Severe childhood asthma and allergy to furry animals: refined assessment using molecular-based allergy diagnostics
Abstract
BACKGROUND: Allergy to cats and dogs and polysensitization towards these animals are associated with severe childhood asthma. Molecular-based allergy diagnostics offers new opportunities for improved characterization and has been suggested to be particularly useful in patients with polysensitization and/or severe asthma. The aim was to use extract- and molecular-based allergy diagnostics to compare patterns of IgE sensitization towards aeroallergens in children with problematic severe and controlled asthma. METHODS: Children with a positive ImmunoCAP towards any furry animal (cat, dog or horse) were recruited from a Nationwide Swedish study on severe childhood asthma. Severe (n = 37, age 13 years) and controlled (n = 28, age 14 years) asthmatics underwent assessment of allergic sensitization by ImmunoCap (kUA /l) and immunosolid-phase allergen chip (ISAC). In addition, Asthma Control Test, spirometry and a methacholine challenge were performed. RESULTS: Children with severe asthma had lower asthma control (p < 0.001) and FEV1 (p = 0.001) and more bronchial hyper-responsiveness (p = 0.008) in spite of high doses of inhaled steroids (≥800 μg budesonide). Children with severe asthma displayed higher levels of IgE antibodies towards cat (17 vs. 3.9, p = 0.027), dog (3.8 vs. 1.2, p = 0.012) and horse (7.4 vs. 0.7, p = 0.014). Sensitization towards Can f 2 (22% vs. 0%, p = 0.009) and Equ c 1 (51% vs. 25%, p = 0.03) was more common in severe asthma. IgE levels towards Equ c 1 correlated with asthma control (r = -0.41, p = 0.04). CONCLUSION: Children with severe allergic asthma had higher sIgE levels to cat, dog and horse. Molecular-based allergy diagnostics revealed a more complex molecular spreading of allergen components in children with the most severe disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
One factor strongly associated with severe asthma in children and adolescents is allergic sensitization.
“One factor strongly associated with severe asthma in children and adolescents is allergic sensitization (82–87).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [86]
Cites
GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION
PAUWELS, R. A. (1996) · Arerugī/Arerugi · doi:10.15036/arerugi.45.792 · Cited by 9,997 · see citing works
Asher, M. I., Montefort, S., Björkstén, B., Lai, C. K., Strachan, D. P., Weiland, S. K., & Williams, H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69283-0 · Cited by 4,223 · see citing works
(2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-710st · Cited by 3,203 · see citing works
Development of the asthma control test
Nathan, R. A., Sorkness, C. A., Kosinski, M., Schatz, M., Li, J. T., Marcus, P., Murray, J. J., & Pendergraft, T. B. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.008 · Cited by 2,906 · see citing works
Analysis of Dose-Response Curves to Methacholine: An Approach Suitable for Population Studies
O’Connor, G. T., Sparrow, D., Taylor, D., Segal, M. R., Weiss, S. T., & Eleuteri, D. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.6.1412 · Cited by 463 · see citing works
A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics
Canonica, G. W., Ansotegui, I. J., Pawankar, R., Schmid-Grendelmeier, P., van Hage, M., Baena-Cagnani, C. E., Melioli, G., Nunes, C., Passalacqua, G., Rosenwasser, L., et al. (2013) · World Allergy Organization Journal · doi:10.1186/1939-4551-6-17 · Cited by 432 · see citing works
Effect of Cat and Dog Ownership on Sensitization and Development of Asthma among Preteenage Children
Perzanowski, M. S., Rönmark, E., Platts‐Mills, T. A. E., & Lundbäck, B. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2201035 · Cited by 301 · see citing works
The functional development of the respiratory system from the period of gestation to adulthood.
