TAL effectors: customizable proteins for DNA targeting

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

Hacein-Bey-Abina, S., Von Kalle, C., Schmidt, M., McCormack, M. P., Wulffraat, N., Leboulch, P., Lim, A., Osborne, C. S., Pawliuk, R., Morillon, E., et al. (2003) · Science · doi:10.1126/science.1088547 · Cited by 3,587 · see citing works

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

Boch, J., Scholze, H., Schornack, S., Landgraf, A., Hahn, S., Kay, S., Lahaye, T., Nickstadt, A., & Bonas, U. (2009) · Science · doi:10.1126/science.1178811 · Cited by 2,707 · see citing works

A One Pot, One Step, Precision Cloning Method with High Throughput Capability

Engler, C., Kandzia, R., & Marillonnet, S. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003647 · Cited by 2,398 · see citing works

A TALE nuclease architecture for efficient genome editing

Miller, J. C., Tan, S., Qiao, G., Barlow, K. A., Wang, J., Xia, D. F., Meng, X., Paschon, D. E., Leung, E., Hinkley, S. J., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1755 · Cited by 2,098 · see citing works

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

Čermák, T., Doyle, E., Christian, M. L., Wang, L., Zhang, Y., Schmidt, C. L., Baller, J. A., Somia, N. V., Bogdanove, A. J., & Voytas, D. F. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr218 · Cited by 2,034 · see citing works

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

Christian, M. L., Čermák, T., Doyle, E., Schmidt, C. L., Zhang, F., Hummel, A. W., Bogdanove, A. J., & Voytas, D. F. (2010) · Genetics · doi:10.1534/genetics.110.120717 · Cited by 2,033 · see citing works

A Simple Cipher Governs DNA Recognition by TAL Effectors

Moscou, M., & Bogdanove, A. J. (2009) · Science · doi:10.1126/science.1178817 · Cited by 1,992 · see citing works

Genetic engineering of human pluripotent cells using TALE nucleases

Hockemeyer, D. F., Wang, H., Kiani, S., Lai, C. S., Gao, Q., Cassady, J. P., Cost, G. J., Zhang, L., Santiago, Y., Miller, J. C., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1927 · Cited by 1,129 · see citing works

Genome Engineering With Zinc-Finger Nucleases

Carroll, D. (2011) · Genetics · doi:10.1534/genetics.111.131433 · Cited by 1,076 · see citing works

Golden Gate Shuffling: A One-Pot DNA Shuffling Method Based on Type IIs Restriction Enzymes

Engler, C., Gruetzner, R., Kandzia, R., & Marillonnet, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005553 · Cited by 1,028 · see citing works

<i>Xanthomonas</i> AvrBs3 Family-Type III Effectors: Discovery and Function

Boch, J., & Bonas, U. (2010) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080508-081936 · Cited by 978 · see citing works

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

Zhang, F., Cong, L., Lodato, S., Kosuri, S., Church, G. M., & Arlotta, P. (2011) · Nature Biotechnology · doi:10.1038/nbt.1775 · Cited by 771 · see citing works

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

Mussolino, C., Morbitzer, R., Lütge, F., Dannemann, N., Lahaye, T., & Cathomen, T. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr597 · Cited by 714 · see citing works

Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification

Maeder, M. L., Thibodeau-Beganny, S., Osiak, A., Wright, D. A., Anthony, R. M., Eichtinger, M., Jiang, T., Foley, J. E., Winfrey, R. J., Townsend, J. A., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.016 · Cited by 708 · see citing works

Targeted Genome Editing Across Species Using ZFNs and TALENs

Wood, A. J., Lo, T., Zeitler, B., Pickle, C. S., Ralston, E. J., Lee, A. H., Amora, R., Miller, J. C., Leung, E., Meng, X., et al. (2011) · Science · doi:10.1126/science.1207773 · Cited by 664 · see citing works

Heritable gene targeting in zebrafish using customized TALENs

Huang, P., Xiao, A., Zhou, M., Zhu, Z., Lin, S., & Zhang, B. (2011) · Nature Biotechnology · doi:10.1038/nbt.1939 · Cited by 658 · see citing works

