The DOI matches its Crossref record; 242 of the 242 references it cites were found in a registry or an index.
Obesity and ageing: Two sides of the same coin
Abstract
Summary: Conditions and comorbidities of obesity mirror those of ageing and age‐related diseases. Obesity and ageing share a similar spectrum of phenotypes such as compromised genomic integrity, impaired mitochondrial function, accumulation of intracellular macromolecules, weakened immunity, shifts in tissue and body composition, and enhanced systemic inflammation. Moreover, it has been shown that obesity reduces life expectancy by 5.8 years in men and 7.1 years in women after the age of 40. Shorter life expectancy could be because obesity holistically accelerates ageing at multiple levels. Besides jeopardizing nuclear DNA and mitochondrial DNA integrity, obesity modifies the DNA methylation pattern, which is associated with epigenetic ageing in different tissues. Additionally, other signs of ageing are seen in individuals with obesity including telomere shortening, systemic inflammation, and functional declines. This review aims to show how obesity and ageing are “two sides of the same coin” through discussing how obesity predisposes an individual to age‐related conditions, illness, and disease. We will further demonstrate how the mechanisms that perpetuate the early‐onset of chronic diseases in obesity parallel those of ageing.
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Cited by
Liu, C., Wong, P. Y., Chung, Y. L., Chow, S. K., Cheung, W. H., Law, S. W., Chan, J. C. N., & Wong, R. M. Y. (2023) · Obesity Reviews · doi:10.1111/obr.13534 · Cited by 247
Involvement of p38 MAPK in Leydig cell aging and age-related decline in testosterone
Luo, D., Qi, X., Xu, X., Yang, L., Yu, C., & Guan, Q. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1088249 · Cited by 48
Aged mice exhibit widespread metabolic changes but preserved major fluxes
Jankowski, C. S. R., Samarah, L. Z., MacArthur, M. R., Mitchell, S. J., Weilandt, D. R., Hunter, C. J., Zeng, X., McReynolds, M. R., & Rabinowitz, J. D. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.09.009 · Cited by 19
Metadata
- Authors
- Tam, B. T., Morais, J. A., & Santosa, S.
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2020-02-05
- Volume
- 21
- Issue
- 4
- Pages
- e12991-e12991
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W3004835557
- Cited by
- 253
- References
- 242
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tam, B. T., Morais, J. A., & Santosa, S. (2020). Obesity and ageing: Two sides of the same coin. Obesity Reviews. https://doi.org/10.1111/obr.12991
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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