The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Effects of nonnutritive sweeteners on body weight and BMI in diverse clinical contexts: systematic review and meta-analysis
Open accessAbstract
There is an ongoing debate about the possible influences of nonnutritive sweeteners (NNS) on body weight. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) with NNS to assess their impact on body weight. We systematically searched for RCTs at least 4 weeks in duration, evaluating the effect of NNS on body weight, both in subjects with healthy weight and in subjects with overweight/obesity at any age, and compared the effects of NNS vs caloric and noncaloric comparators. The primary outcome was the difference in body weight between NNS and comparators. Twenty studies were eligible (n = 2914). Participants consuming NNS showed significant weight/BMI differences favouring NNS compared with nonusers. Grouping by nature of comparator revealed that NNS vs placebo/no intervention and NNS vs water produced no effect. When comparing NNS vs sucrose, significant weight/BMI differences appeared favouring NNS. Consumption of NNS led to significantly negative weight/BMI differences in unrestricted energy diets, but not in weight-reduction diets. Participants with overweight/obesity and adults showed significant favourable weight/BMI differences with NNS. Data suggest that replacing sugar with NNS leads to weight reduction, particularly in participants with overweight/obesity under an unrestricted diet, information that could be utilized for evidence-based public policy decisions.
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“There is mixed evidence from systematic reviews and meta-analyses for nonnutritive sweetener use with regard to weight management, with some finding benefit in weight loss (233-235) while other research suggests an association with weight gain (236,237).”
From 5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes:Standards of Care in Diabetes—2023 (2023) · cites this paper as [235]
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Items 101–115 of 115
Sollid, K. (2025) · ADCES in Practice · doi:10.1177/2633559x251327390
Ko, H.-K., Shi, J., Eidenberger, T., Shi, W., & McCabe, C. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.17.657228
“…— such as saccharin, sucralose, aspartame, cyclamate, and acesulfame K in food and beverages, can help reduce sugar (Shankar et al., 2013) and lead to weight reduction (Rogers & Appleton, 2021) particularly in those overweight/obese under an unrestricted diet (Laviada Molina et al., 2020).”
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TATLANDIRICILAR VE DOĞRU BİLDİĞİMİZ YANLIŞLAR
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“These findings are consistent with systematic reviews and meta-analyses of randomized controlled trials indicating that replacing sugars with NNSs reduces energy intake, contributes to modest weight loss over time, and does not affect cardiometabolic markers [9,28–36].”
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Artificial and Other Non-Nutritive Sweeteners, the Microbiome, and Cardiometabolic Health
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The Role of Low-calorie Sweeteners in Human Health: A Review of their Benefits and Risks
Asif, M., Chandra, P., Jakhmola, V., & Joshi, K. K. (2026) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-026-02544-z
“Similarly, a systematic review concluded that LCS can be an effective tool for reducing body weight and BMI when used as part of structured dietary and lifestyle modification programs [ 6 ].”
Sugar and artificial sweeteners and risk of cardiovascular disease
Manolis, A. A., Manolis, T. A., Vouliotis, A. I., & Manolis, A. S. (2026) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2026.107090
Kowalczyk, A., & Gawryjołek, J. (2026) · Nutrients · doi:10.3390/nu18203390
“Earlier meta-analyses similarly found that estimates of body-weight effects depend strongly on the comparator and the clinical context [10,50].”
Sharata, E. E., Abdel-Samea, A. S., Reda, Y., Abdelnaser, M., Rofaeil, R. R., & Mohyeldin, R. H. (2026) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-026-02757-2
“Telemedicine-delivered obesity treatment has demonstrated outcomes comparable to in-person care in several studies, while dramatically improving access for individuals in rural or underserved areas [ 117 ].”
Metadata
- Authors
- Laviada‐Molina, H., Molina‐Segui, F., Pérez‐Gaxiola, G., Cuello‐García, C., Arjona‐Villicaña, R., Espinosa‐Marrón, A., & Martinez‐Portilla, R. J.
- Affiliations
- Universidad Marista de Mérida (MX)
- Department of Human Nutrition and Metabolism Research, Health Sciences School Universidad Marista de Merida Mérida Mexico
- Pediatric Hospital of Sinaloa (MX)
- McMaster University (CA)
- Endocrinology Service Hospital Regional de Alta Especialidad de la Peninsula de Yucatan Merida Mexico
- Nuffield Department of Primary Health Sciences, Radcliffe Observatory Quarter University of Oxford Centre for Evidence‐Based Medicine Oxford UK
- ORCID
- Venue
- Obesity Reviews
- Publisher
- Wiley
- Published
- 2020-03-25
- Volume
- 21
- Issue
- 7
- Pages
- e13020-e13020
- ISSN
- 1467-7881 (ISSN-L)
- 1467-789X
- OpenAlex
- W3014022032
- Cited by
- 115
- References
- 44
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 25 · 2023: 16 · 2022: 19 · 2021: 13 · 2020: 7
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Obesity Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- artificial sweeteners, body weight, body mass index, obesity, overweight, sucrose replacement, weight loss diet, sugar consumption
- MeSH terms
- Body Weight, Diet, Humans, Obesity, Body Mass Index, Non-Nutritive Sweeteners
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