Polgar, G., & Weng, T. R. (1979) · PubMed · doi:10.1164/arrd.1979.120.3.625 · Cited by 280 · see citing works
Hatzler, L., Panetta, V., Lau, S., Wagner, P., Bergmann, R. L., Illi, S., Bergmann, K. E., Keil, T. O. P., Dramburg, S., Rohrbach, A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.05.053 · Cited by 269 · see citing works
Major increase in allergic sensitization in schoolchildren from 1996 to 2006 in northern Sweden
Rönmark, E., Bjerg, A., Perzanowski, M. S., Platts‐Mills, T. A. E., & Lundbäck, B. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.011 · Cited by 189 · see citing works
Testing children for allergies: why, how, who and when
Eigenmann, P., Atanasković‐Marković, M., Hourihane, J. O., Lack, G., Lau, S., Matricardi, P. M., Muraro, A. M., Namazova-Baranova, L. S., Nieto, A., Papadopoulos, N. G., et al. (2013) · Pediatric Allergy and Immunology · doi:10.1111/pai.12066 · Cited by 129 · see citing works
Environmental assessment and exposure control: a practice parameter—furry animals
Portnoy, J. M., Kennedy, K., Sublett, J. L., Phipatanakul, W., Matsui, E., Barnes, C., Grimes, C., Miller, J. D., Seltzer, J. M., Williams, P. B., et al. (2012) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2012.02.015 · Cited by 123 · see citing works
de Jong, A. B., Dikkeschei, L. D., & Brand, P. L. P. (2010) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2010.00993.x · Cited by 117 · see citing works
Nilsson, O. B., Binnmyr, J., Zoltowska, A., Saarne, T., van Hage, M., & Grönlund, H. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02826.x · Cited by 112 · see citing works
Self-citationMelioli, G., Bonifazi, F., Bonini, S., Maggi, E., Mussap, M., Passalacqua, G., Rossi, E. R., Vacca, A., & Canonica, G. W. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2011.05.007 · Cited by 105 · see citing works
A further evaluation of the clinical use of specific IgE antibody testing in allergic diseases
Söderström, L., Köber, A., Ahlstedt, S., de Groot, H., Lange, C. ‐., Paganelli, R., Roovers, M. H. W. M., & Sastre, J. (2003) · Allergy · doi:10.1034/j.1398-9995.2003.00227.x · Cited by 104 · see citing works
Use of allergen components begins a new era in pediatric allergology
Borres, M. P., Ebisawa, M., & Eigenmann, P. (2011) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2011.01197.x · Cited by 98 · see citing works
Self-citationNordlund, B., Konradsen, J. R., Kull, I., Borres, M. P., Önell, A., Hedlin, G., & Grönlund, H. (2012) · Allergy · doi:10.1111/j.1398-9995.2012.02797.x · Cited by 91 · see citing works
Self-citationPatelis, A., Gunnbjörnsdóttir, M., Malinovschi, A., Matsson, P., Önell, A., Högman, M., Alving, K., & Janson, C. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.03.046 · Cited by 86 · see citing works
Grönlund, H., Adédoyin, J., Reininger, R., Varga, E. M., Zach, M., Fredriksson, M., Kronqvist, M., Szépfalusi, Z., Spitzauer, S., Grönneberg, R., et al. (2008) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2008.03003.x · Cited by 78 · see citing works
Self-citationWHO universal definition of severe asthma
Bush, A., & Zar, H. J. (2011) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0b013e32834487ae · Cited by 75 · see citing works
Mattsson, L.-Å., Lundgren, T., Olsson, P., Sundberg, M., & Lidholm, J. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03533.x · Cited by 75 · see citing works
Mammalian lipocalin allergens – insights into their enigmatic allergenicity
Virtanen, T. I., Kinnunen, T. T., & Rytkönen-Nissinen, M. A. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03903.x · Cited by 71 · see citing works
Konradsen, J. R., Nordlund, B., Lidegran, M. K., Pedroletti, C., Grönlund, H., van Hage, M., Dahlén, B., Hedlin, G., & In Cooperation with the Swedish network of Pediatric Allergists, S. A. N. (2010) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2010.01098.x · Cited by 53 · see citing works
Self-citationCoker, T. R., Elliott, M. N., Wallander, J. L., Cuccaro, P. M., Grunbaum, J. A., Corona, R., Saunders, A. E., & Schuster, M. A. (2011) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2011.13 · Cited by 35 · see citing works
Microarray evaluation of specific IgE to allergen components in elite athletes
Bonini, M., Marcomini, L., Gramiccioni, C., Tranquilli, C., Melioli, G., Canonica, G. W., Bonini, S., & on behalf of the ISAC Study Group (2012) · Allergy · doi:10.1111/all.12029 · Cited by 26 · see citing works
Exposure to Dog Allergens and Subsequent Allergic Sensitization: An Updated Review
Smallwood, J., & Ownby, D. (2012) · Current Allergy and Asthma Reports · doi:10.1007/s11882-012-0277-0 · Cited by 26 · see citing works
Exploring the temporal development of childhood IgE profiles to allergen components
Önell, A., Hjälle, L., & Borres, M. P. (2012) · Clinical and Translational Allergy · doi:10.1186/2045-7022-2-24 · Cited by 24 · see citing works
