European guidelines for topical photodynamic therapy part 1: treatment delivery and current indications – actinic keratoses, Bowen’s disease, basal cell carcinoma
Open accessAbstract
Topical photodynamic therapy (PDT) is a widely used non‐invasive treatment for certain non‐melanoma skin cancers, permitting treatment of large and multiple lesions with excellent cosmesis. High efficacy is demonstrated for PDT using standardized protocols in non‐hyperkeratotic actinic keratoses, Bowen’s disease, superficial basal cell carcinomas (BCC) and in certain thin nodular BCC, with superiority of cosmetic outcome over conventional therapies. Recurrence rates following PDT are typically equivalent to existing therapies, although higher than surgery for nodular BCC. PDT is not recommended for invasive squamous cell carcinoma. Treatment is generally well tolerated, but tingling discomfort or pain is common during PDT. New studies identify patients most likely to experience discomfort and permit earlier adoption of pain‐minimization strategies. Reduced discomfort has been observed with novel protocols including shorter photosensitizer application times and in daylight PDT for actinic keratoses.
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ALA and MAL are absorbed into the skin becoming converted to protoporphyrin IX with a major absorption peak in the blue light spectrum (410 to 420 nm).
“Both are absorbed into the skin becoming converted to protoporphyrin IX with a major absorption peak in the blue light spectrum (410 to 420 nm).61,110”
From Effect of skin color on optical properties and the implications for medical optical technologies: a review (2024) · cites this paper as [110]
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Photodynamic therapy in a series of rosacea patients
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Clinical development and potential of photothermal and photodynamic therapies for cancer
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Allergic contact dermatitis to topical prodrugs used in photodynamic therapy
Cordey, H., & Ibbotson, S. (2016) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/phpp.12252 · Cited by 6 · see citing works
- Authors
- Morton, C. A., Szeimies, R. ‐., Sidoroff, A., & Braathen, L. R.
- Affiliations
- Klinikum Vest (DE)
- Innsbruck Medical University (AT)
- Corresponding author
- Morton, C.A.
- Venue
- Journal of the European Academy of Dermatology and Venereology
- Publisher
- Wiley
- Published
- 2012-11-26
- Volume
- 27
- Issue
- 5
- Pages
- 536-544
- ISSN
- 0926-9959 (ISSN-L)
- 1468-3083
- OpenAlex
- W1955184527
- Cited by
- 344
- References
- 182
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 20 · 2023: 19 · 2022: 20 · 2021: 16 · 2020: 20 · 2019: 26 · 2018: 53 · 2017: 38 · 2016: 33 · 2015: 43 · 2014: 34 · 2013: 8 · 2012: 1
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of the European Academy of Dermatology and Venereology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Keywords
- topical photodynamic therapy, actinic keratosis, Bowen's disease, basal cell carcinoma, superficial basal cell carcinoma, nodular basal cell carcinoma, non-melanoma skin cancer, photosensitizers, cosmetic outcome, recurrence
- MeSH terms
- Administration, Topical, Bowen's Disease, Basal Cell Carcinoma, Europe, Fluorescence, Humans, Photochemotherapy, Skin Neoplasms, Photosensitizing Agents, Practice Guidelines as Topic, Keratosis, Actinic
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