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Cited by 193Plant Stress Responses and ToleranceRedox biology and oxidative stressNitric Oxide and Endothelin Effects

Nitro-oxidative stress vs oxidative or nitrosative stress in higher plants

Corpas, Francisco J., Barroso, Juan B.·2013·New Phytologist
DOI 10.1111/nph.12380
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Abstract

Nitric oxide (NO) is involved in many physiological functions of higher plants. Under stress conditions, a family of NO-derived molecules, called reactive nitrogen species (RNS), can cause nitrosative stress. Reactive oxygen species (ROS) participate in the generation of oxidative stress. Recent data show that these two families of molecules are characterized by rigorous metabolic interplay that can regulate a nitro-oxidative stress response in higher plants. ROS and RNS are necessary by-products of an oxygen- and nitrogen-rich environment. The concept of oxidative stress is very commonly used in plant biology to explain cellular damage caused by the imbalance between ROS production and scavenging antioxidant protective mechanisms. Thousands of research papers have studied their impact on higher plants from many different perspectives in order to elucidate the molecular networks involved in stress perception, signal transduction, and the expression of specific antioxidative stress-related genes and antioxidant metabolites. At the end of the 1990s, some plant researchers began to study the potential involvement of the 'old' NO molecule, which was previously shown to be produced enzymatically in animal cells and to participate in a broad spectrum of functions in cardiovascular, immune, and nervous systems. It is now widely recognized that NO participates in important functions in higher plants through its involvement in physiological and stress-related processes. NO is a free radical associated with a family of molecules called RNS such as peroxyinitrite (ONOO−), nitrogen dioxide (.NO2), dinitrogen trioxide (N2O3) and S-nitrosoglutathione (GSNO) which can mediate post-translational modifications of different bio-molecules, mainly nitration (Corpas et al., 2013) and S-nitrosylation of proteins (Astier & Lindermayr, 2012; Astier et al., 2012). These two families of molecules (ROS and RNS) have been shown to be involved in signaling process of higher plants essentially when they are kept under cellular no-stress situations. However, under adverse environmental conditions, plant cells can be characterized by overproduction of these molecules that are capable of mediating damage to bio-molecules, with proteins being the most frequently studied; a fraction of these same molecules may also have a signaling function in order to attenuate this damage. A good example of interaction between ROS and RNS is the interplay between the superoxide radical (.−) and nitric oxide to generate ONOO−, a powerful oxidant that can mediate the tyrosine nitration of proteins which might be an effective biomarker of nitrosative stress in higher plants (Corpas et al., 2007). Experimental data later confirmed this hypothesis, which was previously observed in an animal system. Thus, it has been verified that diverse abiotic/biotic stresses in different model plants provoke an increase in protein tyrosine nitration (Romero-Puertas et al., 2007; Valderrama et al., 2007; Cecconi et al., 2009; Corpas et al., 2011) that usually involves a loss of function and consequently nitrosative stress. For example, ferredoxin-NADP reductase (FNR) and carbonic anhydrase (CA) are enzymes involved in photosynthesis carbon assimilation where, under high temperature stress, the activity of both enzymes is inhibited due to a process of tyrosine nitration (Chaki et al., 2011, 2013). Similarly, NADP-dependent isocitrate dehydrogenase enzyme is involved in nitrogen metabolism, which also supports the antioxidative system providing NADPH, during root senescence is down-regulated by nitration at Tyr392 (Begara-Morales et al., 2013). Nevertheless, another set of data also indicates that protein S-nitrosylation needs to be regarded as involved in these processes which have signaling functions. For example, the protein NPR1 (nonexpresser of pathogenesis-related gene1 whose conformation is regulated by the cytosolic redox state) and the transcription factor TGA1 (also called a DNA-binding protein TGA1-like protein) are essential components for regulating salicylic acid-dependent gene expression during systemic acquired resistance (SAR). Both elements can be S-nitrosylated by GSNO which increases the DNA binding activity of TGA1 in the presence of NPR1 (Tada et al., 2008; Lindermayr et al., 2010). Additionally, the connection between ROS and RNS is also demonstrated in the case of the antioxidant enzyme peroxiredoxin which has the capacity to detoxify ONOO−, although its activity is inhibited by a process of S-nitrosylation (Romero-Puertas et al., 2007). In the same way, the Arabidopsis NADPH oxidase, also known as AtRBOHD (for respiratory burst oxidase homolog D), which is responsible for the superoxide radical in response to pathogens, is inhibited by S-nitrosylation at Cys890 (Yun et al., 2011). Although an interrelationship could be expected to exist between ROS and RNS metabolisms under physiological and adverse environmental conditions, few studies carried out in p

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  • Redox-mediated formation of heme and protein thiol nitrosyl adducts and protein 3-nitrotyrosine adducts is integral to nitro-oxidative reactions in higher plants.

    “Integral to these events is the redox-mediated formation of heme and protein thiol nitrosyl adducts and protein 3-nitrotyrosine adducts [13].”

    From Olives and olive oil are sources of electrophilic fatty acid nitroalkenes (2014) · cites this paper as [13]

  • There is an emerging body of evidence from higher plants that nitric oxide (NO) and other reactive species mediate nitro-oxidative reactions that regulate plant stress perception, signal transduction and senescence responses.

    “There is also an emerging body of evidence from higher plants that NO and other reactive species mediate nitro-oxidative reactions that regulate plant stress perception, signal transduction and senescence responses.”

    From Olives and olive oil are sources of electrophilic fatty acid nitroalkenes (2014) · cites this paper as [13]

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Authors
Corpas, F. J., & Barroso, J. B.
Affiliations
  • Consejo Superior de Investigaciones Científicas (ES)
  • Universidad de Jaén (ES)
Corresponding author
Corpas, Francisco J.
ORCID
Venue
New Phytologist
Publisher
Wiley
Published
2013-06-13
Volume
199
Issue
3
Pages
633-635
ISSN
  • 0028-646X (ISSN-L)
  • 1469-8137
DOI
10.1111/nph.12380
OpenAlex
W2035326812
Cited by
193
References
35
Citations by year
2026: 9 · 2025: 9 · 2024: 16 · 2023: 15 · 2022: 20 · 2021: 22 · 2020: 23 · 2019: 13 · 2018: 12 · 2017: 16 · 2016: 16 · 2015: 6 · 2014: 12 · 2013: 4
FWCI
15.27
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • New Phytologist (publishedVersion)
  • PubMed (publishedVersion)
Funders
European Regional Development Fund
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords
nitro-oxidative stress, nitric oxide, reactive nitrogen species, reactive oxygen species, oxidative stress, nitrosative stress, S-nitrosoglutathione, S-nitrosylation, protein nitration, antioxidant defense, plant stress response, signal transduction, higher plants, superoxide, antioxidant enzymes, oxidative phosphorylation, nitric oxide synthase
MeSH terms
Oxidation-Reduction, Plants, Stress, Physiological, Nitrosation, Reactive Oxygen Species, Oxidative Stress, Reactive Nitrogen Species

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