Vitamin C supplementation to optimize growth, health and stress resistance in aquatic animals

Abstract

Vitamins are organic compounds that can be synthesized from other essential nutrients; however, they are required in trace amounts from an exogenous source for normal growth, reproduction and health. Vitamin C (ascorbic acid, AA) is an essential micronutrient for normal growth and physiological function of most aquatic animals. In terrestrial animal nutrition, vitamin C has recently spurred scientific interest because of the increasing knowledge on vitamin C involvement in gene expression, cell cycle and reproduction in mammals; in addition, recent advances in molecular biology techniques allow the more effective estimation of the effect of vitamin C on metabolism and physiology. In contrast, this information is scarce in aquatic animal nutrition, as studies have essentially focused on the estimation of minimum vitamin C requirement for maximum growth and immune response as well as for the formulation of least‐cost diet. This scarcity of information is also due to the lack of well‐established indicators of vitamin C status in aquatic organisms. The present review summarizes and discusses information about vitamin C sources, bioavailability, deficiency and requirement in aquatic animals to plan further studies. In the future, vitamin C nutrition studies in aquaculture should also include immune responses, histopathology of the gills, liver, gonad development, gamete quality and quantity, fecundity, larvae survival and gene expression. Dietary vitamin C requirements should be estimated at every life‐history stage of cultured species. All this information will allow a better understanding of the essentiality of vitamin C in aquatic animal growth, development, reproduction and health.