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Cited by 44Pain Management and TreatmentDeep Brain Stimulation and Movement DisordersParkinson's Disease Mechanisms and Treatments

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Beneficial Therapeutic Effects of Spinal Cord Stimulation in Advanced Cases of Parkinson’s Disease With Intractable Chronic Pain: A Case Series

Nishioka, Kenya, Nakajima, Madoka·2015·Neuromodulation: Technology at the Neural Interface
DOI 10.1111/ner.12315
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Abstract

Objectives Pain is one of the common symptoms in patients with Parkinson's disease (PD), with a prevalence of approximately 40-85%. These symptoms affect the quality of life of PD patients. We evaluated the effect of spinal cord stimulation (SCS) to chronic pain and motor symptoms of PD. Materials and methods Three PD patients were treated with SCS to relieve their persistent and intractable pain. One patient had failed back surgery syndrome and the other two had lumbar canal stenosis. All patients had a stooped posture and pain that was resistant to analgesics. We evaluated motor symptoms using Hoehn and Yahr scale and the Unified Parkinson's Disease Rating Scale (UPDRS), and evaluated pain using visual analog scale and widespread pain index, before and after SCS. Results After SCS insertion, chronic pain in the patients decreased in both the lower back and limbs. Moreover, SCS ameliorated the symptoms of PD. One-year follow-up after SCS showed that UPDRS part III scores, rigidity, and tremor were improved without large alterations in levodopa dosage. Dementia and activities of daily living did not improve after SCS. Discussion and conclusion Our results indicate that SCS may be a treatment option for both motor symptoms and chronic pain in PD, especially in cases complicated with lumbar canal stenosis or disc herniation. Further studies are needed to evaluate the efficacy of SCS in PD patients.

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Metadata

Authors
Nishioka, K., & Nakajima, M.
Affiliations
Juntendo University (JP)
Corresponding author
Nishioka, Kenya
ORCID
Venue
Neuromodulation: Technology at the Neural Interface
Publisher
Elsevier BV
Published
2015-12
Volume
18
Issue
8
Pages
751-753
ISSN
1094-7159 (ISSN-L)
DOI
10.1111/ner.12315
OpenAlex
W2107837377
Cited by
44
References
5
Citations by year
2025: 2 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 2
FWCI
4.78
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuromodulation Technology at the Neural Interface (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
spinal cord stimulation, Parkinson's disease, chronic intractable pain, motor symptoms, lumbar spinal stenosis, failed back surgery syndrome, disc herniation, tremor, rigidity, levodopa dose
MeSH terms
Aged, Female, Follow-Up Studies, Humans, Male, Middle Aged, Motor Activity, Pain Measurement, Parkinson Disease, Chronic Pain, Spinal Cord Stimulation

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CoChat. (2026). Citation check: Beneficial Therapeutic Effects of Spinal Cord Stimulation in Advanced Cases of Parkinson’s Disease With Intractable Chronic Pain: A Case Series. https://app.cochat.ai/papers/10.1111/ner.12315
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Nishioka, K., & Nakajima, M. (2015). Beneficial Therapeutic Effects of Spinal Cord Stimulation in Advanced Cases of Parkinson’s Disease With Intractable Chronic Pain: A Case Series. Neuromodulation: Technology at the Neural Interface. https://doi.org/10.1111/ner.12315