Impaired intestinal barrier function and relapsing digestive disease: lessons from a porcine model of early life stress
Open accessAbstract
Within this issue of Neurogastroenterology and Motility, an article by Pohl et al highlights new insights from a powerful porcine model of the link between early life adversity and relapsing functional gastrointestinal disorders. Early weaning stress closely mimics the early life psychosocial stressors that have been linked to adult onset gastrointestinal dysfunction. This early weaning model provides reproducible and highly translatable outcomes in young stress-challenged pigs. Due to the convincingly comparable neurological and gastroenterological anatomy and physiology between pigs and human beings, gastrointestinal stress and injury studies utilizing swine models will provide invaluable insights to improve our understanding and treatment of gastrointestinal disease in human beings. Future studies to examine mechanisms underlying this link between early life adversity and functional gastrointestinal disorders will explore the roles of gender and hypomaturity in gastrointestinal responses to stress.
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Alterations in microbiota due to infection, exposure to antibiotics, lack of natural birth or breastfeeding, psycho- and physiological stress, coupled with genetics of the host, can produce long-term modulation of stress response and behavior.
“Results of both preclinical and clinical studies show that alterations in microbiota due to infection, exposure to antibiotics, lack of natural birth or breastfeeding, psycho-and physiological stress, coupled with genetics of the host, can produce long-term modulation of stress response and behavior [17,21,[40][41][42][43].”
From The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders (2021) · cites this paper as [40]
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The Role of Microbiota-Gut-Brain Axis in Neuropsychiatric and Neurological Disorders
Socała, K., Doboszewska, U., Szopa, A., Serefko, A., Włodarczyk, M., Zielińska, A., Poleszak, E., Fichna, J., & Wlaź, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105840 · Cited by 857 · see citing works
- Authors
- Ziegler, A. L., & Blikslager, A. T.
- Affiliations
- North Carolina State University (US)
- Corresponding author
- Blikslager, A. T.
- Venue
- Neurogastroenterology & Motility
- Publisher
- Wiley
- Published
- 2017-10-20
- Volume
- 29
- Issue
- 11
- Pages
- 1-4
- ISSN
- 1350-1925 (ISSN-L)
- 1365-2982
- PMC
- PMC5940449
- OpenAlex
- W2765217586
- Cited by
- 9
- References
- 38
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 3
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurogastroenterology & Motility (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034987)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Keywords
- early life stress, intestinal barrier function, functional gastrointestinal disorders, porcine model, psychosocial stress, gut-brain axis, sex differences
- MeSH terms
- Animals, Disease Models, Animal, Gastrointestinal Diseases, Humans, Recurrence, Stress, Psychological, Sus scrofa, Translational Research, Biomedical
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