Targeted gene disruption in somatic zebrafish cells using engineered TALENs

Sander, J. D., Cade, L., Khayter, C., Reyon, D., Peterson, R. T., Joung, J. K., & Yeh, J.-R. J. (2011) · Nature Biotechnology · doi:10.1038/nbt.1934 · Cited by 622 · see citing works

A Bacterial Effector Acts as a Plant Transcription Factor and Induces a Cell Size Regulator

Kay, S., Hahn, S., Marois, É., et al. (2007) · Science · doi:10.1126/science.1144956 · Cited by 594 · see citing works

Knockout rats generated by embryo microinjection of TALENs

Tesson, L., Usal, C., Ménoret, S., Leung, E., Niles, B. J., Remy, S., Santiago, Y., Vincent, A. I., Meng, X., Zhang, L., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1940 · Cited by 585 · see citing works

TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain

Li, T., Huang, S., Jiang, W. Z., Wright, D. A., Spalding, M. H., Weeks, D. P., & Yang, B. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq704 · Cited by 547 · see citing works

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

Sander, J. D., Dahlborg, E. J., Goodwin, M. J., Cade, L., Zhang, F., Cifuentes, D., Curtin, S. J., Blackburn, J. S., Thibodeau-Beganny, S., Qi, Y., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1542 · Cited by 518 · see citing works

Rice xa13 Recessive Resistance to Bacterial Blight Is Defeated by Induction of the Disease Susceptibility Gene Os- 11N3

Antony, G., Zhou, J., Huang, S., Li, T., Liu, B., White, F. F., & Yang, B. (2010) · The Plant Cell · doi:10.1105/tpc.110.078964 · Cited by 502 · see citing works

Plant Pathogen Recognition Mediated by Promoter Activation of the Pepper Bs3 Resistance Gene

Römer, P., Hahn, S., Jordan, T., et al. (2007) · Science · doi:10.1126/science.1144958 · Cited by 470 · see citing works

Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly

Kim, H. J., Lee, H. J., Kim, H., Cho, S. W., & Kim, J.-S. (2009) · Genome Research · doi:10.1101/gr.089417.108 · Cited by 466 · see citing works

TAL effectors: finding plant genes for disease and defense

Bogdanove, A. J., Schornack, S., & Lahaye, T. (2010) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2010.04.010 · Cited by 442 · see citing works

De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks

Mahfouz, M. M., Li, L., Shamimuzzaman, M., Wibowo, A. T., Fang, X., & Zhu, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019533108 · Cited by 417 · see citing works

Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

Li, T., Huang, S., Zhao, X., Wright, D. A., Carpenter, S. L., Spalding, M. H., Weeks, D. P., & Yang, B. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr188 · Cited by 414 · see citing works

Homing Endonucleases: From Microbial Genetic Invaders to Reagents for Targeted DNA Modification

Stoddard, B. L. (2011) · Structure · doi:10.1016/j.str.2010.12.003 · Cited by 346 · see citing works

Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors

Morbitzer, R., Römer, P., Boch, J., & Lahaye, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013133107 · Cited by 283 · see citing works

Promoter elements of rice susceptibility genes are bound and activated by specific TAL effectors from the bacterial blight pathogen, Xanthomonas oryzae pv. oryzae

Römer, P., Recht, S., Strauß, T., et al. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03217.x · Cited by 204 · see citing works

Assembly of custom TALE-type DNA binding domains by modular cloning

Morbitzer, R., Elsäesser, J., Hausner, J., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr151 · Cited by 186 · see citing works

Transcriptional Activators of Human Genes with Programmable DNA-Specificity

Geiβler, R., Scholze, H., Hahn, S., Streubel, J., Bonas, U., Behrens, S., & Boch, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019509 · Cited by 164 · see citing works

A single plant resistance gene promoter engineered to recognize multiple TAL effectors from disparate pathogens

Römer, P., Recht, S., & Lahaye, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908812106 · Cited by 157 · see citing works

Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity

Händel, E.-M., Alwin, S., & Cathomen, T. (2008) · Molecular Therapy · doi:10.1038/mt.2008.233 · Cited by 138 · see citing works

