The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR/Cas system
Open accessAbstract
Targeted genome engineering (also known as genome editing) has emerged as an alternative to classical plant breeding and transgenic (GMO) methods to improve crop plants. Until recently, available tools for introducing site-specific double strand DNA breaks were restricted to zinc finger nucleases (ZFNs) and TAL effector nucleases (TALENs). However, these technologies have not been widely adopted by the plant research community due to complicated design and laborious assembly of specific DNA binding proteins for each target gene. Recently, an easier method has emerged based on the bacterial type II CRISPR (clustered regularly interspaced short palindromic repeats)/Cas (CRISPR-associated) immune system. The CRISPR/Cas system allows targeted cleavage of genomic DNA guided by a customizable small noncoding RNA, resulting in gene modifications by both non-homologous end joining (NHEJ) and homology-directed repair (HDR) mechanisms. In this review we summarize and discuss recent applications of the CRISPR/Cas technology in plants.
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Cites
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
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Multiplex Genome Engineering Using CRISPR/Cas Systems
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RNA-Guided Human Genome Engineering via Cas9
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Efficient genome editing in zebrafish using a CRISPR-Cas system
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Cited by
A CRISPR/Cas9 toolkit for multiplex genome editing in plants
Xing, H.-L., Dong, L., Wang, Z.-P., Zhang, H.-Y., Han, C.-Y., Liu, B., Wang, X.-C., & Chen, Q.-J. (2014) · BMC Plant Biology · doi:10.1186/s12870-014-0327-y · Cited by 1,684
Engineering Quantitative Trait Variation for Crop Improvement by Genome Editing
Rodríguez-Leal, D., Lemmon, Z. H., Man, J., Bartlett, M. E., & Lippman, Z. B. (2017) · Cell · doi:10.1016/j.cell.2017.08.030 · Cited by 1,159
Development of broad virus resistance in non‐transgenic cucumber using CRISPR/Cas9 technology
Chandrasekaran, J., Brumin, M., Wolf, D., Leibman, D., Klap, C., Pearlsman, M., Sherman, A., Arazi, T., & Gal‐On, A. (2016) · Molecular Plant Pathology · doi:10.1111/mpp.12375 · Cited by 823
Major Impacts of Widespread Structural Variation on Gene Expression and Crop Improvement in Tomato
Alonge, M., Wang, X., Benoit, M., Soyk, S., Pereira, L., Zhang, L., Suresh, H., Ramakrishnan, S., Maumus, F., Ciren, D., et al. (2020) · Cell · doi:10.1016/j.cell.2020.05.021 · Cited by 819
Editing plant genomes with CRISPR/Cas9
Belhaj, K., Chaparro-Garcia, A., Kamoun, S., Patron, N. J., & Nekrasov, V. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.11.007 · Cited by 537
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Metadata
- Authors
- Belhaj, K., Chaparro-Garcia, A., Kamoun, S., & Nekrasov, V.
- Venue
- Plant Methods
- Published
- 2013-10-11
- Volume
- 9
- Issue
- 1
- Pages
- 39-39
- ISSN
- 1746-4811 (ISSN-L)
- OpenAlex
- W2163820831
- Cited by
- 585
- References
- 36
- FWCI
- 23.13
- Type
- journal article
- Language
- en
- Open access
- gold
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