Cited by 56Nutritional Studies and DietChronic Kidney Disease and DiabetesDialysis and Renal Disease Management

Mediterranean diet and the risk of chronic kidney disease: A systematic review and meta‐analysis

Hansrivijit, Panupong, Oli, Sharad, Khanal, Resha, Ghahramani, Nasrollah, Thongprayoon, Charat, Cheungpasitporn, Wisit·2020·Nephrology

Abstract

Objective: Mediterranean diet has been shown to be associated with lower risk of cardiovascular disease. However, its association with chronic kidney disease (CKD) remains inconclusive as the results were not consistent among population‐based studies. This study aims to assess the association between Mediterranean diet adherence and CKD prevention. Methods: We performed a systematic review and meta‐analysis of studies describing the risk for CKD in community‐dwelling subjects ≥18 years of age. Mediterranean diet adherence was assessed by standardized food frequency questionnaires. The search was conducted through MEDLINE, EMBASE and Cochrane Library. Results: Of 168 citations, a total of nine (n = 19 151) and four studies (n = 8467) were included in the systematic review and meta‐analysis, respectively. Only studies adopting Mediterranean Diet Scale (MDS) were included in the analysis. The mean score was 3.8 ± 0.3 points. With the mean follow‐up duration of 20.6 ± 7.0 years, the pooled odds ratio (OR) for CKD was 0.901 (95% confidence interval [CI] 0.868‐0.935) for each 1‐point increment of MDS. The incidence of CKD was 0.026 events per person‐year (95% CI 0.008‐0.045). Moreover, male sex was associated with the incidence of CKD in an adjusted meta‐regression analysis. In contrast, there was no significant association between age, black race, smoking, diabetes, hypertension estimated glomerular filtration rate and total daily energy intake vs CKD incidence. Conclusion: Adherence to Mediterranean diet by a 1‐point increment of MDS was associated with 10% lower risk of CKD. However, there were insufficient data on patients with pre‐existing CKD or dialysis.

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Crossref · 10.1111/nep.13778

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  • Increases in Mediterranean diet score by 1 point were associated with 10% lower risk of chronic kidney disease.

    “Of note, increases in MD score by 1-point were associated with 10% lower risk of CKD (mean follow-up 20.6 ± 7.0 years) as shown in a meta-analysis (13 studies, n = 27,618 individuals) [67].”

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Authors
Hansrivijit, P., Oli, S., Khanal, R., Ghahramani, N., Thongprayoon, C., & Cheungpasitporn, W.
Affiliations
  • Harrisburg Hospital (US)
  • Maimonides Medical Center (US)
  • Pennsylvania State University (US)
  • Mayo Clinic (US)
  • University of Mississippi Medical Center (US)
Corresponding author
Hansrivijit, Panupong
Venue
Nephrology
Publisher
Wiley
Published
2020-09-07
Volume
25
Issue
12
Pages
913-918
ISSN
  • 1320-5358 (ISSN-L)
  • 1440-1797
OpenAlex
W3080822864
Cited by
56
References
35
Citations by year
2026: 17 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 2
FWCI
0.92
Type
journal article
Language
en
Open access
closed
Locations
  • Nephrology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
Mediterranean diet, chronic kidney disease, dietary adherence, CKD incidence, sex differences, cardiovascular disease
MeSH terms
Humans, Diet, Mediterranean, Renal Insufficiency, Chronic

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