Cited by 344Nonmelanoma Skin Cancer StudiesPhotodynamic Therapy Research StudiesSkin Protection and Aging

European guidelines for topical photodynamic therapy part 1: treatment delivery and current indications – actinic keratoses, Bowen’s disease, basal cell carcinoma

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Morton, C.A., Szeimies, R.‐M., Sidoroff, A., Braathen, L.R.·2013·Journal of the European Academy of Dermatology and Venereology

Abstract

Topical photodynamic therapy (PDT) is a widely used non‐invasive treatment for certain non‐melanoma skin cancers, permitting treatment of large and multiple lesions with excellent cosmesis. High efficacy is demonstrated for PDT using standardized protocols in non‐hyperkeratotic actinic keratoses, Bowen’s disease, superficial basal cell carcinomas (BCC) and in certain thin nodular BCC, with superiority of cosmetic outcome over conventional therapies. Recurrence rates following PDT are typically equivalent to existing therapies, although higher than surgery for nodular BCC. PDT is not recommended for invasive squamous cell carcinoma. Treatment is generally well tolerated, but tingling discomfort or pain is common during PDT. New studies identify patients most likely to experience discomfort and permit earlier adoption of pain‐minimization strategies. Reduced discomfort has been observed with novel protocols including shorter photosensitizer application times and in daylight PDT for actinic keratoses.

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Crossref · 10.1111/jdv.12031

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Authors
Morton, C. A., Szeimies, R. ‐., Sidoroff, A., & Braathen, L. R.
Affiliations
  • Klinikum Vest (DE)
  • Innsbruck Medical University (AT)
Corresponding author
Morton, C.A.
Venue
Journal of the European Academy of Dermatology and Venereology
Publisher
Wiley
Published
2012-11-26
Volume
27
Issue
5
Pages
536-544
ISSN
  • 0926-9959 (ISSN-L)
  • 1468-3083
OpenAlex
W1955184527
Cited by
344
References
182
Citations by year
2026: 5 · 2025: 8 · 2024: 20 · 2023: 19 · 2022: 20 · 2021: 16 · 2020: 20 · 2019: 26 · 2018: 53 · 2017: 38 · 2016: 33 · 2015: 43 · 2014: 34 · 2013: 8 · 2012: 1
FWCI
3.43
Type
journal article
Language
en
Open access
Locations
  • Journal of the European Academy of Dermatology and Venereology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
topical photodynamic therapy, actinic keratosis, Bowen's disease, basal cell carcinoma, superficial basal cell carcinoma, nodular basal cell carcinoma, non-melanoma skin cancer, photosensitizers, cosmetic outcome, recurrence
MeSH terms
Administration, Topical, Bowen's Disease, Basal Cell Carcinoma, Europe, Fluorescence, Humans, Photochemotherapy, Skin Neoplasms, Photosensitizing Agents, Practice Guidelines as Topic, Keratosis, Actinic

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