Effect of pore size in bone regeneration using polydopamine‐laced hydroxyapatite collagen calcium silicate scaffolds fabricated by 3D mould printing technology
Open accessAbstract
Structured Abstract: Objective: The pore size of the scaffold is a critical factor in repairing large bone defect. Here, we investigated the potential of bone regeneration using novel nanocomposite polydopamine‐laced hydroxyapatite collagen calcium silicate ( HCCS ‐ PDA ) scaffolds with two different pore sizes, 250 and 500 μm. Samples/Setting: A total of 12 male Sprague‐Dawley rats were implanted with HCCS ‐ PDA scaffold with pore size of either 250 or 500 μm into surgically created critical‐sized defect ( CSD ). Methods: HCCS ‐ PDA scaffolds were fabricated using mould printing technique. The effect of pore size on mechanical strength of the scaffolds was assessed by compression testing. After seeding with rat mesenchymal stem cells ( rMSC s), the scaffolds were implanted, and new bone formation was evaluated using micro CT and histomorphometric analysis after 8 weeks. Results: Micro CT and histology analysis demonstrated restricted peripheral new bone formation in either dural or periosteal side and limited new bone formation in the 250 μm pore scaffold. Conversely, the 500‐μm pore scaffold showed more penetration of new bone into the scaffold and greater bone regeneration in the rat CSD . Conclusion: Based on our results, which demonstrated improved new bone formation in 500 μm pores scaffold, we can conclude that effective scaffold pore size that induces osteointegration and bone regeneration is around 500 μm for HCCS ‐ PDA nanocomposite scaffold.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The opposite charge on the outer and inner surface of HNTs makes them attractive for electrostatic bonding with polymers and drugs.
“Also, the opposite charge on the outer and inner surface of HNTs makes them attractive for electrostatic bonding with polymers and drugs (Lee Y. J. et al., 2019; Zare and Rhee, 2021a).”
From Osteogenesis Improvement of Gelatin-Based Nanocomposite Scaffold by Loading Zoledronic Acid (2022) · cites this paper as Lee Y. J. et al., 2019
The Introduction and Methods describe polydopamine-laced hydroxyapatite collagen calcium silicate scaffolds, not HNTs. Searches for HNT surface charge and electrostatic bonding with polymers or drugs found no passage addressing the claim; page numbers were unavailable in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Porosity of 3D biomaterial scaffolds and osteogenesis
Karageorgiou, V., & Kaplan, D. L. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.002 · Cited by 6,639 · see citing works
Potential of ceramic materials as permanently implantable skeletal prostheses
Hulbert, S., Young, F. A., Mathews, R. S., Klawitter, J. J., Talbert, C. D., & Stelling, F. H. (1970) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820040309 · Cited by 1,017 · see citing works
3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949 · see citing works
Three‐dimensional printing of porous ceramic scaffolds for bone tissue engineering
Seitz, H., Rieder, W., Irsen, S. H., Leukers, B., & Tille, C. (2005) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.30291 · Cited by 742 · see citing works
Evaluation of bone regeneration using the rat critical size calvarial defect
Spicer, P. P., Kretlow, J. D., Young, S. W., Jansen, J. A., Kasper, F. K., & Mikos, A. G. (2012) · Nature Protocols · doi:10.1038/nprot.2012.113 · Cited by 666 · see citing works
Preparation of hydroxyapatite-gelatin nanocomposite
Chang, M. C., Ko, C., & DOUGLAS, W. H. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00115-7 · Cited by 428 · see citing works
Self-citationBai, F., Jinkang, Z., Wang, Z., Jian-xi, L., Jiang, C., Jian, L., Guolin, M., & Xin, D. (2011) · Biomedical Materials · doi:10.1088/1748-6041/6/1/015007 · Cited by 252 · see citing works
Optimally Porous and Biomechanically Compatible Scaffolds for Large-Area Bone Regeneration
Amini, A. R., Adams, D. J., Laurencin, C. T., & Nukavarapu, S. P. (2012) · Tissue Engineering Part A · doi:10.1089/ten.tea.2011.0076 · Cited by 146 · see citing works
Li, J., Zhi, W., Xu, T., Shi, F., Duan, K., Wang, J., Mu, Y., & Weng, J. (2016) · Regenerative Biomaterials · doi:10.1093/rb/rbw031 · Cited by 72 · see citing works
Lee, D. J., Lee, Y.-T., Zou, R. X., Daniel, R., & Ko, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-13326-y · Cited by 36 · see citing works
Self-citationLee, D. J., Padilla, R., Zhang, H., Hu, W., & Ko, C. (2014) · BioMed Research International · doi:10.1155/2014/837524 · Cited by 27 · see citing works
Self-citationKo, C., Wang, Z., Tseng, H. C., Lee, D. J., & Guez, C. (2014) · Ceramic transactions /Ceramic transactions · doi:10.1002/9781118771587.ch13 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [1]Ko CC, Guez C, Lee DJ, Wang Z, Tseng H. Advances in Bioceramics and Biotechnologies II: Ceramic Transactions California: Wiley-American Ceramic Society; 2014 135– 148 p.
