Cytokines during periodontal wound healing: potential application for new therapeutic approach
Abstract
Regeneration of periodontal tissues is one of the main goals of periodontal therapy. However, current treatment, including surgical approach, use of membrane to allow maturation of all periodontal tissues, or use of enamel matrix derivatives, presents limitations in their indications and outcomes leading to the development of new tissue engineering strategies. Several cytokines are considered as key molecules during periodontal destruction process. However, their role during each phase of periodontal wound healing remains unclear. Control and modulation of the inflammatory response and especially, release of cytokines or activation/inhibition in a time- and spatial-controlled manner may be a potential perspective for periodontal tissue engineering. The aim of this review was to summarize the specific role of several cytokines during periodontal wound healing and the potential therapeutic interest of inflammatory modulation for periodontal regeneration especially related to the expression sequence of cytokines.
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Medullasin activates the inflammatory response via modulating cytokines.
“The mediator medullasin activates the inflammatory response via modulating cytokines [31].”
From An Update on the Mechanisms of Phenytoin Induced Gingival Overgrowth (2019) · cites this paper as [31]
The immune system can be stimulated by phenytoin via induction of lymphoid overgrowth and cell-mediated immunological reaction via IL-1β, TNFα, IL-6, IL-8 and medullasin.
“The immune system could be stimulated by the drug phenytoin via mechanisms including the induction of lymphoid overgrowth and cell-mediated immunological reaction via interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNFα), IL-6 and IL-8 and also medullasin [ 31].”
From An Update on the Mechanisms of Phenytoin Induced Gingival Overgrowth (2019) · cites this paper as [31]
Cites
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792 · see citing works
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works
Inflammatory cells during wound repair: the good, the bad and the ugly
Martin, P., & Leibovich, S. J. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.09.002 · Cited by 1,340 · see citing works
Resolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996 · see citing works
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An Update on the Mechanisms of Phenytoin Induced Gingival Overgrowth
Farook, F. F., M. Nizam, M. N., & Alshammari, A. (2019) · The Open Dentistry Journal · doi:10.2174/1874210601913010430 · Cited by 18 · see citing works
“The immune system could be stimulated by the drug phenytoin via mechanisms including the induction of lymphoid overgrowth and cell-mediated immunological reaction via interleukin-1β (IL-1β) and tumor necrosis factor alpha (TNFα), IL-6 and IL-8 and also medullasin [31].”
Background
- Authors
- Morand, D., Davideau, J., Clauss, F., Jessel, N., Tenenbaum, H., & Huck, O.
- Affiliations
- INSERM (French National Institute of Health and Medical Research) UMR 1109 Osteoarticular and Dental Regenerative Nanomedicine Laboratory Faculté de Médecine de Strasbourg Fédération de Médecine Translationnelle de Strasbourg (FMTS) Strasbourg France
- Inserm (FR)
- Corresponding author
- Huck, O
- Venue
- Oral Diseases
- Publisher
- Wiley
- Published
- 2016-03-28
- Volume
- 23
- Issue
- 3
- Pages
- 300-311
- ISSN
- 1354-523X (ISSN-L)
- 1601-0825
- OpenAlex
- W2289153234
- Cited by
- 80
- References
- 4
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 3 · 2021: 10 · 2020: 11 · 2019: 14 · 2018: 13 · 2017: 4 · 2016: 1
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oral Diseases (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Keywords
- cytokines, periodontal healing, periodontal regeneration, periodontal tissue engineering, inflammation modulation, cytokine expression, periodontal tissue destruction, periodontal treatment
- MeSH terms
- Anti-Inflammatory Agents, Non-Steroidal, Anti-Bacterial Agents, Biological Products, Humans, Inflammation, Periodontium, Regeneration, Wound Healing, Cytokines, Guided Tissue Regeneration, Periodontal, Cell Proliferation
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