Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, β‐carotene, and L actobacillus johnsonii : results from a randomized, placebo‐controlled, double‐blinded study
Abstract
BACKGROUND: Polymorphic light eruption (PLE) is the most common photodermatosis. Little is known about the efficacy of systemic photoprotection provided by nutritional supplements in PLE patients. PURPOSE: The purpose of this study was to assess efficacy of nutritional supplement containing lycopene, β-carotene, and Lactobacillus johnsonii to diminish skin lesions induced by 'photoprovocation' testing in PLE patients. METHODS: In this randomized, placebo-controlled, double-blinded study, 60 PLE patients were supplemented with the nutritional supplement or placebo. For inducing skin lesions, patient skin was exposed to single daily doses of 100 J/cm2 ultraviolet A1 (UVA1) for two consecutive days. Skin lesions were evaluated using a PLE score. Skin biopsies were taken before and after supplementation from unexposed and exposed skin, and intercellular adhesion molecule 1 (ICAM-1) mRNA expression was assessed by real-time polymerase chain reaction. RESULTS: Prior to supplementation, skin lesions were induced in all patients with comparable PLE scores. After 12 weeks, intake of the supplement significantly reduced the PLE score after one exposure as compared with patients taking placebo (P<0.001). After two exposures, these differences were no longer significant. At a molecular level, the development of skin lesions was associated with an increased expression of ICAM-1 mRNA, which was significantly reduced after supplementation (P=0.022), but not with placebo. CONCLUSION: The nutritional supplement provides protection against the development of UVA-induced PLE lesions at clinical and molecular levels.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Oral administration of a nutritional supplement containing lycopene, beta-carotene, and Lactobacillus johnsonii prevents skin damage from polymorphic light eruption.
“Oral administration of a nutritional supplement containing lycopene, β-carotene, and Lactobacillus johnsonii prevents skin damage from polymorphic light eruption.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [101]
In a 12-week randomized placebo-controlled double-blinded study, intake of a supplement containing lycopene, beta-carotene, and Lactobacillus johnsonii significantly reduced the polymorphic light eruption score after UVA exposure compared with placebo.
“In a 12-week, randomized, placebo-controlled, double-blinded study, intake of the supplement significantly reduced the polymorphic light eruption score after UVA exposure as compared with patients taking a placebo.”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [101]
Development of skin lesions in polymorphic light eruption was associated with increased expression of intercellular adhesion molecule 1 mRNA.
“At a molecular level, the development of skin lesions was associated with increased expression of intercellular adhesion molecule 1 mRNA [101].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [101]
Cites
Fitzpatrick’s Dermatology in General Medicine
Dunnick, C. A. (2008) · JAMA · doi:10.1001/jama.299.10.1195-b · Cited by 1,164 · see citing works
Hölzle, E., Plewig, G., Hofmann, C., & Roser-Maass, E. (1982) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(82)80018-2 · Cited by 159 · see citing works
Protection from Sunburn with β‐Carotene—A Meta‐analysis<sup>†</sup>
Köpcke, W., & Krutmann, J. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00253.x · Cited by 137 · see citing works
Self-citationBouilly-Gauthier, D., Jeannes, C., Maubert, Y., Duteil, L., Queille‐Roussel, C., Piccardi, N., Montastier, C., Manissier, P., Piérard, G. E., & Ortonne, J. ‐. (2010) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.09888.x · Cited by 113 · see citing works
Self-citationGuéniche, A., Benyacoub, J., Buetler, T. M., Smola, H., & Blum, S. (2006) · PubMed · Cited by 87 · see citing works
Krutmann, J., & Humbert, P. G. (2010) · Springer eBooks · doi:10.1007/978-3-642-12264-4 · Cited by 81 · see citing works
Self-citationNavarro, J., Dezutter‐Dambuyant, C., Buetler, T. M., Leclaire, J., Smola, H., Blum, S., Bastien, P., Breton, L., & Guéniche, A. (2008) · PubMed · doi:10.1684/ejd.2008.0496 · Cited by 78 · see citing works
Tanew, A., Radaković, S., González, S., Venturini, M., & Calzavara‐Pinton, P. (2011) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2010.09.773 · Cited by 78 · see citing works
Gruber‐Wackernagel, A., Bambach, I., Legat, F. J., et al. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2011.10333.x · Cited by 63 · see citing works
Marionnet, C., Grether‐Beck, S., Seité, S., Marini, A., Jaenicke, T., Lejeune, F., Bastien, P., Rougier, A., Bernerd, F., & Krutmann, J. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01265.x · Cited by 48 · see citing works
Self-citationHadshiew, I., Treder-Conrad, C., Bülow, R. V., Klette, E., Mann, T., Stäb, F., Moll, I., & Rippke, F. (2004) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2004.00103.x · Cited by 31 · see citing works
A simple method to assess severity of polymorphic light eruption
Palmer, R. A., Pas, C. B. V. D., Campalani, E., et al. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.06100.x · Cited by 25 · see citing works
Bayer, M., Proksch, P., Felsner, I., et al. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01350.x · Cited by 24 · see citing works
A Protective Effect of Glutathione-S-Transferase GSTP1*Val105 against Polymorphic Light Eruption
Millard, T. P., Fryer, A. A., & McGregor, J. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.14 · Cited by 24 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Grether-Beck, S., Marini, A., Jaenicke, T., Stahl, W., & Krutmann, J. (2017) · British Journal of Dermatology · doi:10.1111/bjd.15080 · Cited by 166 · see citing works
Self-citationBoosting the Photoaged Skin: The Potential Role of Dietary Components
Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116 · see citing works
Do We Utilize Our Knowledge of the Skin Protective Effects of Carotenoids Enough?
Balić, A., & Mokos, M. (2019) · Antioxidants · doi:10.3390/antiox8080259 · Cited by 104 · see citing works
- Authors
- Marini, A., Jaenicke, T., Grether‐Beck, S., Le Floc'h, C., Cheniti, A., Piccardi, N., & Krutmann, J.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Laboratoires Inneov R& D Asnières sur Seine France
- Corresponding author
- Krutmann, Jean
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 2014-01-02
- Volume
- 30
- Issue
- 4
- Pages
- 189-194
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W1527804378
- Cited by
- 36
- References
- 14
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 2 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 4 · 2015: 1 · 2014: 1
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- polymorphous light eruption, photoprotection, dietary supplements, lycopene, beta-carotene, Lactobacillus johnsonii, ICAM-1 mRNA expression, photodermatosis, oral supplementation
- MeSH terms
- Lycopene, Administration, Oral, Adolescent, Adult, Carotenoids, Double-Blind Method, Female, Humans, Lactobacillus, Male, Middle Aged, Photosensitivity Disorders, Radiation-Protective Agents, Skin, Ultraviolet Rays, Vitamins, Intercellular Adhesion Molecule-1, beta Carotene, Dietary Supplements
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