Cited by
Sorted by citations
On the road to smart biomaterials for bone research: definitions, concepts, advances, and outlook
Montoya, C., Du, Y., Gianforcaro, A. L., Orrego, S., Yang, M., & Lelkes, P. I. (2021) · Bone Research · doi:10.1038/s41413-020-00131-z · Cited by 305 · see citing works
3D Bioprinted Scaffolds for Bone Tissue Engineering: State-Of-The-Art and Emerging Technologies
Yazdanpanah, Z., Johnston, J. D., Cooper, D. M. L., & Chen, D. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.824156 · Cited by 201 · see citing works
Conductive Scaffolds for Bone Tissue Engineering: Current State and Future Outlook
Dixon, D. T., & Gomillion, C. T. (2021) · Journal of Functional Biomaterials · doi:10.3390/jfb13010001 · Cited by 117 · see citing works
Oral Bone Tissue Regeneration: Mesenchymal Stem Cells, Secretome, and Biomaterials
Gugliandolo, A., Fonticoli, L., Trubiani, O., Rajan, T. S., Marconi, G. D., Bramanti, P., Mazzon, E., Pizzicannella, J., & Diomede, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105236 · Cited by 110 · see citing works
Personalized bioceramic grafts for craniomaxillofacial bone regeneration
de Carvalho, A. B. G., Rahimnejad, M., Oliveira, R. L. M. S., Sikder, P., Saavedra, G. D. S. F. A., Bhaduri, S. B., Gawlitta, D., Malda, J., Kaigler, D., Trichês, E. S., et al. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00327-7 · Cited by 103 · see citing works
The Effect of Physical Cues of Biomaterial Scaffolds on Stem Cell Behavior
Wang, S., Hashemi, S., Stratton, S., & Arinzeh, T. L. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001244 · Cited by 97 · see citing works
3D printing of acellular scaffolds for bone defect regeneration: A review
Ghorbani, F., Li, D., Ni, S., Zhou, Y., & Yu, B. (2020) · Materials Today Communications · doi:10.1016/j.mtcomm.2020.100979 · Cited by 83 · see citing works
Foroughi, A. H., & Razavi, M. J. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.04.051 · Cited by 80 · see citing works
3D printing of inorganic-biopolymer composites for bone regeneration
van der Heide, D., Cidonio, G., Stoddart, M. J., & D’Este, M. (2022) · Biofabrication · doi:10.1088/1758-5090/ac8cb2 · Cited by 73 · see citing works
3D-Printed Ceramic Bone Scaffolds with Variable Pore Architectures
Lim, H., Hong, S. J., Byeon, S., Chung, S.-M., On, S.-W., Yang, B., Lee, J.-H., & Byun, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186942 · Cited by 70 · see citing works
Liu, Y., Wang, R., Chen, S., Xu, Z., Wang, Q., Yuan, P., Zhou, Y., Zhang, Y., & Chen, J. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.01.109 · Cited by 58 · see citing works
Santos, D. M. D., Moon, J.-I., Kim, D., Bassous, N. J., Marangon, C. A., Filho, S. P. C., Correa, D. S., Kang, M., Kim, W.-J., & Shin, S. R. (2024) · ACS Nano · doi:10.1021/acsnano.4c05558 · Cited by 53 · see citing works
Clinical Applications of Cell-Scaffold Constructs for Bone Regeneration Therapy
Venkataiah, V. S., Yahata, Y., Kitagawa, A., Inagaki, M., Kakiuchi, Y., Nakano, M., Suzuki, S., Handa, K., & Saito, M. (2021) · Cells · doi:10.3390/cells10102687 · Cited by 51 · see citing works
Jeyachandran, D., & Cerruti, M. (2023) · Advanced Engineering Materials · doi:10.1002/adem.202201743 · Cited by 50 · see citing works
