The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Effects of varying dietary content of fermentable short‐chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome
Abstract
Background: A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP s) is increasingly recommended for patients with irritable bowel syndrome (IBS). We aimed to investigate the effects of a blinded low‐FODMAP vs high‐fructo‐oligosaccharides (FOS) diet on symptoms, immune activation, gut microbiota composition, and short‐chain fatty acids (SCFA s). Methods: Twenty patients with diarrhea‐predominant or mixed IBS were instructed to follow a low‐FODMAP diet (LFD) throughout a 9‐week study period. After 3 weeks, they were randomized and double‐blindly assigned to receive a supplement of either FOS (FODMAP) or maltodextrin (placebo) for the next 10 days, followed by a 3‐week washout period before crossover. Irritable bowel syndrome severity scoring system (IBS‐SSS) was used to evaluate symptoms. Cytokines (interleukin [IL]‐6, IL‐8, and tumor necrosis factor alpha) were analyzed in blood samples, and gut microbiota composition (16S rRNA) and SCFA s were analyzed in fecal samples. Key Results: Irritable bowel syndrome symptoms consistently improved after 3 weeks of LFD, and significantly more participants reported symptom relief in response to placebo (80%) than FOS (30%). Serum levels of proinflammatory IL‐6 and IL‐8, as well as levels of fecal bacteria (Actinobacteria, Bifidobacterium, and Faecalibacterium prausnitzii), total SCFA s, and n‐butyric acid, decreased significantly on the LFD as compared to baseline. Ten days of FOS supplementation increased the level of these bacteria, whereas levels of cytokines and SCFA s remained unchanged. Conclusions and Inferences: Our findings support the efficacy of a LFD in alleviating IBS symptoms, and show changes in inflammatory cytokines, microbiota profile, and SCFA s, which may have consequences for gut health.
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The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review
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Diets that differ in their FODMAP content alter the colonic luminal microenvironment
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Irritable bowel syndrome: A clinical review
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Plasma cytokine profiles in females with irritable bowel syndrome and extra-intestinal co-morbidity
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Colonic butyrate- algesic or analgesic?: Colonic butyrate function
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Diagnosis of Irritable Bowel Syndrome: Role of Potential Biomarkers
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Cited by
ACG Clinical Guideline: Management of Irritable Bowel Syndrome
Lacy, B. E., Pimentel, M., Brenner, D. M., Chey, W. D., Keefer, L. A., Long, M. D., & Moshiree, B. (2021) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000001036 · Cited by 893
Faecalibacterium: a bacterial genus with promising human health applications
Martín, R., Rios-Covian, D., Huillet, E., Auger, S., Khazaal, S., Bermúdez-Humarán, L. G., Sokol, H., Chatel, J.-M., & Langella, P. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad039 · Cited by 566
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Li, L., Ning, Z., Zhang, X., Mayne, J., Cheng, K., Stintzi, A., & Figeys, D. (2020) · Microbiome · doi:10.1186/s40168-020-00806-z · Cited by 328
Metadata
- Authors
- Hustoft, T. N., Hausken, T., Ystad, S. O., Valeur, J., Brokstad, K., Hatlebakk, J. G., & Lied, G. A.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2016-10-16
- Volume
- 29
- Issue
- 4
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- OpenAlex
- W2533620810
- Cited by
- 218
- References
- 10
- FWCI
- 22.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hustoft, T. N., Hausken, T., Ystad, S. O., Valeur, J., Brokstad, K., Hatlebakk, J. G., & Lied, G. A. (2017). Effects of varying dietary content of fermentable short‐chain carbohydrates on symptoms, fecal microenvironment, and cytokine profiles in patients with irritable bowel syndrome. Neurogastroenterology & Motility. https://doi.org/10.1111/nmo.12969
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