Improving immunity in crops: new tactics in an old game

Wulff, B. B. H., Horvath, D. M., & Ward, E. R. (2011) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2011.04.002 · Cited by 81 · see citing works

Designed transcription factors as tools for therapeutics and functional genomics

Urnov, F. D., & Rebar, E. J. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01150-4 · Cited by 38 · see citing works

One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495 · see citing works

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

Jiang, W., Bikard, D., Cox, D., Zhang, F., & Marraffini, L. A. (2013) · Nature Biotechnology · doi:10.1038/nbt.2508 · Cited by 2,429 · see citing works

RNA-programmed genome editing in human cells

Jinek, M., East, A., Cheng, A., Lin, S., Ma, E., & Doudna, J. (2013) · eLife · doi:10.7554/elife.00471 · Cited by 2,098 · see citing works

CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo

Moreno-Mateos, M. A., Vejnar, C. E., Beaudoin, J.-D., Fernandez, J. P., Mis, E. K., Khokha, M. K., & Giraldez, A. J. (2015) · Nature Methods · doi:10.1038/nmeth.3543 · Cited by 1,290 · see citing works

A CRISPR/Cas9 Toolbox for Multiplexed Plant Genome Editing and Transcriptional Regulation

Lowder, L. G., Zhang, D., Baltes, N. J., Paul, J. W., Tang, X., Zheng, X., Voytas, D. F., Hsieh, T.-F., Zhang, Y., & Qi, Y. (2015) · Plant Physiology · doi:10.1104/pp.15.00636 · Cited by 707 · see citing works

Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies

Poirot, L., Philip, B., Schiffer-Mannioui, C., Le Clerre, D., Chion-Sotinel, I., Derniame, S., Potrel, P., Bas, C., Lemaire, L., Galetto, R., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3321 · Cited by 605 · see citing works

CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery

Wang, H.-X., Li, M., Lee, C. M., Chakraborty, S., Kim, H.-W., Bao, G., & Leong, K. W. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00799 · Cited by 560 · see citing works

Epigenetic mechanisms in neurological disease

Jakovcevski, M., & Akbarian, S. (2012) · Nature Medicine · doi:10.1038/nm.2828 · Cited by 450 · see citing works

High-efficiency targeted editing of large viral genomes by RNA-guided nucleases

Bi, Y., Sun, L., Gao, D., Ding, C., Li, Z., Li, Y., Cun, W., & Li, Q. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004090 · Cited by 148 · see citing works

Evaluation of the mature grain phytase candidate HvPAPhy_a gene in barley (Hordeum vulgare L.) using CRISPR/Cas9 and TALENs

Holme, I. B., Wendt, T., Gil-Humanes, J., Deleuran, L. C., Starker, C. G., Voytas, D. F., & Brinch-Pedersen, H. (2017) · Plant Molecular Biology · doi:10.1007/s11103-017-0640-6 · Cited by 71 · see citing works

Towards a new era in medicine: therapeutic genome editing

Porteus, M. H. (2015) · Genome Biology · doi:10.1186/s13059-015-0859-y · Cited by 69 · see citing works

Genome Editing for the β-Hemoglobinopathies

Porteus, M. H. (2017) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-7299-9_8 · Cited by 8 · see citing works

Crucial Roles of Effectors in Interactions between Horticultural Crops and Pathogens

Liu, T., Chen, Y., Tian, S., et al. (2023) · Horticulturae · doi:10.3390/horticulturae9020250 · Cited by 9 · see citing works

20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades

Orth, K., Dixon, J. E., & Bliska, J. B. (2002) · Methods in microbiology · doi:10.1016/s0580-9517(02)31021-3

Prediction of effector proteins and their implications in pathogenicity of phytopathogenic filamentous fungi: A review

Wu, Y., Xie, L., Jiang, Y., & Li, T. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.02.133 · Cited by 35 · see citing works

Remote homology clustering identifies lowly conserved families of effector proteins in plant-pathogenic fungi

Jones, D., Moolhuijzen, P., & Hane, J. K. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000637 · Cited by 13 · see citing works

Microbial Pathogen Effectors in Plant Disease

Pelgrom, A. J. E., & den Ackerveken, G. F. J. M. V. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0023724 · Cited by 7 · see citing works