Body weight gain and risk of colorectal cancer: a systematic review and meta‐analysis of observational studies
Abstract
While the relationship between body mass index as an indicator of excess body weight and the risk of colorectal cancer (CRC) is well established, the association between body weight gain in adulthood and risk of CRC remains unresolved. We quantified this association in a meta-analysis of 12 observational studies published until November 2014 with a total of 16,151 incident CRC cases. Random effect models were used to obtain summary relative risks (RR) and 95% confidence intervals (95% CIs). Between-study heterogeneity was assessed using I(2) statistics. Overall, the summary RR (95% CI) was 1.22 (1.14-1.30) for high body weight gain (midpoint: 15.2 kg) compared with stable weight (P for heterogeneity = 0.182; I(2) = 21.2%). In a dose-response analysis, each 5 kg weight gain was associated with a 4% (95% CI: 2%-5%) higher risk of CRC. The association persisted after adjustment for body weight at younger age and was present for both men and women, as well as for colon and rectal cancer. Differences by sex were detected for colon cancer (P for interaction = 0.003, with higher risk for men than women), but not for rectal cancer (P for interaction = 0.613). In conclusion, these data underscore the importance of body weight management from early adulthood onwards for the prevention of CRC development.
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Some reports suggest potential harm from using resveratrol, selenium, and vitamin D.
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From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1717]
Resveratrol, selenium, and vitamin D have mixed effects on glycemic control and other cardiovascular risk factors.
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From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1717]
Cites
Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis
Greenland, S., & Longnecker, M. P. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116237 · Cited by 2,353 · see citing works
Weight, Weight Change, and Coronary Heart Disease in Women: Risk Within the 'Normal' Weight Range
Willett, W. C. (1995) · JAMA · doi:10.1001/jama.1995.03520300035033 · Cited by 924 · see citing works
Leisure-Time Physical Activity, Body Size, and Colon Cancer in Women
Martinez, M. E., Giovannucci, E., Spiegelman, D., Willett, W. C., Hunter, D. J., & Colditz, G. A. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.13.948 · Cited by 419 · see citing works
Intentional weight loss and incidence of obesity-related cancers: the Iowa Women's Health Study
Parker, E. D., & Folsom, A. R. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802437 · Cited by 203 · see citing works
Dietary Fiber Intake Reduces Risk for Colorectal Adenoma: A Meta-analysis
Ben, Q., Sun, Y., Chai, R., Qian, A., Xu, B., & Yuan, Y. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.11.003 · Cited by 156 · see citing works
Metabolic risk score and cancer risk: pooled analysis of seven cohorts
Stocks, T., Bjørge, T., Ulmer, H., Manjer, J., Häggström, C., Nagel, G., Engeland, A., Johansen, D., Hallmans, G., Selmer, R., et al. (2015) · International Journal of Epidemiology · doi:10.1093/ije/dyv001 · Cited by 146 · see citing works
Prospective weight change and colon cancer risk in male US health professionals
Thygesen, L. C., Grønbæk, M., Johansen, C., Fuchs, C. S., Willett, W. C., & Giovannucci, E. (2008) · International Journal of Cancer · doi:10.1002/ijc.23612 · Cited by 78 · cited 4× · see citing works
“Data for several studies (11,18,19) were additionally adapted as described in the succeeding text.”
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Adiposity and cancer at major anatomical sites: umbrella review of the literature
Kyrgiou, M., Kalliala, I., Markozannes, G., Gunter, M. J., Paraskevaidis, E., Gabra, H., Martin-Hirsch, P., & Tsilidis, K. K. (2017) · BMJ · doi:10.1136/bmj.j477 · Cited by 803 · see citing works
Blonde, L., Umpierrez, G. E., Reddy, S. S., McGill, J. B., Berga, S. L., Bush, M., Chandrasekaran, S., DeFronzo, R. A., Einhorn, D., Galindo, R. J., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.08.002 · Cited by 507 · see citing works
Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer
Zheng, X., Hur, J., Nguyen, L. H., Liu, J., Song, M., Wu, K., Smith-Warner, S. A., Ogino, S., Willett, W. C., Chan, A. T., et al. (2021) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djaa164 · Cited by 136 · see citing works
- Authors
- Schlesinger, S., Lieb, W., Koch, M., Fedirko, V., Dahm, C. C., Pischon, T., Nöthlings, U., Boeing, H., & Aleksandrova, K.
- Affiliations
- Christian-Albrechts-Universität zu Kiel (DE)
- Emory University (US)
- Aarhus University (DK)
- Max Delbrück Center (DE)
- University of Bonn (DE)
- German Institute of Human Nutrition (DE)
- Corresponding author
- Schlesinger, S.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2015-04-29
- Volume
- 16
- Issue
- 7
- Pages
- 607-619
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W2113273056
- Cited by
- 70
- References
- 7
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 7 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 6 · 2015: 1
- FWCI
- 0.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- weight gain, colorectal cancer, colon cancer, rectal cancer, body mass index, overweight, cancer risk, dose-response relationship, sex differences, weight management, cancer prevention
- MeSH terms
- Humans, Obesity, Risk Factors, Sex Factors, Colorectal Neoplasms, Weight Gain, Risk Assessment, Risk Reduction Behavior, Waist Circumference, Observational Studies as Topic
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