H. E., & Windhorst, A. D. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13649 · Cited by 61 · see citing works

Reformulating Pro-Oxidant Microglia in Neurodegeneration

García‐Revilla, J., Alonso-Bellido, I. M., Burguillos, M. Á., Herrera, A. J., Espinosa‐Oliva, A. M., Ruiz, R., Cruz-Hernández, L., García-Domínguez, I., Roca-Ceballos, M. A., Santiago, M., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101719 · Cited by 62 · see citing works

The Amyloid-Beta Clearance: From Molecular Targets to Glial and Neural Cells

Cai, W., Wu, T., & Chen, N. (2023) · Biomolecules · doi:10.3390/biom13020313 · Cited by 61 · see citing works

Sustained Trem2 stabilization accelerates microglia heterogeneity and Aβ pathology in a mouse model of Alzheimer’s disease

Dhandapani, R., Neri, M., Bernhard, M., Brzak, I., Schweizer, T., Rudin, S., Joller, S., Berth, R., Kernen, J., Neuhaus, A., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110883 · Cited by 60 · see citing works

Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology

Wood, J. I., Wong, E., Joghee, R., Balbaa, A., Vitanova, K. S., Stringer, K. M., VanSchoiack, A., Phelan, S.-L. J., Launchbury, F., Desai, S., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111686 · Cited by 61 · see citing works

Sirtuins as Potential Therapeutic Targets for Mitigating Neuroinflammation Associated With Alzheimer’s Disease

Fernando, K., & Wijayasinghe, Y. S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.746631 · Cited by 57 · see citing works

Implicative role of cytokines in neuroinflammation mediated AD and associated signaling pathways: Current progress in molecular signaling and therapeutics

Kumari, S., Dhapola, R., Sharma, P., Singh, S. K., & HariKrishnaReddy, D. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102098 · Cited by 57 · see citing works

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions

Zhao, P., Xu, Y., Jiang, L.-L., Fan, X., Ku, Z., Li, L., Liu, X., Deng, M., Arase, H., Zhu, J.-J., et al. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00550-y · Cited by 54 · see citing works

Role of TREM2 in Alzheimer’s Disease: A Long Road Ahead

Kulkarni, B., Kumar, D., Martins, N. A., & Sellamuthu, S. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02477-9 · Cited by 52 · see citing works

Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer’s disease

Ruganzu, J. B., Peng, X., He, Y., Wu, X., Zheng, Q., Ding, B., Lin, C., Guo, H., Yang, Z., Zhang, X. L., et al. (2021) · Molecular Immunology · doi:10.1016/j.molimm.2021.12.018 · Cited by 54 · see citing works

Precise gene delivery systems with detachable albumin shell remodeling dysfunctional microglia by TREM2 for treatment of Alzheimer's disease

Wang, P., Yang, P., Qian, K., Li, Y., Xu, S., Meng, R., Guo, Q., Cheng, Y., Cao, J., Xu, M., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121360 · Cited by 54 · see citing works

Overview of the blood biomarkers in Alzheimer's disease: Promises and challenges

Delaby, C., Hirtz, C., & Lehmann, S. (2022) · Revue Neurologique · doi:10.1016/j.neurol.2022.09.003 · Cited by 56 · see citing works

News in brief

(2004) · Refocus · doi:10.1016/s1471-0846(04)00122-2

TREM2, microglia, and neurodegenerative diseases

Yeh, F. L., Hansen, D. V., & Sheng, M. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.03.008 · Cited by 440 · see citing works

The role of TREM2 in microglia function and Alzheimer's disease

Lu, Y. (2020) · D-Scholarship@Pitt (University of Pittsburgh)

The TREM2 Receptor Puzzle in Alzheimer's Disease

Shareena, G., Kumar, D., & Sellamuthu, S. (2025) · CRC Press eBooks · doi:10.1201/9781003506317-4

The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer’s Disease

Zhong, L., & Chen, X. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00328 · Cited by 40 · see citing works