Allergic contact dermatitis to topical prodrugs used in photodynamic therapy
Open accessAbstract
Topical photodynamic therapy (PDT) is a well-established treatment for actinic keratosis, Bowen's disease and superficial basal cell carcinoma and its use has also been explored for a variety of other indications.(1,2,3) Treatment involves application of a pro-drug (either 5-aminolaevulinic acid (ALA) or its methlyester, methylaminolevulinate (MAL)) which is preferentially taken up by dysplastic or neoplastic cells and converted into the active photosensitiser protoporphyrin IX (PPIX). Subsequent activation of PPIX by red light results in the production of cytotoxic oxygen species, inflammation and relatively selective diseased tissue destruction. This article is protected by copyright. All rights reserved.
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Guidelines for topical photodynamic therapy: update
Morton, C. A., McKenna, K. E., & Rhodes, L. E. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08882.x · Cited by 469 · see citing works
Morton, C. A., Szeimies, R. ‐., Sidoroff, A., & Braathen, L. R. (2013) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12031 · Cited by 344 · see citing works
Morton, C. A., Szeimies, R. M., Sidoroff, A., & Braathen, L. R. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.12026 · Cited by 112 · see citing works
Wulf, H. C., & Philipsen, P. A. (2004) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2004.05723.x · Cited by 65 · see citing works
Allergic contact dermatitis to methyl aminolevulinate (Metvix®) cream used in photodynamic therapy
Harries, M. J., Street, G., Gilmour, E. R., et al. (2007) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/j.1600-0781.2007.00270.x · Cited by 39 · see citing works
Allergic reactions to Metvix® (ALA‐ME)
Jungersted, J. M., Dam, T. N., Bryld, L. E., et al. (2008) · Contact Dermatitis · doi:10.1111/j.1600-0536.2007.01241.x · Cited by 14 · see citing works
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Photodynamic Therapy for Non-Melanoma Skin Cancers
Cohen, D., & Lee, P. (2016) · Cancers · doi:10.3390/cancers8100090 · Cited by 128 · see citing works
- Authors
- Cordey, H., & Ibbotson, S.
- Affiliations
- University of Dundee (GB)
- Corresponding author
- Cordey, Helen
- ORCID
- Ibbotson, Sally
- Venue
- Photodermatology, Photoimmunology & Photomedicine
- Publisher
- Wiley
- Published
- 2016-08-15
- Volume
- 32
- Issue
- 5-6
- Pages
- 320-322
- ISSN
- 0905-4383 (ISSN-L)
- 1600-0781
- OpenAlex
- W2475196167
- Cited by
- 6
- References
- 6
- Citations by year
- 2025: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Photodermatology Photoimmunology & Photomedicine (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- allergic contact dermatitis, topical photodynamic therapy, prodrugs, 5-aminolevulinic acid, methyl aminolevulinate, protoporphyrin IX, photosensitizers, actinic keratosis, Bowen's disease, superficial basal cell carcinoma
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