Pektas, H. K., Demidov, Y., Ahvan, A., Abie, N., Georgieva, V. S., Chen, S., Farè, S., Brachvogel, B., Mathur, S., & Maleki, H. H. (2023) · ACS Materials Au · doi:10.1021/acsmaterialsau.3c00040 · Cited by 50 · see citing works
Frontiers of Hydroxyapatite Composites in Bionic Bone Tissue Engineering
Shi, J., Dai, W., Gupta, A., Zhang, B., Wu, Z., Zhang, Y., Pan, L., & Wang, L. (2022) · Materials · doi:10.3390/ma15238475 · Cited by 47 · see citing works
An overview of collagen/bioceramic and synthetic collagen for bone tissue engineering
Mallick, M., Are, R. P., & Babu, A. R. (2022) · Materialia · doi:10.1016/j.mtla.2022.101391 · Cited by 45 · see citing works
Santos, D. M. D., de Annunzio, S. R., Carmello, J. C., Pavarina, A. C., Fontana, C. R., & Correa, D. S. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c01019 · Cited by 45 · see citing works
Shape optimization of orthopedic porous scaffolds to enhance mechanical performance
Foroughi, A. H., & Razavi, M. J. (2022) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2022.105098 · Cited by 45 · see citing works
Rahimnejad, M., Rezvaninejad, R., Rezvaninejad, R., & França, R. (2021) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ac21ab · Cited by 39 · see citing works
Foroughi, A. H., Valeri, C., & Razavi, M. J. (2024) · Progress in Biomedical Engineering · doi:10.1088/2516-1091/ad879a · Cited by 38 · see citing works
Hallman, M. J., Driscoll, J. A., Lubbe, R., Jeong, S., Chang, K. Y., Haleem, M. S., Jakus, A. E., Pahapill, R. R., Yun, C., Shah, R. N., et al. (2020) · Tissue Engineering Part A · doi:10.1089/ten.tea.2020.0004 · Cited by 37 · see citing works
Garot, C., Schoffit, S., Monfoulet, C., Machillot, P., Deroy, C., Roques, S., Vial, J., Vollaire, J., Renard, M., Ghanem, H., et al. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301692 · Cited by 36 · see citing works
Structural influences on bone tissue engineering: A review and perspective
Sebastiani, S., Buccino, F., Zhao Qin, A., & Vergani, L. M. (2025) · Matter · doi:10.1016/j.matt.2025.102252 · Cited by 35 · see citing works
Polydopamine functionalized VEGF gene-activated 3D printed scaffolds for bone regeneration
Chakka, L. R. J., Acri, T. M., Laird, N. Z., Zhong, L., Shin, K., Elangovan, S., & Salem, A. K. (2021) · RSC Advances · doi:10.1039/d1ra01193f · Cited by 35 · see citing works
Geopolymer Materials for Bone Tissue Applications: Recent Advances and Future Perspectives
Ricciotti, L., Apicella, A. M., Perrotta, V., & Aversa, R. M. (2023) · Polymers · doi:10.3390/polym15051087 · Cited by 35 · see citing works
In vivo therapeutic effect of wollastonite and hydroxyapatite on bone defect
Ge, R., Xun, C., Yang, J., Jia, W., & Li, Y. (2019) · Biomedical Materials · doi:10.1088/1748-605x/ab4238 · Cited by 34 · see citing works
Santos-Rosales, V., Magariños, B., Starbird, R., Suárez-González, J., Fariña, J. B., Alvarez-Lorenzo, C., & García-González, C. A. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120801 · Cited by 32 · see citing works
Oleshko, O., Husak, Y., Korniienko, V. V., Pshenychnyi, R., Varava, Y., Kalinkevich, A. N., Pisarek, M., Grundšteins, K., Погорєлова, О. С., Mishchenko, O., et al. (2020) · Nanomaterials · doi:10.3390/nano10122401 · Cited by 32 · see citing works