Self-citationIgE and IgG Binding Patterns and T-cell Recognition of Fel d 1 and Non–Fel d 1 Cat Allergens
Hales, B. J., Chai, L. Y., Hazell, L. A., Elliot, C. E., Stone, S. R., O’Neil, S., Smith, W.-A., & Thomas, W. R. (2013) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2013.08.008 · Cited by 22 · see citing works
Mammal‐Derived Respiratory Lipocalin Allergens do not Exhibit Dendritic Cell‐Activating Capacity
Parviainen, S., Kinnunen, T. T., Rytkönen-Nissinen, M. A., Nieminen, A., Liukko, A., & Virtanen, T. I. (2013) · Scandinavian Journal of Immunology · doi:10.1111/sji.12023 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Epidemiology of Asthma in Children and Adults
Dharmage, S. C., Perret, J. L., & Custovic, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00246 · Cited by 1,200 · see citing works
EAACI Molecular Allergology User's Guide
Matricardi, P. M., Kleine‐Tebbe, J., Hoffmann, H. J., Valenta, R., Hilger, C., Hofmaier, S., Aalberse, R. C., Agache, I., Asero, R., Ballmer‐Weber, B., et al. (2016) · Pediatric Allergy and Immunology · doi:10.1111/pai.12563 · Cited by 932 · see citing works
Asarnoj, A., Hamsten, C., Wadén, K., Lupinek, C., Andersson, N., Kull, I., Curin, M., Anto, J., Bousquet, J., Valenta, R., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.09.052 · Cited by 162 · see citing works
Del Giacco, S. R., Bakirtas, A., Bel, E., Custovic, A., Diamant, Z., Hamelmann, E., Heffler, E., Kalayci, Ö., Saglani, S., Sergejeva, S., et al. (2017) · Allergy · doi:10.1111/all.13072 · Cited by 130 · see citing works
Bonnet, B., Messaoudi, K., Jacomet, F., Michaud, E., Fauquert, J. L., Caillaud, D., & Evrard, B. (2018) · Allergy, Asthma & Clinical Immunology · doi:10.1186/s13223-018-0239-8 · Cited by 96 · see citing works
Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years
Simpson, A., Lazic, N., Belgrave, D. C. M., Johnson, P., Bishop, C., Mills, C., & Custovic, A. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.03.027 · Cited by 83 · see citing works
Satyaraj, E., Wedner, H. J., & Bousquet, J. (2019) · Allergy · doi:10.1111/all.14013 · Cited by 78 · see citing works
Clinical relevance of molecular diagnosis in pet allergy
Uriarte, S. A., & Sastre, J. (2016) · Allergy · doi:10.1111/all.12917 · Cited by 69 · see citing works
Caraballo, L., Valenta, R., Puerta, L., Pomés, A., Zakzuk, J., Fernandez-Caldas, E., Acevedo, N., Sanchez-Borges, M., Ansotegui, I., Zhang, L., et al. (2020) · World Allergy Organization Journal · doi:10.1016/j.waojou.2020.100118 · Cited by 68 · see citing works
Multiplex component‐based allergen microarray in recent clinical studies
Patelis, A., Borres, M. P., Kober, A., & Berthold, M. (2016) · Clinical & Experimental Allergy · doi:10.1111/cea.12761 · Cited by 49 · see citing works
Self-citationCharacterization of sensitization to furry animal allergen components in an adult population
Suzuki, S., Nwaru, B. I., Ekerljung, L., Sjölander, S., Mincheva, R., Rönmark, E. P., Rönmark, E., Lundbäck, B., Borres, M. P., & Lötvall, J. (2019) · Clinical & Experimental Allergy · doi:10.1111/cea.13355 · Cited by 45 · see citing works
Self-citationFurry animal allergen component sensitization and clinical outcomes in adult asthma and rhinitis
Nwaru, B. I., Suzuki, S., Ekerljung, L., Sjölander, S., Mincheva, R., Rönmark, E. P., Rådinger, M., Rönmark, E., Borres, M. P., Lundbäck, B., et al. (2019) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2018.12.018 · Cited by 45 · see citing works
Self-citationvan Hage, M., Käck, U., Asarnoj, A., & Konradsen, J. R. (2023) · Molecular Immunology · doi:10.1016/j.molimm.2023.03.003 · Cited by 40 · see citing works
Self-citation
- Authors
- Konradsen, J. R., Nordlund, B., Onell, A., Borres, M. P., Grönlund, H., & Hedlin, G.
- Affiliations
- Karolinska University Hospital (SE)
- Thermo Fisher Scientific Uppsala Sweden
- Uppsala University (SE)
- Karolinska Institutet (SE)
- Corresponding author
- Konradsen, Jon R.
- Venue
- Pediatric Allergy and Immunology
- Publisher
- Wiley
- Published
- 2014-01-27
- Volume
- 25
- Issue
- 2
- Pages
- 187-192
- ISSN
- 0905-6157 (ISSN-L)
- 1399-3038
- OpenAlex
- W2078120808
- Cited by
- 109
- References
- 30
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 9 · 2020: 8 · 2019: 8 · 2018: 11 · 2017: 8 · 2016: 9 · 2015: 12 · 2014: 3
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Allergy and Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Keywords
- cat allergen, dog allergen, horse allergens, polysensitization, IgE sensitization, asthma control, airway hyperresponsiveness, inhaled corticosteroids
- MeSH terms
- Adolescent, Age Factors, Allergens, Animals, Asthma, Cats, Child, Cross-Sectional Studies, Dogs, Female, Hair, Horses, Humans, Immunoglobulin E, Immunologic Tests, Lung, Male, Pollen, Predictive Value of Tests, Severity of Illness Index, Biomarkers, Case-Control Studies, Molecular Diagnostic Techniques, Pets
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
