The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
PD ‐L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti‐ PD ‐1/ PD ‐ L 1 clinical trials
Abstract
Summary: This study evaluated the expression of PD ‐ L 1 in immunotherapy‐naïve metastatic melanoma patients to determine longitudinal intrapatient concordance and correlate PD ‐ L 1 status with clinicopathologic characteristics and outcome. PD ‐ L 1 expression was assessed by immunohistochemistry in 58 patients (43 primary tumors, 96 metastases). Seventy‐two percent of patients had at least one specimen expressing PD ‐ L 1 in ≥1% of tumor cells. Median positive tumor cell count overall was low (8% in nonzero specimens). PD ‐ L 1 expression was frequently discordant between primary tumors and metastases and between intrapatient metastases, such that 23/46 longitudinal patient specimens were discordant. PD ‐ L 1 was associated with higher TIL grade but not with other known prognostic features. There was a positive univariate association between PD ‐ L 1 expression in locoregional metastases and melanoma‐specific survival, but the effect was not observed for primary melanoma. In locoregional lymph node metastasis, PD ‐ L 1+/ TIL + patients had the best outcome, and PD ‐ L 1+/ TIL − patients had poor outcome.
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Cites
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Self-citationPrimary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
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The future of immune checkpoint therapy
Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878
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Self-citationLong, G. V., Dummer, R., Hamid, O., Gajewski, T. F., Caglevic, C., Dalle, S., Arance, A., Carlino, M. S., Grob, J.-J., Kim, T. M., et al. (2019) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30274-8 · Cited by 960
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Metadata
- Authors
- Madore, J., Vilain, R. E., Menzies, A. M., Kakavand, H., Wilmott, J. S., Hyman, J., Yearley, J. H., Kefford, R. F., Thompson, J. F., Long, G. V., Hersey, P., & Scolyer, R. A.
- Venue
- Pigment Cell & Melanoma Research
- Publisher
- Wiley
- Published
- 2014-12-22
- Volume
- 28
- Issue
- 3
- Pages
- 245-253
- ISSN
- 1755-1471 (ISSN-L)
- 1755-148X
- OpenAlex
- W2022465587
- Cited by
- 398
- References
- 22
- FWCI
- 16.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Madore, J., Vilain, R. E., Menzies, A. M., Kakavand, H., Wilmott, J. S., Hyman, J., Yearley, J. H., Kefford, R. F., Thompson, J. F., Long, G. V., Hersey, P., & Scolyer, R. A. (2015). PD ‐L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti‐ PD ‐1/ PD ‐ L 1 clinical trials. Pigment Cell & Melanoma Research. https://doi.org/10.1111/pcmr.12340
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