Unraveling the influence of channel size and shape in 3D printed ceramic scaffolds on osteogenesis
Entezari, A., Wu, Q., Mirkhalaf, M., Lu, Z., Roohani, I., Li, Q., Dunstan, C. R., Jiang, X., & Zreiqat, H. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.04.020 · Cited by 31 · see citing works
Jaber, M., Poh, P. S. P., Duda, G. N., & Checa, S. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.995266 · Cited by 31 · see citing works
Bello, S. A., Cruz-Lebrón, J., Rodríguez-Rivera, O. A., & Nicolau, E. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00432 · Cited by 28 · see citing works
Material extrusion 3D printing of bioactive smart scaffolds for bone tissue engineering
Sabahi, N., Roohani, I., Wang, C., & Li, X. (2025) · Additive manufacturing · doi:10.1016/j.addma.2024.104636 · Cited by 27 · see citing works
Natural hollow clay nanotubes and their applications as polymer nanocomposites in tissue engineering
Wong, L. W., Goh, C. B. S., Pasbakhsh, P., & Tan, J. B. L. (2022) · Journal of Science Advanced Materials and Devices · doi:10.1016/j.jsamd.2022.100431 · Cited by 26 · see citing works
Chen, Y., Huang, J., Liu, J., Wei, Y., Yang, X., Lei, L., Chen, L., Wu, Y., & Gou, Z. (2021) · Regenerative Biomaterials · doi:10.1093/rb/rbab007 · Cited by 25 · see citing works
Progress in microsphere-based scaffolds in bone/cartilage tissue engineering
Pan, Q., Su, W., & Yao, Y. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acfd78 · Cited by 25 · see citing works
Bone Morphogenic Protein 2-Loaded Porous Silicon Carriers for Osteoinductive Implants
Rosenberg, M., Shilo, D., Galperin, L., Capucha, T., Tarabieh, K., Rachmiel, A., & Segal, E. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11110602 · Cited by 25 · see citing works
Pereira, A. R., Lipphaus, A., Ergin, M., Salehi, S., Gehweiler, D., Rudert, M., Hansmann, J., & Herrmann, M. (2021) · Materials · doi:10.3390/ma14164431 · Cited by 25 · see citing works
Pei, B., Hu, M., Wu, X., Lu, D.-Y., Zhang, S., Zhang, L., & Wu, S. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1230682 · Cited by 24 · see citing works
Khodabandeh, A., Yousefi, A. A., Jafarzadeh-Holagh, S., & Vasheghani‐Farahani, E. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.214053 · Cited by 22 · see citing works
D’Andrea, L., Gabrieli, R., Milano, L., Magagnin, L., Cet, A. D., Alidoost, D., Schwentenwein, M., Verné, E., Baino, F., & Vena, P. (2025) · Acta Materialia · doi:10.1016/j.actamat.2025.120776 · Cited by 20 · see citing works
Silver Decorated βTCP-Poly(3hydroxybutyrate) Scaffolds for Bone Tissue Engineering
Czechowska, J. P., Skibiński, S., Guzik, M. W., & Zima, A. (2021) · Materials · doi:10.3390/ma14154227 · Cited by 19 · see citing works
Liu, Z., Tian, G., Liu, L., Li, Y., Xu, S., Du, Y., Li, M., Wei, J., Wei, P., Zhao, B., et al. (2024) · Journal of Materials Research and Technology · doi:10.1016/j.jmrt.2024.04.253 · Cited by 19 · see citing works
Luo, Y., & Kim, J.-H. (2024) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2024.2304709 · Cited by 17 · see citing works
Effect of different dopants on porous calcium silicate composite bone scaffolds by 3D gel-printing
