The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Targeted molecular trait stacking in cotton through targeted double‐strand break induction
Open accessAbstract
Summary: Recent developments of tools for targeted genome modification have led to new concepts in how multiple traits can be combined. Targeted genome modification is based on the use of nucleases with tailor‐made specificities to introduce a DNA double‐strand break (DSB) at specific target loci. A re‐engineered meganuclease was designed for specific cleavage of an endogenous target sequence adjacent to a transgenic insect control locus in cotton. The combination of targeted DNA cleavage and homologous recombination–mediated repair made precise targeted insertion of additional trait genes (hppd, epsps) feasible in cotton. Targeted insertion events were recovered at a frequency of about 2% of the independently transformed embryogenic callus lines. We further demonstrated that all trait genes were inherited as a single genetic unit, which will simplify future multiple‐trait introgression.
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Cites
Efficient genome editing in zebrafish using a CRISPR-Cas system
Hwang, W. Y., Fu, Y., Reyon, D., Maeder, M. L., Tsai, S. Q., Sander, J. D., Peterson, R. T., Yeh, J.-R. J., & Joung, J. K. (2013) · Nature Biotechnology · doi:10.1038/nbt.2501 · Cited by 2,937
TAL effectors: customizable proteins for DNA targeting
Bogdanove, A. J., & Voytas, D. F. (2011) · Science · doi:10.1126/science.1204094 · Cited by 984
Chimeric nucleases stimulate gene targeting in human cells
Porteus, M. H., & Baltimore, D. (2003) · Science · doi:10.1126/science.1078395 · Cited by 741
Cited by
Svitashev, S., Young, J. K., Schwartz, C., Gao, H., Falco, S. C., & Cigan, A. M. (2015) · Plant Physiology · doi:10.1104/pp.15.00793 · Cited by 733
Belhaj, K., Chaparro-Garcia, A., Kamoun, S., & Nekrasov, V. (2013) · Plant Methods · doi:10.1186/1746-4811-9-39 · Cited by 585
Targeted genome modifications in soybean with CRISPR/Cas9
Jacobs, T. B., LaFayette, P. R., Schmitz, R. J., & Parrott, W. A. (2015) · BMC Biotechnology · doi:10.1186/s12896-015-0131-2 · Cited by 577
Schiml, S., Fauser, F., & Puchta, H. (2014) · The Plant Journal · doi:10.1111/tpj.12704 · Cited by 342
Hartung, F., & Schiemann, J. (2014) · The Plant Journal · doi:10.1111/tpj.12413 · Cited by 277
Metadata
- Authors
- D'Halluin, K., Vanderstraeten, C., Van Hulle, J., Rosolowska, J., Van Den Brande, I., Pennewaert, A., D'Hont, K., Bossut, M., Jantz, D., Ruiter, R., & Broadhvest, J.
- Venue
- Plant Biotechnology Journal
- Publisher
- Wiley
- Published
- 2013-06-18
- Volume
- 11
- Issue
- 8
- Pages
- 933-941
- ISSN
- 1467-7644 (ISSN-L)
- 1467-7652
- OpenAlex
- W2136457138
- Cited by
- 162
- References
- 3
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- D'Halluin, K., Vanderstraeten, C., Van Hulle, J., Rosolowska, J., Van Den Brande, I., Pennewaert, A., D'Hont, K., Bossut, M., Jantz, D., Ruiter, R., & Broadhvest, J. (2013). Targeted molecular trait stacking in cotton through targeted double‐strand break induction. Plant Biotechnology Journal. https://doi.org/10.1111/pbi.12085
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