Nonnutritive sweeteners in weight management and chronic disease: a review
Open accessAbstract
Objective: The objective of this review was to critically review findings from recent studies evaluating the effects of nonnutritive sweeteners (NNSs) on metabolism, weight, and obesity‐related chronic diseases. Biologic mechanisms that may explain NNS effects will also be addressed. Methods: A comprehensive review of the relevant scientific literature was conducted. Results: Most cross‐sectional and prospective cohort studies report positive associations between NNS consumption, body weight, and health conditions, including type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease. Although findings in cellular and rodent models suggest that NNSs have harmful effects on metabolic health, most randomized controlled trials in humans demonstrate marginal benefits of NNS use on body weight, with little data available on other metabolic outcomes. Conclusions: NNS consumption is associated with higher body weight and metabolic disease in observational studies. In contrast, randomized controlled trials demonstrate that NNSs may support weight loss, particularly when used alongside behavioral weight loss support. Additional long‐term, well‐controlled intervention studies in humans are needed to determine the effects of NNSs on weight, adiposity, and chronic disease under free‐living conditions.
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Nutritional Recommendations for People with Type 1 Diabetes Mellitus
Rubin, D., Bosy‐Westphal, A., Kabisch, S., Kronsbein, P., Simon, M., Tombek, A., Weber, K. S., & Skurk, T. (2023) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1946-3753 · Cited by 1 · see citing works
Aspartame: A review of functional properties and physiology impacts of aspartame
Zhang, Y. (2024) · Theoretical and Natural Science · doi:10.54254/2753-8818/45/20240521 · Cited by 1 · see citing works
Sucralose Mouth Rinse Enhances Cephalic Phase Insulin Release
Cogan, B., Mance, S. A., vanDellen, M. R., Paton, C. M., & Cooper, J. A. (2024) · American Journal of Health Behavior · doi:10.5993/ajhb.48.3.24 · Cited by 1 · see citing works
Nutritional Recommendations for People with Type 1 Diabetes Mellitus
Rubin, D., Bosy‐Westphal, A., Kabisch, S., Kronsbein, P., Simon, M., Tombek, A., Weber, K. S., & Skurk, T. (2020) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/a-1284-6036 · Cited by 1 · see citing works
- Authors
- Sylvetsky, A. C., & Rother, K. I.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Sylvetsky, Allison C.
- Venue
- Obesity
- Publisher
- Wiley
- Published
- 2018-03-23
- Volume
- 26
- Issue
- 4
- Pages
- 635-640
- ISSN
- 1930-7381 (ISSN-L)
- 1930-739X
- PMC
- PMC5868411
- OpenAlex
- W2794613736
- Cited by
- 143
- References
- 94
- Citations by year
- 2026: 22 · 2025: 19 · 2024: 18 · 2023: 16 · 2022: 15 · 2021: 11 · 2020: 24 · 2019: 12 · 2018: 6
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- public-domain
- onlinelibrary.wiley.com/termsAndConditions#vor (vor)
- Locations
- Obesity (publishedVersion, public-domain)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- George Washington University
- NIDDK
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Keywords
- artificial sweeteners, weight management, type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease, metabolic health, weight loss, adiposity, chronic disease
- MeSH terms
- Body Weight Maintenance, Body Weight, Chronic Disease, Female, Humans, Male, Obesity, Non-Nutritive Sweeteners
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