Zhang, Z., Lin, T., Shao, H., Peng, J. C., Wang, Y., Zhang, Y., Yu, X., Liu, S., Wang, L., & Zhao, M. (2019) · Ceramics International · doi:10.1016/j.ceramint.2019.08.266 · Cited by 17 · see citing works
Engineered magnetoactive collagen hydrogels with tunable and predictable mechanical response
Karagiorgis, S., Tsamis, A., Voutouri, C., Turcu, R. P., Porav, A. S., Socoliuc, V., Vékás, L., Louca, M., Stylianopoulos, T., Vavourakis, V., et al. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111089 · Cited by 15 · see citing works
Three-Dimensional Impression of Biomaterials for Alveolar Graft: Scoping Review
Francisco, I., Basílio, Â., Ribeiro, M. P., Nunes, C., Travassos, R., Marques, F., Pereira, F. P., Paula, A. B., Carrilho, E., Marto, C. M., et al. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14020076 · Cited by 14 · see citing works
Animut, T. Y., Ningsih, H. S., Shih, H.-H., Wu, M., & Shih, S. (2023) · Ceramics · doi:10.3390/ceramics6010033 · Cited by 14 · see citing works
Osteogenesis Improvement of Gelatin-Based Nanocomposite Scaffold by Loading Zoledronic Acid
Abdulahy, S. B., Esmaeili Bidhendi, M., Vaezi, M. R., & Moosazadeh Moghaddam, M. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.890583 · Cited by 13 · see citing works
Direct Integration of 3D Printing and Cryogel Scaffolds for Bone Tissue Engineering
Olevsky, L. M., Anup, A., Jacques, M., Keokominh, N., Holmgren, E. P., & Hixon, K. R. (2023) · Bioengineering · doi:10.3390/bioengineering10080889 · Cited by 13 · see citing works
Ke, D., Yu, J., Liu, P., Niu, C., & Yang, X. (2022) · Materialia · doi:10.1016/j.mtla.2022.101339 · Cited by 13 · see citing works
Baek, J. W., Park, H., Kim, K.-S., Chun, S., & Kim, B. (2022) · Materials · doi:10.3390/ma15103413 · Cited by 12 · see citing works
Ebrahim, N. A. A., & Soliman, S. M. A. (2025) · Biomedical Materials & Devices · doi:10.1007/s44174-025-00317-1 · Cited by 11 · see citing works
Collagen-based biomaterials for tissue engineering applications
Amirthalingam, S., & Hwang, N. S.-Y. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-98827-8.00025-4 · Cited by 11 · see citing works
Wang, L., Wu, T., Hu, X., Liu, J., Wu, D., Miguez, P. A., Wright, J. T., Zhang, S., Chi, J., Tseng, H. C., et al. (2021) · Biomaterials Science · doi:10.1039/d1bm01119g · Cited by 11 · see citing works
Self-citationLiu, Q., Zhang, Y., Yu, S., Zhao, C., Wang, Y., Yan, J., Wang, Y., Liu, D., Liu, Y., & Zhang, X. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114290 · Cited by 10 · see citing works
Li, J., Zhong, H., Cao, B., Ran, Z., Tan, J., Deng, L., Hao, Y., & Yan, J. (2023) · Acta Metallurgica Sinica (English Letters) · doi:10.1007/s40195-023-01573-0 · Cited by 10 · see citing works
Skubis-Sikora, A., Hudecki, A., Sikora, B., Wieczorek, P., Hermyt, M., Hreczka, M., Likus, W., Markowski, J., Siemianowicz, K., Kolano-Burian, A., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12091949 · Cited by 9 · see citing works
Bóvári‐Biri, J., Miskei, J. A., Kövér, Z., Steinerbrunner‐Nagy, A., Kardos, K., Maróti, P., & Pongracz, J. E. (2025) · Cells · doi:10.3390/cells14020145 · Cited by 9 · see citing works
Wang, L., Lee, D. J., Han, H., Zhao, L., Tsukamoto, H., Kim, Y., Musicant, A. M., Parag‐Sharma, K., Hu, X., Tseng, H. C., et al. (2021) · Journal of Tissue Engineering · doi:10.1177/2041731421995465 · Cited by 9 · see citing works
