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Cited by 114Oral microbiology and periodontitis researchRheumatoid Arthritis Research and TherapiesPeriodontal Regeneration and Treatments

Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients

Erciyas, K, Sezer, U, Üstün, K, Pehlivan, Y, Kısacık, B, Şenyurt, SZ, Tarakçıoğlu, M, Onat, AM·2013·Oral Diseases
DOI 10.1111/odi.12017
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Abstract

Objective: This observational prospective cohort study aimed to evaluate the effects of non‐surgical periodontal treatment on clinical periodontal measurements and systemic inflammatory mediator levels in low or moderate to highly active rheumatoid arthritis (RA) patients with chronic periodontitis. Subjects and methods: Rheumatoid arthritis activity was assessed with disease activity score test (DAS 28). Thirty patients with RA with moderate to high disease activity (DAS 28 ≥ 3.2) and chronic periodontitis (MHDA group) and thirty patients with RA with low disease activity (DAS 28 < 3.2) and chronic periodontitis (LDA group) were enrolled in the study. The patients were monitored at the beginning and 3 months after undergoing periodontal therapy. Erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), tumour necrosis factor‐alpha (TNF‐α) levels in serum, DAS 28 and periodontal parameters were evaluated. Results: Erythrocyte sedimentation rate, CRP, TNF‐α levels in serum, DAS 28 and periodontal parameters exhibited similar and significant reduction 3 months after the non‐surgical periodontal treatment. Conclusion: Non‐surgical periodontal treatment may prove beneficial in reducing RA severity as measured by ESR, CRP, TNF‐α levels in serum and DAS 28 in low or moderate to highly active RA patients with chronic periodontitis.

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  • Antibodies against P gingivalis virulence factors are elevated in patients with rheumatoid arthritis in a way that correlates with disease severity.

    “Antibodies against P gingivalis virulence factors are elevated in patients with rheumatoid arthritis in a way that correlates with disease severity.209, 210”

    From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [210]

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Authors
Erciyas, K., Sezer, U., Üstün, K., Pehlivan, Y., Kısacık, B., Şenyurt, S., Tarakçıoğlu, M., & Onat, A.
Affiliations
  • Department of Periodontology Faculty of Dentistry Gaziantep University Gaziantep Turkey
  • Gaziantep University (TR)
Corresponding author
Sezer, U
ORCID
Venue
Oral Diseases
Publisher
Wiley
Published
2012-09-24
Volume
19
Issue
4
Pages
394-400
ISSN
  • 1354-523X (ISSN-L)
  • 1601-0825
DOI
10.1111/odi.12017
OpenAlex
W2100415541
Cited by
114
References
45
Citations by year
2026: 6 · 2025: 3 · 2024: 4 · 2023: 11 · 2022: 9 · 2021: 10 · 2020: 5 · 2019: 12 · 2018: 10 · 2017: 6 · 2016: 14 · 2015: 9 · 2014: 7 · 2013: 8
FWCI
9.25
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Oral Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • Bursa Uludag University - AVESIS (submittedVersion)
Topics
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
Keywords
rheumatoid arthritis, chronic periodontitis, non-surgical periodontal therapy, systemic inflammation, TNF-α, C-reactive protein, erythrocyte sedimentation rate, DAS28, disease activity, periodontal parameters
MeSH terms
Adult, Arthritis, Rheumatoid, Blood Sedimentation, C-Reactive Protein, Female, Humans, Inflammation, Male, Middle Aged, Prospective Studies, Dental Scaling, Tumor Necrosis Factor-alpha, Cohort Studies, Statistics, Nonparametric, Inflammation Mediators, Chronic Periodontitis

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