Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions
Open accessAbstract
PURPOSE OF REVIEW: This review was conducted to focus on the recent clinical and translational research related to the associations between periodontal disease and rheumatoid arthritis. RECENT FINDINGS: There is a growing interest in the associations between oral health and autoimmune and inflammatory diseases. A number of epidemiologic studies have described associations between rheumatoid arthritis and periodontal disease. Recent clinical studies continue to support these reports, and are increasingly linked with biological assessments to better understand the nature of these relationships. A number of recent studies have evaluated the periopathogenic roles of Porphyromonas gingivalis, the oral microbiome, and mechanisms of site-specific and substrate-specific citrullination. These are helping to further elucidate the interactions between these two inflammatory disease processes. SUMMARY: Studies of clinical oral health parameters, the gingival microenvironment, autoantibodies and biomarkers, and rheumatoid arthritis disease activity measures are providing a better understanding of the potential mechanisms responsible for rheumatoid arthritis and periodontal disease associations. The cumulative results and ongoing studies have the promise to identify novel mechanisms and interventional strategies to improve patient outcomes for both conditions.
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Porphyromonas gingivalis expresses peptidyl arginine deaminase, which citrullinates gingival proteins and bacterial peptides, and also undergoes autocitrullination.
“Porphyromonas gingivalis also expresses peptidyl arginine deaminase, which citrullinates gingival proteins and bacterial peptides, and also undergoes autocitrullination.208”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [208]
When rheumatoid arthritis is treated, the oral microbiome is partially restored, and vice versa.
“When rheumatoid arthritis is treated, the oral microbiome is partially restored, and vice versa.207, 208”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [208]
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- Authors
- Bingham, C. O., & Moni, M.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Bingham, Clifton O.
- ORCID
- Bingham, Clifton O.
- Venue
- Current Opinion in Rheumatology
- Published
- 2013-05
- Volume
- 25
- Issue
- 3
- Pages
- 345-353
- ISSN
- 1040-8711 (ISSN-L)
- PMC
- PMC4495574
- OpenAlex
- W2055264417
- Cited by
- 174
- References
- 89
- Citations by year
- 2026: 17 · 2025: 9 · 2024: 17 · 2023: 20 · 2022: 9 · 2021: 21 · 2020: 19 · 2019: 9 · 2018: 11 · 2017: 13 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 3 · 2012: 1
- FWCI
- 1.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American College of Rheumatology Research and Education Foundation
- Arthritis Foundation
- Rheumatology Research Foundation
- Arthritis Center, Johns Hopkins University
- National Institute of Dental and Craniofacial Research (R03DE018094)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Keywords
- periodontal disease, rheumatoid arthritis, Porphyromonas gingivalis, oral microbiota, citrullination, autoantibodies, biomarkers, disease activity
- MeSH terms
- Animals, Arthritis, Experimental, Arthritis, Rheumatoid, Citrulline, Disease Models, Animal, Humans, Periodontal Diseases, Bacteroidaceae Infections, Porphyromonas gingivalis, Evidence-Based Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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