Self-citationApplication of the ZIF‐8‐Based Composites in Bone Scaffolds
Tahamtan, M. S., Rafiee, Z., Oryan, A., & Vaez, A. (2025) · Advanced Engineering Materials · doi:10.1002/adem.202402749 · Cited by 7 · see citing works
Yazdanpanah, Z., Ketabat, F., Gómez‐Picos, P., Raquin, A., Anvari‐Yazdi, A. F., Eames, B. F., Johnston, J. D., Cooper, D. M. L., & Chen, D. (2023) · Nano Select · doi:10.1002/nano.202300048 · Cited by 6 · see citing works
The application of synthetic wollastonite in digital light processing 3D printing
Gineika, A., Baltakys, K., Navaruckienė, A., Ostrauskaitė, J., Skliutas, E., & Malinauskas, M. (2024) · Ceramics International · doi:10.1016/j.ceramint.2024.09.161 · Cited by 5 · see citing works
Nanomaterials in bone tissue engineering
Shanmugavadivu, A., Lavanya, K., & Selvamurugan, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95513-3.00013-7 · Cited by 5 · see citing works
Damerau, A., Buttgereit, F., & Gaber, T. (2022) · Processes · doi:10.3390/pr10030550 · Cited by 5 · see citing works
Namnabat, M., Tamjid, E., Najafi, P., & Bazazzadeh, E. (2025) · Scientific Reports · doi:10.1038/s41598-025-28284-z · Cited by 4 · see citing works
Takeda, S., Tsuchiya, A., Moriyama, M., & Ishikawa, K. (2024) · Ceramics International · doi:10.1016/j.ceramint.2024.10.203 · Cited by 4 · see citing works
[Advances in the Application of Hydroxyapatite Composite Materials in Bone Tissue Engineering].
Li, W., Ma, B., Shao, J., & Ge, S. (2021) · 四川大学学报:医学版 · doi:10.12182/20210560303 · Cited by 4 · see citing works
3D Printing for Craniofacial Bone Regeneration
Sarkar, N., Zhou, Y., & Grayson, W. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824552-1.00008-6 · Cited by 4 · see citing works
Zhou, Y., Hu, Y., Uemura, M., Xia, L., Yu, X., & Xu, Y. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.842530 · Cited by 4 · see citing works
Wang, S., Jia, Z., Dai, M., Feng, X., Tang, C., Liu, L., & Cao, L. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.131874 · Cited by 3 · see citing works
Naturally Derived a-Tricalcium Phosphate Based Porous Composite Bead Production
Aydın, G., Yıldırım, K., & Kalemtaş, A. (2019) · Material Science Research India · doi:10.13005/msri/160307 · Cited by 2 · see citing works
Butorina, N. N., Payushina, O. V., Шевелева, О. Н., Novokreshchenova, A. N., Domaratskaya, E. I., Istranov, L. P., & Istranova, E. V. (2020) · Bulletin of Experimental Biology and Medicine · doi:10.1007/s10517-020-04843-4 · Cited by 2 · see citing works
Ghim, M.-S., Jang, S.-J., Choi, E.-Y., Quan, M., Kim, Y., & Cho, Y. (2025) · Journal of Bionic Engineering · doi:10.1007/s42235-025-00758-w · Cited by 1 · see citing works
Self-citationTissue Engineering Application of Decellularized Bone for Cranial Defect Repair
Shin, H. W. (2020) · Global Journal of Orthopedics Research · doi:10.33552/gjor.2020.02.000536 · Cited by 1 · see citing works
Sabahi, N., Roohani, I., Kilian, K. A., Wang, C. H., & Li, X. (2026) · Biofabrication · doi:10.1088/1758-5090/ae8a85 · Cited by 1 · see citing works
Siddiqui, V. U., Sapuan, S. M., Khan, A., Shukri, M. U. B. M., Hisham, M. A. B. M., Ishak, M. A. B., & Zuhairi, U. H. B. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22414-0.00008-9 · Cited by 1 · see citing works
Abdelrahman, H., Yacout, Y. M., Hassan, D., Hassan, M. G., & Hassan, G. A. (2024) · Journal of the World Federation of Orthodontists · doi:10.1016/j.ejwf.2024.08.003 · Cited by 1 · see citing works
Form and Functionality of Additively Manufactured Parts with Internal Structure
Ahsan, A. N. (2019) · NDSU Repository (North Dakota State University)
The use of bone grafts in dental practice
de Matos, J. D. M., Diamantino, P. J. S., Nishioka, R. S., Bottıno, M. A., Lopes, G. D. R. S., & Andrade, V. C. (2019) · Revista Nacional de Odontología · doi:10.16925/2357-4607.2019.02.09
Possible application of glassy carbon composite scaffolds in bone tissue engineering
Timoshchuk, E. I., Ponomareva, D. V., & Gareev, A. R. (2025) · Genij Ortopedii · doi:10.18019/1028-4427-2025-31-1-28-41
Refined in vivo model for bone regeneration: insights into scaffold architecture and porosity
Marger, L., Freudenreich, M., Mekki, M., Manoil, D., Marger, F., Harane, S. E., Charbonnier, B., Charmet, J., Brembilla, N. C., Preynat‐Seauve, O., et al. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1725958
Eggshell-inspired scaffolds for tissue engineering
Chen, N., Kwan, J. C., & Tran, S. D. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-27438-1.00015-3
Li, Z., Shafiee, B., Qu, N., Chen, R., Xie, M., Wei, J., Grynpas, M. D., & Zou, Y. (2026) · ACS Applied Bio Materials · doi:10.1021/acsabm.6c00504
Porous scaffolds for vascularized bone regeneration: a review of recent advances
Liu, X., Xu, D., & Wang, C. (2026) · Biomedical Materials · doi:10.1088/1748-605x/ae8ee7
He, H., Chen, Z., Liu, H., Qiao, Z., Yang, S., Yang, H., Chen, X., Yang, Y., Wang, Z., & Li, Z. (2026) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2026.1957296
- Authors
- Lee, D. J., Kwon, J., Kim, Y., Wang, X., Wu, T., Lee, Y., Kim, S., Miguez, P., & Ko, C.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Oral and Craniofacial Health Sciences Research School of Dentistry University of North Carolina Chapel Hill North Carolina
- Corresponding author
- Ko, Ching‐Chang
- Venue
- Orthodontics & Craniofacial Research
- Publisher
- Wiley
- Published
- 2019-05
- Volume
- 22
- Issue
- S1
- Pages
- 127-133
- ISSN
- 1601-6335 (ISSN-L)
- 1601-6343
- PMC
- PMC6512819
- OpenAlex
- W2943906508
- Cited by
- 86
- References
- 12
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 15 · 2023: 13 · 2022: 15 · 2021: 14 · 2020: 9 · 2019: 6
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Orthodontics and Craniofacial Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R01DE022816)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- bone regeneration, scaffold pore size, polydopamine, hydroxyapatite, collagen, calcium silicate, nanocomposite scaffolds, critical-size bone defect, mesenchymal stem cells, new bone formation, osseointegration, scaffold mechanical strength
- MeSH terms
- Animals, Bone Regeneration, Calcium, Collagen, Indoles, Male, Polymers, Porosity, Rats, Sprague-Dawley, Calcium Compounds, Silicates, Durapatite, Tissue Engineering, Rats, Tissue Scaffolds, Printing, Three-Dimensional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review